Medicine and Health Sciences Commons^™

The Effectiveness Of Serotonin And Tricyclic Antidepressants In Tinnitus Management: A Rapid Review, Dr. Emilie Vos, Dr. Nannette Nicholson, Melinda Johnson, Dr. Karah Gottschalk

Internet Journal of Allied Health Sciences and Practice

Background: Tinnitus can be defined as a health condition characterized by the perception of sound, either in the head and/or ears, in the absence of any external acoustic stimulus. Perception is often quantified by self-report, or the use of patient reported outcome measures (PROMs). The purpose of this rapid review was to evaluate the level and quality of evidence regarding the use of serotonin and norepinephrine reuptake inhibitors (SNRI), selective serotonin reuptake inhibitors (SSRI), and tricyclic antidepressants as measured by tinnitus patient-reported outcome measures (PROMs) and/or Visual Analog Scales (VAS). Methods: The Cochrane Rapid Review guidelines were followed. The PICO …

Evidence-Based Practice In The Management Of Tinnitus In Children And Adolescents: A Systematic Review Of The Literature, Rivka Deutsch

Dissertations, Theses, and Capstone Projects

Objective: The purpose of this investigation is to conduct a systematic review of the literature to compile and evaluate the known research on the management of tinnitus in children/ The specific aims of this paper are to determine what approaches can be considered best practice for the management of tinnitus in this population, what aspects of adult management (if any) can be adapted for children, and whether the literature supports one management approach over another.

Methods and Results: A comprehensive search utilizing the Medline and Cumulated Index to Nursing and Allied Health Literature (CINAHL), and Google Scholar databases, accessible via …

Outcome Of Different Treatment Methods In Patients With Tinnitus And Temporomandibular Joint Dysfunction, Sanaa Mahran Mohamed Andeil, Anwar Moawad Elbatawy, Zienab Shalaby Farid Shalaby

Journal of Medicine in Scientific Research

Introduction: Otology symptoms can be the presenting complain among patients with temporomandibular joint (TMJ) dysfunction. The ear symptoms related to Temporomandibular joint dysfunction are hearing loss and tinnitus. Tinnitus related to TMJ dysfunction is referred to as a type of somatic tinnitus, and it is caused by a musculoskeletal problem, which should be investigated with different methods of treatment to increase the best efficiency of treatment. Objective: Evaluation of different outcomes of different treatment modalities for patients with tinnitus and TMJ dysfunction by using the advantage of Tinnitus Retraining Therapy versus night guard and medication to determine which of these …

Predicting The Outcomes Of Internet-Based Cognitive Behavioral Therapy For Tinnitus: Applications Of Artificial Neural Network And Support Vector Machine, Hansapani Rodrigo, Eldré W. Beukes, Gerhard Andersson, Vinaya Manchaiah

School of Mathematical and Statistical Sciences Faculty Publications and Presentations

Purpose:

Internet-based cognitive behavioral therapy (ICBT) has been found to be effective for tinnitus management, although there is limited understanding about who will benefit the most from ICBT. Traditional statistical models have largely failed to identify the nonlinear associations and hence find strong predictors of success with ICBT. This study aimed at examining the use of an artificial neural network (ANN) and support vector machine (SVM) to identify variables associated with treatment success in ICBT for tinnitus.

Method:

The study involved a secondary analysis of data from 228 individuals who had completed ICBT in previous intervention studies. A 13-point reduction …

Combined Amplification And Sound Therapy For Individuals With Tinnitus And Coexisting Hearing Loss: A Retrospective Cohort Study, Purushothaman Ganesan, Hansapani Rodrigo, Jason Schmiedge, Rob Reiter, Simham Swapna, Vinaya Manchaiah

School of Mathematical and Statistical Sciences Faculty Publications and Presentations

BACKGROUND: The heterogeneity of tinnitus perception and its impact necessitates a tailor-made management approach in everyone. The current study examined the effects of residual inhibition in combined amplification and sound therapy in individuals with tinnitus and coexisting hearing loss.

