Medicine and Health Sciences Commons^™

Interaction Between Fluoxetine And Risperidone And Its Association With Clinical Outcomes In Schizophrenic Patients, Fitri Rachmaini, Dian Ayu Juwita, Rahmad Abdillah, Rezy Dwi Afrianti, Fatma Sri Wahyuni

Pharmaceutical Sciences and Research

---

The concurrent use of fluoxetine and risperidone to treat schizophrenia may result in drug interactions. This study aims to analyse the clinical outcomes of fluoxetine-risperidone therapy and the possibility of their interaction in schizophrenic patients. The clinical outcomes are patient status at the time of hospital discharge, the length of hospitalisation and the Positive and Negative Syndrome Scale- Excitement Component (PANSS-EC). This study was conducted prospectively in psychiatric ward of HB Saanin Mental Hospital from May to October 2021 and study subjects were selected using consecutive sampling technique with inclusion criteria. Forty-three patients were eligible for this study. Research data …

---

Cannabidiol: An Adjunctive Therapy To Risperidone For Autistic Children Experiencing Behavioral Outbursts, Cherie Dowell

Physician Assistant Scholarly Project Papers

---

The purpose of this systemic literature review was to evaluate the safety, efficacy, and tolerability of medical cannabis in the treatment of aggression, irritability, and self-injurious behaviors in autistic children that are currently receiving risperidone. For this literature review, DynaMed, Cochrane, PubMed, ClinicalKey, and CINAHL were searched using various keywords and phrases. Studies that were included in this review were published after 2005, were peer-reviewed, and included systemic reviews, journal articles, clinical trials, randomized control trials, and meta-analyses. Studies that did not directly discuss autism and behavioral issues; autism treatment with risperidone, medical cannabis, or cannabidiol; that did not specifically …

---

Cannabidiol: An Adjunctive Therapy To Risperidone For Autistic Children Experiencing Behavioral Outbursts, Cherie Dowell

Physician Assistant Scholarly Project Posters

---

The purpose of this systemic literature review was to evaluate the safety, efficacy, and tolerability of medical cannabis in the treatment of aggression, irritability, and self-injurious behaviors in autistic children that are currently receiving risperidone. For this literature review, DynaMed, Cochrane, PubMed, ClinicalKey, and CINAHL were searched using various keywords and phrases. Studies that were included in this review were published after 2005, were peer-reviewed, and included systemic reviews, journal articles, clinical trials, randomized control trials, and meta-analyses. Studies that did not directly discuss autism and behavioral issues; autism treatment with risperidone, medical cannabis, or cannabidiol; that did not specifically …

---

Pharmacological Intervention In Children With Autism Spectrum Disorder With Standard Supportive Therapies Significantly Improves Core Signs And Symptoms: A Single-Center, Retrospective Case Series, Hamza A. Alsayouf, Haitham Talo, Marisa L. Biddappa, Mohammad Qasaymeh, Shadi Qasem, Emily De Los Reyes

Pathology and Laboratory Medicine Faculty Publications

---

Purpose: Autism spectrum disorder (ASD) is a debilitating neurodevelopmental disorder with high heterogeneity and no clear common cause. Several drugs, in particular risperidone and aripiprazole, are used to treat comorbid challenging behaviors in children with ASD. Treatment with risperidone and aripiprazole is currently recommended by the Food and Drug Administration (FDA) in the USA for children aged 5 and 6 years and older, respectively. Here, we investigated the use of these medications in younger patients aged 4 years and older.

