Medicine and Health Sciences Commons^™

Korean Sibling Caregivers Of Individuals Diagnosed With Schizophrenia, Mijung Park, Kwang-Ja Lee

Asian/Pacific Island Nursing Journal

Siblings of individuals diagnosed with schizophrenia are an important source of family caregiving. Unfortunately, limited information is available about sibling caregivers because existing studies have focused on other family relationships such as parents, spouses, and children. To fill the knowledge gap, the purpose of this study is to describe Korean sibling caregivers’ experience with individuals diagnosed with schizophrenia.

Guided by Colaizzi’s descriptive phenomenological methodology, we conducted in-depth, semi-structured, face-to-face interviews with eight individuals who have a sibling (1) diagnosed with schizophrenia and (2) hospitalized in an inpatient psychiatric unit. We discerned six key themes: sorrow, burnout, shame, different perspectives in …

Exome Sequences Of Multiplex, Multigenerational Families Reveal Schizophrenia Risk Loci With Potential Implications For Neurocognitive Performance, Mark Kos, Melanie A. Carless, Juan M. Peralta, Joanne E. Curran, Ellen E. Quillen, Marcio Almeida, August N. Blackburn, Lucy Blondell, David Roalf, Michael F. Pogue-Geile, Harald H. H. Goring, Laura Almasy

School of Medicine Publications and Presentations

Schizophrenia is a serious mental illness, involving disruptions in thought and behavior, with a worldwide prevalence of about one percent. Although highly heritable, much of the genetic liability of schizophrenia is yet to be explained. We searched for susceptibility loci in multiplex, multigenerational families affected by schizophrenia, targeting protein-altering variation with in silico predicted functional effects. Exome sequencing was performed on 136 samples from eight European-American families, including 23 individuals diagnosed with schizophrenia or schizoaffective disorder. In total, 11,878 non-synonymous variants from 6,396 genes were tested for their association with schizophrenia spectrum disorders. Pathway enrichment analyses were conducted on gene-based …

Community Mental Health Services: A Way Forward To Rehabilitate Chronic Mentally Ill Client., Ambreen Tharani, Salima Farooq, Anila Naveed

Ambreen Tharani

Schizophrenia and other mental illnesses produce devastating effects on a clients' personal and psychosocial wellbeing. Besides the sufferer, it has irrevocable impacts on the lives of their loved ones. With advancement in the treatment modalities, researches have proven that hospital based care and psychotropic drugs are not the sole solution in managing the client symptoms. Deinstitutionalization is the paradigm shift from hospital based to community based care model that allows client/s to spend rest of their lives in the community setting. A well-structured community care based programme that focuses on psychosocial interventions has significant contribution in treatment and rehabilitation of …

Compliance To Antipsychotic Medication: A Challenge For Client, Family And Health Care Providers., Ambreen Tharani, Salima Farooq, Faiza Saleem, Anila Naveed

Ambreen Tharani

Compliance with anti-psychotic medications plays a significant role in managing clients with schizophrenia. It not only helps in controlling the symptoms, but also decreases the risk of relapses and ultimately improves quality of life (QoL) for the clients. However, compliance with anti-psychotic medication remains a challenge for the client, family and healthcare providers. Identification of these associated factors is vital to make appropriate plan to enhance medication compliance. In this paper, various factors are highlighted that are associated with medication compliance in clients with schizophrenia.

Factors Influencing Health Behaviors In Those At Risk For Developing Schizophrenia, Adriana C. Pennacchi

Theses and Dissertations

Significant health concerns are common among those with schizophrenia- spectrum disorders and are associated with an average lifespan reduction of 15-20 years compared to the general public (Saha, Chant, & McGrath, 2007). Although symptoms of the disorder can disrupt self-care and health behaviors, evidence also suggests that problematic health behaviors are present before the onset of the manifest disorder. One example includes nicotine use which is elevated in those with a family history of schizophrenia (Ferchiou et al., 2012) and in those who show subclinical signs of risk for schizophrenia (Esterberg, Jones, Compton, & Walker, 2007). Despite these findings, there …

