Medicine and Health Sciences Commons^™

Classification Of Colorectal Cancer Using Resnet And Efficientnet Models, Abhishek Ranjan, Priyanshu Srivastva, B Prabadevi, R Sivakumar, Rahul Soangra, Shamala K. Subramaniam

Physical Therapy Faculty Articles and Research

Introduction:

Cancer is one of the most prevalent diseases from children to elderly adults. This will be deadly if not detected at an earlier stage of the cancerous cell formation, thereby increasing the mortality rate. One such cancer is colorectal cancer, caused due to abnormal growth in the rectum or colon. Early screening of colorectal cancer helps to identify these abnormal growth and can exterminate them before they turn into cancerous cells.

Aim:

Therefore, this study aims to develop a robust and efficient classification system for colorectal cancer through Convolutional Neural Networks (CNNs) on histological images.

Methods:

Despite challenges in …

The Role Of Digital Pathology For Histological Diagnosis, Ellen Faherty

International Undergraduate Journal of Health Sciences

Digital pathology is on its way to becoming a widespread alternative for routine diagnostics. Rapid whole slide image scanning has accelerated this advancement, but large-scale implementation is complex on technical, logistical, and financial levels. Although validation studies have published encouraging data on safety and feasibility, implementation experiences highlight the importance of training and knowledge of possible consequences. International pathology organisations' guidelines are intended to safeguard digital pathology, from image capture to long-term image archiving, but they should only be viewed as a starting point. Cost-efficiency reviews and occupational health issues must be thoroughly addressed. Image analysis is incorporated into traditional …

Radiologic And Histologic Findings Of Locally Advanced Mucoepidermoid Carcinoma Managed With Total Surgical Excision, Christopher R. Huber, Don Truong, Joseph Hatem, Joel Thompson, Bryan Scott

Advances in Clinical Medical Research and Healthcare Delivery

The present case report provides images from computed tomography and histology of a patient with a salivary gland neoplasm consistent with mucoepidermoid carcinoma.

Case Series Of Common Skin Lesions Encountered In Elderly Cadavers: A Dermatopathology Analysis, Tamryn L. Van Der Horn, Brigitte L. Cochran, Savita Arya

Research Day

INTRODUCTION: Gaining hands-on experience in both dermatology and pathology is a common barrier that prevents first and second year medical students from refining skills that are not later taught until residency. This prompted a study to develop gross differential diagnostic skills and how to analyze histopathology slides to diagnose common skin lesions to refine skills in both clinical and histology presentation for medical students.

METHODS: A case series was designed to examine multiple shave biopsies on all abnormal skin lesions observed from nine cadavers used for the first-year medical students gross anatomy lab during the year 2022-2023. Biopsies were stained …

Effect Of Amputation On Muscle Structure Properties In A Rabbit Model, Roy Caleb Stubbs

Masters Theses

After amputation, muscles in the residual limb are detached from their insertion points and no longer span the missing joints. Our objective was to quantify the effect of amputation-induced disuse on residual muscle structure, an indirect indicator of muscle force-generating capacity. One hind paw was surgically removed at the ankle joint of ten rabbits. At two weeks (n=5) and 4 weeks (n=5) post-amputation and for select muscles (gastrocnemius, soleus, tibialis cranialis, extensor digitorum, and flexor digitorum superficialis), we measured and computed several muscle structure properties. Additionally, we qualitatively assessed the muscle fiber appearance of histological samples at each timepoint. At …

Histological Changes Of Bronchopulmonary Dysplasia And Pulmonary Hypertension: An Autopsy Series Of 42 Preterm Infants, Amelia Stone Md, Janet Poulik Md, Sara I. Koussa, Y Xin, A Sharma, Beena Sood Md, Ms

Medical Student Research Symposium

Background: Bronchopulmonary Dysplasia (BPD), a significant cause of perinatal morbidity and mortality, leads to disrupted pulmonary vascular growth and ultimately pulmonary hypertension (PH). The diagnosis of BPD is made by oxygen requirement for at least first 28 days of life. We hypothesized that histologic changes of BPD are evident before 28 days of age.

