The Effect Of Parabiotic Reuterin On The Expression Of Genes Involved In Candida Albicans Biofilm Formation: An Ex Vivo Study, Anastasya Muna Riad, Armelia Sari Widyarman

Journal of Dentistry Indonesia

Candida albicans has a number of properties, including resistance to various antimicrobial agents, which allow it to survive in the root canals. Lactobacillus reuteri plays a role in maintaining oral health through interactions with the oral microbiome. L. reuteri has potential as a preventive and therapeutic agent against inflammatory diseases. Objective: The aim of this study was to investigate the effect of irrigation with a reuterin-containing solution on BCR1, ACE2, EFG1, and TEC1 gene expression in C. albicans root canal biofilms. Methods: L. reuteri was cultured in MRS broth and incubated anaerobically for 24 hours at 37°C. C. albicans was …

Antibacterial And Antibiofilm Efficacy Of Pineapple Hump (Ananas Comosus) On Porphyromonas Gingivalis In Vitro, Abdul Gani Soulissa, Billy Lombardo, Armelia Sari Widyarman

Journal of Dentistry Indonesia

Background: Periodontal disease is one of the most prevalent oral health problems in Indonesia that affects supporting tissues of the teeth. Porphyromonas gingivalis plays an important role in the pathogenesis of periodontal disease. Alternative therapy with natural plant extracts, including pineapple (Ananas comosus) hump extract may inhibit the growth of bacteria that cause periodontal disease. Objective: To determine the effect of pineapple hump extract on bacterial growth and adhesion of Porphyromonas gingivalis biofilms. Method: The bacterial inhibition test was performed by the agar well diffusion method, and biofilm density measurements were made using the biofilm assay method. Results: Pineapple hump …

Effects Of Different Finishing Procedures On Surface Roughness Of Hybrid Cad/Cam Materials, Ender Akan, Ozlem Colgecen, Ibrahim Talha Meşe, Bora Bağiş

Journal of Dentistry Indonesia

Hybrid ceramics combine the beneficial properties of resin with the advantage of glass ceramics. However, there are limited study about on roughness properties of hybrid materials. Objective: To investigate of the effects of surface finishing methods on roughness of dental restorations made from hybrid CAD/CAM blocks. Methods: A total of 60 samples were produced (n=20) for three main material groups, two different hybrid ceramic (LAVA Ultimate and VITA Enamic) and a conventional glass ceramic (IPS e.max CAD). Each material group was divided into two subgroups (n=10). Ten samples were polished and 10 were glazed according to related manufacturer instructions. Surface …

Attenuating Effect Of Vitamin E Against Silver Nano Particles Toxicity In Submandibular Salivary Glands, Mahmoud Bakr, Mahmoud Al Ankily, Sara M. Shogaa, Mohamed Shamel

Dentistry

Open AccessArticle

Attenuating Effect of Vitamin E against Silver Nano Particles Toxicity in Submandibular Salivary Glands

Eradication Of Enterococcus Faecalis In Conventional Endodontic Retreatments (A Randomized Clinical Trial), Fadl H. Khaled, Roula S. Abiad, Khaled Abd El Galil, Essam Osman

BAU Journal - Creative Sustainable Development

Enterococcus faecalis is the most common bacteria isolated in conventional endodontic retreatments. Aim: To compare the impact of three irrigation modalities on the elimination of the isolated microbial strains of Enterococcus faecalis. Materials and Methods: Thirty patients requiring conventional endodontic retreatment for one of their mandibular premolars and tested positive for E. faecalis were chosen. Patients were randomly divided into three groups (n=10) according to the irrigation modality to be used; group I: syringe irrigation (NaOCl 2.625%), group II: NaOCl 2.625%+EndoActivator and group III: NaOCl 2.625%+diode laser. Before obturation, samples S2 were collected and PCR analysis was performed to identify …

The Interleukin-17 (Il-17) Concentration In Saliva Of Patients With Oral Lichen Planus, Mai Talaat Elgendi, Radwa Ragheb Hussien, Ahmed Abdel Aziz Hassan, Olfat Shaker

Future Dental Journal

Background: The aim of the present study was to measure the clinical and pain score in these patients and to measure the level of IL-17 in saliva of patients having different forms of Oral lichen planus lesions (OLP).