Computational Modeling Of Contrast Sensitivity And Orientation Tuning In Schizophrenia, Steven M. Silverstein, Docia L. Demmin, James A. Bednar

MODVIS Workshop

Computational modeling is being increasingly used to understand schizophrenia, but, to date, it has not been used to account for the common perceptual disturbances in the disorder. We manipulated schizophrenia-relevant parameters in the GCAL (gain control, adaptation, laterally connected) model (Stevens et al., 2013), run using the Topographica simulator (Bednar, 2012), to model low-level visual processing changes in the disorder. Our models incorporated: separate sheets for retinal, LGN, and V1 activity; gain control in the LGN; homeostatic adaptation in V1 based on a weighted sum of all inputs and limited by a logistic (sigmoid) nonlinearity; lateral excitation and inhibition in …

Schizophrenia And Its Effects On An American Family: A Call To Action For The 21st Century, Cynthia Newton Captain

Senior Theses

Our country’s healthcare system is at a moral crossroads. The way we treat those whom we call “the homeless” is deplorable. The majority of the homeless are mentally ill and need treatment. Our country needs to treat those with the severe brain diseases of schizophrenia, schizo-affective disorder, and bi-polar disorder just as we would Alzheimer’s disease and Parkinson’s disease. Those with severe mental illness, who have no insight into their illness, should not be allowed to dictate their own treatment. If a homeless person is brought to San Francisco General Hospital and is found to be a schizophrenic in psychiatric …

Receptor-Associated Protein (Rap) Models In Vivo Reelin Haploinsufficiency: Implications In Schizophrenia, Jamileh Ahmed

USF Tampa Graduate Theses and Dissertations

The “two-hit” schizophrenia hypothesis suggests genetic and environmental abnormalities interrupt early CNS function. This increases vulnerability of a “second hit” and schizophrenia onset. Chronic stress and decreased Reelin signaling are reportedly associated with schizophrenia. Heterozygous Reeler Mice (HRM) show a 50% reduction in Reelin and display major schizophrenia phenotypes. Receptor-Associated Protein (RAP) blocks ligand-association to Reelin receptor Apolipoprotein E receptor 2 (ApoER2). In this study, we sought to replicate major heterozygous reeler mouse (HRM) phenotypes using in vivo RAP studies to establish an experimental in vitro model. Using an in vitro model, we investigated the effects of chronic stress and …

Transcriptome Sequencing Study Implicates Immune-Related Genes Differentially Expressed In Schizophrenia: New Data And A Meta-Analysis, Alan R. Sanders, Eugene I. Drigalenko, Jubao Duan, Jessica Freda, Harald H. H. Goring, Pablo V. Gejman

School of Medicine Publications and Presentations

We undertook an RNA sequencing (RNAseq)-based transcriptomic profiling study on lymphoblastoid cell lines of a European ancestry sample of 529 schizophrenia cases and 660 controls, and found 1058 genes to be differentially expressed by affection status. These differentially expressed genes were enriched for involvement in immunity, especially the 697 genes with higher expression in cases. Comparing the current RNAseq transcriptomic profiling to our previous findings in an array-based study of 268 schizophrenia cases and 446 controls showed a highly significant positive correlation over all genes. Fifteen (18%) of the 84 genes with significant (false discovery rateo0.05) expression differences between cases …

Health Care Resource Utilization And Costs Of California Medicaid Patients With Schizophrenia Treated With Paliperidone Palmitate Once Monthly Or Atypical Oral Antipsychotic Treatment, Jacqueline A. Pesa,, Dilesh Doshi, Li Wang, Huseyin Yuce, Onur Baser

Publications and Research

Objective: To compare all-cause health care utilization and costs between patients with schizophrenia treated with once monthly paliperidone palmitate (PP1M; Invega Sustenna1) and atypical oral antipsychotic therapy (OAT).