Methods: All live born preterm infants born <37 weeks of gestational age (GA), who received an autopsy between 2010 and 2017 at Children’s Hospital of Michigan or Hutzel Women’s Hospital, were identified by autopsy records. Infants with major congenital defects were excluded. Clinical data were extracted from electronic medical records. Autopsy specimens of lung and heart tissue were examined by a single pathologist, and classified according to presence or absence of defining features of BPD and PH.

Results: Of the 42 preterm infants that met the study criteria, 79% were <32 weeks GA, 55% were male, 55% were African American, 33% were SGA, and 17% were twins. Infants that died at <28 days of life were statistically more likely to be African American and receiving high frequency ventilation and were less likely to have preterm premature rupture of membranes (PPROM) and an echocardiogram obtained as part of their clinical workup.

Of infants <32 weeks GA, 61% died at <28 days of age; histological BPD was observed in 25% of infants and PH was observed in 65%. Of infants <32 weeks GA, 39% died at ≥28 days; histological BPD was observed in 92% and histological PH was observed in 85% of subjects.

Of infants ≥32 weeks GA, 78% died at <28 days of age; histological BPD was observed in 0% of infants and PH was observed in 71%. Of infants ≥32 weeks GA, 22% died at ≥28 days; histological BPD and PH were both observed in 50% of subjects.

Histological changes of BPD observed in 5 infants born <32 weeks GA who died before 28 days of age were identified as early as 6.73 days of age. Histologic PH was identified in 4 of the 5 infants with the earliest evidence being observed in an infant that died at 6.73 days of age.

Conclusion: Histologic changes consistent with BPD …

Modified Periodic Acid-Schiff (Pas) Is An Alternative To Safranin O For Discriminating Bone–Cartilage Interfaces, Kelsey M. Kjosness, Philip Reno, Maria A. Serrat

PCOM Scholarly Papers

Cartilage histomorphometry is often performed on decalcified, paraffin-embedded bone sections, which provide versatility in staining applications from basic morphology to immunohistochemistry. Safranin O is a cationic dye that binds to proteoglycans in cartilage and is routinely used to assess growth plate dynamics and/or fracture repair at bone–cartilage interfaces. When used with a counterstain such as fast green, safranin O can offer exquisite differentiation of cartilage from surrounding bone. However, various decalcification and processing methods can deplete proteoglycans, rendering inconsistent, weak, or absent safranin O staining with indiscriminate bone–cartilage boundaries. We sought to develop an alternative staining methodology that preserves the …

Optimizing Rna Isolation And Histology Protocols For Characterization Of Preclinical Models Of Tendon Disease, Deirdre Finnigan, Melika Meshkat, Ali Naeij, Dawn Bryce, Matthew W. Grol

Undergraduate Student Research Internships Conference

Tendons join muscle to bone and are essential for posture and movement. Tenocytes are the resident tendon cells. Isolating RNA from small animal models such as mice can be difficult, especially from tendon, as much of the time, they are extremely small samples. Downstream analysis such as qPCR and especially RNA sequencing require greater quantity and quality of RNA than is often achievable. RNA degradation is extremely rapid following tendon isolation, with RNA quality decreasing as time increases between the collection of tendons and RNA isolation. Even tendons whose RNA was isolated immediately following tendon isolation had imperfect quality. The …

Concurrent Malignant And Benign Nephrosclerosis In An Elderly Cadaver With Previously Diagnosed Cerebral Atherosclerosis, Destiny Sciuva, Jake Winchester, Emon Alavi, Sritha Moram, Dhruvi Patel, Alexander Cohen, Shiv Dhiman, Savita Arya

