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Full-Text Articles in Medicine and Health Sciences
Rethinking Metabotropic Glutamate Receptor 5 Pathological Findings In Psychiatric Disorders: Implications For The Future Of Novel Therapeutics, Kelly A. Newell, Natalie Matosin
Rethinking Metabotropic Glutamate Receptor 5 Pathological Findings In Psychiatric Disorders: Implications For The Future Of Novel Therapeutics, Kelly A. Newell, Natalie Matosin
Faculty of Science, Medicine and Health - Papers: part A
Background Pharmacological modulation of metabotropic glutamate receptor 5 (mGluR5) is of marked interest as a novel therapeutic mechanism to treat schizophrenia and major depression. However, the status of mGluR5 in the pathophysiology of these disorders remains unknown. Discussion The majority of studies in the schizophrenia post-mortem brain indicate that total mGluR5 expression is unaltered. However, close examination of the literature suggests that these findings are superficial, and in actuality, a number of critical factors have not yet been considered; alterations may be highly dependent on brain region, neuronal population or molecular organisation in specific cellular compartments. A number of genetic …
Diabetes And Cognitive Deficits In Chronic Schizophrenia: A Case-Control Study, Mei Han, Xu-Feng Huang, Da Chun Chen, Meihong Xiu, Thomas R. Kosten, Xiang Yang Zhang
Diabetes And Cognitive Deficits In Chronic Schizophrenia: A Case-Control Study, Mei Han, Xu-Feng Huang, Da Chun Chen, Meihong Xiu, Thomas R. Kosten, Xiang Yang Zhang
Faculty of Science, Medicine and Health - Papers: part A
Cognitive impairment occurs in both schizophrenia and diabetes. There is currently limited understanding whether schizophrenia with diabetes has more serious cognitive deficits than schizophrenia without diabetes or diabetes only. This study assessed cognitive performance in 190 healthy controls, 106 diabetes only, 127 schizophrenia without diabetes and 55 schizophrenia with diabetes. This study was conducted from January 2008 to December 2010. Compared to healthy controls, all patient groups had significantly decreased total and five index RBANS scores (all p<0.01-p
Expression Of Proteins Within The Nogo Receptor Complex Are Altered In The Dorsolateral Prefrontal Cortex In Schizophrenia, J Andrews, K Newell, F Fernandez
Expression Of Proteins Within The Nogo Receptor Complex Are Altered In The Dorsolateral Prefrontal Cortex In Schizophrenia, J Andrews, K Newell, F Fernandez
Faculty of Science, Medicine and Health - Papers: part A
No abstract provided.
Molecular Evidence Of N-Methyl-D-Aspartate Receptor Hypofunction In Schizophrenia, C S. Weickert, S J. Fung, V S. Catts, P R. Schofield, K M. Allen, L T. Moore, Kelly A. Newell, D Pellen, Xu-Feng Huang, S V. Catts, T W Weickert
Molecular Evidence Of N-Methyl-D-Aspartate Receptor Hypofunction In Schizophrenia, C S. Weickert, S J. Fung, V S. Catts, P R. Schofield, K M. Allen, L T. Moore, Kelly A. Newell, D Pellen, Xu-Feng Huang, S V. Catts, T W Weickert
Faculty of Science, Medicine and Health - Papers: part A
Blockade of N-methyl-D-aspartate receptors (NMDARs) produces behavior in healthy people that is similar to the psychotic symptoms and cognitive deficits of schizophrenia and can exacerbate symptoms in people with schizophrenia. However, an endogenous brain disruption of NMDARs has not been clearly established in schizophrenia. We measured mRNA transcripts for five NMDAR subunit mRNAs and protein for the NR1 subunit in the dorsolateral prefrontal cortex (DLPFC) of schizophrenia and control (n=74) brains. Five NMDAR single-nucleotide polymorphisms (SNPs) previously associated with schizophrenia were tested for association with NMDAR mRNAs in postmortem brain and for association with cognitive ability in an antemortem cohort …
Metabotropic Glutamate Receptor 5 Binding And Protein Expression In Schizophrenia And Following Antipsychotic Drug Treatment, Natalie Matosin, Elisabeth Frank, Chao Deng, Xu-Feng Huang, Kelly A. Newell
Metabotropic Glutamate Receptor 5 Binding And Protein Expression In Schizophrenia And Following Antipsychotic Drug Treatment, Natalie Matosin, Elisabeth Frank, Chao Deng, Xu-Feng Huang, Kelly A. Newell
Faculty of Science, Medicine and Health - Papers: part A
Metabotropic glutamate receptor 5 (mGluR5) has been identified as a potential therapeutic target for schizophrenia, primarily due to its ability to indirectly modulate glutamatergic signalling through the NMDA receptor (NMDAR). Despite its potential, molecular studies characterising mGluR5 in schizophrenia are limited. We therefore aimed to determine if the mGluR5 binding site or protein levels were altered in schizophrenia or by current antipsychotics. Using in-situ radioligand binding and immunoblot, we measured [3H]MPEP binding to mGluR5 and mGluR5 protein density in the post-mortem dorsolateral prefrontal cortex (DLPFC; BA46) of 37 schizophrenia and 37 matched control subjects. Subsequently, we measured [3H]MPEP binding in …
Does Food Addiction Heighten The Propensity Towards Obesity In Schizophrenia?, N Pai, S I. Vella
Does Food Addiction Heighten The Propensity Towards Obesity In Schizophrenia?, N Pai, S I. Vella
Faculty of Science, Medicine and Health - Papers: part A
Abstract of poster that presented at the 15th ISAM Annual Meeting: Managing Addiction through Evidence-Based Medical and Psychosocial Interventions, 21-23 November 2013, Kuala Lumpur, Malaysia.
