Medicine and Health Sciences Commons^™

Characterizing Thalamo-Cortical Disturbances In Schizophrenia And Bipolar Illness, Alan Anticevic, Michael W. Cole, Grega Repovs, John D. Murray, Margaret S. Brumbaugh, Anderson M. Winkler, Aleksandar Savic, John H. Krystal, Godfrey D. Pearlson, David Glahn

School of Medicine Publications and Presentations

Schizophrenia is a devastating neuropsychiatric syndrome associated with distributed brain dysconnectivity that may involve large-scale thalamo-cortical systems. Incomplete characterization of thalamic connectivity in schizophrenia limits our understanding of its relationship to symptoms and to diagnoses with shared clinical presentation, such as bipolar illness, which may exist on a spectrum. Using resting-state functional magnetic resonance imaging, we characterized thalamic connectivity in 90 schizophrenia patients versus 90 matched controls via: (1) Subject-specific anatomically defined thalamic seeds; (2) anatomical and data-driven clustering to assay within-thalamus dysconnectivity; and (3) machine learning to classify diagnostic membership via thalamic connectivity for schizophrenia and for 47 bipolar …

Community Mental Health Services And The Prevalence Of Severe Mental Illness In Local Jails: Are They Related, William Fisher, Ira Packer, Lorna Simon, David Smith

Ira K Packer

The excessive prevalence of severe mental illness noted in correctional settings has sometimes been attributed to the inadequacy of community based mental health services. This study examines the prevalence of severe mental illness in two jails situated within catchment areas featuring markedly different levels of community mental health services. We use these settings to test the hypothesis that greater levels of services in a community are associated with lower prevalence of severe mental illness in the community's jail. An epidemiologic approach, using standardized field instruments, was used to estimate the prevalence of major mental illness in detainees arriving at the …

Fieldwork Summary Report-World Health Organization, Anna Cross

Master's Projects and Capstones

My fieldwork experience took place at the World Health Organization in Geneva, Switzerland, where I completed over 420 hours of practical experience. My fieldwork focused in the field of mental health, working on disorders management (psychosis, depression and suicide) and evidence-based research, but more specifically focusing on schizophrenia, premature death in severe mental disorders, and maternal mental health. Although my fieldwork focused within these areas, for the purpose of this final report, I have opted to focus on my contributions to the research around schizophrenia and premature death within severe mental disorders. Specifically, I contributed to multiple fact/information sheets for …

Impaired Theory Of Mind In Psychotic And Affective Disorders, Erik Nelson Ringdahl

UNLV Theses, Dissertations, Professional Papers, and Capstones

Psychotic symptoms in bipolar I disorder during mood episodes has been associated with several negative outcomes raising the question as to whether psychosis is a risk factor for a more severe form of this chronic and debilitating condition. However, relatively little research has been directed at understanding the relationships among social cognitive functioning in bipolar I disorder with and without a history of psychosis. Impaired social cognition has been identified as a putative endophenotypic markers in schizophrenia and the evidence is mounting as to whether similar impairments also exist in bipolar I disorder. Given the plethora of research supporting the …

First Episode Is The Best Episode: Lessons And Limitations In Duration Of Untreated Psychosis (Dup) And Outcome In Schizophrenia, Amresh Srivastava, Larry Stitt, Meghana Thakar, Gurusamy Chinnasamy, Nilesh Shah

Amresh Srivastava

Background: Early intervention in psychosis is an opportunity. Research ahs shown that if any thing community members can do to prevent psychosis is to report early. This has opened newer vistas for understanding the complexity of brain and behaviour in schizophrenia. At the same time it has raised the bar of expectations regarding its correlation to outcome. It finally narrows down to meaningful public campaign for awareness, which will decide success of research to clinics in schizophrenia management. Duration of untreated psychosis (DUP) has emerged as a reliable predictor of outcome and provides credence to development of early intervention services. …

Eating Disorders Remain Undetected In Psychiatric Hospitalization: Study Of Electronic Chart Review Of 8000 Patients, Amresh Srivastava, Miky Kaushal, Megan Johnston, Robbie Campbell

Amresh Srivastava

No abstract provided.

