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Hsv-1 Induced Ocular Angiogenesis: Antiangiogenic Strategies To Prevent Herpetic Stromal Keratitis Pathogenesis, Bum Seok Kim

Doctoral Dissertations

Herpetic stromal keratitis (SK) is an immunopathological and tissue destructive corneal lesion caused by herpes simplex virus (HSV) infection, which induces an intense autoimmune inflammatory response and finally leads blindness. Accumulating evidence using the murine model has shown that Th-1 phenotype CD4⁺ T cells orchestrating the inflammation mainly contribute the immunopathological reaction in HSV-1 infected cornea. However, prior to CD4⁺ T cell infiltration into corneal lesions, various innate immune cells recruit and produce numerous inflammatory molecules into the corneal stroma. Interestingly, one prominent event early in the pathogenesis of SK is neovascularization of the usually avascular cornea. It …