Subjects and methods: According to sample size calculation, the present study was done on a total of 40 subjects divided into 3 groups Group (I) Twenty patients having erosive/atrophic OLP. Group (II) Ten patients having reticular OLP and Group (III) Ten healthy control patients. Salivary samples were collected from the subjects of the three groups to evaluate the levels of IL-17 using …

The Effect Of Doxorubicin And Thioridazine On Squamous Carcinoma Cell Line, Bassant Mahmoud Moustafa

Future Dental Journal

Abstract

Background: Head and neck squamous cell carcinoma (HNSCC) is one of the most common cancers occupying the sixth position worldwide. PI3k/Akt signaling pathway plays a significant role in regulating diverse cellular functions. This includes cell growth, proliferation and survival via inhibition of apoptosis, transcription and protein synthesis. One of the most acknowledged and approved chemotherapeutic agents is Doxorubicin (DOX) which is a non- selective class I anthracycline. In spite of DOX being one of the most acknowledged chemotherapeutic agents, its use has been limited by its toxic side effects and the development of chemoresistance. Nowadays, Thioridazine (TZ) which is …

The Potential Ameliorating Effect Of Bone Marrow Derived Mesenchymal Stem Cells On The Tongue Papillae Of Rats With Experimentally Induced Hypothyroidism, Aya Reyad, Rehab Abdel Moneim

Future Dental Journal

Purpose: This study aimed to evaluate the potential ameliorating effect of bone marrow derived mesenchymal stem cells (BM-MSCs) on tongue papillae of rats with experimentally induced hypothyroidism using environmental scanning electron microscope (ESEM) and fluorescent microscopic evaluation. Material and Methods: For this study 30 adult male albino rats were divided into three groups (ten rats each): (1) Control group: The rats allowed to access freely balanced diet and freshwater supply during the course of the experimental period (8 weeks). (2) Hypothyroidism group: To induce hypothyroidism the rats received carbimazole dissolved in distilled water (5 mg/250g body weight/day) for 35 …

Congenital Epulis: A Two-Case Report, Monica Ivanov, Bianca Stroe, Valeriu Ardeleanu, Razvan Hainarosie, Vlad Denis Constantin, Anca Silvia Dumitriu, Stana Paunica, Anna Kadar

Journal of Mind and Medical Sciences

Congenital epulis is a rare benign tumor of the newborn that could be detected in the prenatal period. Females are more often affected than males and the premaxillary region is usually the predilection site for this oral mass. Excision is the treatment of choice and no recurrences have been reported so far.

We present our experience with two cases of congenital epulis, detected in the second trimester of gestation and treated shortly after birth with no further complications. Histopathology should differentiate between congenital epulis and other congenital oral tumors even if its clinical appearance is usually enough to make a …

Interrelationship Between Orthodontics And Implantology In Anterior Aesthetic Rehabilitation: A Case Report, Adailton De Morais Cavalcante, Renata Cordeiro Teixeira Medeiros, Danilo Lopes Ferreira Lima, Saulo Ellery Santos

Journal of Dentistry Indonesia

The rehabilitation of complex cases in the anterior region of the maxilla may require knowledge of several dental specialties. when dental involvement also causes bone and gingival involvement, management usually requires adjustment of gingival zenitis and bone graft to compensate for bone loss.

Objective: to discuss a case of previous orthodontic treatment for implant-prosthetic rehabilitation in the anterior region.

Case report: This case report describes a 40-year-old patient who came with the intention of extracting the tooth and installing a bridge. The implant-prosthetic treatment was performed after previous orthodontic treatment to adapt the gingiva and space.

Conclusion: The interrelationship of …

Holistic Management For Severe Oral Lichen Planus: A Case Report, Nik Mohd Mazuan Nik Mohd Rosdy, Nyi Mas Siti Purwaningsih

Journal of Dentistry Indonesia

Oral lichen planus (OLP) is an immunologically mediated mucocutaneous disease associated with various factors including systemic diseases, with a higher prevalence in females than males. The majority of OLP cases are accompanied by symptoms of discomfort and/or pain. Treatment of OLP can be challenging due to its unknown aetiology and involvement of multiple contributing factors.

Objective: Our aim is to report a long-term follow-up case of oral lichen planus with holistic management approach. This report will provide some options to clinicians who are having difficulties in managing OLP cases especially with the medications.

Case Report: This case report discusses a …

Evaluation Of The Relationship Between Sella Turcica Bridging And Dental Anomalies, Ahmet Karaman, Saadet Cinarsoy Cigerim Assistant Professor, Nourtzan Kechagia Research Assistant

Journal of Dentistry Indonesia

Objectives: This study aims to evaluate the relationship between the morphological variations of Sella Turcica (ST) and dental anomalies.