Eating Disorders Remain Undetected In Psychiatric Hospitalization: Study Of Electronic Chart Review Of 8000 Patients, Amresh Srivastava, Miky Kaushal, Megan Johnston, Robbie Campbell

Amresh Srivastava

No abstract provided.

Risk, Vulnerability And Resilience: An Epigenetic Trajectory Of Psychiatric Disorders, Amresh Srivastava

Amresh Srivastava

ABSTRACT: Risk, Vulnerability and Resilience: An epigenetic trajectory of psychiatric disorders Amresh Shrivastava. Biopsychosocial model is generally widely accepted for pathogenesis of mental disorder, recent research shows a different concept. . Social, cultural, environmental factors possibly interact in a complex way to give rise to behavioral symptoms in a particular disorder. Such factors are considered 'risk factors'. but their discrete role in causation of illness is less clear. Two main factors appear to play important role which may partially explain this process. 1. risk-vulnerability and stress diathesis model and the 2. Gene-environment interaction. Both may be operating simultaneously. Our understanding …

Factors Affecting Attitudes Towards Individuals With Schizophrenia: Perceptions Of Mexican American College Students, Valerie Paredes

Theses and Dissertations - UTB/UTPA

This study is designed to examine the effects of acculturation and level of familiarity on stigma of Mexican American college students towards individuals with schizophrenia along the border of Texas and Mexico (N = 223). The area has a history of high levels of disparity in regards to the utilization of mental health services. Data was collected by surveying Mexican American college students through a convenience sample at two separate post-secondary southwestern Hispanic-Serving Institutions (HSIs) along a border community. The instrumentation for the study was composed of a demographic questionnaire, The Acculturation Scale for Mexican-Americans-II (Cuéllar, Arnold, & Maldonado, 1995), …

Firesetting Behavior And Associated Comorbid Psychiatric Disorders, Stephanie Stockburger, Hatim A. Omar

Pediatrics Faculty Publications

Firesetting behavior results in serious damage to lives and property every year. Firesetting has been linked to a number of comorbid psychiatric disorders including depression, substance abuse, conduct disorder, antisocial personality disorder, obsessive compulsive disorder, psychotic disorder, schizoid personality disorder, and schizophrenia. Psychiatric disorders differ by gender. In addition, juvenile firesetters have history of a separate set of psychiatric comorbidities. The strong correlation between psychiatric comorbidities and firesetting behavior illustrates the need for fire service and mental health collaboration.

The Hospital Always Wins: Review 2, Michelle Boyd

RadioDoc Review

This documentary raises crucial questions about our definitions of mental health and healing as well as the meaning of forgiveness. It also illustrates how an individual’s ability to extract themselves from the grip of institutional power is highly dependent on luck and money and privilege. Perhaps most importantly, this piece gives voice, in a complex, respectful manner, to Ibrahim and other schizophrenics whose struggles remain buried and ignored. One element that is missing from this story is an account of how race complicates this unequal power dynamic. Ibrahim is black… “Hospital’s” impact might have been even wider had …

The Hospital Always Wins: Review 1, Sharon Davis

RadioDoc Review

This documentary gives a graphic and challenging insight into the thinking of a schizophrenic mind. But whose story is it, producer Laura Starecheski’s or mental inpatient Issa Ibrahim’s? The process of recording a documentary over such a long period of time (ten years) is tough and always difficult to negotiate. What starts out as a journalistic exercise becomes something very different as your relationship develops over time with the people you are recording. Here, it’s the narrator who drives the story on, weaving in and out of the interviews and actuality, and it’s the strength of the writing that compels …

Early Psychosis Symptoms, Haider A. Naqvi, Sajjad Hussain, Muhammad Islam, Shafqat Huma