Methods: This was a retrospective claims-based analysis among adult California Medicaid (Medi-Cal) patients with schizophrenia having 2 claims for PP1M or OAT from 1 July 2009 to 31 December 2013 and continuous health plan enrollment for 1 year pre- and post-index date (PP1M or OAT initiation date). Baseline characteristics were reported descriptively. Propensity score matching with a 1:1 greedy match method was used to create two matched cohorts. Treatment patterns, all-cause health …

Adolescent Cannabinoid Exposure Induces A Persistent Sub-Cortical Hyper-Dopaminergic State And Associated Molecular Adaptations In The Prefrontal Cortex., Justine Renard, Laura G Rosen, Michael Loureiro, Cleusa De Oliveira, Susanne Schmid, Walter J Rushlow, Steven R Laviolette

Brain and Mind Institute Researchers' Publications

Considerable evidence suggests that adolescent exposure to delta-9-tetrahydrocanabinol (THC), the psychoactive component in marijuana, increases the risk of developing schizophrenia-related symptoms in early adulthood. In the present study, we used a combination of behavioral and molecular analyses with in vivo neuronal electrophysiology to compare the long-term effects of adolescent versus adulthood THC exposure in rats. We report that adolescent, but not adult, THC exposure induces long-term neuropsychiatric-like phenotypes similar to those observed in clinical populations. Thus, adolescent THC exposure induced behavioral abnormalities resembling positive and negative schizophrenia-related endophenotypes and a state of neuronal hyperactivity in the mesocorticolimbic dopamine (DA) pathway. …

The Effects Of Abilify On Memory, Coordination, And Stereotypy In Cd-1 Mice, Jostein Andersen

Undergraduate Honors College Theses 2016-

The atypical antipsychotic Abilify is the second most popular treatment for schizophrenia and other related disorders. Its popularity and wide use is due to its unique pharmacological profile, working differently at dopamine and serotonin receptors compared to other antipsychotics. Schizophrenia is an infamous mental dysfunction involving cognitive impairment, positive symptoms, and negative symptoms. The current study investigated Abilify’s effect in a dose-dependent manner on memory, coordination and stereotypic movement. The sample consisted of 15 male and 15 female CD-1 mice. Memory was tested in a cognitive maze, the Rota-Rod series 8 model measured coordination, and the Coulbourn Tru-Scan Activity Box …

Effect Of Family Intervention On Functioning Among Patients With Chronic Schizophrenia, Sreeja I Ms

Manipal Journal of Nursing and Health Sciences

Introduction: Schizophrenia is a chronic major psychotic disorder, manifested by distorted thinking and poor emotional response. Patients diagnosed with schizophrenia have inability in performing basic individual and social roles or activities. Improving personal, occupational, and social aspects of functioning is an important treatment aim for such patients. Objective: 1. To assess the effect of family intervention on patient functioning, and 2. To find out association of patient functioning with demographic variables. Methods: A quasi-experimental nonequivalent control group design and consecutive sampling was adopted for the study. The population under study was patients having chronic schizophrenia and their caregivers in Thiruvananthapuram …

Neurovascular Unit Dysfunction And Blood-Brain Barrier Hyperpermeability Contribute To Schizophrenia Neurobiology: A Theoretical Integration Of Clinical And Experimental Evidence, S. Najjar, S. Pahlajani, V. De Sanctis, J. N.H. Stern, A. Najjar, D. Chong

Journal Articles

No abstract provided.

Emotion Learning And Memory In Schizophrenia, M. N. Strong, D. N. Allen

McNair Poster Presentations

• Prior research indicates that processing of emotional information is particularly problematic for individuals with schizophrenia. • An important component of emotional processing is the accurate encoding and recall of emotionally valenced information. • The current study addresses this matter by investigating performance on a task assessing learning, recall, and recognition in patients with schizophrenia. • In this manner, recall of emotionally valenced information may be investigated

Is Aristada (Aripiprazole Lauroxil) A Safe And Effective Treatment For Schizophrenia In Adult Patients?, Kyle J. Knowles

PCOM Physician Assistant Studies Student Scholarship

OBJECTIVE: The objective of this selective EBM review is to determine whether or not “Is Aristada (aripiprazole lauroxil) a safe and effective treatment for schizophrenia in adult patients?”