Methods: This study included 765 individuals between the ages of 13 and 35. ST morphology was examined in 3 groups as no calcification, partially calcified and completely calcified according to the interclinoid ligament (ICL) on lateral cephalometric films, and it was examined and evaluated in terms of its relationship to impacted canines (unilateral and bilateral), impacted teeth (except 3rd molars), root dilaceration, tooth deficiency (upper incisor lateral - lower and upper second premolar), supernumerary tooth and taurodontism.

Results: The rates of …

Effect Of Natural And Industrial Juices On Surface Microhardness Of Microhybrid And Nanohybrid Composites, Razieh Meshki, Hanieh Hoseini

Journal of Dentistry Indonesia

Numerous studies have been conducted on the effect of various beverages on the mechanical properties of tooth-colored materials, however, little is known about the effects of these materials on composites, particularly newer types such as nanocomposites.

Objectives: This study aimed to evaluate the surface microhardness of two types of composites, micro-hybrid (point 4) and nanohybrid (premise), after exposure to natural and industrial juices.

Methods: In this experimental study, 90 disc-shaped specimens with a thickness of 2 mm and a diameter of 10 mm were taken from two composites, micro-hybrid Point4 (Kerr) and nanohybrid premise (kerr) (two groups of 45). Then, …

Evaluation Of The Bone Thickness Of Mandibular Molars Using Cone Beam Computed Tomography, Deniz Yanık, Ahmet Mert Nalbantoglu

Journal of Dentistry Indonesia

Objective: To investigate buccal and lingual bone thicknesses and fenestration rate of mandibular first and second molars using cone-beam computed tomography (CBCT).

Methods: A total of CBCT images of 41 patients were selected and overall 120 mandibular molars were investigated. The buccal and lingual alveolar bone widths were measured at apex of the roots. The prevalence of fenestration in mandibular molars was recorded. Statistical analyses were performed.

Results: The buccal bone widths of mesial root of second molars were significantly lower than the lingual (p<0.05). The lingual bone widths of mesial and distal root of second molars were lower than the buccal (p<0.05). The lowest thickness of buccal and lingual bone was observed in mesial root of first molar and distal root of second molar. The prevalence of fenestration in mandibular first and second molars was 5% and 10%.

Conclusion: The buccal bone widths were lower at the first molar than the second molar. …

Comparative Analysis Of Proteomics Biomarkers Associated With Residual Ridge Resorption Induced By Denture Wear, Rohana Ahmad, Ainin Sofia Mohamad Napi, Tong Wah Lim, Su Keng Tan, Saiful Anuar Karsani, Musalmah Mazlan, Lay Kek Teh, Steven M. Morgano, Nadim Z. Baba

Makara Journal of Health Research

Background: The biochemical bone turnover markers for residual ridge resorption (RRR) are unclear. Therefore, the present study aimed to determine the biochemical bone turnover markers associated with RRR by comparing proteomics between the compressed mucosa of denture wearers and the non-compressed mucosa of non-denture wearers.

Methods: The mucosal specimens of 11 complete-denture wearers were obtained from the alveolar ridge during surgical implant exposure for implant-retained overdentures. All denture wearers had been edentulous and worn dentures for at least 5 years. The tissues of 11 non-denture wearers were taken from the ridge during minor preprosthetic surgery. The mucosal proteins …

Association Of Oral Microbiota With Lung Cancer Risk In A Low-Income Population In The Southeastern Usa, Jiajun Shi, Yaohua Yang, Hua Xie, Xiaofei Wang, Jie Wu, Jirong Long, Regina Courtney, Xiao-Ou Shu, Wei Zheng, William J. Blot, Qiuyin Cai

Biology Faculty Research

Purpose

Oral microbiome plays an important role in oral health and systemic diseases, including cancer. We aimed to prospectively investigate the association of oral microbiome with lung cancer risk.

Methods

We analyzed 156 incident lung cancer cases (73 European Americans and 83 African Americans) and 156 individually matched controls nested within the Southern Community Cohort Study. Oral microbiota were assessed using 16S rRNA gene sequencing in pre-diagnostic mouth rinse samples. Paired t test and the permutational multivariate analysis of variance test were used to evaluate lung cancer risk association with alpha diversity or beta diversity, respectively. Conditional logistic regression models …

Molecular Screening And Analysis Reveal Novel Oral Site-Specific Locations For The Cariogenic Pathogen Scardovia Wiggsiae, Steven Mcdaniel, Jaydene Mcdaniel, Katherine M. Howard, Karl Kingsley

Dental Medicine Faculty Publications

Introduction: Scardovia wiggsiae (SW) is a newly identified cariogenic pathogen associated with severe early childhood caries and oral disease. New studies have confirmed the presence of this organism among clinical samples from both pediatric and adult patients. However, the recent discovery of this organism has left researchers with only limited information available regarding the prevalence of this organism—and virtually no information regarding oral site-specific locations. Based upon this lack of information, the overall objective of this study was to perform an oral site-specific analysis of SW prevalence from clinical samples. Methods: Using an approved human subjects protocol, samples (n = …