Patients and Methods: This retrospective case series included 18 children (mean age, 5.7 years) with ASD treated at the Kids …

---

Off-Label Use Of Second Generation Antipsychotics In Primary Care -An Exploratory Study, Nima Gheisarzadeh

Electronic Thesis and Dissertation Repository

---

Over the past two decades, the use of antipsychotics has increased tremendously worldwide, and second-generation antipsychotics (SGAs) have been the main driver of this trend. The extensive use of SGAs for off-label purposes has raised concerns over their role in clinical practice. In particular, studies have revealed serious metabolic and cardiovascular effects, and evidence is lacking on SGAs’ effectiveness. Despite the concerns, the extent and pattern of SGAs’ off-label use is largely unknown within the context of the Canadian primary health care system. Using electronic medical record (EMR) data from 14 practices in southwestern Ontario, we investigated the number of …

---

Comparison Of Quetiapine Abuse And Misuse Reports To The Fda Adverse Event Reporting System With Other Second-Generation Antipsychotics, Kirk E. Evoy, Chengwen Teng Pharm.D., Ph.D., Victor G. Encarnacion, Brian Frescas, John Hakim, Stephen Saklad, Christopher R. Frei

Faculty Publications

---

Background:

Second-generation antipsychotics (SGAs) are assumed to have little abuse potential. However, reports of quetiapine abuse have emerged as prescribing has increased in recent years. The US Food and Drug Administration’s (FDA) Adverse Event Reporting System (FAERS) provides postmarketing information regarding adverse drug events (ADEs). This is the first study to analyze quetiapine abuse-related ADEs reported to FAERS to determine whether a disproportionate rate of such events have been reported when compared with other commonly used SGAs.

Methods:

A cross-sectional analysis of FAERS data from January 1, 2015, to December 31, 2017, was performed. The total number of all-cause and …

---

Long-Term Effectiveness Of Oral Second-Generation Antipsychotics In Patients With Schizophrenia And Related Disorders: A Systematic Review And Meta-Analysis Of Direct Head-To-Head Comparisons, T. Kishimoto, K. Hagi, M. Nitta, J. M. Kane, C. U. Correll

Journal Articles

---

No abstract provided.

---

Phenoconversion And Therapeutic Drug Monitoring, Jose De Leon

Psychiatry Faculty Publications

---

No abstract provided.

---

False Negative Studies May Systematically Contaminate The Literature On The Effects Of Inducers In Neuropsychopharmacology. Part Ii: Focus On Bipolar Disorder, Jose De Leon

Psychiatry Faculty Publications

---

No abstract provided.

---

Time-Dependence Of Risperidone And Asenapine Sensitization And Associated D2 Receptor Mechanism, Jun Gao, Ming Li

Department of Psychology: Faculty Publications

---

When an antipsychotic drug is given repeatedly and intermittently, there is often a long-term increase in its behavioral efficacy, termed antipsychotic sensitization. With the passage of time, the magnitude of antipsychotic sensitization may increase or decrease depending on the principle of Time-Dependent Sensitization (TDS) or memory decay, respectively. In the present study, we examined the time-dependent feature and possible dopamine D₂ receptor mechanism of sensitization induced by the antipsychotics risperidone and asenapine in the conditioned avoidance response test. Well-trained male adult Sprague-Dawley rats were first repeatedly treated with risperidone (1.0 mg/kg) or asenapine (0.2 mg/kg) and tested for avoidance …

---

Is Brain-Derived Neurotrophic Factor A Possible Mechanism Underlying Risperidone Sensitization In Adolescent Rats?, Qing Shu, Gang Hu, Ming Li

Department of Psychology: Faculty Publications

---

Risperidone is one of the most widely used atypical antipsychotic drugs and is approved for the treatment of mental disorders (eg. schizophrenia, autism) in children and adolescents. The present study investigated the repeated treatment effect of risperidone and associated neurotropic mechanism in the phencyclidine (PCP)-induced hyperlocomotion model in adolescent rats. We examined whether repeated risperidone treatment would cause a sensitized inhibition of PCP-induced hyperlocomotion in adolescent rats, and whether such a sensitization effect was mediated by risperidone-induced alterations in Brain-Derived Neurotrophic Factor (BDNF), an important biomarker which plays a role in neuropathology of schizophrenia and action of antipsychotic medications. Male …

---

Olanzapine And Risperidone Disrupt Conditioned Avoidance Responding In Phencyclidine-Pretreated Or Amphetamine-Pretreated Rats By Selectively Weakening Motivational Salience Of Conditioned Stimulus, Ming Li, Wei He, Alexa Mead

