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Lean And Obese Zucker Rats Exhibit Different Patterns Of P70s6 Kinase Regulation In The Tibialis Anterior Muscle In Response To High-Force Muscle Contraction, Anjaiah Katta, Sunil K. Karkala, Miaozong Wu, Sarath Meduru, Devashish H. Desai, Kevin M. Rice, Eric R. Blough
Lean And Obese Zucker Rats Exhibit Different Patterns Of P70s6 Kinase Regulation In The Tibialis Anterior Muscle In Response To High-Force Muscle Contraction, Anjaiah Katta, Sunil K. Karkala, Miaozong Wu, Sarath Meduru, Devashish H. Desai, Kevin M. Rice, Eric R. Blough
Eric Blough
Increased phosphorylation of the 70-kDa ribosomal S6 kinase (p70S6k) signaling is strongly correlated with the degree of muscle adaptation following exercise. Herein we compare the phosphorylation of p70S6k, Akt, and mammalian target of rapamycin (mTOR) in the tibialis anterior (TA) muscles of lean and obese Zucker rats following a bout of eccentric exercise. Exercise increased p70S6k (Thr389) phosphorylation immediately after (33.3 ± 7.2%) and during [1 h (24.0 ± 14.9%) and 3 h (24.6 ± 11.3%)] recovery in the lean TA and at 3 h (33.5 ± 8.0%) in the obese TA Zucker rats. mTOR (Ser2448) phosphorylation was elevated in …
Acetaminophen: Beyond Pain And Fever-Relieving, Eric R. Blough, Miaozong Wu
Acetaminophen: Beyond Pain And Fever-Relieving, Eric R. Blough, Miaozong Wu
Eric Blough
Acetaminophen, also known as APAP or paracetamol, is one of the most widely used analgesics (pain reliever) and antipyretics (fever reducer). According to the U.S. Food and Drug Administration, currently there are 235 approved prescription and over-the-counter drug products containing acetaminophen as an active ingredient. When used as directed, acetaminophen is very safe and effective; however when taken in excess or ingested with alcohol hepatotoxicity and irreversible liver damage can arise. In addition to well known use pain relief and fever reduction, recent laboratory and pre-clinical studies have demonstrated that acetaminophen may also have beneficial effects on blood glucose levels, …