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Tumor Immunity Following Adenovirus Mediated Herpes Simplex Thymidine Kinase Gene Transfer To Experimental Rat Gliomas, Maulik Raj Shah
Tumor Immunity Following Adenovirus Mediated Herpes Simplex Thymidine Kinase Gene Transfer To Experimental Rat Gliomas, Maulik Raj Shah
Theses and Dissertations
Previous studies have determined adenovirus mediated herpes simplex thymidine kinase gene transfer (AV-TK) to be effective for the treatment of experimental gliomas. In this study we report three distinct phenomenon. First, animals with complete regression of subcutaneous tumors upon intratumoral injections of AV-TK with concomitant Ganciclovir® (GCV) administration developed tumor immunity. These animals had the ability to reject a subsequent inoculum of lethal doses of tumor cells. This tumor immunity was long standing and protective as far as 6 months from the time of initial tumor ablation. Of interest, adoptive transfer of splenocytes from AV-TK treated-tumor ablated animals to naive …