Medicine and Health Sciences Commons^™

Let Kids Sleep: The Role Of Interdisciplinary Neuroscience Outreach In Stimulating Brains And Developing Research-Informed Approaches To Community Concerns, Marc Chenard

University Honors Theses

Northwest Noggin (NW Noggin), an all-volunteer neuroscience education outreach non-profit, serves its community by bringing students, artists, scientists and other participants together for artistic collaboration and learning. The outreach takes place in K-12 schools and other institutions (such as museums, coffee shops and correctional facilities) all over the Pacific Northwest. Neuroscience education outreach generates discourse surrounding community concerns through illuminating the brain-centric qualities of issues and by drawing on neuroscience research to create solutions. The neuroscience research-informed perspectives on these concerns stimulate awareness, create momentum towards evidence-based reform, and can result in policy interventions. This thesis details how NW Noggin …

Cancer Neuroscience: State Of The Field, Emerging Directions, Frank Winkler, David H Gutmann, Et Al.

2020-Current year OA Pubs

The nervous system governs both ontogeny and oncology. Regulating organogenesis during development, maintaining homeostasis, and promoting plasticity throughout life, the nervous system plays parallel roles in the regulation of cancers. Foundational discoveries have elucidated direct paracrine and electrochemical communication between neurons and cancer cells, as well as indirect interactions through neural effects on the immune system and stromal cells in the tumor microenvironment in a wide range of malignancies. Nervous system-cancer interactions can regulate oncogenesis, growth, invasion and metastatic spread, treatment resistance, stimulation of tumor-promoting inflammation, and impairment of anti-cancer immunity. Progress in cancer neuroscience may create an important new …

Multiple Sclerosis, Rachel Marie Wainwright, Terryn Dyche

Client Educational Handouts

Multiple Sclerosis is a long lasting disease where the immune system attacks parts of the nerves, which result in slowing down of signals from the brain to various parts of the body. It is hard to predict one’s journey with MS, but can decrease life expectancy up to 14 years. Symptoms vary from person to person and can include heat sensitivity, fatigue, pain, cognitive dysfunction, and tremors. Unfortunately we do not know the cause of MS however genetics, infectious agents like viruses, and environments with lower Vitamin D levels can be contributing factors (Files et al., 2015; Forwell et al., …

Open Neuroscience Initiative, Austin Lim

College of Science and Health Full Text Publications

The Open Neuroscience Initiative is a free-to-use textbook

This project began as a means to overcoming the financial burden that face undergraduate neuroscience students when buying textbooks. By compiling and writing a completely free-to-access textbook that covers the foundations of a typical college introduction to neuroscience course, students would have one less obstacle to overcome in their educational career, allowing them to focus their valuable time and attention on learning rather than finances. To make this project a reality, I began with a humble tweet in May 2019 that managed to gain a tiny bit of traction among the neuroscience …

Using Fmri Bold Imaging To Motion-Correct Associated, Simultaneously Imaged Pet Data, Joseph M. Williamitis

Browse all Theses and Dissertations

Because magnetic resonance (MR) and positron emission tomography (PET) scanning sessions last long durations, motion blur during scanning constitutes a problem for clinical interpretation. To counteract this, motion-correction algorithms have been developed to reduce smearing between scan slices of MRI, but these algorithms are not commonplace for PET. This feasibility study determined if applying MRI motion-correction algorithms to simultaneously acquired PET data improved PET signal clarity in specific brain regions. Seven subjects received increasing levels of PET tracers while undergoing two separate simultaneous PET/MRI scans. We modified existing fMRI algorithms to apply them to the accompanying PET data. We hypothesized …

Mean Arterial Pressure In Acute Ischemic Stroke Study, Mary Angela Grove

Theses and Dissertations (ETD)

Background. There is little, if any, evidence available on the validation of blood pressure (BP) measurements obtained in the acute care setting. Despite this, acute stroke practitioners trust and rely on non-invasive blood pressure (NIBP) devices to guide acute ischemic stroke (AIS) patients’ treatment. Although systolic blood pressure (SBP) has been found to be the most unreliable measurement displayed on NIBP devices, treatment decisions for AIS are based on them. Today, 25 years after the FDA’s approval of alteplase, practitioners continue to use BP parameters of 185/110 and 180/105 to guide the initiation of alteplase bolus and infusion, although the …

Central Nervous System Complications Associated With Sars-Cov-2 Infection: Integrative Concepts Of Pathophysiology And Case Reports, S. Najjar, A. Najjar, D. J. Chong, B. K. Pramanik, C. Kirsch, R. Kuzniecky, S. Pacia, S. Azhar

Journal Articles

No abstract provided.