STUDY DESIGN: Review of three randomized controlled studies. All three trials were conducted between 2014 and 2015.

DATA SOURCES: One randomized, controlled trial and two randomized, controlled, doubleblind trials found via Cochrane Library and PubMed.

OUTCOMES MEASURED: The outcomes that were measured include adverse events (pain at injection site, insomnia, headache, toothache, abdominal discomfort, constipation, diarrhea, akathisia, back pain, dyskinesia, dystonia, nasopharyngitis) measured by vital signs, physical examination, …

A Systematic Review Of The Effect Of Cannabidiol On Cognitive Function: Relevance To Schizophrenia, Ashleigh L. Osborne, Nadia Solowij, Katrina Weston-Green

Illawarra Health and Medical Research Institute

Background and objectives Cognitive impairment is a core symptom domain of schizophrenia, neurological disorders and substance abuse. It is characterised by deficits in learning, memory, attention and executive functioning and can severely impact daily living. Antipsychotic drugs prescribed to treat schizophrenia provide limited cognitive benefits and novel therapeutic targets are required. Cannabidiol (CBD), a component of the cannabis plant, has anti-inflammatory and antipsychotic-like properties; however, its ability to improve cognitive impairment has not been thoroughly explored. The aim of this systematic review was to evaluate preclinical and clinical literature on the effects of CBD in cognitive domains relevant to schizophrenia. …

The Effect Of Saha On The Expression Of Genes In Wild Type And Hdac2 Knockout Mouse Models And Its Potential Use As Treatment For Schizophrenia, Maryum K. Ijaz

Theses and Dissertations

The symptoms of schizophrenia have been categorized into three subsets including positive, negative, and cognitive symptoms. Although atypical antipsychotic use has shown promising reduction in positive and negative symptoms of schizophrenia, such as hallucination, delusions and flat affect, the cognitive subset of symptoms remains and has an adverse impact on those affected. Chronic treatment with the atypical/secondary antipsychotic clozapine is one example that has ameliorated hallucinations and delusions but results in cognitive memory deficits. When chronically given in conjunction with the HDAC inhibitor, SAHA, the cognitive memory deficits of mouse models decline. HDAC2KO mice were bred and used in chronic …

Longitudinal Changes In Prospective Memory And Their Clinical Correlates At 1-Year Follow-Up In First-Episode Schizophrenia, Fu-Chun Zhou, Chuan-Yue Wang, Gabor S. Ungvari, Chee H. Ng, Yan Zhou, Liang Zhang, Jingjing Zhou, David H.K. Shum, David Man, Deng-Tang Liu, Jun Li, Yu-Tao Ziang

Medical Papers and Journal Articles

This study aimed to investigate prospective memory (PM) and the association with clinical factors at 1-year follow-up in first-episode schizophrenia (FES). Thirty-two FES patients recruited from a university-affiliated psychiatric hospital in Beijing and 17 healthy community controls (HCs) were included. Time- and event-based PM (TBPM and EBPM) performances were measured with the Chinese version of the Cambridge Prospective Memory Test (CCAMPROMPT) at baseline and at one-year follow-up. A number of other neurocognitive tests were also administered. Remission was determined at the endpoint according to the PANSS score _ 3 for selected items. Repeated measures analysis of variance revealed a significant …

Meta Analysis Of Human Alzgene Database: Benefits And Limitations Of Using C. Elegans For The Study Of Alzheimer's Disease And Co-Morbid Conditions, Behrad Vahdati Nia, Christine Kang, Michelle G. Tran, Deborah Lee, Shin Murakami

Faculty Publications & Research of the TUC College of Osteopathic Medicine

Human genome-wide association studies (GWAS) and linkage studies have identified 695 genes associated with Alzheimer's disease (AD), the vast majority of which are associated with late-onset AD. Although orthologs of these AD genes have been studied in several model species, orthologs in the nematode, Caenorhabditis elegans, remain incompletely identified, with orthologs to only 17 AD-related genes identified in the C. elegans database, WormBase. Therefore, we performed a comprehensive search for additional C. elegans orthologs of AD genes using well-established programs, including OrthoList, which utilizes four ontology prediction programs. We also validated 680 of the AD genes as a unique …

