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Full-Text Articles in Anatomy
The Relationship Between The Osteonal Cement Line And Bone Strength, Avery Kazuhiro Egerer
The Relationship Between The Osteonal Cement Line And Bone Strength, Avery Kazuhiro Egerer
Loma Linda University Electronic Theses, Dissertations & Projects
Bone includes many structural and chemical components which provide both flexibility and strength. One such structure is the cement line, a 1-5 μm-thin structure located primarily in compact bone. Past research has correlated the pathological condition of “shin splints” with the micro-damage of bone, which often follows cement lines. It has been suggested that cement lines have rather paradoxical properties. Upon fatigue fracture of bone, microcracks often travel along cement lines and become trapped. This trapping and subsequent dispersion of energy have been hypothesized to prevent a complete fracture from occurring, extending bone life. Cement lines have been implicated in …
Inducible Gene Expression In Cell Cultures And In Microencapsulated Cells, Yong Yu
Inducible Gene Expression In Cell Cultures And In Microencapsulated Cells, Yong Yu
Loma Linda University Electronic Theses, Dissertations & Projects
The mifepristone-regulated transcriptional activation system provides a means to exogenously control gene expression in transformed mammalian cells in a temporal and spatial fashion. Such a promoter activation system consists of three components: The first of these is a steroidal inducer drug, mifepristone. This drug binds to the second component, a chimeric transcription factor complex, consisting of the mutant human progesterone receptor fused to the yeast GAL4 DNA-binding domain and the Herpes simplex virus protein VP 16 activation domain. The third component is a synthetic promoter, consisting of a series of GAL4 recognition sequences upstream of the adenovirus major late E1B …