Covid-19 Outcomes In Ms Observational Study Of Early Experience From Nyu Multiple Sclerosis Comprehensive Care Center, E. Parrotta, I. Kister, L. Charvet, C. Sammarco, V. Saha, R. E. Charlson, J. Howard, J. M. Gutman, C. Fernandez-Carbonell, L. Z. Ryerson, +5 Additional Authors

Journal Articles

No abstract provided.

Elevated Matrix Metalloproteinase-9 Levels In Neuronal Extracellular Vesicles In Alzheimer's Disease, D. Gu, F. Liu, M. Meng, L. Zhang, M. L. Gordon, Y. Wang, L. Cai, N. Zhang

Journal Articles

No abstract provided.

Prolonged Targeted Cardiovascular Epidural Stimulation Improves Immunological Molecular Profile: A Case Report In Chronic Severe Spinal Cord Injury, O. Bloom, J. M. Wecht, B. E. Ditterline, S. Wang, A. Ovechkin, C. A. Angeli, A. A. Arcese, S. J. Harkema

Journal Articles

No abstract provided.

Intramuscular Injection Of Vectorized-Scfvmc1 Reduces Pathological Tau In Two Different Tau Transgenic Models, F. Vitale, J. Ortolan, B. T. Volpe, P. Marambaud, L. Giliberto, C. D'Abramo

Journal Articles

No abstract provided.

Deep Brain Stimulation For Refractory Obsessive-Compulsive Disorder (Ocd): Emerging Or Established Therapy?, H. Wu, M. Hariz, V. Visser-Vandewalle, L. Zrinzo, V. A. Coenen, S. A. Sheth, C. Bervoets, M. Naesstrom, M. Schulder, B. Nuttin, +45 Additional Authors

Journal Articles

No abstract provided.

Sleep Spindles Promote The Restructuring Of Memory Representations In Ventromedial Prefrontal Cortex Through Enhanced Hippocampal-Cortical Functional Connectivity, E. Cowan, A. Liu, S. Henin, S. Kothare, O. Devinsky, L. Davachi

Journal Articles

No abstract provided.

Characterization Of B3galt2 And Heg1 Expression In Dorsal Root Ganglia, Alexander H. Nguyen

Browse all Theses and Dissertations

Proprioception provides unique sensory feedback about the body’s orientation in space and this sensation is essential for creating specific motor functions and coordinated movement. During neurogenesis, unique genetic markers are expressed and classified as early, transient/middle, and late markers depending on their timing of expression. This study focuses on the expression patterns of two late markers: Heg1 and B3galt2. We investigated how expression of these two markers respond to peripheral nerve injury (PNI). We cloned and generated riboprobes to detect expression of B3galt2 and Heg1 in DRGs using in situ hybridization after transection of the sciatic nerve. B3galt2 hybridization in …

Large-Scale Validation Of The Paddling Pool Task In The Clockmaze For Studying Hippocampus-Based Spatial Cognition In Mice, R. Sankowski, T. S. Huerta, R. Kalra, T. J. Klein, J. Strohl, A. Al-Abed, S. Robbiati, P. T. Huerta

Journal Articles

No abstract provided.

Spectrotemporal Modulation Provides A Unifying Framework For Auditory Cortical Asymmetries, A. Flinker, W. K. Doyle, A. D. Mehta, O. Devinsky, D. Poeppel

Journal Articles

No abstract provided.

Cholinergic Control Of Inflammation, Metabolic Dysfunction, And Cognitive Impairment In Obesity-Associated Disorders: Mechanisms And Novel Therapeutic Opportunities, E. H. Chang, S. S. Chavan, V. A. Pavlovh

Journal Articles

No abstract provided.

Neurogenesis In Neurodegenerative Diseases: Role Of Mfg-E8, C. Cheyuo, M. Aziz, P. Wang

Journal Articles

No abstract provided.