The Impact Of Drug And Gene Interaction On The Antipsychotic Medication For Schizophrenia, Michelle Cho, Adriana Contreras, Ashley Garza, Samantha Olvera, David Castillo, Gabriel A. De Erausquin, Chun Xu

Health & Biomedical Sciences Faculty Publications and Presentations

Objective: Schizophrenia, a neuropsychiatric disorder, is known to be neurodevelopmentally progressive. Due to the extensive interindividual variability found in the responses of patients, management of schizophrenia has proven to be challenging. This interindividual variability to treatment could be justified by the variation of the enzymes in charge of metabolizing medications, especially those associated with cytochrome P450. Since genetic factors influence the phenotypic responses to drugs, researchers are involved in identifying schizophrenic genetic factors, which could impact responses and severe effects for commonly known neuroleptic drugs known as pharmacogenetics. In order to predict drug response at the personal level, genetic variants …

Genetic Association Analysis Of Erbb4 Polymorphisms With The Risk Ofschizophrenia Susceptibility In A Jordanian Population Of Arab Descent, Laith Aleitan, Sahar Al-Habahbeh, Rami Alkhatib

Turkish Journal of Medical Sciences

Background/aim: The ERBB4 gene encodes a transmembrane tyrosine kinase and is considered to be one of the risk genes of schizophrenia. Although there is evidence of the roles of genes and the environment in the etiology of schizophrenia, a comprehensive biological and genetic background of the disease is still lacking. The aim of this study is to assess whether genetic variation in the human ERBB4 gene is associated with vulnerability to schizophrenia in the Jordanian Arab population. Materials and methods: A total of 185 inpatients with schizophrenia participated in this study and 195 healthy genetically homogeneous individuals were also used …

Electroconvulsive Therapy For Agitation In Schizophrenia: Meta-Analysis Of Randomized Controlled Trials, Xiaojing Gu, Wei Zheng, Tong Guo, Gabor S. Ungvari, Helen F.K. Chiu, Xiaolan Cao, Carl D'Arcy, Xiangfei Meng, Yuping Ning, Yu-Tao Xiang

Medical Papers and Journal Articles

Background: Agitation poses a significant challenge in the treatment of schizophrenia. Electroconvulsive therapy (ECT) is a fast, effective and safe treatment for a variety of psychiatric disorders, but no meta-analysis of ECT treatment for agitation in schizophrenia has yet been reported.

Aims: To systematically evaluate the efficacy and safety of ECT alone or ECT-antipsychotics (APs) combination for agitation in schizophrenia.

Methods: Systematic literature search of randomized controlled trials (RCTs) was performed. Two independent evaluators selected studies, extracted data about outcomes and safety with available data, conducted quality assessment and data synthesis. The Grades of Recommendation, Assessment, Development, and Evaluation (GRADE) …

Prevalence Of Smoking In Patients With Bipolar Disorder, Major Depressive Disorder And Schizophrenia And Their Relationships With Quality Of Life, Xiao-Hong Li, Feng-Rong An, Gabor S. Ungvari, Chee H. Ng, Helen F.K. Chiu, Ping-Ping Wu, Xin Jin, Yu-Tao Xiang

Medical Papers and Journal Articles

Few studies have compared the prevalence of smoking between patients with bipolar disorder, major depressive disorder (MDD) and schizophrenia. This study examined the prevalence of smoking and its relationships with demographic and clinical characteristics, and quality of life (QOL) in patients with these psychiatric disorders. A total of 1,102 inpatients were consecutively screened. Psychopathology and QOL were measured with standardized instruments. The prevalence of current smoking in the whole sample was 16.7%; 17.5% in bipolar disorder, 10.6% in MDD and 18.5% in schizophrenia. The rates of smoking in bipolar disorder (p = 0.004, OR = 2.5, 95%CI: 1.3–4.7) and schizophrenia …

Prevalence, Characteristics And Management Of Headache Experienced By People With Schizophrenia And Schizoaffective Disorder: A Cross Sectional Cohort Study, J Connaughton, B Wand

Physiotherapy Papers and Journal Articles

Objective: Headache is the most common type of pain reported by people with schizophrenia. This study aimed to establish prevalence, characteristics and management of these headache.

