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Investigation Of A Factor Released By Neoplastic Cells Which Produces A Chemokinetic Response In Activated Macrophages, Richard Durelle Lane
Investigation Of A Factor Released By Neoplastic Cells Which Produces A Chemokinetic Response In Activated Macrophages, Richard Durelle Lane
Theses and Dissertations
The increase in rate of random migration (chemokinesis) of C. parvum activated macrophages in media conditioned by Lewis Lung (LL) carcinoma cells was attributed to a trypsin sensitive, heat stable, high molecular weight factor released from the membrane of the tumor cells.
A capillary tube assay was developed to expediently monitor the chemokinetic activity of macrophages incubated in whole and fractionated media. The capillary tube assay was found to be capable of detecting both chemokinetic and chemotactic (directional movement) factors present in the test media. Statistical analysis revealed the capillary tube assay provided reproducible data both within and between experiments. …