Reward And Punishment: The Neural Correlates Of Reinforcement Feedback During Motor Learning, Christopher Mark Hill

Electronic Theses and Dissertations

‘By the carrot or the stick’ reward or punishment has been contemplated by instructors to motivate their pupils to learn a new motor skill. The reinforcements of reward and punishment have demonstrated dissociable effects on motor learning with punishment enhancing the learning rate and reward increasing retention of the motor task. However it is still unclear how the brain processes reward and punishment during motor learning. This study sought to investigate the role of reinforcement feedback in cortical neural activity associated with motor learning. A novel visuomotor rotation task was employed with reward punishment or null feedback as the participants …

A Neuroimaging Web Interface For Data Acquisition, Processing And Visualization Of Multimodal Brain Images, Gabriel M. Lizarraga

FIU Electronic Theses and Dissertations

Structural and functional brain images are generated as essential modalities for medical experts to learn about the different functions of the brain. These images are typically visually inspected by experts. Many software packages are available to process medical images, but they are complex and difficult to use. The software packages are also hardware intensive. As a consequence, this dissertation proposes a novel Neuroimaging Web Services Interface (NWSI) as a series of processing pipelines for a common platform to store, process, visualize and share data. The NWSI system is made up of password-protected interconnected servers accessible through a web interface. The …

Induction And Quantification Of Excitability Changes In Human Cortical Networks, C. J. Keller, Y. Huang, J. L. Herrero, M. E. Fini, V. Du, F. A. Lado, C. J. Honey, A. D. Mehta

Journal Articles

No abstract provided.

Reproducible Network And Regional Topographies Of Abnormal Glucose Metabolism Associated With Progressive Supranuclear Palsy: Multivariate And Univariate Analyses In American And Chinese Patient Cohorts, J. Ge, J. Wu, S. Peng, P. Wu, J. Wang, H. Zhang, Y. Guan, D. Eidelberg, C. Zuo, Y. Ma

Journal Articles

No abstract provided.

Altered Leukocyte Gene Expression After Traumatic Spinal Cord Injury: Clinical Implications, P. E. Herman, O. Bloom

Journal Articles

No abstract provided.

Investigation Of Superior Longitudinal Fasciculus Fiber Complexity In Recent Onset Psychosis, P. R. Szeszko, E. T. Tan, A. M. Ulug, P. B. Kingsley, J. A. Gallego, K. Rhindress, A. K. Malhotra, D. G. Robinson, L. Marinelli

Journal Articles

No abstract provided.

Integration Of Routine Qa Data Into Mega-Analysis May Improve Quality And Sensitivity Of Multisite Diffusion Tensor Imaging Studies, P. Kochunov, E. W. Dickie, J. D. Viviano, J. Turner, P. B. Kingsley, N. Jahanshad, P. M. Thompson, M. C. Ryan, A. K. Malhotra, A. N. Voineskos, +6 Additional Authors

Journal Articles

No abstract provided.

Greater Extracellular Free-Water In First-Episode Psychosis Predicts Better Neurocognitive Functioning, A. E. Lyall, O. Pasternak, D. G. Robinson, D. Newell, J. W. Trampush, J. A. Gallego, M. Fava, A. K. Malhotra, K. H. Karlsgodt, P. R. Szeszko, +1 Additional Author

Journal Articles

No abstract provided.

Smri Biomarkers Predict Electroconvulsive Treatment Outcomes: Accuracy With Independent Data Sets, R. Jiang, C. C. Abbott, T. Jiang, Y. Du, R. Espinoza, K. L. Narr, B. Wade, M. Argyelan, G. Petrides, V. D. Calhoun, +6 Additional Authors

Journal Articles

No abstract provided.

Dopamine Modulates Striatal Response To Reward And Punishment In Patients With Parkinson's Disease: A Pharmacological Challenge Fmri Study, M. Argyelan, M. Herzallah, W. Sako, I. Delucia, D. Sarpal, V. An, T. Fitzpatrick, A. A. Moustafa, D. Eidelberg, M. Gluck

Journal Articles

No abstract provided.

Impact Of Paliperidone Palmitate One-Month Formulation On Relapse Prevention In Patients With Schizophrenia: A Post-Hoc Analysis Of A One-Year, Open-Label Study Stratified By Medication Adherence, T. Si, N. Li, H. Lu, S. Cai, J. Zhuo, C. U. Correll, L. Zhang, Y. Feng

Journal Articles

No abstract provided.

The Age-Related Perfusion Pattern Measured With Arterial Spin Labeling Mri In Healthy Subjects, N. Zhang, M. L. Gordon, Y. Ma, B. Chi, J. J. Gomar, S. Peng, P. B. Kingsley, D. Eidelberg, T. E. Goldberg

Journal Articles

No abstract provided.