Open Access. Powered by Scholars. Published by Universities.®
Alternative and Complementary Medicine Commons™
Open Access. Powered by Scholars. Published by Universities.®
- Institution
- Keyword
-
- Ketogenic diet (2)
- PINK1 (2)
- Parkinson's disease (2)
- Alternative medicine (1)
- Attitude (1)
-
- Colitis (1)
- Conservative (1)
- Gut bacteria (1)
- Gut microbiota (1)
- Inflammatory Bowel Disease (1)
- Integrative Medicine (1)
- MicroRNA (1)
- Mind/body (1)
- Nerve (1)
- Orthopedic (1)
- Physicians (1)
- Placebo (1)
- Prebiotics (1)
- Prostate cancer (1)
- Psoriasis (1)
- Regulatory T cells (1)
- Scapula (1)
- Therapeutics (1)
- Tumor cell behavior (1)
- Winged (1)
- Publication
- Publication Type
Articles 1 - 8 of 8
Full-Text Articles in Alternative and Complementary Medicine
Effects Of Prebiotics On Gut Bacterial Communities And Healing Of Induced Colitis In Mice, Krystyn Elizabeth Davis
Effects Of Prebiotics On Gut Bacterial Communities And Healing Of Induced Colitis In Mice, Krystyn Elizabeth Davis
Master's Theses
Inflammatory Bowel Diseases (IBD) cause chronic inflammation of the gastrointestinal tract and debilitating symptoms in those suffering from the diseases. After inducing colitis in a mouse model using Dextran Sulfate Sodium (DSS), prebiotics inulin and oligofructose enriched inulin (OEI) were used as treatments to determine their effects on the gut microbial community, physiological healing process, and immune response in the mice after initial inflammation and before subsequent inflammation, or relapse. The treatment with inulin led to an increase in regulatory T cell number, but this increase was not as significant as the increase induced by the OEI. Inulin increased the …
An Initial Analysis Of A Long-Term Ketogenic Diet’S Impact On Motor Behavior, Brain Purine Systems, And Nigral Dopamine Neurons In A New Genetic Rodent Model Of Parkinson’S Disease, Jacob Rubin, William H. Church
An Initial Analysis Of A Long-Term Ketogenic Diet’S Impact On Motor Behavior, Brain Purine Systems, And Nigral Dopamine Neurons In A New Genetic Rodent Model Of Parkinson’S Disease, Jacob Rubin, William H. Church
Senior Theses and Projects
A growing body of research suggests that dopaminergic cell death seen in Parkinson’s disease is caused by mitochondrial dysfunction. Oxidative stress, with subsequent generation of reactive oxygen species, is the hallmark biochemical product of mitochondrial dysfunction. The ketogenic diet has been found to enhance mitochondrial energy production, protect against reactive oxygen species-generated cell death, and increase adenosine, a purine that modulates dopamine activity. The current study evaluates the effects of a long-term (5-month) ketogenic diet on behavioral, neurochemical, and neuroanatomical measures in PINK1-KO rats, a new animal model of Parkinson’s disease. Both wild-type and PINK1-KO animals fed a ketogenic diet …
Microrna-186 And Metastatic Prostate Cancer., Dominique Zilpha Jones
Microrna-186 And Metastatic Prostate Cancer., Dominique Zilpha Jones
Electronic Theses and Dissertations
MicroRNA (miR) dysregulation alters cancer-associated gene expression, which contributes to cancer pathogenesis. For example, miR-186 over expression lead to enhanced proliferation and migration in pancreatic cancer cell models. However, the role of miR-186 in prostate cancer (PCa) remains controversial. Previously, miR-186-5p was up-regulated in PCa patient serum (stage III/IV) compared to controls. Furthermore, miR-186-5p was up-regulated in metastatic PCa (PC-3, MDA PCa 2b, LNCaP) relative to normal prostate epithelial cells (RWPE1). We hypothesized miR-186 inhibition will reduce aggressive PCa using metastatic cell models. To test this, we evaluated whether miR-186-5p inhibition would reduce aggressive PCa behavior and overexpression induce malignant …
Ca2+ Signaling Modulates Cytolytic T Lymphocyte Effector Functions, Mark T. Esser, Doris M. Haverstick, Claudette L. Fuller, Charles A. Gullo Phd, Vivian Lam Braciale
Ca2+ Signaling Modulates Cytolytic T Lymphocyte Effector Functions, Mark T. Esser, Doris M. Haverstick, Claudette L. Fuller, Charles A. Gullo Phd, Vivian Lam Braciale
Charles Gullo
