Medicine and Health Sciences Commons^™

Age-Related Decline In Hippocampal Tyrosine Phosphatase Ptpro Is A Mechanistic Factor In Chemotherapy-Related Cognitive Impairment., Zhimeng Yao, Hongmei Dong, Jianlin Zhu, Liang Du, Yichen Luo, Qing Liu, Shixin Liu, Yusheng Lin, Lu Wang, Shuhong Wang, Wei Wei, Keke Zhang, Qingjun Huang, Xiaojun Yu, Weijiang Zhao, Haiyun Xu, Xiaofu Qiu, Yunlong Pan, Xingxu Huang, Sai-Ching Jim Yeung, Dianzheng Zhang, Hao Zhang

PCOM Scholarly Papers

Chemotherapy-related cognitive impairment (CRCI) or "chemo brain" is a devastating neurotoxic sequela of cancer-related treatments, especially for the elderly individuals. Here we show that PTPRO, a tyrosine phosphatase, is highly enriched in the hippocampus, and its level is tightly associated with neurocognitive function but declined significantly during aging. To understand the protective role of PTPRO in CRCI, a mouse model was generated by treating Ptpro-/- female mice with doxorubicin (DOX) because Ptpro-/- female mice are more vulnerable to DOX, showing cognitive impairments and neurodegeneration. By analyzing PTPRO substrates that are neurocognition-associated tyrosine kinases, we found that SRC and EPHA4 are …

One And A Half-Stage Revision With Prosthetic Articulating Spacer For Definitive Management Of Knee Periprosthetic Joint Infection., Ahmed Siddiqi, Yusuf Mahmoud, Salvador A. Forte, Thomas A Novack, James Nace

Orthopedic Surgery Resident Research

This paper is a comprehensive review that describes indications, contraindications, clinical outcomes, and pearls and pitfalls of 1.5-stage revision total knee arthroplasty (TKA) utilizing a primary TKA femoral component, all-polyethylene tibial component, and hand-crafted antibiotic cement for the management of chronic periprosthetic joint infection. The 1.5-stage exchange TKA details placement of an articulating spacer for an indefinite period, prolonging revision until reinfection, deterioration of functional status, or construct failure. A 1.5-stage revision TKA technique is a viable option for treatment of chronic periprosthetic knee infections. The inherent advantages of decreased health-care costs, decreased morbidity and mortality, and improved emotional ease …

A Scoping Review Of Injuries In Amateur And Professional Men's Ice Hockey, Patrick F Szukics, Peters T Otlans, Alfonso Arevalo, Matthew Meade, Peter Deluca, John P Salvo

Orthopedic Surgery Resident Research

Background: Orthopaedic injuries are common in ice hockey at all levels and can result in physical and psychological adverse effects on these athletes.

Purpose: Primarily, to summarize published data on orthopaedic hockey injuries at the junior through professional level. Secondarily, to characterize the literature based on anatomic site injured, return-to-play rates, cause/mechanism of injury, time lost, and treatments used.

Study Design: Scoping review; Level of evidence, 4.

Methods: PubMed, EMBASE, Cochrane library, and SCOPUS were searched using the terms "hockey" and "injuries" using PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) guidelines, and 4163 studies involving orthopaedic injuries were …

A Scoping Review Of Injuries In Amateur And Professional Men's Ice Hockey., Patrick F Szukics, Peters T Otlans, Alfonso Arevalo, Matthew Meade, Peter Deluca, John P Salvo

Orthopedic Surgery Resident Research

Background: Orthopaedic injuries are common in ice hockey at all levels and can result in physical and psychological adverse effects on these athletes.

Purpose: Primarily, to summarize published data on orthopaedic hockey injuries at the junior through professional level. Secondarily, to characterize the literature based on anatomic site injured, return-to-play rates, cause/mechanism of injury, time lost, and treatments used.

Study Design: Scoping review; Level of evidence, 4.

Methods: PubMed, EMBASE, Cochrane library, and SCOPUS were searched using the terms "hockey" and "injuries" using PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) guidelines, and 4163 studies involving orthopaedic injuries were …

Examination Of Care Processes And Treatment Optimization For Head And Neck Cancer Patients In A Community Setting “Hub And Hub” Model, Harleen K. Sethi, Elijah Walker, Travis Weinsheim, Matthew J. Brennan, Christopher E. Fundakowski

Otolaryngology (ENT) Resident Research

Objective

To examine referral pattern, the timing of diagnostic/staging processes, and treatment initiation for new head and neck cancer patients in a community setting.