METHODS: A retrospective analysis was performed on patients with tinnitus and coexisting hearing loss between 2016 and 2019. A total of 72 patients provided with combined amplification and sound therapy were divided into 3 groups based on residual inhibition: (i) complete residual inhibition, (ii) partial residual inhibition, and (iii) negative residual inhibition. Tinnitus severity was measured using the Tinnitus …

Exploratory Data Mining Techniques (Decision Tree Models) For Examining The Impact Of Internet-Based Cognitive Behavioral Therapy For Tinnitus: Machine Learning Approach, Hansapani Rodrigo, Eldré W. Beukes, Gerhard Andersson, Vinaya Manchaiah

School of Mathematical and Statistical Sciences Faculty Publications and Presentations

Background: There is huge variability in the way that individuals with tinnitus respond to interventions. These experiential variations, together with a range of associated etiologies, contribute to tinnitus being a highly heterogeneous condition. Despite this heterogeneity, a “one size fits all” approach is taken when making management recommendations. Although there are various management approaches, not all are equally effective. Psychological approaches such as cognitive behavioral therapy have the most evidence base. Managing tinnitus is challenging due to the significant variations in tinnitus experiences and treatment successes. Tailored interventions based on individual tinnitus profiles may improve outcomes. Predictive models of treatment …

Tinnitus Effects And Correlations Between Capd, Language Processing, And Asd: A Capstone Case Series, Kristin Williford, Antony Joseph

AuD Capstone Projects - Communication Sciences and Disorders

Introduction: Some people with tinnitus have normal audiometric hearing thresholds. Even when hearing is within normal limits, patients can suffer a myriad of symptoms from tinnitus, including depression and other mental health problems. Case Presentation: A male adult presented to the clinic with complaints of bothersome tinnitus, asymmetric hearing loss, and a long history of environmental noise exposure, including both occupational and recreational noise. Discussion: Audiologists should determine the primary concerns of their tinnitus patients and how the condition affects their health and wellbeing. To do this, a thorough case history, audiologic assessment, outcome measures, and empathetic listening should be …

A Young Female With Chronic Debilitating Tinnitus And A Middle-Aged Male With Life-Long Noise Exposure And Bothersome Tinnitus, Lindsey Petras, Antony Joseph

AuD Capstone Projects - Communication Sciences and Disorders

Introduction: Tinnitus is characterized by a sporadic or constant ringing, chirping, buzzing, or related characteristics that are perceived auditorily and can range in intensity. Case Presentation: A young adult female with normal hearing sensitivity presented to the clinic with constant unilateral pulsatile tinnitus in the right ear that was intensified with physical activity and caffeine. It was reported as sudden in onset and classified as severely debilitating. After extensive audiologic testing, personalized counseling, and a thorough medical evaluation, the patient received an open-fit monaural hearing aid to promote safe sound therapy and tinnitus habituation. Discussion: Thorough audiologic and medical evaluation, …

Case Reports On Disorders Of Sound Tolerance: Misophonia And Hyperacusis, Madison Mcconville, Antony Joseph

AuD Capstone Projects - Communication Sciences and Disorders

Introduction: Misophonia is a rare disorder affecting approximately one in 1,500 people, of which, a small percentage are pediatric patients. Misophonia is characterized by the dislike of an explicit sound in a specific context. Treatment for misophonia includes a four-step program that can be modified for pediatrics. Case Presentation: A young female presented to the clinic with a significant distressed reaction when in the presence of specific sounds that included chewing, clicking pens, and loud music bass tones. Discussion: Treatment of misophonia is comparable to a care-plan for both tinnitus and hyperacusis. For this case, a four-step approach was used …

Tinnitus And Decreased Subcortical And Cortical Inhibition, Kenneth Vincent Morse

