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Articles 1 - 17 of 17
Full-Text Articles in Medicine and Health Sciences
Psychiatric Comorbidities In Human-Immunodeficiency Virus-Infected/-Acquired Immunodeficiency-Syndrome Patients, Ahmed N. Ramadan, Ahmed M.M. S. Azzam, Ayman A. El-Hadad, Mohamed A. Gabber
Psychiatric Comorbidities In Human-Immunodeficiency Virus-Infected/-Acquired Immunodeficiency-Syndrome Patients, Ahmed N. Ramadan, Ahmed M.M. S. Azzam, Ayman A. El-Hadad, Mohamed A. Gabber
Menoufia Medical Journal
Objective The aim of this study was to study the psychiatric comorbidities, signs, symptoms, and general functioning in HIV-infected/AIDS patients. Background Co-occurring psychiatric disease has direct clinical impact on patients infected with HIV, such as worsening quality of life and rapid progression of HIV/AIDS symptoms. Patients and methods This study was carried out in Shebin Elkom tropical hospital 'outpatient clinics' on 30 patients with positive HIV infection/AIDS patients. The tools used are mental-state examination, Hamilton Anxiety Scale, Hamilton Depression Scale, drug-of-abuse urine-screen test, and Karnofsky Performance Scale Test. Results There was a statistically significant association between the presence of depression …
Undetectable Mannose Binding Lectin Is Associated With Hrct Proven Bronchiectasis In Rheumatoid Arthritis (Ra), Krista Makin, Tracie Easter, Monica Kemp, Peter Kendall, Max Bulsara, Sophie Coleman, Graeme J. Carroll
Undetectable Mannose Binding Lectin Is Associated With Hrct Proven Bronchiectasis In Rheumatoid Arthritis (Ra), Krista Makin, Tracie Easter, Monica Kemp, Peter Kendall, Max Bulsara, Sophie Coleman, Graeme J. Carroll
Medical Papers and Journal Articles
Aim: The aim of this study was to ascertain whether mannose binding lectin deficiency is implicated in coexistent rheumatoid arthritis and bronchiectasis and to determine whether undetectable mannose binding lectin confers poorer long-term survival in coexistent rheumatoid arthritis and bronchiectasis or in rheumatoid arthritis in general.
Materials and methods: A retrospective audit was conducted in a rheumatoid arthritis cohort in which mannose binding lectin had been measured by enzyme linked immunosorbent assay from 2007–11. Rheumatoid arthritis patients with physician diagnosed HRCT proven bronchiectasis were recruited during this time and compared to those with uncomplicated rheumatoid arthritis. Survival from disease onset …
Use Of Dried-Blood-Spot Samples And In-House Assays To Identify Antiretroviral Drug Resistance In Hiv-Infected Children In Resource-Constrained Settings, Carrie Ziemniak, Yohannes Mengistu, Andrea Ruff, Ya-Hui Chen, Leila Khaki, Abubaker Bedri, Birgitte B. Simen, Paul Palumbo
Use Of Dried-Blood-Spot Samples And In-House Assays To Identify Antiretroviral Drug Resistance In Hiv-Infected Children In Resource-Constrained Settings, Carrie Ziemniak, Yohannes Mengistu, Andrea Ruff, Ya-Hui Chen, Leila Khaki, Abubaker Bedri, Birgitte B. Simen, Paul Palumbo
Dartmouth Scholarship
Monitoring HIV drug resistance is an important component of the World Health Organization's global HIV program. HIV drug resistance testing is optimal with commercially available clinically validated test kits using plasma; however, that type of testing may not be feasible or affordable in resource-constrained settings. HIV genotyping from dried blood spots (DBS) with noncommercial (in-house) assays may facilitate the capture of HIV drug resistance outcomes in resource-constrained settings but has had varying rates of success. With in-house assays for HIV reverse transcriptase, we evaluated the yield of genotyping DBS samples collected from HIV-infected children who were enrolled in two clinical …
Primary Human Mammary Epithelial Cells Endocytose Hiv-1 And Facilitate Viral Infection Of Cd4+ T Lymphocytes, Stephanie M. Dorosko, Ruth I. Connor
Primary Human Mammary Epithelial Cells Endocytose Hiv-1 And Facilitate Viral Infection Of Cd4+ T Lymphocytes, Stephanie M. Dorosko, Ruth I. Connor
Dartmouth Scholarship