Methods

Patients with a newly diagnosed previously untreated diagnosis of head neck cancer managed at Asplundh Cancer Pavilion/Abington Memorial Hospital from October 2018 to March 2020. Source of referral and preceding workup were examined as well as intervals between initial head and neck consult and various timepoints of treatment initiation.

Results

One hundred and five patients were included in the study. The primary referral sources were external general otolaryngology (56.3%). Oral surgery and dermatology obtained tissue …

The Use Of Dietary Interventions In Pediatric Patients, Shirin Madzhidova, Lusine Sedrakyan

PCOM Scholarly Papers

Complementary and alternative treatment approaches are becoming more common among children with chronic conditions. The prevalence of CAM use among US adults was estimated to be around 42% in 2015 and around 44% to 50% among adults with neurologic disorders. Studies demonstrate that children with certain chronic illnesses such as asthma, cancer, genetic disorders, attention-deficit/hyperactivity disorder (ADHD), and other neurodevelopmental disorders are treated with complementary and alternative treatments at higher rates. Dietary therapies are gaining increasing popularity in the mainstream population. Although the majority of "fad" diets do not have enough supporting evidence, some dietary therapies have been utilized for …

Is Virtual Reality For Acute Pain Reduction In Adolescents Undergoing Burn Wound Care Effective?, Michelle Wood

PCOM Physician Assistant Studies Student Scholarship

OBJECTIVE: The objective of this selective EBM review is to determine whether or not the use of virtual reality (VR) is an effective method of pain reduction in adolescents undergoing burn wound care.

STUDY DESIGN: Includes a review of two English based randomized controlled trials, and one English based descriptive exploratory study. These studies were published in 2007-2014.

DATA SOURCES: Two randomized control trials (RCT’s) and one exploratory study were found searching PubMed database. Both the random control trials and the exploratory study compare the use of virtual reality interventions against either medical management only or a combination of medical …

Is Intranasal Ketorolac Both Safe And Effective In Reducing Acute Postoperative Pain For Patients Over 18 Years Of Age That Require Inpatient Hospitalization?, Courtney Koukal

PCOM Physician Assistant Studies Student Scholarship

OBJECTIVE: The objective of this selective EBM review is to determine whether or not intranasal ketorolac is both safe and effective in reducing acute postoperative pain for patients over 18 years of age that require inpatient hospitalization.

STUDY DESIGN: Review of three double-blind randomized controlled trials (RCTs) were used, all are from 2008 to present and all are in the English language.

DATA SOURCES: Data sources include articles that were published on both PubMed and Cochrane databases and were selected based on their relevance to the research question as well as patient measured outcomes.

OUTCOMES MEASURED: Outcomes measured include efficacy …

Is Phototherapy An Effective Treatment For Herpes Simplex Labialis?, Sarah Landis

PCOM Physician Assistant Studies Student Scholarship

Objective: The objective of this evidence based medicine review is to determine if laser phototherapy is an effective treatment for herpes simplex labialis.

Study Design: Review of one case study published in 2009, and two randomized controlled trials published in 2010 and 2013. All studies were published in English.

Data Source: One case study and two randomized controlled trials were retrieved from PubMed database to write this EBM review

Outcomes measured: Decreases in healing time or size based on patient reporting, scoring systems, or photo documentation.

Results: The study conducted by Marotti et al determined …

Is Radiofrequency Energy A Safe And Effective Treatment For Reducing Symptoms Of Gastroesophageal Reflux Disease In Patients 18 Years Or Older?, Kristen L. Schaffer

PCOM Physician Assistant Studies Student Scholarship

OBJECTIVE: The objective of this selective evidence based medicine review is to determine whether or not “Is radiofrequency energy a safe and effective treatment for reducing symptoms of gastroesophageal reflux disease in patients 18 years or older?”

STUDY DESIGN: Review of two double-blind, randomized control trials and one double-blind, randomized cross-over study published between 2003 and 2012. All studies were published in the English language in peer reviewed journals.

DATA SOURCES: Two randomized control trials and one randomized cross-over study were found using PubMed.