Ming Li

---

The rat conditioned avoidance response model is a well-established preclinical behavioral model predictive of antipsychotic efficacy. All clinically approved antipsychotic drugs disrupt conditioned avoidance responding – a feature that distinguishes them from other psychotherapeutics. We previously showed that the typical antipsychotic drug haloperidol disrupts avoidance responding by progressively attenuating the motivational salience of the conditioned stimulus (CS) in normal rats. In this study, using two pharmacological rat models of schizophrenia [e.g. phencyclidine (PCP) or amphetamine sensitization], we examined whether atypicals such as olanzapine or risperidone disrupt avoidance responding through the same behavioral mechanism. Rats were first pretreated with PCP, amphetamine, …

---

Anxiolytic-Like Property Of Risperidone And Olanzapine As Examined In Multiple Measures Of Fear In Rats, Tao Sun, Wei He, Gang Hu, Ming Li

Ming Li

---

Atypical antipsychotics are also used in the treatment of anxiety-related disorders. Clinical and preclinical evidence regarding their intrinsic anxiolytic efficacy has been mixed. In this study, we examined the potential anxiolytic-like effects of risperidone and olanzapine, and compared them with haloperidol, chlordiazepoxide (a prototype of sedative–anxiolytic drug) or citalopram (a selective serotonin reuptake inhibitor). We used a composite of two-way avoidance conditioning and acoustic startle reflex model and examined the effects of drug treatments during the acquisition phase (Experiment 1) or extinction phase (Experiments 2 and 3) on multiple measures of conditioned and unconditioned fear/anxiety-like responses. In Experiment 4, we …

---

Interactions Between Antiepileptics And Second-Generation Antipsychotics, Jose De Leon, Vincenza Santoro, Concetta D'Arrigo, Edoardo Spina

Psychiatry Faculty Publications

---

INTRODUCTION: Pharmacokinetic and pharmacodynamic drug interactions (DIs) can occur between antiepileptics (AEDs) and second-generation antipsychotics (SGAPs). Some AED and SGAP pharmacodynamic mechanisms are poorly understood. AED-SGAP combinations are used for treating comorbid illnesses or increasing efficacy, particularly in bipolar disorder.

AREAS COVERED: This article provides a comprehensive review of the interactions between antiepileptics and second-generation antipsychotics. The authors cover pharmacokinetic AED-SGAP DI studies, the newest drug pharmacokinetics in addition to the limited pharmacodynamic DI studies.

EXPERT OPINION: Dosing correction factors and measuring SGAP levels can help to compensate for the inductive properties of carbamazepine, phenytoin, phenobarbital and primidone. Further studies …

---

Review Of The Pharmacological Treatment Of Delirium In The Pediatric Population With Accompanying Protocol, Nathan Lavid M.D., Lawrence J. Budner M.D., F.A.A.C.A.P.

Jefferson Journal of Psychiatry

---

Objective: To review the current state of pharmacological treatment of delirium in the pediatric population and to derive a treatment protocol from our review.

Method: Medline-assisted search of the literature. Articles pertaining to the pharmacological treatment of delirium in children and adolescents were reviewed. Due to the paucity of articles, studies of treatment guidelines for delirium in the adult population were reviewed. Also presented for reference, are studies of optimal dosing regimens of psychotropic agents potentially useful in treating pediatric delirium. Our protocol is extrapolated from previously established guidelines for adult treatment meshed with the current knowledge presented in …

---

Time Course Of The Attenuation Effect Of Repeated Antipsychotic Treatment On Prepulse Inhibition Disruption Induced By Repeated Phencyclidine Treatment, Ming Li, Erik He, Nick Volf