The contribution of mammary epithelial cells (MEC) to human immunodeficiency virus type 1 (HIV-1) in breast milk remains largely unknown. While breast milk contains CD4(+) cells throughout the breast-feeding period, it is not known whether MEC directly support HIV-1 infection or facilitate infection of CD4(+) cells in the breast compartment. This study evaluated primary human MEC for direct infection with HIV-1 and for indirect transfer of infection to CD4(+) target cells. Primary human MEC were isolated and assessed for expression of HIV-1 receptors. MEC were exposed to CCR5-, CXCR4- and dual-tropic strains of HIV-1 and evaluated for viral reverse transcription …
Human Uterine Natural Killer Cells But Not Blood Natural Killer Cells Inhibit Human Immunodeficiency Virus Type 1 Infection By Secretion Of Cxcl12, Teddy F. Mselle, Aexandra L. Howell, Mimi Ghosh, Charles R. Wira, Charles L. Sentman
Human Uterine Natural Killer Cells But Not Blood Natural Killer Cells Inhibit Human Immunodeficiency Virus Type 1 Infection By Secretion Of Cxcl12, Teddy F. Mselle, Aexandra L. Howell, Mimi Ghosh, Charles R. Wira, Charles L. Sentman
Dartmouth Scholarship
Natural killer (NK) cells derived from the human female reproductive tract (FRT) are phenotypically and functionally distinct from those obtained from peripheral blood. Because the FRT is a primary site of human immunodeficiency virus type 1 (HIV-1) infection in women, we determined whether soluble factors secreted by uterine-derived NK (uNK) cells inhibit HIV-1 infection. Clonal populations of uNK cells were activated with interleukin-12 (IL-12) and IL-15, and conditioned media (CM) from these cultures evaluated for their ability to inhibit infection of cells by HIV-1IIIB, HIV-1NL4.3, and HIV-1HC4 (X4-tropic) or HIV-1BaL (R5-tropic) viruses. We found …
The Role Of Cd4 T Cells In The Pathogenesis Of Murine Aids, Wen Li, William R. Green
The Role Of Cd4 T Cells In The Pathogenesis Of Murine Aids, Wen Li, William R. Green
Dartmouth Scholarship
LP-BM5, a retroviral isolate, induces a disease featuring retrovirus-induced immunodeficiency, designated murine AIDS (MAIDS). Many of the features of the LP-BM5-induced syndrome are shared with human immunodeficiency virus-induced disease. For example, CD4 T cells are critical to the development of MAIDS. In vivo depletion of CD4 T cells before LP-BM5 infection rendered genetically susceptible B6 mice MAIDS resistant. Similarly, MAIDS did not develop in B6.nude mice. However, if reconstituted with CD4 T cells, B6.nude mice develop full-blown MAIDS. Our laboratory has shown that the interaction of B and CD4 T cells that is central to MAIDS pathogenesis requires ligation of …
Human Immunodeficiency Virus Type 1-Induced Macrophage Gene Expression Includes The P21 Gene, A Target For Viral Regulation, Nancy Vazquez, Teresa Greenwell-Wild, Nancy J. Marinos, William D. Swaim, Salvador Nares, David E. Ott, Ulrich Schubert, Peter Henklein, Jan M. Orenstein, Michael B. Sporn, Sharon M. Wahl
Human Immunodeficiency Virus Type 1-Induced Macrophage Gene Expression Includes The P21 Gene, A Target For Viral Regulation, Nancy Vazquez, Teresa Greenwell-Wild, Nancy J. Marinos, William D. Swaim, Salvador Nares, David E. Ott, Ulrich Schubert, Peter Henklein, Jan M. Orenstein, Michael B. Sporn, Sharon M. Wahl
Dartmouth Scholarship
In contrast to CD4+ T cells, human immunodeficiency virus type 1 (HIV-1)-infected macrophages typically resist cell death, support viral replication, and consequently, may facilitate HIV-1 transmission. To elucidate how the virus commandeers the macrophage's intracellular machinery for its benefit, we analyzed HIV-1-infected human macrophages for virus-induced gene transcription by using multiple parameters, including cDNA expression arrays. HIV-1 infection induced the transcriptional regulation of genes associated with host defense, signal transduction, apoptosis, and the cell cycle, among which the cyclin-dependent kinase inhibitor 1A (CDKN1A/p21) gene was the most prominent. p21 mRNA and protein expression followed a bimodal pattern which was …
Role Of A Cytotoxic-T-Lymphocyte Epitope-Defined, Alternative Gag Open Reading Frame In The Pathogenesis Of A Murine Retrovirus-Induced Immunodeficiency Syndrome, Arti Gaur, William R. Green
Role Of A Cytotoxic-T-Lymphocyte Epitope-Defined, Alternative Gag Open Reading Frame In The Pathogenesis Of A Murine Retrovirus-Induced Immunodeficiency Syndrome, Arti Gaur, William R. Green
Dartmouth Scholarship