OUTCOMES MEASURED: The outcomes measured include changes in GERD symptom scores for …

Digest Of The Philadelphia College Of Osteopathic Medicine (Winter 2015-2016), Philadelphia College Of Osteopathic Medicine

Digest

The Winter 2015/2016 issue of the Digest of the Philadelphia College of Osteopathic Medicine includes the following articles:

• Message from the President
• PCOM Updates
• Inauguration of the eighth President, Jay S. Feldstein, DO '81
• Trained for Trauma Care: PCOM Alumni Were Well Prepared to Treat the Mass Casualties of May's Amtrak Derailment
• Remembering Camille DiLullo, PhD, Professor of Anatomy
• Class Notes
• My Turn

Glanzmann's Thrombasthenia: Pathogenesis, Diagnosis, And Current And Emerging Treatment Options, Tia Solh, Ashley Botsford, Melhem Solh

PCOM Scholarly Papers

Glanzmann’s thrombasthenia (GT) is a genetic platelet surface receptor disorder of GPIIb/IIIa (ITG αIIbβ3), either qualitative or quantitative, which results in faulty platelet aggregation and diminished clot retraction. Spontaneous mucocutaneous bleeding is common and can lead to fatal bleeding episodes. Control and prevention of bleeding among patients with GT is imperative, and remains challenging. Local measures, including anti-fibrinolytic therapy, with or without platelet transfusions, used to be the mainstay of therapy. However, in recent years the use of recombinant factor VIIa (rFVIIa) has increased significantly, with excellent response rates in treating and preventing hemorrhage among GT patients. Gene therapy and …

A Combined Therapeutic Regimen Of Buspirone And Environmental Enrichment Is More Efficacrious Than Either Alone In Enhancing Spatial Learning In Brain-Injured Rats, Christina M. Monaco, Kory M. Gebhardt, Sarah M. Chlebowski, Kaitlyn E. Shaw, Jeffrey P. Cheng

PCOM Scholarly Papers

Abstract Buspirone, a 5-HT1A receptor agonist, and environmental enrichment (EE) enhance cognition and reduce histopathology after traumatic brain injury (TBI) in adult rats, but have not been fully evaluated after pediatric TBI, which is the leading cause of death in children. Hence, the aims of this study were to assess the efficacy of buspirone alone (Experiment 1) and in combination with EE (Experiment 2) in TBI postnatal day-17 male rats. The hypothesis was that both therapies would confer cognitive and histological benefits when provided singly, but their combination would be more efficacious. Anesthetized rats received a cortical impact or sham …

Digest Of The Philadelphia College Of Osteopathic Medicine (Winter 2013-2014), Philadelphia College Of Osteopathic Medicine

Digest

The Winter 2013 issue of the Digest of the Philadelphia College of Osteopathic Medicine includes the following articles:

• Message from the President
• PCOM Updates
• Development News
• Diversity: The Changing Face of Osteopathic Medical Education
• Reducing Disparities through Cultural Competence
• Toward a Culture of Inclusion: The Diversity Office at Philadelphia College of Osteopathic Medicine
• Cultural Sensitivity Enhances Palliative Care
• Sherman Leis, DO ’67, FACOS: Aiding in Journeys of Transition
• Language, Diversity & Learning
• Class Notes
• In Memoriam
• My Turn Essay

Digest Of The Philadelphia College Of Osteopathic Medicine (Summer 2013), Philadelphia College Of Osteopathic Medicine

Digest

The Summer issue of the Digest of the Philadelphia College of Osteopathic Medicine includes the following articles:

• Message from the President
• PCOM Updates
• Commencement 2013
• Development News
• Back in the (Founders') Day: Faculty Pioneers, 1899 to World War I
• Teach Me So I May Remember—Alumni: On Faculty Mentors and Awakeners
• My Father’s Precious Legacy: A Reflection On the Influence of Nicholas S. Nicholas, DO, upon His Sons, his Family, Philadelphia College of Osteopathic Medicine and the Osteopathic Profession
• Love and Change: A Health Crisis Compels a Longtime Physician to Reevaluate his Approach to Teaching and Practicing Preventative Patient Care
• Philosophical …

Synapsis: Philadelphia Campus (2013), Philadelphia College Of Osteopathic Medicine

All Yearbooks

This yearbook includes American Medical Association (AMA), American Medical Student Association (AMSA), American Medical Women's Association (AMWA), Association of the American College of Osteopathic Family Physicians (ACOFP), Asian Pacific American Medical Student Association (APAMSA), Robert Berger, DO Pediatrics Society, Christian Medical Dental Association (CMDA), Kappa Sigma Phi, KSPh, (ΚΣΦ) Women's Osteopathic Society, Medical Students for Choice, Military Osteopathic Physicians and Surgeons (AMOPS), Muslim Student Medical Association, National Latino Health Organization (NLHO), Phi Sigma Gamma PSG, (ΦΣΓ) Fraternity, Physicians for Human Rights Club, Physicians for Social Responsibility Club, Sigma Sigma Phi SSPh, (ΣΣΦ) Honorary Osteopathic Service Fraternity, Student American Osteopathic Academy …