Assessment Of Microrna (Mir)-365 Effects On Oral Squamous Carcinoma Cell Line Phenotypes, Jeffery Coon, Karl Kingsley

Dental Medicine Faculty Publications

miR-365 is a microRNA that regulates transcription and has been demonstrated to promote oncogenesis and metastasis in some cancers while suppressing these effects in others. Virtually no information is known about the presence or function of miR-365 in oral cancers. Based upon this information, the primary goal of this project was to evaluate the expression of miR-365 in existing oral cancer cell lines. Five commercially available oral cancer cell lines (SCC4, SCC9, SCC15, SCC25, and CAL27) were obtained and cultured. RNA was then screened by PCR using primers specific for miR-365, as well as matrix metalloproteinase (MMP-2) and a downstream …

Microbial Screening Reveals Oral Site-Specific Locations Of The Periodontal Pathogen Selenomonas Noxia, Jaydene Mcdaniel, Steven Mcdaniel, Beanca Jhanine Samiano, Matthew Marrujo, Karl Kingsley, Katherine M. Howard

Dental Medicine Faculty Publications

Introduction: Selenomonas noxia (SN) is an important periodontal pathogen, associated with gingivitis and periodontitis. Many studies have found associations between SN and indicators of poor health outcomes, such as smoking, low socioeconomic status and obesity. However, less is known about the prevalence of this organism and more specifically about other oral site-specific locations that may harbor this organism. Methods: Using an existing patient repository (n = 47) of DNA isolated from saliva and other oral sites (n = 235), including the dorsum of the tongue, lower lingual incisor, upper buccal molar and gingival crevicular fluid (GCF), molecular screening for SN …

Mesenchymal Chondrosarcoma Simulating A Periodontal Disease: A Case Report, Adham Fahmy, Abanoub Selim, Yara Youssef, Iman Mostafa, Hala El-Kammar

Future Dental Journal

Mesenchymal chondrosarcoma (MCS) is a rare high-grade variant of chondrosarcoma. MSC`s represent about 1% to 9% of chondrosarcomas. Less than 500 cases of MCS have been reported in literature, so far. As opposed to other variants, MSC develops outside of the bone in almost third of the cases. Pain and swelling are the most common symptoms at presentation. The overall prognosis of MSC is poor, with frequent distant metastases. Histopathologically, MCS typically exhibits a biphasic pattern consisting of both small cells, and islands of atypical cartilage. The immunohistochemical profile of this lesion overlaps with several other entities. Resection with wide …

Raman Spectroscopic Characterisation Of Non Stimulated And Stimulated Human Whole Saliva, Genecy Calado, Isha Behl, Hugh Byrne, Fiona Lyng

Articles

Human saliva is a unique biofluid which can reflect the physiopathological state of an individual. The wide spectrum of molecules present in saliva, compounded by the close association of salivary composition to serum metabolites, can provide valuable information for clinical diagnostic applications through highly sensitive vibrational spectroscopic techniques such as Raman spectroscopy. However, the nature of saliva, in terms of collection and patient-related characteristics, can be considered factors which may strongly affect the Raman spectral profile of salivary samples and disrupt the search for specific salivary biomarkers in the detection of diseases. The main objective of this study was to …

Oral Manifestations Of Covid-19, Ibeth Erazo

Publications and Research

Some oral manifestations have been observed in patients with coronavirus disease 2019 (COVID-19). However, there is still a question about whether these lesions are due to coronavirus infection or secondary manifestations resulting from patient's stress, medications, and/or other related immunosuppressive factors and systemic conditions or by the actions of opportunistic infections brought by other viruses, bacteria, and fungi in the oral cavity. There is growing evidence that angiotensin-converting enzyme 2 (ACE2), the main host cell receptor of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is highly expressed on the cells of the oral mucosal epithelia and of the salivary glands, …

Enamel Histological Indicator: Growth In Incisors Vs. Canines, Nisha Zaver

Chancellor’s Honors Program Projects

No abstract provided.