Research Day

We report histopathological features of concurrent malignant and benign nephrosclerosis in an 83-year-old elderly cadaver. Upon routine dissection in a medical school cadaveric anatomy lab, the abdomen of an 83-year-old female showed contracted and granular bilateral kidneys, with subsequent measurements identifying decreased size. Tissue samples were retrieved from the left anterior descending artery, left ventricle wall, bilateral kidneys and lungs. Histopathology slides were prepared using hematoxylin and eosin (H&E) stains. The samples were retrieved from a female cadaver in the Philadelphia College of Osteopathic Medicine, Georgia Body Donor Program. Histopathological findings in the kidneys included fibrinoid necrosis of arterioles, diffuse …

The Time For A Consensus Regarding The Coeliac Disease Diagnosis In Adults Has Come: Balancing The Pros And Cons Of Omitting The Biopsy, Carolina Ciacci, Julio C. Bao

Translational Medicine @ UniSa

How balancing the pros and cons of omitting the biopsy in diagnosing CeD in adults?

Effect Of Feed Supplementation With Effective Microorganisms (Em) Bokashi Onhepatopancreas And Gut Histology, Growth Performance, And Survival Rate Of Freshwatercrayfish Pontastacus Leptodactylus (Eschscholtz, 1823), Hasan Batuhan Emre Özdoğan, Seval Bahadir Koca, Özlem Özmen, Kami̇l Eki̇nci̇, Emi̇ne Eki̇nci̇, Habi̇l Uğur Koca, Nalan Özgür Yi̇ği̇t

Turkish Journal of Veterinary & Animal Sciences

A sixty-day feeding trial was conducted to investigate the effect of dietary effective microorganisms (EM) Bokashi on organ histology, growth performance, and survival rate of freshwater crayfish Pontastacus leptodactylus (Eschscholtz, 1823). Bokashi serum and powder consisted of two major microorganisms as Bacillus amyloliquefaciens spp. plantarum and Lactobacillus plantarum. Four treatment groups were established in control (without bokashi), bokashi powder 1% and 5% supplemented to diets. Bokashi serum was added at a ratio of 0.01% (v/v) of the total volume of the tank water once a week into which there was a constant flow of fresh water at a flow rate …

Investigation Of Igg, Vimentin, Cd45 Distribution, And Density In Mouse Placenta Atdifferent Periods Of Pregnancy, Seçi̇l Koç, Şadi̇ye Kum

Turkish Journal of Veterinary & Animal Sciences

The aim of this study was to investigate the distribution and density of IgG, vimentin, and CD45 in mouse placenta on the fourth, tenth, and seventeenth days of pregnancy. Strept avidin-biotin-peroxidase complex (streptABC) staining method was used. On the fourth day of pregnancy, the expression of IgG, vimentin, and CD45 was more intense around the uterine glands. On the tenth day, IgG, vimentin and CD45 positive cells were demonstrated in decidua basalis and mesometrial parietal trophoblast giant cells (P-TGCs) and mesometrial lymphocyte groups (MLAp) portions. The formation of the placenta was completed on the seventeenth day of pregnancy. The expression …

Anatomical And Histological Structures Of Eye And Lacrimal Gland In Norduz Andmorkaraman Sheep, Semi̇ne Dalga, Serap İlhan Aksu, Kadi̇r Aslan, Turgay Deprem, Reşi̇t Uğran

Turkish Journal of Veterinary & Animal Sciences

The current study was conducted to determine the morphological, morphometric, and histological characteristics of bulbus oculi and lacrimal gland in sheep. For this purpose, 28 pairs (n = 7 males and n = 7 females) of bulbus oculi from Morkaraman and (n = 7 males and n = 7 females) Norduz sheep were analyzed. The bulbus oculi in the skulls were dissected from the orbit and removed. The morphometric data such as distance between endpoints of the dissected bulbus oculi in temporal, nasal, and dorsal directions, the length between endpoints of the pupil in dorsal and ventral directions, and as …

Under The Microscope: Painting From Histology, Meg Smith

Senior Theses and Projects

My goal as an artist is to create paintings which explore the intersections of biology, philosophy, aesthetics, and personal experience. I want to challenge the viewer to engage with their own anatomy and physiology on a microscopic scale. I also aspire to communicate my sense of awe and wonder at the structures and mechanisms of life on every scale, from the cellular to the cosmic.