Method: One-hundred participants with schizophrenia/schizoaffective disorder completed a reliable and valid headache questionnaire. Two clinicians independently classified each headache as migraine (MH), tension-type (TTH), cervicogenic (CGH) or other (OH).

Results: The twelve-month prevalence of headache (57%) was higher than the general population (46%) with no evidence of a relationship between psychiatric clinical characteristics and presence of headache. Prevalence of CGH (5%) and MH (18%) was comparable to the general population. TTH …

Schizophrenia’S Relationship With Cardiovascular Morbidity And Mortality, Hannah Jorgensen

Theses and Graduate Projects

Premature morbidity and mortality due to cardiovascular disease (CVD) disproportionately affects individuals with schizophrenia. This research paper systematically reviews articles that examine the theories and causes of increased CVD risk in individuals with schizophrenia. The findings of the review indicate that there are biological, environmental and sociocultural components of the relationship between schizophrenia and cardiovascular disease. Inflammation from the progression of chronic schizophrenia appears to play a part. The side-effect profile of the medications used to treat schizophrenia cause CVD risk factors. The secondary and tertiary symptoms of the disease process result in problems in motivation, cognitive function and self- …

Association Between Schizophrenia And Violence Among Chinese Female Offenders, Jun Wang, Xiao-Min Zhu, Si-Mei Zhang, Jian-Song Zhou, Qiguang Li, Qun Wang, Shao-Ling Zhong, Chee H. Ng, Gabor S. Ungvari, Yu-Tao Xiang, Xiao-Ping Wang

Medical Papers and Journal Articles

Little is known about the association between schizophrenia and violence in women in China. This study aimed to examine the association between schizophrenia and violence in Chinese female offenders. Fifty-two schizophrenia patients were identified from the female offenders who received forensic psychiatric assessments in 2011 in Hunan province, China. Using a propensity score matching method, 104 matched controls without psychiatric disorders were selected from female criminals in Hunan province. Violent offences and homicides were verified and recorded. The percentages of violent offences and homicides were significantly higher in female offenders with schizophrenia than in controls (78.8% vs. 30.8%, P < 0.001; 44.2% vs. 18.3%, P = 0.001, respectively). Multivariate logistic regression analyses revealed that diagnosis of schizophrenia, younger age at first offence, living in rural area and a lower education level were independently and positively associated with violent offences, while having a diagnosis of schizophrenia and lower education level were associated with homicides. There appears to be an independent and positive association between schizophrenia and violent offence in Chinese female offenders. Effective preventive approaches on violence in female schizophrenia patients are warranted.

Evaluating Prescribing Patterns Of Long-Acting Injectable Antipsychotics At A Community Health System, Chelsea L Ferguson Pharmd, Jamie Gaul Pharmd, Bcps, Jared Netley Pharmd

Parkview Pharmacy Department

2017 ASHP Midyear Clinical Meeting / Orlando, Florida / Poster 10-084

Poster Presentation

Objective: Describe prescribing patterns for long-acting injectable antipsychotics and identify knowledge gaps in prescribing within our health system.

A Study Of Media Portrayal Of Schizophrenics To Understand How Stigma Associated With Schizophrenia May Be Reversed, Rainielle M. Cua

Undergraduate Research Posters

The news media are one of the most influential sources of information regarding mental illness. Media coverage on schizophrenia, one of the most stigmatized mental illnesses, tends to be negative, focusing on high risks of violence, failure, and unpredictability. Such perceptions may cause a detrimental impact on the mentally ill and cause them to internalize a stigmatizing stereotype and hinder the public’s understanding of mental illness. I studied how media portrayal in newspaper coverage of schizophrenics has evolved to discover how nonfiction media representation has affected people’s perceptions and attitudes towards schizophrenics and to propose an implementable solution to reduce …