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Analytical, Diagnostic and Therapeutic Techniques and Equipment Commons™
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Full-Text Articles in Analytical, Diagnostic and Therapeutic Techniques and Equipment
The Search For Novel Inhibitors Of The Mycobacterial Enoyl Reductase Inha, Esther Saul
The Search For Novel Inhibitors Of The Mycobacterial Enoyl Reductase Inha, Esther Saul
The Science Journal of the Lander College of Arts and Sciences
Isoniazid (INH), one of two first-line drugs used to treat tuberculosis (TB), has been shown to be a potent inhibitor of InhA, the mycobacterial enoyl reductase. However, the increasing resistance to INH makes it imperative to find alternative drugs that are as effective as the first-line drugs, yet active against INH-resistant strains. Since InhA has been validated as an excellent target of TB, there have been attempts to find novel inhibitors of InhA. Through rational drug design, a variety of high affinity InhA inhibitors were synthesized. Triclosan itself was observed to be a suboptimal inhibitor of InhA with a K …
Stem Cells As A Cure For Amyotrophic Lateral Sclerosis, Chaya K. Hirsch
Stem Cells As A Cure For Amyotrophic Lateral Sclerosis, Chaya K. Hirsch
The Science Journal of the Lander College of Arts and Sciences
Amyotrophic Lateral Sclerosis (ALS) is a fatal motor neuron disease which affects approximately 30,000 Americans at any given time (alsa.org, 2010). The etiology of this terminal disease unfortunately remains an unsolved mystery and has therefore severely limited the ability to find a cure. The use of stem cells to regenerate neurons has been vastly studied and have produced very promising results. However, its practicality as a cure or treatment for neurodegenerative diseases, such as ALS, is greatly compromised. Three different therapies involving stem cells were examined, Embryonic Stem Cells (ESC), induced pluripotent stem cells, (iPSC) and direct reprogramming of adult …
Biomarkers In Nsclc Epidermal Growth Factor Receptor Mutations, Suzanne Freidman
Biomarkers In Nsclc Epidermal Growth Factor Receptor Mutations, Suzanne Freidman
The Science Journal of the Lander College of Arts and Sciences
Lung Cancer is the most common global cause of cancer related deaths in men and women (Markus, Alain, 2013). As standard radiation and chemotherapy have proved ineffective, novel target therapies are in the midst of development. This review will analyze the success of the inhibitor drugs targeting the Epidermal Growth Factor Receptor (EGFR) mutation, commonly found amongst Lung Cancer patients. Numerous studies and reviews are utilized to determine the cause of the 10% success rate currently exhibited for these drugs. The L858R and E746-A750 point mutations and deletions respectively, were found prevalent in responsive patients as well as clinical-pathological features …
The Efficacy And Safety Of The Human Papillomavirus Vaccine, Gail Tessler
The Efficacy And Safety Of The Human Papillomavirus Vaccine, Gail Tessler
The Science Journal of the Lander College of Arts and Sciences
The HPV virus is said to be the cause of many infections, warts, and cancers. In addition to the fact that the treatment for HPV is not always successful, not every individual knows that s/he is infected and is very likely to infect his or her partner, too. This is one factor that explains why 14 million people each year in America alone contract HPV and makes cervical cancer so threatening to many people worldwide. In light of this and the known dangers of cervical, anal, vaginal and penile cancers, the HPV vaccine was created to prevent an infection of …