Digest Of The Philadelphia College Of Osteopathic Medicine (Fall 2012), Philadelphia College Of Osteopathic Medicine

Digest

The Fall 2012 issue of the Digest of the Philadelphia College of Osteopathic Medicine includes the following articles:

• Message from the President
• PCOM Updates
• Development News
• Protecting Human Rights
• Relieving Suffering
• On Leaders and Legacies
• Profiles of Nine PCOM Alumni Who Influence Osteopathic Medical Education
• Pharmacists’ Changing Role: From Behind the Counter to Direct Patient Care
• PCOM School of Pharmacy Is Preparing Students to Practice as Part of the Healthcare Team
• Class Notes
• In Memoriam
• My Turn Essay
• The Fund for PCOM

Synapsis: Philadelphia Campus (2012), Philadelphia College Of Osteopathic Medicine

All Yearbooks

This yearbook includes American Medical Association (AMA), American Medical Student Association (AMSA), American Medical Women's Association (AMWA), Association of the American College of Osteopathic Family Physicians (ACOFP), Asian Pacific American Medical Student Association (APAMSA), Robert Berger, DO Pediatrics Society, Christian Medical Dental Association (CMDA), Kappa Sigma Phi, KSPh, (ΚΣΦ) Women's Osteopathic Society, Medical Students for Choice, Military Osteopathic Physicians and Surgeons (AMOPS), Muslim Student Medical Association, National Latino Health Organization (NLHO), Phi Sigma Gamma PSG, (ΦΣΓ) Fraternity, Physicians for Human Rights Club, Physicians for Social Responsibility Club, Sigma Sigma Phi SSPh, (ΣΣΦ) Honorary Osteopathic Service Fraternity, Student American Osteopathic Academy …

Digest Of The Philadelphia College Of Osteopathic Medicine (Fall 2011), Philadelphia College Of Osteopathic Medicine

Digest

The Fall 2011 issue of the Digest of the Philadelphia College of Osteopathic Medicine includes the following articles:

• Opening Remarks
• PCOM Updates
• Mindfulness: Helping Patients Reduce Stress, Accept Life’s Challenges
• International Practice Rights for Osteopathic Physicians: Room for Global Growth
• Class Notes
• In Memoriam
• My Turn Essay

Digest Of The Philadelphia College Of Osteopathic Medicine (Winter 2010), Philadelphia College Of Osteopathic Medicine

Digest

The Winter 2010 issue of the Digest of the Philadelphia College of Osteopathic Medicine includes the following articles:

• Opening Remarks
• PCOM Updates
• Development News
• Wounded Healers
• Founders’ Day 2010
• Mining the Connection between Mind & Body
• Keeping Healthcare Providers Safe from Youth Gang Violence
• Class Notes
• In Memoriam
• My Turn Essay

Digest Of The Philadelphia College Of Osteopathic Medicine (Fall 2009), Philadelphia College Of Osteopathic Medicine

Digest

The Fall 2009 issue of the Digest of the Philadelphia College of Osteopathic Medicine includes the following articles:

• Opening Remarks
• PCOM Updates and Kudos
• PCOM–World’s Oldest College of Osteopathic Medicine
• Helping Patients During Difficult Times
• Global Outreach Inspires Students
• Class Notes
• In Memoriam
• My Turn Essay
• PCOM Events

Digest Of The Philadelphia College Of Osteopathic Medicine (Spring 2007), Philadelphia College Of Osteopathic Medicine

Digest

The Spring 2007 issue of the Digest of the Philadelphia College of Osteopathic Medicine includes the following articles:

• Opening Remarks
• PCOM Updates and Kudos
• Development News
• Humanism in Medicine
• Leaders on the New Frontier of High Technology Surgery
• Breaking the Silence Surrounding Selective Mutism
• Remembering Ida Schmidt, DO ’35
• Class Notes
• In Memoriam
• My Turn
• PCOM Golf Classic
• PCOM Events

Digest Of The Philadelphia College Of Osteopathic Medicine (Summer 2006), Philadelphia College Of Osteopathic Medicine

Digest

The Summer 2006 issue of the Digest of the Philadelphia College of Osteopathic Medicine includes the following articles:

• Opening Remarks
• PCOM Updates and Kudos
• Osteopathic Philosophy at the Forefront of “New Medicine”
• Making the Professional Grade
• Annual Fund Supports Teaching Osteopathic Manipulative Medicine to the Next Generation
• Galen S. Young, Sr., DO ’35, Remembered
• Class Notes
• In Memoriam
• My Turn
• Andrew Taylor Still Legacy Society
• PCOM Events

Digest Of The Philadelphia College Of Osteopathic Medicine (Winter 2006), Philadelphia College Of Osteopathic Medicine

Digest

The Winter 2006 issue of the Digest of the Philadelphia College of Osteopathic Medicine includes the following articles:

• Opening Remarks
• PCOM Updates and Kudos
• Will the Doctor be In?
• Recognizing Leadership, Loyalty, Service
• Bringing Hope & Help after Hurricane Katrina
• Bridging Bench to Bedside
• Class Notes
• In Memoriam
• My Turn
• PCOM Alumni Weekend 2006
• PCOM Events

Digest Of The Philadelphia College Of Osteopathic Medicine (Fall 2005), Philadelphia College Of Osteopathic Medicine

Digest

The Fall 2005 issue of the Digest of the Philadelphia College of Osteopathic Medicine includes the following articles:

• Opening Remarks
• PCOM Updates and Kudos
• Uncommon Callings
• Take a Deep Breath
• Remembering Dr. Meals
• Class Notes
• In Memoriam
• My Turn
• Andrew Taylor Still Legacy Society
• PCOM Events

Digest Of The Philadelphia College Of Osteopathic Medicine (Summer 2004), Philadelphia College Of Osteopathic Medicine

Digest

The Summer 2004 issue of the Digest of the Philadelphia College of Osteopathic Medicine includes the following articles:

• Opening Remarks
• PCOM Updates
• Leaving a Legacy of Strength
• Alumni Association News
• Physician Helps the Needy – Wherever They Are
• Cover Story: Primary Care and Psychology: Perfect Together
• He’s Got Heart
• Class Notes
• In Memoriam
• My Turn
• Andrew Taylor Still Legacy Society
• PCOM Events

Digest Of The Philadelphia College Of Osteopathic Medicine (Fall 2002), Philadelphia College Of Osteopathic Medicine

Digest

The Fall 2002 Digest of the Philadelphia College of Osteopathic Medicine includes the following articles:

• Opening Remarks
• PCOM Updates
• Alumnus Marks 100th Birthday
• Cover Story: College Moves Forward with Strategic Plan
• Aging and the Immune Response
• Class Notes
• In Memoriam
• My Turn
• 2003 Annual Fund
• PCOM Events

Digest Of The Philadelphia College Of Osteopathic Medicine (Winter 2002), Philadelphia College Of Osteopathic Medicine

Digest

The Winter 2002 issue of the Digest of the Philadelphia College of Osteopathic Medicine includes the following articles:

• Opening Remarks
• PCOM Updates
• Founders’ Day 2002: Presidential Inauguration
• College Bestows Highest Award on Joseph M. Pellettiere, Jr., DO ’48
• Mason W. Pressly Memorial Medal Awarded
• The Inflammation Puzzle
• Kenya Trip Opens Student’s Eyes
• Class Notes
• In Memoriam
• My Turn
• Alumni Weekend 2002
• PCOM Events

Digest Of The Philadelphia College Of Osteopathic Medicine (Fall 1999), Philadelphia College Of Osteopathic Medicine

Digest

The Fall 1999 issue of the Digest of the Philadelphia College of Osteopathic Medicine includes the following articles:

• Opening Remarks
• PCOM Salutes Dr. Finkelstein
• PCOM Updates
• Commencement 2000
• Rethinking Alzheimer's Disease
• A DO Saves Lives Half a World Away
• Follies Leaves PCOM in Stitches
• Alumni Weekend Brings Grads Together
• Class Notes
• In Memoriam
• “My Turn” Essay
• Save the Date! Winter CME
• Coming Events

Digest Of The Philadelphia College Of Osteopathic Medicine (Spring 1996), Philadelphia College Of Osteopathic Medicine

Digest

The Spring 1996 issue of the Digest of the Philadelphia College of Osteopathic Medicine includes the following articles:

• President’s Perspective
• Primary Care Research
• College Board Profile
• PCOM Students Show their Diversity
• Alumni Board Profile
• Capital Campaign Developments
• Spring Convention Highlights
• Class Acts
• PCOM Merchandise
• Coming Events