Anatomy Commons^™

Immunomodulators In Senescent Mice, Kevin R. Mccormick

Theses and Dissertations

The suppression of the immune response in senescent animals, including humans, is not complete and may be ameliorated by specific interventions. Previous studies have suggested that the replacement of thymus factors lost with age may rejuvenate senescent immune function. Similarly, exogenous growth hormone has been reported to improve senescent immune function in certain mammals. Other studies with the immunomodulator PSK claim to restore tumor-induced immunosuppression even in aged mice. This project investigated the abilities of thymus supernatant, ovine growth hormone, and PSK to rejuvenate different

parameters of the senescent immune response.

In the first series of experiments, erythroid depleted bone …