Department of Psychology: Faculty Publications

---

Antagonism of prepulse inhibition (PPI) deficits produced by psychotomimetic drugs has been widely used as an effective tool for the study of the mechanisms of antipsychotic action and identifying potential antipsychotic drugs. Many studies have relied on the acute effect of a single administration of antipsychotics, whereas patients with schizophrenia are treated chronically with antipsychotic drugs. The clinical relevance of acute antipsychotic effect in this model is still an open question. In this study, we investigated the time course of repeated antipsychotic treatment on persistent PPI deficit induced by repeated phencyclidine (PCP) treatment. After a baseline test with saline, male …

---

Olanzapine And Risperidone Disrupt Conditioned Avoidance Responding By Selectively Weakening Motivational Salience Of Conditioned Stimulus: Further Evidence, Chen Zhang, Yiru Fang, Ming Li

Department of Psychology: Faculty Publications

---

Suppression of conditioned avoidance response is a preclinical behavioral index of antipsychotic activity. Previous work shows that olanzapine and risperidone disrupt avoidance response elicited by a less salient conditioned stimulus (CS2) to a greater extent than avoidance elicited by a more salient stimulus (CS1), suggesting that antipsychotic drugs may have a weakening action on motivational salience of stimuli. In the present study, we further examined this mechanism of antipsychotic action, focusing on the possible impact of baseline difference of CS1 and CS2 response rates on the avoidance-disruptive effect of olanzapine and risperidone. Rats were first trained to acquire avoidance responding …

---

Anxiolytic-Like Property Of Risperidone And Olanzapine As Examined In Multiple Measures Of Fear In Rats, Tao Sun, Wei He, Gang Hu, Ming Li

Department of Psychology: Faculty Publications

---

Atypical antipsychotics are also used in the treatment of anxiety-related disorders. Clinical and preclinical evidence regarding their intrinsic anxiolytic efficacy has been mixed. In this study, we examined the potential anxiolytic-like effects of risperidone and olanzapine, and compared them with haloperidol, chlordiazepoxide (a prototype of sedative–anxiolytic drug) or citalopram (a selective serotonin reuptake inhibitor). We used a composite of two-way avoidance conditioning and acoustic startle reflex model and examined the effects of drug treatments during the acquisition phase (Experiment 1) or extinction phase (Experiments 2 and 3) on multiple measures of conditioned and unconditioned fear/anxiety-like responses. In Experiment 4, we …

---

Olanzapine And Risperidone Disrupt Conditioned Avoidance Responding In Phencyclidine-Pretreated Or Amphetamine-Pretreated Rats By Selectively Weakening Motivational Salience Of Conditioned Stimulus, Ming Li, Wei He, Alexa Mead

Department of Psychology: Faculty Publications

---

The rat conditioned avoidance response model is a well-established preclinical behavioral model predictive of antipsychotic efficacy. All clinically approved antipsychotic drugs disrupt conditioned avoidance responding – a feature that distinguishes them from other psychotherapeutics. We previously showed that the typical antipsychotic drug haloperidol disrupts avoidance responding by progressively attenuating the motivational salience of the conditioned stimulus (CS) in normal rats. In this study, using two pharmacological rat models of schizophrenia [e.g. phencyclidine (PCP) or amphetamine sensitization], we examined whether atypicals such as olanzapine or risperidone disrupt avoidance responding through the same behavioral mechanism. Rats were first pretreated with PCP, amphetamine, …

---

A Comparative Study Of Sexual Dysfunction Involving Risperidone, Quetiapine, And Olanzapine, Anil Kumar Nagaraj, Nagesh B. Pai, Satheesh Rao

Graduate School of Medicine - Papers (Archive)

---

Background: With the advent of newer antipsychotic drugs, side effects such as sexual dysfunction have been a major contributor toward treatment compliance. There are only a few studies that have compared different atypical antipsychotic agents regarding sexual dysfunction. We have not come across any data in this area on Indian population. Aims: To determine and compare the frequency of sexual dysfunction associated with risperidone, olanzapine, and quetiapine, among patients with clinically stable schizophrenia. Settings and Design: It is a cross-sectional hospital-based study. The subjects were recruited for the study by the purposive sampling technique. Materials and Methods: The total sample …

---