I am deeply interested in how physiological processes generate the human experience

—I became a neuroscience major because I was interested in the mechanisms of sensation and perception. My love of histology—the study of the …

Evaluation Of Dermal Toxicity Study Of Ethanolic Extract Of Morinda Citrifolia Fruit In Spraque Dawley Rats, Farhan Hanif Reduan Mohd, Rosly Shaari Mohd, Nurul Syahirah Ahmad Sayuti, Abdullahi Aliyu, Noordin Mohamed Mustapha, Md Zuki Abu Bakar, Shanmugavelu Sithambaram, Hazilawati Hamzah

The Thai Journal of Veterinary Medicine

Plant-based preparations are widely known to complement dermatological therapy, however toxic profiles of these plants are lacking and limited. To investigate the toxicity of Morinda citrifolia fruit ethanol extract applied to the skin of rats daily for 28 days, thirty female Sprague Dawley rats were grouped into five groups (n=5 rats for each group) for each study. The experimental period was set at 14 days and 28 days for acute and subacute dermal toxicity, respectively. Rats in the treatment groups were topically applied with the plant extract at three different doses; 2.5%, 5% and 10% on a shaved area of …

Some Histological Reveals On Reproduction Of One Of The Lessepsian Species, Nemipterus Randalli In Antalya (Turkey), Mehmet Rüştü Özen

Turkish Journal of Veterinary & Animal Sciences

In this study, the reproduction of Nemipterus randalli, one of the lessepsian fish catch from the Gulf of Antalya, Turkey was interpreted histologically. Regarding the fish used in this study (N = 1715), it is noteworthy to mention that male individuals are larger than females. The first sexual maturity in males was determined 17 cm TL and 60 g in BW, whereas 13 cm TL and 25 g BW in females. Females reached sexual maturity at age I+ and males at the age of II+. Seven different stages (O1-O7) were identified in oocyte maturation in the ovaries. The spawning time …

Details On The Histomorphological Characteristics Of Marine Sea Pen, Virgularia Gustaviana, From The Persian Gulf, Zeinab Rezaei, Abdolali Movahedinia, Negin Salamat, Mohammad Sharif Ranjbar

Turkish Journal of Veterinary & Animal Sciences

Sea pens or pennatulaceans (Phylum Cnidaria, Order Pennatulacea) are colonial marine octocorals that typically anchor themselves into soft sediment. They make large colonies from the intertidal zone down to the abyssal plain that provide an important structural habitat to other organisms. In the present study, the morphological and histological characteristics of the dominant species of Virgularia gustaviana, the dominant sea pen species of the Persian Gulf, were surveyed. Samples of V. gustaviana were collected along the coastal intertidal zone of the Soru and Bandar Abbas beaches, located at the northeast of the Persian Gulf. The sea pens were then fixed …

The Effect Of The Metabolic Syndrome On The Histological Structure Of The Testes Tissue And The Sperm Morphology In The Rats, Ayşe Alkandurur, Şadi̇ye Kum

Turkish Journal of Veterinary & Animal Sciences

In this study, we aimed to investigate the effect of metabolic syndrome on spermatozoon morphology and histological, histochemical, histomorphometric changes in the testes. Twenty-four male Sprague Dawley rats (60 day-olds) were used for this purpose. The rats in the control group were fed only water and rat food, while the rats in the experimental group were fed with water containing 20% D-fructose and rats food for 16 weeks with ad libitum. At the end of the experimental period, the testes and epididymis of the rats were removed. The testes were embedded in paraffin by performing the necessary histological procedure. In …