Neuregulin-1 Signalling And Antipsychotic Treatment: Potential Therapeutic Targets In A Schizophrenia Candidate Signalling Pathway, Chao Deng, Bo Pan, Martin Engel, Xu-Feng Huang
Neuregulin-1 Signalling And Antipsychotic Treatment: Potential Therapeutic Targets In A Schizophrenia Candidate Signalling Pathway, Chao Deng, Bo Pan, Martin Engel, Xu-Feng Huang
Faculty of Science, Medicine and Health - Papers: part A
Identifying the signalling pathways underlying the pathophysiology of schizophrenia is an essential step in the rational development of new antipsychotic drugs for this devastating disease. Evidence from genetic, transgenic and post-mortem studies have strongly supported neuregulin-1 (NRG1)-ErbB4 signalling as a schizophrenia susceptibility pathway. NRG1-ErbB4 signalling plays crucial roles in regulating neurodevelopment and neurotransmission, with implications for the pathophysiology of schizophrenia. Post-mortem studies have demonstrated altered NRG1-ErbB4 signalling in the brain of schizophrenia patients. Antipsychotic drugs have different effects on NRG1-ErbB4 signalling depending on treatment duration. Abnormal behaviours relevant to certain features of schizophrenia are displayed in NRG1/ErbB4 knockout mice or …
Gender Differences In Cognitive Function Of Patients With Chronic Schizophrenia, Mei Han, Xu-Feng Huang, Da Chun Chen, Mei Hong Xiu, Li Hui, Haibo Liu, Thomas R. Kosten, Xiang Yang Zhang
Gender Differences In Cognitive Function Of Patients With Chronic Schizophrenia, Mei Han, Xu-Feng Huang, Da Chun Chen, Mei Hong Xiu, Li Hui, Haibo Liu, Thomas R. Kosten, Xiang Yang Zhang
Faculty of Science, Medicine and Health - Papers: part A
Schizophrenic patients have cognitive impairments, but gender differences in these cognitive deficits have had limited study. This study assessed cognitive functioning in 471 subjects including 122 male and 78 female schizophrenic patients and 141 male and 130 female healthy controls. We found that immediate memory, language, delayed memory and total RBANS scores were significantly decreased in schizophrenia compared with healthy controls for both genders. Male patients had significant lower immediate memory, delayed memory and total RBANS scores than female patients, and healthy controls showed a similar gender difference. The RBANS showed modest correlations with PANSS scores, duration of illness and …
Schizophrenia And Resilience: What Does It Mean?, Susan Liersch, Lorna Moxham, Peter Caputi, Janette Curtis
Schizophrenia And Resilience: What Does It Mean?, Susan Liersch, Lorna Moxham, Peter Caputi, Janette Curtis
Faculty of Science, Medicine and Health - Papers: part A
A doctoral research examined the meaning of resilience for someone who is living with schizophrenia. What it didn't examine was what makes people with schizophrenia resilient.
Quality Of Life For People With Schizophrenia: A Literature Review, Amira Alshowkan, Janette Curtis, Yvonne White
Quality Of Life For People With Schizophrenia: A Literature Review, Amira Alshowkan, Janette Curtis, Yvonne White
Faculty of Science, Medicine and Health - Papers: part A
Objective: In recent years, there has been a growing interest in the study and evaluation of the quality of life for people with schizophrenia. The aim of this paper is to provide a comprehensive literature review on the quality of life for people with schizophrenia who are living in the community. Method: An integrative literature review was undertaken to review literature in the field of medical/mental health in relevant databases. Results: A total of 21 studies were reviewed and categorised according to three themes identified from the literature: the quality of life and socio-demographic characteristics of people with schizophrenia; the …