LP-BM5 murine leukemia virus-infected C57BL/6 mice develop profound immunodeficiency and B-cell lymphomas. The LP-BM5 complex contains a mixture of defective (BM5def) and replication-competent helper viruses among which BM5def is the primary causative agent of disease. The BM5def primary open reading frame (ORF1) encodes the single gag precursor protein (Pr60gag). Our lab has recently demonstrated that a novel immunodominant cytotoxic-T-lymphocyte (CTL) epitope (SYNTGRFPPL) is expressed from a +1-nucleotide translational open reading frame of BM5def during the course of normal retrovirus expression. The SYNTGRFPPL CTL epitope may be generated from either of two initiation methionines present, ORF2a or ORF2b, located …
Cd40-Associated Traf 6 Signaling Is Required For Disease Induction In A Retrovirus-Induced Murine Immunodeficiency, Kathy A. Green, Cory L. Ahonen, W. James Cook, William R. Green
Cd40-Associated Traf 6 Signaling Is Required For Disease Induction In A Retrovirus-Induced Murine Immunodeficiency, Kathy A. Green, Cory L. Ahonen, W. James Cook, William R. Green
Dartmouth Scholarship
LP-BM5 retrovirus-infected C57BL/6 mice develop splenomegaly, lymphadenopathy, hypergammaglobulinemia, and immunodeficiency; thus, this disease has been named mouse AIDS. In this syndrome, CD154/CD40 interactions are required for but do not mediate disease by upregulation of CD80 or CD86. We report here that there is nonetheless a necessity for CD40 signaling competence, specifically an intact tumor necrosis factor receptor-associated factor 6 (TRAF 6) binding site.
Immune Deficiency And Cryptosporidiosis In Rats, Ahmet Üner, Tonay İnceboz, Medi̇ha Uysalci, Hande Dağci
Immune Deficiency And Cryptosporidiosis In Rats, Ahmet Üner, Tonay İnceboz, Medi̇ha Uysalci, Hande Dağci
Turkish Journal of Veterinary & Animal Sciences
This study was intended to establish whether there is any relation between immune deficiency and cryptosporidiosis by using an animal model. Forty Rattus norvegicus rats obtained from the Experimental Animal Laboratories of the Ege University Faculty of Medicine were divided into two groups. The first group (n = 20) received corticosteroids (dexamethasone, 1.5 mg, subcutaneously, twice weekly) for eight weeks for immunosuppression, while the control group (n = 20) received no treatment. Drinking water was supplemented with tetracycline (500 mg/L) to avoid secondary infections. The animals were kept in groups of five in separate cages under the same environment and …
Clinical And Epidemiological Correlates Of Genotypes Within The Mycobacterium Avium Complex Defined By Restriction And Sequence Analysis Of Hsp65, Sandra C. Smole, Fionnuala Mcaleese, Jutamas Ngampasutadol, C. Fordham Von Reyn, Robert D. Arbeit
Clinical And Epidemiological Correlates Of Genotypes Within The Mycobacterium Avium Complex Defined By Restriction And Sequence Analysis Of Hsp65, Sandra C. Smole, Fionnuala Mcaleese, Jutamas Ngampasutadol, C. Fordham Von Reyn, Robert D. Arbeit
Dartmouth Scholarship
Species identification of isolates of the Mycobacterium avium complex (MAC) remains a difficult task. Although M. avium and Mycobacterium intracellulare can be identified with expensive, commercially available probes, many MAC isolates remain unresolved, including those representing Mycobacterium lentiflavum as well as other potentially undefined species. PCR restriction analysis (PRA) of the hsp65 gene has been proposed as a rapid and inexpensive approach. We applied PRA to 278 MAC isolates, including 126 from blood of human immunodeficiency virus (HIV)-infected patients, 59 from sputum of HIV-negative patients with chronic obstructive pulmonary disease, 88 from environmental sources, and 5 pulmonary isolates from …
Is Old Bridge High School Meeting The Needs Of All Students' Knowledge With Respect To The Hiv/Aids Curriculum?, Dawn Forgerson
Is Old Bridge High School Meeting The Needs Of All Students' Knowledge With Respect To The Hiv/Aids Curriculum?, Dawn Forgerson
Seton Hall University Dissertations and Theses (ETDs)
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Emotional Dysregulation In Children With Aids-Diagnosed Mothers: A Comparative Study, Kathleen O'Brien-Sheber
Emotional Dysregulation In Children With Aids-Diagnosed Mothers: A Comparative Study, Kathleen O'Brien-Sheber
Seton Hall University Dissertations and Theses (ETDs)
