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Full-Text Articles in Medicine and Health Sciences
Herpes Simplex Virus Type 1 And Chlamydia Pneumoniae Co-Infection In Human Astrocytes Alter Host Cell Transcription Of Adam10, Bacel And Psen1, Secretases Implicated In Alzheimer Disease, Sidra Montaha Haque
Herpes Simplex Virus Type 1 And Chlamydia Pneumoniae Co-Infection In Human Astrocytes Alter Host Cell Transcription Of Adam10, Bacel And Psen1, Secretases Implicated In Alzheimer Disease, Sidra Montaha Haque
PCOM Biomedical Studies Student Scholarship
Background Alzheimer disease includes plaques consisting of aggregates of amyloid beta (Aβ). Aβ is the product of abnormal cleavage of amyloid precursor protein (APP) by the secretases β-APP cleaving enzyme-I (BACE1), Presenilin-1 (PSEN1) and disintegrin and metalloprotcinase-10 (ADAM10). Recent studies postulate a correlation between amyloidogenic processing of APP and infection of neuronal cells by bacteria or viruses. Here we examine the ability of Herpes simplex virus type I (HSV-1) and Chlamydia pneumoniae (Cpn) to modify the expression of BACE1, PSEN1, and ADAM10 in infected astrocytes. Knowing how these two pathogens might affect the neurodegenerative pathway to Aβ may give us …
Changes In Expression Of Genes Associated With Autophagy And Apoptosis In Neuronal Cells Infected With Hsv-1may Suggest Infection-Induced Mechanisms Of Neurodegeneration, Alexis Mark, Fiora D. Zoga, Brian J. Balin Phd, Denah M. Appelt Phd, Susan T. Hingley
Changes In Expression Of Genes Associated With Autophagy And Apoptosis In Neuronal Cells Infected With Hsv-1may Suggest Infection-Induced Mechanisms Of Neurodegeneration, Alexis Mark, Fiora D. Zoga, Brian J. Balin Phd, Denah M. Appelt Phd, Susan T. Hingley
Research Day
Background:This study investigates the potential role of herpes simplex virus type 1 (HSV-1) in the pathogenesis of neurodegenerative disorders, such as Alzheimer’s disease (AD), by exploring changes in gene expression related to antiviral immunity and the autophagic pathway. Autophagy is a process that recycles organelles and proteins to create more energy for the cell. This pathway has been linked to neurodegeneration, as malfunctions in the completion of this process lead to a decline in overall cellular health and function. Interestingly, HSV-1 has been shown to block the completion of autophagy, which would potentially contribute to the cytopathic changes observed …