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Full-Text Articles in Medicine and Health Sciences

Modulating Tumour Hypoxia In Prostate Cancer Through Exercise: The Impact Of Redox Signalling On Radiosensitivity, Malcolm Brown, Amélie Rébillard, Nicolas H. Hart, Dominic O’Connor, Gillian Prue, Joe M. O’Sullivan, Suneil Jain Apr 2022

Modulating Tumour Hypoxia In Prostate Cancer Through Exercise: The Impact Of Redox Signalling On Radiosensitivity, Malcolm Brown, Amélie Rébillard, Nicolas H. Hart, Dominic O’Connor, Gillian Prue, Joe M. O’Sullivan, Suneil Jain

Research outputs 2022 to 2026

Prostate cancer is a complex disease affecting millions of men globally. Radiotherapy (RT) is a common treatment modality although treatment efficacy is dependent upon several features within the tumour microenvironment (TME), especially hypoxia. A hypoxic TME heightens radioresistance and thus disease recurrence and treatment failure continues to pose important challenges. However, the TME evolves under the influence of factors in systemic circulation and cellular crosstalk, underscoring its potential to be acutely and therapeutically modified. Early preclinical evidence suggests exercise may affect tumour growth and some of the benefits drawn, could act to radiosensitise tumours to treatment. Intracellular perturbations in skeletal …


The Importance Of Functional Diagnostics In Preventing And Rehabilitating Gymnast Injuries With The Assistance Of The Tensiomyography (Tmg) Method: A Case Study, Almir Atikovic, Mitija Samardzija Pavletic, Muhamed Tabakovic Mar 2022

The Importance Of Functional Diagnostics In Preventing And Rehabilitating Gymnast Injuries With The Assistance Of The Tensiomyography (Tmg) Method: A Case Study, Almir Atikovic, Mitija Samardzija Pavletic, Muhamed Tabakovic

Baltic Journal of Health and Physical Activity

Background: The tensiomyography assessment offers information, in the time domain, regarding the following parameters: maximal radial deformation or displacement of the muscle belly, contraction time, reaction time, sustain time and relaxation time. The aim of this study is to provide information about muscle stiffness, the mechanic and contractile properties using the TMG muscles after 4 months rehabilitation process gymnast. Material/Methods: Four muscles were chosen on both lateral sides involved in artistic gymnastics performance: biceps femoris, erector spinae, gluteus maximus, rectus femoris. The testing sample in this study was taken from the Croatian Republic’s senior representative who won third place 2012 …