Cytolytic T cells use two mechanisms to kill virally infected cells, tumor cells, or other potentially autoreactive T cells in short-term in vitro assays. The perforin/granule exocytosis mechanism uses preformed cytolytic granules that are delivered to the target cell to induce apoptosis and eventual lysis. FasL/Fas (CD95 ligand/CD95)–mediated cytolysis requires de novo protein synthesis of FasL by the CTL and the presence of the death receptor Fas on the target cell to induce apoptosis. Using a CD8+ CTL clone that kills via both the perforin/granule exocytosis and FasL/Fas mechanisms, and a clone that kills via the FasL/Fas mechanism only, we …
An Initial Analysis Of A Long-Term Ketogenic Diet’S Impact On Motor Behavior, Brain Purine Systems, And Nigral Dopamine Neurons In A New Genetic Rodent Model Of Parkinson’S Disease, Jacob Rubin, William H. Church
An Initial Analysis Of A Long-Term Ketogenic Diet’S Impact On Motor Behavior, Brain Purine Systems, And Nigral Dopamine Neurons In A New Genetic Rodent Model Of Parkinson’S Disease, Jacob Rubin, William H. Church
Masters Theses
A growing body of research suggests that dopaminergic cell death seen in Parkinson’s disease is caused by mitochondrial dysfunction. Oxidative stress, with subsequent generation of reactive oxygen species, is the hallmark biochemical product of mitochondrial dysfunction. The ketogenic diet has been found to enhance mitochondrial energy production, protect against reactive oxygen species-generated cell death, and increase adenosine, a purine that modulates dopamine activity. The current study evaluates the effects of a long-term (5-month) ketogenic diet on behavioral, neurochemical, and neuroanatomical measures in PINK1-KO rats, a new animal model of Parkinson’s disease. Both wild-type and PINK1-KO animals fed a ketogenic diet …
Book Review Of Cure, David Yells
Book Review Of Cure, David Yells
Journal of Social, Behavioral, and Health Sciences
In Cure: A Journey Into The Science of Mind Over Body, Dr. Jo Marchant explores the world of complementary and alternative medicine. The context for her exploration is the limitations of standard, Western medicine. In some cases, traditional Western medicine has been unable to provide reliably effective treatment for medical conditions. In other cases, the treatment may result in intolerable side effects. Marchant addresses approaches such as hypnotherapy, virtual reality, and even the power of belief (as reflected in the placebo effect) in the treatment of such disparate conditions as Parkinson’s disease, Irritable Bowel Syndrome, and Fibromyalgia. She combines …
Therapy Options For Winged Scapula Patients: A Literature Review, Samantha L. Normand
Therapy Options For Winged Scapula Patients: A Literature Review, Samantha L. Normand
Honors Undergraduate Theses
Winged scapula is a condition characterized by lateral or medial protrusion of the scapula caused by nerve damage leading to muscular paralysis. The purpose of this systematic review of literature is to evaluate the current research literature related to the effectiveness of therapy options for winged scapula. Eleven peer reviewed English language research articles published from 1998 to present were included for evaluation. Study results revealed positive therapeutic outcomes for physical therapy and scapular bracing. Results also showed positive outcomes for the use of transcutaneous electrical nerve stimulation and acupuncture for the treatment of nerve related conditions similar to winged …
Medical Interns', Residents' And Attending Physicians' Attitudes Towards Integrative Medicine And Recommended Treatments For Patients With Psoriasis, Jennifer L. Pacyon
Medical Interns', Residents' And Attending Physicians' Attitudes Towards Integrative Medicine And Recommended Treatments For Patients With Psoriasis, Jennifer L. Pacyon
PCOM Psychology Dissertations
Background: Psoriasis is a multifactorial disease that effect approximately 7.5 million Americans. There are a variety of traditional treatments for psoriasis (e.g. topical medications, biologics) that for many, are effective in combating the disease. However, traditional treatments often have aversive side effects and may not be appropriate for every patient (e.g. pregnant women). Additionally, the efficacy of these medications are variable leaving some looking for adjunctive treatment options. There is increasing evidence to support the use of adjunctive treatments for psoriatic patients (e.g. psychotherapy, mindfulness). However, research is variable in regards to medical professionals’ attitudes towards integrative medicine (IM) as …