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Full-Text Articles in Analytical, Diagnostic and Therapeutic Techniques and Equipment
Synthesis And Evaluation Of Polysialic Acid-Polycaprolactone Based Micelles For Drug Delivery, Weston Ryan
Synthesis And Evaluation Of Polysialic Acid-Polycaprolactone Based Micelles For Drug Delivery, Weston Ryan
Honors Capstone Projects - All
The growing use and investigation of pharmaceuticals to treat disease has offered the field of drug delivery an opportunity to further improve upon the effects provided, as well as address therapeutic complications. An effective long-term treatment for rheumatoid arthritis (RA) has yet be developed, while many current treatments pose disadvantageous side effects due to undesirable reactions outside of the diseased tissue. Therefore, there is a need for an improved strategy for RA treatment. A previously developed drug carrier system based on polysialic acid (PSA) and polycaprolactone (PCL) micelles was shown to be effective for in vitro therapeutic use. The evaluated …
Development Of Polyhydroxyalkanoate Nanoparticles For Cancer Therapy, Philip Choiniere
Development Of Polyhydroxyalkanoate Nanoparticles For Cancer Therapy, Philip Choiniere
Honors Capstone Projects - All
Polyhydroxyalkanoates (PHAs), a class of biopolyesters produced and stored by bacteria, have garnered attention for a number of industrial and biomedical applications. The goal of the current study was to extend the use of PHAs to drug delivery for the treatment of cancer. As a first step, the cytotoxicity of poly(3- hydroxy-octanoate-co-10-undecanoate) (PHOU) towards the A549 lung carcinoma cell line was determined and nanoparticles were prepared via a single emulsion technique. Elution tests, whereby cells were grown in fluid extracts obtained from media incubated for 24 hours at 37°C with PHOU films, did not result in any significant changes in …
Fracture Toughness Of Irradiated Bone In A Murine Model, Lynda Marie Brady
Fracture Toughness Of Irradiated Bone In A Murine Model, Lynda Marie Brady
Honors Capstone Projects - All
Cancer is a prevalent and diverse disease affecting fourteen million people in the United Sates alone. While some cancers can be treated effectively with one-time operations such as surgery, other cancers require more persistent treatments, commonly chemotherapy and radiation. These latter two treatments can have extreme side-effects and long-term ramifications. One long-term side effect of radiation therapy is a higher incidence of insufficiency fractures in bones of the skeleton. The mechanism responsible for this apparent weakness in bone is not well understood. In order to quantify changes in ductility following radiation therapy, femora from mice treated with 20 Gy radiation …
Comparison Of Neutral Versus Extended Wrist Pushup For Patients With Wrist Injury, Emily Tucci
Comparison Of Neutral Versus Extended Wrist Pushup For Patients With Wrist Injury, Emily Tucci
Honors Capstone Projects - All
The scapholunate interosseous ligament (SLIL) is a crucial stabilizing structure of the wrist. Damage to this ligament often results from falling upon an outstretched hand, leading to carpal instability.1,2,3 Tears to the SLIL create a gap in the scapholunate joint and allow the scaphoid to flex and the lunate to extend, rather than moving with one another as they do in healthy physiologic motion.4,5 The SLIL is normally repaired following injury in order to decrease the risk of arthritis and pain.1,2,5,6,7 Patients will often begin rehabilitation exercises after SLIL repair in order to reduce recovery time.8,9 …
The Incidence Of Chagas Coinfections Amongst Acute Dengue Patients In Machala, Ecuador, Elizabeth A. Mcmahon
The Incidence Of Chagas Coinfections Amongst Acute Dengue Patients In Machala, Ecuador, Elizabeth A. Mcmahon
Honors Capstone Projects - All
Dengue fever is a febrile illness found throughout the tropics that, in severe cases, can be deadly. The most rapidly spreading of any mosquito-borne disease, dengue is re-emerging as an illness of great concern in Latin America and around the globe. The CDC estimates that as many as 400 million cases of dengue occur each year. The pathogenesis of dengue virus is complicated and acts through modulation of the host immune system. Dengue polarizes the immune system balance of T helper 1 (Th1) and T helper 2 (Th2) cells towards a Th1 inflammatory response. Parasitic infections have also been shown …