Dissertations - ALL

Background: The perception of tinnitus may be triggered by a reduction in inhibitory function in the central auditory nervous system. Evidence, primarily from invasive studies of animal models of tinnitus, indicates that these changes occur at both the subcortical and cortical level. Auditory evoked potential (AEP) indices of subcortical inhibition [auditory brainstem response (ABR) 〖"V/I" 〗_"amp ratio" ] and cortical inhibition [cortical auditory evoked potential (CAEP) sensory gating ratios] may provide an objective index of whether reduced subcortical and/or cortical inhibition is associated with tinnitus perception in humans. The aims of this study were to assess whether ABR and/or CAEP …

The Power Of A Sound Mind: Exploring Meditation And Sound Therapies For Treating The Emotional Impact Of Tinnitus, Sabeena A. Ramnanan

Dissertations, Theses, and Capstone Projects

Tinnitus is described as a sound perceived by an individual that has no external source. Some individuals with tinnitus can habituate to this phantom sound, while others become emotionally disturbed by it. There are several theories which attempt to rationalize the cause of tinnitus, and various treatments which aim to eliminate, mask, or facilitate habituation to one’s tinnitus. Current common treatments include sound therapies and cognitive-behavioral therapy (CBT), either in isolation or in combination with one another. However, not all these treatments aim to address the emotional impact of tinnitus. Novel treatments are emerging, with some attempting to reduce the …

Identifying Molecular Pathways Underlying Noise-Induced Tinnitus, Mckenzie Rice

Williams Honors College, Honors Research Projects

Tinnitus is a serious neurological condition effecting 10-15% of adults, and can lead to other symptoms such as difficulty concentrating and sleeping, anxiety, and depression. Currently there are no FDA approved drugs to prevent or treat tinnitus, mainly due to a lack of understanding of its cellular and molecular pathways. T- and L- type calcium channels have been implicated in the modulation of tinnitus, as well as the dysfunction of gamma-aminobutyric acid (GABA) neurons. This study used the sound-based avoidance detection (SBAD) method in order to detect tinnitus and determine whether pharmacological treatments had an effect in mediating tinnitus. T-type …

Pathogenesis And Onset Of Tinnitus And Use Of Holistic And Traditional Audiological Approaches For Management, Christy Mahrt, Antony Joseph

AuD Capstone Projects - Communication Sciences and Disorders

Introduction: Tinnitus is the subjective sensation of noise perceived at the peripheral or central level. Occasionally, tinnitus perception may be severe enough to present debilitating effects on daily activities. The occurrence of tinnitus can be related to occupational or non-occupational hazardous noise exposure. Case Presentation: A 60-year-old male presented with bilateral tinnitus with an initial onset at age 21. The progression of his tinnitus has caused disruptions in sleeping patterns and concentration. His history included extensive occupational and non-occupational noise exposure. Discussion: Hearing conservation is an important aspect of facilitating tinnitus management for individuals who have noise-related tinnitus. Hearing aids, …

Global Resting-State Functional Connectivity Of Neural Oscillations In Tinnitus With And Without Hearing Loss, Carly Demopoulos, Xuan Duong, Leighton B. Hinkley, Kamalini G. Ranasinghe, Danielle Mizuiri, Coleman Garrett, Susanne Honma, Jennifer Henderson-Sabes, Anne Findlay, Caroline Racine-Belkoura, Steven W. Cheung, Srikantan S. Nagarajan

All Faculty Scholarship

This study examined global resting-state functional connectivity of neural oscillations in individuals with chronic tinnitus and normal and impaired hearing. We tested the hypothesis that distinct neural oscillatory networks are engaged in tinnitus with and without hearing loss. In both tinnitus groups, with and without hearing loss, we identified multiple frequency band-dependent regions of increased and decreased global functional connectivity. We also found that the auditory domain of tinnitus severity, assayed by the Tinnitus Functional Index, was associated with global functional connectivity in both auditory and nonauditory regions. These findings provide candidate biomarkers to target and monitor treatments for tinnitus …