Department of Psychiatry

Objective: To determine the prodromal symptoms of schizophrenia in the pathways to help-seeking.STUDY Design: A cross-sectional study.PLACE AND DURATION OF STUDY: The Department of Psychiatry, the Aga Khan University, Karachi, from 2008 to 2009.METHODOLOGY: A total of 93 patients were interviewed in the pathways to care of schizophrenia. The diagnosis was based on ICD-10 criteria. The pathways to care were assessed through a semi-structured questionnaire. The onset, course and symptoms of psychosis were assessed through Interview for Retrospective Assessment at Age at Onset of Psychosis (IROAS).Results: Fifty five (59%) participants were male while 41% (n=38%) were female. Using IROAS, 108 …

Biological Basis For Cerebral Dysfunction In Schizophrenia In Contrast With Alzheimer’S Disease, Rodrigo O. Kuljis, Luis V. Colom, Leonel E. Rojo

Health & Biomedical Sciences Faculty Publications and Presentations

Schizophrenia and Alzheimer’s disease are two disorders that, while conceptualized as pathophysiologically and clinically distinct, cause substantial cognitive and behavioral impairment worldwide, and target apparently similar – or nearby – circuitry in regions such as the temporal and frontal lobes.We review the salient differences and similarities from selected historical, nosological, and putative mechanistic viewpoints, as a means to help both clinicians and researchers gain a better insight into these intriguing disorders, for which over a century of research and decades of translational development was needed to begin yielding treatments that are objectively effective, but still very far from entirely satisfactory. …

Activation Of Mglur2/3 Receptors In The Ventral Prefrontal Cortex Reverses Sensorimotor Gating Deficits Induced By A Systemic Nmda Receptor Antagonist, Bridget Valsamis, Michael Chang, Marei Typlt, Susanne Schmid

Anatomy and Cell Biology Publications

Prepulse inhibition (PPI) of acoustic startle is an operational measure of sensorimotor gating, which is disrupted in schizophrenia. NMDA receptor (NMDAR) antagonist induced PPI disruption has become an important pharmacological model for schizophrenia; however, knowledge of the underlying mechanism remains incomplete. This study examines the role of NMDAR in the caudal pontine reticular nucleus (PnC) and the medial prefrontal cortex (mPFC) in NMDARs antagonist induced PPI deficits, as well as the NMDA receptor subtypes involved. We administered the NMDA antagonist MK-801 locally into the caudal pontine reticular formation (PnC), where the PPI mediating pathway converges with the primary startle pathway, …

Analysis Of Schizophrenia Data Using A Nonlinear Threshold Index Logistic Model., Zhenyu Jiang, Chengan Du, Assen Jablensky, Hua Liang, Zudi Lu, Yang Ma, Kok Lay Teo

GW Biostatistics Center

Genetic information, such as single nucleotide polymorphism (SNP) data, has been widely recognized as useful in prediction of disease risk. However, how to model the genetic data that is often categorical in disease class prediction is complex and challenging. In this paper, we propose a novel class of nonlinear threshold index logistic models to deal with the complex, nonlinear effects of categorical/discrete SNP covariates for Schizophrenia class prediction. A maximum likelihood methodology is suggested to estimate the unknown parameters in the models. Simulation studies demonstrate that the proposed methodology works viably well for moderate-size samples. The suggested approach is therefore …

A Computational Perspective Of Schizophrenia, Ernesto H. Bedoy, Geoff Powell, Jefferson Kinney

McNair Poster Presentations

The etiology of schizophrenia remains largely elusive, thus dampening the effectiveness of current treatment strategies. Abnormal neural migration and neurogenesis in the hippocampus have been suggested to be involved in schizophrenia (Jakob & Beckmann, 1994). A few approaches, including computational modeling, have investigated schizophrenia as a network disorder. Computational modeling uses mathematics to predict the behavior of biological systems based on the input of a set of parameters collected from laboratory experiments. In this study, we constructed a computational model to explore the ramifications of additional PV neurons migrating to an aberrant location in the hippocampus and interfering with a …

Is Animal Assisted Therapy Using Dogs An Effective Treatment For Positive And Negative Symptoms For Adult Inpatient Schizophrenics?, Brian Davidson

PCOM Physician Assistant Studies Student Scholarship

OBJECTIVE: The objective of this selective EBM review is to determine whether or not Animal Assisted Therapy (AAT) using dogs is an effective treatment for positive and negative symptoms for adult inpatient schizophrenics.