Multiple Oral Ulcerations In A Seizure Patient With Undiagnosed Brain Arteriovenous Malformation, Ambar Kusuma Astuti, Febrina Rahmayanti

Journal of Dentistry Indonesia

Multiple ulcerations are rarely caused by a traumatic event, but seizures can induce repeated injury to the oral mucosa. A patient with a seizure history possesses a challenge in their dental management. Objective: In order to describe a case of multiple oral ulceration in a post-seizure patient with undiagnosed arteriovenous malformation (AVM) in the left parietal lobe and provide short guidelines for dentists in managing patient with a seizure history. Case report: A 23-years old female had multiple oral ulceration in the right and left buccal mucosa and her tongue. She reported having a seizure attack six days before. …

A Case Of Ameloblastic Fibrodentinoma In The Posterior Maxilla, Akane Mochizuki, Rei Fukui, Toshihiko Amemiya, Yoshinori Arai, Masatake Asano

Journal of Dentistry Indonesia

Ameloblastic fibrodentinoma (AFD) is a rare tumor with an incidence rate of less than 1%. When lesion with the histomorphology of ameloblastic fibroma(AF), which is true neoplasms, form dysplastic dentin, and had been referred to as AFD. It histologically consists of odontogenic ectomesenchyme resembling the dental papilla, epithelial strands, and nests resembling dental lamina and enamel organ with dentin formation. Although newly categorized as an odontoma by the WHO in 2017, this lesion was previously referred to as a rare odontogenic tumor by the WHO in 2005. Objective: We aim to summarize our case with other previous case reports …

Associations Of Electromyographic Activity Of Anterior Temporalis Muscles, Sex, And Occlusal Classes In Asymptomatic Young Adults, Aneta Wieczorek, Marcin Czarnek, Jolanta E. Loster

Journal of Dentistry Indonesia

Symmetry evaluation of the craniofacial complex generally involves models of mandibular movement and masticatory muscle activity, especially during the growth of the craniofacial complex. Objectives: The aim of the study was to determine what, if any, associations exist between the activity of the masticatory muscles, sex, and occlusal classes in asymptomatic young adults. Methods:18-year-old volunteers, showing no symptoms of TMD based on an RDC/TMD examination, were included in the study.Surface electromyography (sEMG) recording was used to quantify the activity of masticatory muscles. The occlusal contact points were analyzed using a T-scan III Evolution 7.01 device. Occlusal classes were …

Assessment Of Gingival Status And Gingival Overgrowth Among Immunosuppressed Patients In Universiti Sains Malaysia Hospital, Wan Majdiah Wan Mohamad, Syamimi Izzati Mat Zaid, Haslina Taib

Journal of Dentistry Indonesia

Drug-induced gingival overgrowth (DIGO) is defined as an abnormal growth of the gingiva due to adverse effect of some drugs such as immunosuppressant, calcium channel blocker, and anticonvulsant. Immunosuppressive drugs play an important role in controlling organ transplant rejection and were widely used to treat different diseases. Objective: Immunosuppressive drugs are used for prevention of transplant rejection and management of autoimmune disease. Drug-induced gingival overgrowth (GO) is abnormal growth of gingiva due to adverse effect of these drugs. This study aimed to assess the gingival status, the prevalence of gingival overgrowth and its associated factors among immunosuppressed patients. Methods …

Periodontal Parameters And Anti-Cardiolipin Antibodies Following Periodontal Therapy In Chronic Periodontitis, Wan Majdiah Wan Mohamad, Noor Rashidah Saad, Siti Lailatul Akmar Zainuddin, Haslina Taib

Journal of Dentistry Indonesia

Anti-cardiolipin (anti-CL) antibodies are autoantibodies which are directed against cell membrane phospholipids. A significant number of periodontitis patients showed positive for anti-CL antibody. Objective: This study aimed to determine the periodontal parameters and anti-CL antibodies levels before and after non-surgical periodontal therapy in chronic periodontitis. Methods: This cross-sectional study had been carried out at Periodontal Clinic, Hospital Universiti Sains Malaysia, Kubang Kerian, Kelantan, Malaysia. Thirty five chronic periodontitis (CP) and 39 non-periodontitis (NP) patients underwent clinical periodontal examination at baseline. Plaque index (PI), gingival index (GI), periodontal pocket depth (PPD), and clinical attachment loss (CAL) were measured. Scaling …

B13: The Cd5 Coreceptor’S Effect On T Cell Proliferation In Periodontal Disease, Yuko Sperry

Annual Research Symposium

No abstract provided.

B6: In- Vitro Anticancer Effects Of Cinnamomum Verum J. Presl, Cinnamaldeyde, 4 Hydroxyvcinnamic Acid And Eugenol On An Oral Squamous Cell Carcinoma Cell Line, Saranya Varadarajan, Thodur Madapusi Balaji, Malathi Narasimhan, Durai Pandian Chamundeeswari, Dhanapal Sakthisekaran

Annual Research Symposium

No abstract provided.