Standardization Of The Arabic Version Of Beck Anxiety Inventory In Egyptian Population, Ahmed M. Z. El Abedein, Enas I. Abdelfatah, Hossam S. Talaat

Menoufia Medical Journal

Objective The aim was to diagnose anxiety in patients with tinnitus using Beck anxiety inventory (BAI) after modification and standardization on the Egyptian population. Background Tinnitus is a common complaint that can affect life aspects, such as emotions, increasing anxiety. Early diagnosis of anxiety helps treatment of tinnitus. The aim of this study was to standardize the Arabic version of BAI in the Egyptians and apply the standardized form on patients with tinnitus. Patients and methods BAI was modified to suite Egyptians. It was backtranslated and judged by an expert committee. It was then applied on 100 healthy adult participants, …

A New Method In Subjective Tinnitus Management: The Use Of A Nutraceutical Formulation To Improve Patient Outcomes, Jade Faulkner

Dissertations, Theses, and Capstone Projects

Objective: This project aims to implement an evidence-based clinical practice guideline at the International Hearing Centre (IHC) in Lagos, Nigeria for future research and data collection of their subjective tinnitus management using a nutraceutical formulation called ‘NHANCED Hearing (NH). After learning the IHC had incomplete charting in regard to tinnitus questionnaires pre- and post-administration of the NH formula, this capstone project sought to apply evidence-based guidelines for proper diagnostic evaluations and charting to assist in future research of the NH formula.

Methodology: A review and synthesis of current clinical practice guidelines in the United States, Germany, the Netherlands, Sweden, Denmark, …

Outcomes Of Tinnitus Post-Cochlear Implantation In Adult Populations: A Systematic Review, Evangeline Wong

Dissertations, Theses, and Capstone Projects

The purpose of this investigation is to conduct a systematic review on the outcomes of tinnitus, in both its characteristics and psychosocial impact, post-cochlear implantation in profound bilateral and single-sided deafness (SSD) adult populations. A longitudinal case study will also be presented to show long-term effects of tinnitus outcomes in a cochlear implant recipient in a clinical setting. The investigation may, in turn, provide information regarding tinnitus in the selection criteria of which ear to implant, considerations in implantation eligibility for patients with bilateral and unilateral severe hearing loss associated with severe tinnitus, and to inform patients about the possible …

Is Cognitive Behavioral Therapy Effective In Decreasing The Severity Of Distress In Abnormal Auditory Perception Of Sound?, Samantha Crago

PCOM Physician Assistant Studies Student Scholarship

OBJECTIVE: The objective of this selective review is to determine whether or not cognitive behavioral therapy (CBT) is effective in decreasing the severity of distress in abnormal auditory perception of sound.

STUDY DESIGNS: Review of two randomized controlled trials and one open trial, published in the English language in 2008, 2014, and 2017.

DATA SOURCES: The three studies used in this review were published in peer-reviewed journals, in English and found in PubMed.

OUTCOMES MEASURED: Decrease in severity of distress by the patient after receiving treatment. Recording methods included the Symptom Checklist 90 (SCL-90-R), The Quality of Life Inventory (QOLI), …

Is Mindfulness-Based Cognitive Therapy An Effective Treatment For Adult Patients With Tinnitus?, Ashlyn C. Smith

PCOM Physician Assistant Studies Student Scholarship

OBJECTIVE: The objective of this selective EBM review is to determine whether or not mindfulness-based cognitive therapy (MBCT) is an effective treatment for adult patients with tinnitus.

STUDY DESIGN: Systematic review of two randomized controlled trials (RCTs) published in 2012 and 2017 and one cohort study published in 2018.

DATA SOURCES: Data sources for this review are articles published in peer-reviewed journals retrieved from PubMed and Cochrane Library.