STUDY DESIGN: Systematic review of 3 articles published in English in peer reviewed journals between 2005-2009

DATA SOURCES: Two randomized controlled trials and one allocation by minimization controlled trial comparing the effects of AAT using dogs on positive and negative symptoms of schizophrenia to control groups. All articles were found using PubMed and PROQuest

OUTCOMES MEASURED: Focused questionnaires were given before and after …

Rethinking Metabotropic Glutamate Receptor 5 Pathological Findings In Psychiatric Disorders: Implications For The Future Of Novel Therapeutics, Kelly A. Newell, Natalie Matosin

Faculty of Science, Medicine and Health - Papers: part A

Background Pharmacological modulation of metabotropic glutamate receptor 5 (mGluR5) is of marked interest as a novel therapeutic mechanism to treat schizophrenia and major depression. However, the status of mGluR5 in the pathophysiology of these disorders remains unknown. Discussion The majority of studies in the schizophrenia post-mortem brain indicate that total mGluR5 expression is unaltered. However, close examination of the literature suggests that these findings are superficial, and in actuality, a number of critical factors have not yet been considered; alterations may be highly dependent on brain region, neuronal population or molecular organisation in specific cellular compartments. A number of genetic …

Novel Implications Of Lingo-1 And Its Signaling Partners In Schizophrenia, F Fernandez-Enright, J L. Andrews, K A. Newell, C Pantelis, Xu-Feng Huang

Illawarra Health and Medical Research Institute

Myelination and neurite outgrowth both occur during brain development, and their disturbance has been previously been implicated in the pathophysiology of schizophrenia. Leucine-rich repeat and immunoglobulin domain-containing protein (Lingo-1) is a potent negative regulator of axonal myelination and neurite extension. As co-factors of Lingo-1 signaling (Nogo receptor (NgR), With No Lysine (K) (WNK1) and Myelin transcription factor 1 (Myt1)) have been implicated in the genetics of schizophrenia, we explored for the first time the role of Lingo-1 signaling pathways in this disorder. Lingo-1 protein, together with its co-receptor and co-factor proteins NgR, tumor necrosis factor (TNF) receptor orphan Y (TROY), …

Hypothalamic Ghrelin Signalling Mediates Olanzapine-Induced Hyperphagia And Weight Gain In Female Rats, Qingsheng Zhang, Meng He, Chao Deng, Hongqin Wang, Jiamei Lian, Xu-Feng Huang

Illawarra Health and Medical Research Institute

Excessive weight gain is a major metabolic side effect of second-generation antipsychotics (SGAs) in the treatment of schizophrenia. Ghrelin is an orexigenic hormone secreted mainly from the stomach, which can induce weight gain and hyperphagia through regulating neuropeptides at the hypothalamus. Accumulating evidence implicates a relationship between ghrelin signalling and SGA-induced hyperphagia and weight gain. We report that olanzapine (a SGA with high weight gain liability) potently and time-dependently up-regulate ghrelin and ghrelin signalling, leading to hyperphagia and weight gain in female Sprague-Dawley rats, an action reversed by i.c.v. injection of a ghrelin receptor (GHS-R1a) antagonist. These findings indicate a …

Using Neuroimaging To Predict Treatment Response In Patients With Schizophrenia, Nathan Lyle Hutcheson

