Medicine and Health Sciences Commons^™

Investigation Of Dna Damage And Genomic Organization In The Cellular Response To Platinum Chemotherapy, Abdulhadi Abdulwahed

FIU Electronic Theses and Dissertations

Ovarian cancer (OC) is the primary reason for gynecological cancer-related deaths among women. This cancer rarely has specific symptoms making early detection challenging. Platinum compounds have been used as the first-line treatment for OC. However, OC patients often develop chemoresistance to current platinum/taxane chemotherapy regimens upon recurrence, leaving patients with no alternative treatment options. The purpose of this thesis was to investigate the molecular basis of chemoresistance in OC by analyzing the damage of DNA response and gene positioning after treatment exposure. A modified comet assay was used to measure interstrand cross-link (ICL) formation and repair in chemoresistant (CR) (SKOV-3) …

Impact Of A Lifestyle Modification Intervention On Health Behaviors And Health Outcomes In A Mexican American Population: A Mixed-Methods Study, Ramandeep Kaur

FIU Electronic Theses and Dissertations

Metabolic syndrome (MetS), a global public health problem, is the primary cause of type 2 diabetes and cardiovascular disorders. Lifestyle modification interventions (dietary and physical activity modifications) are effective in preventing and ameliorating MetS and associated comorbidities. However, the impact of lifestyle changes on MetS among Mexican Americans has yet to be investigated, particularly due to high attrition rates in this population.

The overall goal of the explanatory mixed-methods study presented in this dissertation was to identify efficacious lifestyle modification efforts directed towards Mexican Americans to promote their retention in lifestyle modification programs, ameliorate the severity of MetS, and understand …

Exploring The Nutrition And Physical Activity Knowledge, Attitudes, And Behaviors Of Low-Income Parents Of Peruvian Preschool Children, Kathleen Mcinvale

FIU Electronic Theses and Dissertations

Obesity and related chronic diseases are emerging public health issues among children in Peru, where more than 13 percent of children five years and younger are overweight or obese. Although parents have been identified as one of the most important determinants of healthy weight in young children, there are no known studies that have explored the perceptions of Peruvian parents regarding obesity prevention. This study assessed the nutrition and physical activity knowledge, attitudes and behaviors of Peruvian parents, and sought to determine if there is a relationship between their knowledge, attitudes and behaviors. The cross-sectional survey study sampled 204 parents …

Exploring Oral Health Problems In Adult Hispanic Migrant Farmworkers: A Mixed-Methods Approach, Claudia A. Serna

FIU Electronic Theses and Dissertations

This mixed-methods study examined patterns of dental health care utilization in adult Hispanic migrant farmworkers (AHMFW) with special emphasis on non-compliance with the American Dental Association (ADA) and the American Dental Hygienists Association (ADHA) recommendation of visiting the dentist at least once a year; while also exploring the group’s social and cultural construction of oral health.

A total of 278 farmworkers responded to a close ended survey. Binary and hierarchical logistic regression analysis were employed in identifying predisposing, enabling, and needs factors associated with non-compliance. Following the survey, fourteen ethnographic interviews were conducted with respondents who volunteered to participate in …