OUTCOMES MEASURED: The outcomes evaluated are tinnitus severity and tinnitus distress as determined by the Tinnitus Questionnaire (TQ) and overall negative affect as determined by the Tinnitus Psychological Impact Questionnaire (QIPA). The …

Tinnitus And Self-Perceived Hearing Handicap In Firefighters: A Cross-Sectional Study, Samson Jamesdaniel, Kareem G Elhage, Rita Rosati, Samiran Ghosh, Bengt Arnetz, James Blessman

Journal Articles

Firefighters are susceptible to auditory dysfunction due to long-term exposure to noise from sirens, air horns, equipment, and tools used in forcible entry, ventilation, and extrication. In addition, they are exposed to ototoxic chemicals, particularly, during overhaul operations. Studies indicate that 40% of firefighters have hearing loss in the noise-sensitive frequencies of 4 and 6 kHz. Noise-induced hearing loss (NIHL) is often accompanied by tinnitus, which is characterized by ringing noise in the ears. The presence of phantom sounds can adversely affect the performance of firefighters. However, there has been limited research conducted on the prevalence of tinnitus in firefighters. …

Counseling For Patients With Hyperacusis, Mary Maraist

Communication Sciences and Disorders: Student Scholarship & Creative Works

Hyperacusis is the phenomenon of experiencing moderately loud sounds as overly loud and/or intensely annoying. Hyperacusis can also cause fear or pain in response to sound. There is no one known cause of hyperacusis, and because of the variety of ways it presents itself, the approximate prevalence is difficult to determine. Despite the ambiguity of hyperacusis, the audiologist is an important part of diagnosing and educating clients with hyperacusis. During this project we aimed to discover the challenges individuals with hyperacusis face. These include anxiety, depression and avoidance behavior, and sometimes co-occurring tinnitus and hearing loss. Another aim was to …

Acoustic Reflex And Extended High-Frequency Testing In Relation To Tinnitus, Deborah Kim

Honors Theses

Tinnitus, a growing concern among adults, is the perception of sound without an external acoustic source. Tinnitus can sound like ringing, buzzing, and clicking and is typically caused by noise-induced hearing loss. Noise-induced hearing loss is caused by prolonged exposure to high levels of noise, which damages the cochlea, and can be temporary or permanent. The purpose of this study is to determine if there are any common factors or characteristics in Acoustic Reflex, standard pure tone and/or Extended High-Frequency testing results between two groups: people who report and do not report tinnitus. This study explores whether Acoustic Reflex testing …

Recreational Sound Risk For A University Student: Case Study, Michele Wattman, Antony Joseph

AuD Capstone Projects - Communication Sciences and Disorders

Concern about noise exposure in recreational settings is growing and unsafe levels of sound are frequently being experienced in a variety of non-occupational settings such as pubs, nightclubs, concerts, parties, and fitness classes. Damage to the auditory system may occur with regular participation in these loud activities. A case study was conducted to estimate sound exposure levels and risk associated with common activities. Findings demonstrated that pubs presented a hazardous sound environment, so information about health-oriented behavior is essential to effectively improve hearing conservation awareness for university students. Public awareness and personal hearing protection should be strongly considered to prevent …

Can Apelin Play A Role In The Etiology Of Tinnitus?, Nuray Ensari̇, Özer Erdem Gür, Ni̇lgün Gür, Ömer Tarik Selçuk, Levent Renda, Mustafa Deni̇z Yilmaz, Mehmet Türker Öztürk, Yeşi̇m Çeki̇n

Turkish Journal of Medical Sciences

Background/aim: Tinnitus is seen in 15% of the general population; in 1%-6% of this number, the quality of life is seriously affected by this chronic condition. Chemical, oxidative, and emotional stressors are important in terms of the clinical course of tinnitus. Apelin is an endogenous peptide which is an oxidative stress mediator. It has been shown that the apelin/APJ (apelin junction receptor) system plays various roles in the physiology and pathophysiology of many organs. However, the role of the apelin/APJ system as an oxidative stress mediator in tinnitus is unknown. We investigated the level of apelin in patients with normal …