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Attachment Theory And Self-Disclosure Of Hiv Status, Amy H. Grimshaw
Attachment Theory And Self-Disclosure Of Hiv Status, Amy H. Grimshaw
Psychology Theses & Dissertations
This study examined the influence of attachment style on self-disclosure of HIV seropositive status. Subjects were classified according to Bartholomew's model of adult attachment (i.e., secure, preoccupied, fearful, or dismissing). Steps were then taken to assess differences in the subjects' willingness to disclose their HIV seropositive status, the communication style chosen for disclosure, the subjects' perceptions of the importance of disclosing their HIV seropositive status, and the feared negative consequences of disclosure. To increase generalizability subjects were asked to assess their self-disclosure to three types of target persons: lover, same-sex friend, and opposite-sex friend. Attachment style significantly affected perceived importance …
Polyclonal Infections Due To Mycobacterium Avium Complex In Patients With Aids Detected By Pulsed-Field Gel Electrophoresis Of Sequential Clinical Isolates., Alexander M. Slutsky, Robert D. Arbeit, Thomas W. Barber, Josiah Rich, C Fordham Von Reyn
Polyclonal Infections Due To Mycobacterium Avium Complex In Patients With Aids Detected By Pulsed-Field Gel Electrophoresis Of Sequential Clinical Isolates., Alexander M. Slutsky, Robert D. Arbeit, Thomas W. Barber, Josiah Rich, C Fordham Von Reyn
Dartmouth Scholarship
Invasive infection with organisms of the Mycobacterium avium complex (MAC) is common among patients with advanced human immunodeficiency virus infection. In previous studies, we analyzed multiple individual colonies of MAC isolated from specimens obtained at the same time and observed that 14 to 20% of patients are simultaneously infected with more than one strain. In this study, we examined sequential isolates from 12 patients with AIDS who had two or more MAC isolates available from clinical specimens collected more than 1 week apart; the intervals between the first and last specimens ranged from 8 to 192 (median, 46) days. For …
Adoptive Transfer Of Polyclonal And Cloned Cytolytic T Lymphocytes (Ctl) Specific For Mouse Aids-Associated Tumors Is Effective In Preserving Ctl Responses: A Measure Of Protection Against Lp-Bm5 Retrovirus-Induced Immunodeficiency., William R. Green, Kathy A. Green, Karen M. Crassi
Adoptive Transfer Of Polyclonal And Cloned Cytolytic T Lymphocytes (Ctl) Specific For Mouse Aids-Associated Tumors Is Effective In Preserving Ctl Responses: A Measure Of Protection Against Lp-Bm5 Retrovirus-Induced Immunodeficiency., William R. Green, Kathy A. Green, Karen M. Crassi
Dartmouth Scholarship
Cytolytic T lymphocytes (CTL) can be raised against C57BL/6 B-cell lymphomas from mice with LP-BM5 murine leukemia virus-induced AIDS (MAIDS). Adoptive transfer of polyclonal anti-MAIDS tumor CTL or two CTL clones specific for the B6-1710 MAIDS lymphoma caused preservation of major histocompatibility complex-restricted and allogeneic CTL responses, which may be interpreted as indices of protection from LP-BM5 murine leukemia virus-induced immunodeficiency.
The Effect Of Human Immunodeficiency Virus/Acquired Immune Deficiency Syndrome Education Program On Knowledge, Attitudes And Sexual Behavior Of Selected College Students, Arlene Jaine Jackson Montgomery
The Effect Of Human Immunodeficiency Virus/Acquired Immune Deficiency Syndrome Education Program On Knowledge, Attitudes And Sexual Behavior Of Selected College Students, Arlene Jaine Jackson Montgomery
Health Services Research Dissertations
The problem studied in this investigation was whether a behaviorally focused Human Immunodeficiency Virus (HIV)/Acquired Immune Deficiency Syndrome (AIDS) Program affects the knowledge, sexual attitudes and sexual behavior of college students.
Three hundred and six first-and third-year college students were included in the study from one university located in Southeastern Virginia. The sample was predominately female, African-American and mainly between the ages of 16-22 years of age.
Freshmen students were presently enrolled in the institution's HIV/AIDS education program, which was a part of a required course. The class sessions consisted of a pretest prior to student's completing the reading assignment …