Alternative and Complementary Medicine Commons^™

Effect Of Dietary Treatment With Stearidonic Acid And Eicosapentaenoic Acid On Membrane Phospholipid Fatty Acid Composition And Glycogen-Elicited Peritoneal Neutrophil Survival In Absence Or Presence Of Bacterial Endotoxin, Jonathan Earl Phipps

Masters Theses

We previously found that enteral nutrition with diets containing elevated levels of eicosapentaenoic acid (EPA; 20:5 n-3) reduced the number of neutrophils in bronchoalveolar lavage fluid and improved clinical outcome of patients with or at risk for adult respiratory distress syndrome (ARDS). We have also shown that the treatment of the neutrophil-like cell line, HL-60, with EPA can induce apoptosis. It is not known, however, if the addition of EPA to the diet would result in similar occurrences in neutrophils.

It has been suggested that the use of diets enriched with stearidonic acid (SDA; 18:4 n-3) may provide a novel …

Hsv-1 Induced Ocular Angiogenesis: Antiangiogenic Strategies To Prevent Herpetic Stromal Keratitis Pathogenesis, Bum Seok Kim

Doctoral Dissertations

Herpetic stromal keratitis (SK) is an immunopathological and tissue destructive corneal lesion caused by herpes simplex virus (HSV) infection, which induces an intense autoimmune inflammatory response and finally leads blindness. Accumulating evidence using the murine model has shown that Th-1 phenotype CD4⁺ T cells orchestrating the inflammation mainly contribute the immunopathological reaction in HSV-1 infected cornea. However, prior to CD4⁺ T cell infiltration into corneal lesions, various innate immune cells recruit and produce numerous inflammatory molecules into the corneal stroma. Interestingly, one prominent event early in the pathogenesis of SK is neovascularization of the usually avascular cornea. It …

The Experience Of American And Canadian Cancer Patients In Deciding To Seek Alternative Care In Mexican Cancer Clinics, Alicia Bright

Dissertations, Masters Theses, Capstones, and Culminating Projects

Background. Each year, despite warnings from the American Cancer Association, many US and Canadian citizens travel to Tijuana, Mexico, for cancer care. The main criticism of these clinics is that they provide treatments that are unproven, potentially unsafe, and expensive. Despite this, about 35 clinics exist in Tijuana that provide alternative care to patients who pay cash for these services.

Objectives. To understand the lived experience of people who have made the choice to receive cancer treatment at alternative cancer clinics in Tijuana, and gain insight into the process by which that decision occurs.

Population. 5 participants were interviewed. Three …

Reasons For Complementary And Alternative Medicine Usage In Japanese Americans, Theodora Stratis

Loma Linda University Electronic Theses, Dissertations & Projects

Complementary and Alternative Medicine (CAM) has received much research attention in the last several years due to marked increase in usage in the U.S. To date, findings indicate that 34% of adults in the U.S. report using at least one form of CAM for the maintenance of general health and acute symptoms and such use continue to increase (Astin, 1998; Eisenberg et al., 1993). CAM therapies are also used by those who suffer from chronic physical and psychological symptoms not successfully treated by conventional medicine (Testerman et al., 2004). Though researchers have examined who is using CAM and why they …

Polycyclic Aromatic Hydrocarbons From The Chattanooga Creek Flood Plain And Their Effects On Endothelial Cells Via Group Ivc Phospholipase A2, Meghan Scott Mcneilly

Masters Theses

Exposure to environmental pollution can be a contributing factor to the development of cardiovascular disease (CVD). Due to contamination produced by long-term discharge of coal tar wastes into the creek, a 2.5-mile section of the Chattanooga Creek in south Chattanooga was designated as a Superfund site by the USEPA in 1994. In order to further investigate the potential health risks posed by creek contamination, 12 PAHs found in high levels in the sediment of the creek as compared to an uncontaminated control site were evaluated for their effects on the human coronary artery endothelial cell (HCAEC) phospholipase A_{2 (PLA2)/arachidonic …}

Computational Studies Of Melatonin Analogues, Jessica Lynne Baima

Honors Theses

Melatonin (MLT, N-Acetyl-5-methoxytryptamine), a naturally occurring hormone produced by the pineal gland, plays a crucial role in the regulation of circadian rhythms. Melatonin supplements are utilized in treating various sleep disorders, but detrimental side effects currently discourages its use in space. Computer generated molecular models of MLT analogues were studied with the purpose of resolving the deficiencies within existing therapeutic agents by constructing an enhanced MLT analogue. The MT receptor binding data for each analogue was obtained from the literature and Sybyl 6.9 was used to perform 3-D quantitative structure-activity relationship (QSAR) studies on eight data sets, using the comparative …