Cortical Stimulation Mapping Of Heschl’S Gyrus In The Auditory Cortex For Tinnitus Treatment, Austin Huang

CMC Senior Theses

Tinnitus is the perception of sound in the absence of an actual sound stimulus. Recent developments have shifted the focus to the central nervous system and the neural correlate of tinnitus. Broadly, tinnitus involves cortical map rearrangement, pathological neural synchrony, and increased spontaneous firing rates. Various cortical regions, such as Heschl’s gyrus in the auditory cortex, have been found to be associated with different aspects of tinnitus, such as perception and loudness. I propose a cortical stimulation mapping study of Heschl’s gyrus using a depth and subdural electrode montage to conduct electrocorticography. This study would provide high-resolution data on abnormal …

Auditory/Vestibular/Tbi Mini-Series: Effects Of Tbi On Auditory Processing, Vestibular Function, And Tinnitus, Frederick Gallum, Paula Myers, Faith W. Akin

Faith W. Akin

This session is developed by, and presenters invited by, Hearing, Balance, Tinnitus – Assessment and Intervention: Adult. This combined mini-series will present both clinical and research findings addressing the auditory and vestibular consequences of traumatic brain injury (TBI). Presenters will elucidate TBI’s effect on auditory processing, vestibular function, and tinnitus with case studies to illustrate management strategies relevant for each of the patient groups.

Military Trauma And Its Influence On Loudness Perception, Marc A. Fagelson

Marc A. Fagelson

Excerpt: It is often the case that veterans who experience hyperacusis have hearing loss and tinnitus; what sets the patient with PTSD apart is an increased likelihood that will rate sound tolerance problems as more severe than tinnitus and hearing loss.

Tinnitus And Trauma, Marc A. Fagelson

Marc A. Fagelson

Trauma-provoked tinnitus challenges patients and clinicians. Effects of trauma may exacerbate tinnitus, and patients with both tinnitus and posttraumatic stress disorder rate distress levels as higher than patients who experience only one or the other. This presentation will highlight links between tinnitus and trauma histories relevant to clinical audiologists.

Implementing Psychological Methods In The Management Of Trauma-Associated Tinnitus, Marc A. Fagelson

Marc A. Fagelson

Dr. Fagelson, (Professor Audiology, ETSU) will discuss the unusual challenges facing patients and providers when tinnitus severity is linked to traumatic exposure. Interactions between neural mechanisms associated with tinnitus, posttraumatic stress-disorder (PTSD), and traumatic memory will be reviewed with particular attention to the way and degree to which such interactions affect tinnitus and disorders of sound tolerance. Conference attendees will be provided theoretical models of emotional memory consolidation that underscore trauma‘s durable effects on a patient‘s emotional state, reaction to the tinnitus signal, and to potentially-triggering environmental sounds. The putative benefits of tinnitus counseling will be presented in the context …

Implementing Psychological Methods In The Management Of Trauma-Associated Tinnitus, Marc A. Fagelson

ETSU Faculty Works

Dr. Fagelson, (Professor Audiology, ETSU) will discuss the unusual challenges facing patients and providers when tinnitus severity is linked to traumatic exposure. Interactions between neural mechanisms associated with tinnitus, posttraumatic stress-disorder (PTSD), and traumatic memory will be reviewed with particular attention to the way and degree to which such interactions affect tinnitus and disorders of sound tolerance. Conference attendees will be provided theoretical models of emotional memory consolidation that underscore trauma‘s durable effects on a patient‘s emotional state, reaction to the tinnitus signal, and to potentially-triggering environmental sounds. The putative benefits of tinnitus counseling will be presented in the context …