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Nanofluidity Of Fatty Acid Hydrocarbon Chains As Monitored By Benchtop Time-Domain Nuclear Magnetic Resonance, David P. Cistola
Nanofluidity Of Fatty Acid Hydrocarbon Chains As Monitored By Benchtop Time-Domain Nuclear Magnetic Resonance, David P. Cistola
David P Cistola
The functional properties of lipid-rich assemblies such as serum lipoproteins, cell membranes, and intracellular lipid droplets are modulated by the fluidity of the hydrocarbon chain environment. Existing methods for monitoring hydrocarbon chain fluidity include fluorescence, electron spin resonance, and nuclear magnetic resonance (NMR) spectroscopy; each possesses advantages and limitations. Here we introduce a new approach based on benchtop time-domain 1H NMR relaxometry (TD-NMR). Unlike conventional NMR spectroscopy, TD-NMR does not rely on the chemical shift resolution made possible by homogeneous, high-field magnets and Fourier transforms. Rather, it focuses on a multiexponential analysis of the time-decay signal. In this study, we …