All ETDs from UAB

Schizophrenia is a severe debilitating mental illness that affects approximately 1% of people worldwide. Compared to healthy controls (HC), patients with schizophrenia (SZ) have memory deficits, specifically prominent disruptions in their episodic memory. These memory disruptions are thought to be caused by altered structure and function of areas within the memory network, specifically the prefrontal and temporal lobe including the hippocampus. Recently, identifying biomarkers of treatment response by using neuroimaging has become a prominent area of interest in schizophrenia. Biomarkers in schizophrenia could help by allowing for more efficient treatment using current method and also the development of novel treatments. …

Pd_Ngsatlas: A Reference Database Combining Next-Generation Sequencing Epigenomic And Transcriptomic Data For Psychiatric Disorders, Zheng Zhao, Yongsheng Li, Hong Chen, Jianping Lu, Peter M. Thompson, Juan Cheng, Zishan Wang, Juan Xu, Chun Xu, Xia Li

Health & Biomedical Sciences Faculty Publications and Presentations

Background: Psychiatric disorders such as schizophrenia (SZ) and bipolar disorder (BP) are projected to lead the global disease burden within the next decade. Several lines of evidence suggest that epigenetic- or genetic-mediated dysfunction is frequently present in these disorders. To date, the inheritance patterns have been complicated by the problem of integrating epigenomic and transcriptomic factors that have yet to be elucidated. Therefore, there is a need to build a comprehensive database for storing epigenomic and transcriptomic data relating to psychiatric disorders.

Description: We have developed the PD_NGSAtlas, which focuses on the efficient storage of epigenomic and transcriptomic data based …

Identifying Functional Variation In Schizophrenia Gwas Loci By Pooled Sequencing, Erik Loken

Theses and Dissertations

Schizophrenia demonstrates high heritability in part accounted for by common simple nucleotide variants (SNV), rare copy number variants (CNV) and, most recently, rare SNVs Although heritability explained by rare SNVs and CNVs is small compared to that explained by common SNVs, rare SNVs in functional sequences may identify specific disease mechanisms. However, current exome methods do not capture a large proportion of potentially functional bases where rare variation may impact disease risk: as much as two-thirds of conserved sequences lie outside the exome in non-coding regions of cross-species evolutionary constraint. We reasoned that the candidate loci from the Psychiatric Genomics …

Best Practice For Antipsychotic Medication Management In Community Dwelling Older Adults With Schizophrenia, Estelle Marie Brown

Theses and Dissertations

Schizophrenia, aging, and medication factors combine to present a very complex clinical presentation in caring for the elderly population with schizophrenia. The aging body displays a slowing of physiological processes, which alters the pharmacokinetics and pharmacodynamics of medications prescribed. Multiple comorbid health factors and the medications recommended for treatment may become detrimental to the overall body health, causing more problems for the older individual. This evidence based practice project reviewed literature and evidence to focus on the question, "In community dwelling older adults with schizophrenia, what is best practice for antipsychotic medication management?" The literature search resulted in classifying 16 …

Trajectories Of Symptom Dimensions In Short-Term Response To Antipsychotic Treatment In Patients With A First Episode Of Non-Affective Psychosis, J. M. Pelayo-Terán, Francisco J. Diaz, R. Pérez-Iglesias, P. Suárez-Pinilla, R. Tabarés-Seisdedos, Jose De Leon, B. Crespo-Facorro

Psychiatry Faculty Publications

Background Trajectory patterns of positive, disorganized and negative dimension symptoms during antipsychotic treatment in drug-naive patients with first-episode psychosis have yet to be examined by using naturalistic data.

Method This pragmatic clinical trial randomized 161 drug-naive patients with a first episode of psychosis to olanzapine, risperidone or haloperidol. Patients were assessed with the Scale for the Assessment of Negative Symptoms (SANS) and Positive Symptoms (SAPS) at baseline and at the end of weeks 1, 2, 3, 4 and 6 of antipsychotic treatment. Censored normal models of response trajectories were developed with three dimensions of the SAPS-SANS scores (positive, disorganized and …