Deep Neural Network Analysis Of Pathology Images With Integrated Molecular Data For Enhanced Glioma Classification And Grading, Linmin Pei, Karra A. Jones, Zeina A. Shboul, James Y. Chen, Khan M. Iftekharuddin

Electrical & Computer Engineering Faculty Publications

Gliomas are primary brain tumors that originate from glial cells. Classification and grading of these tumors is critical to prognosis and treatment planning. The current criteria for glioma classification in central nervous system (CNS) was introduced by World Health Organization (WHO) in 2016. This criteria for glioma classification requires the integration of histology with genomics. In 2017, the Consortium to Inform Molecular and Practical Approaches to CNS Tumor Taxonomy (cIMPACT-NOW) was established to provide up-to-date recommendations for CNS tumor classification, which in turn the WHO is expected to adopt in its upcoming edition. In this work, we propose a novel …

Influence Of Season On Stereological And Histomorphometric Characteristics Of Testes Of Ouled Djellal Rams In Algeria, Yamina Belkhiri, Souheyla Benbia, Amal Djaout

The Thai Journal of Veterinary Medicine

The aim of this study was to investigate the influence of season on testicular morphometry, on ram body weight, testosterone concentration and on stereological structure of the testes in Ouled Djellalrams. Twenty seven rams were randomly selected and the live weight and testicular size were recorded. At the beginning of each season (autumn, winter, spring), among the study group, three rams were randomly selected, slaughtered and their left testes were removed and weighed. For microscopic study, tissue samples were excised from the left testes, fixed in formalin solution and embedded in paraffin and, afterwards, quantitative evaluation was performed. Statistical analysis …

Histological And Functional Characterization Of Cervical Spinal Cord Injury After Graded Contusion, Chrystine Gallegos

Dissertations & Theses (Open Access)

Most spinal cord injuries (SCIs) are cervical contusions and result in deficits for both locomotion and reaching and grasping functions. Previous studies have characterized histological and functional deficits in locomotion using primarily thoracic contusions, but most patients have cervical injuries. Damage to descending long spinal tracts (dLSTs) is one well-established cause of functional loss after SCI and has been explored in laceration and transection models, but these are not clinically relevant. In this study, I will explore the histological and functional deficits after graded cervical hemicontusion SCI and examine the potential contribution of different histological deficits to forelimb function after …

Impact Of Treatment Modality On Overall Survival In Localized Ductal Prostate Adenocarcinoma: A National Cancer Database Analysis, Chandler Bronkema, Sohrab Arora, Nikola Rakic, Akshay Sood, Deepansh Dalela, Jacob Keeley, Marcus Jamil, James O. Peabody, Craig G. Rogers, Mani Menon, Firas Abdollah

Medical Student Research Symposium

INTRODUCTION AND OBJECTIVE: Ductal adenocarcinoma is considered a rare histological variant of prostate adenocarcinoma (PCa). Given the rarity of this subtype, optimal treatment strategies for men with nonmetastatic ductal PCa is largely unknown. We aimed to describe the impact of surgery, radiotherapy, and systemic therapy on overall survival (OS) in men with nonmetastatic ductal PCa.

METHODS: We retrospectively selected 2209 cases of ductal PCa, diagnosed between 2004 and 2015, within the National Cancer Database (NCDB). Exclusion of metastatic patients yielded a total sample of 1993 individuals. Cox regression analysis tested the impact of treatment (surgery, radiotherapy, systemic therapy and no …

Hippocampal Subfields Revealed Through Unfolding And Unsupervised Clustering Of Laminar And Morphological Features In 3d Bigbrain, J. Dekraker, J. C. Lau, K. M. Ferko, A. R. Khan, S. Köhler

Brain and Mind Institute Researchers' Publications

© 2019 Elsevier Inc. The internal structure of the human hippocampus is challenging to map using histology or neuroimaging due to its complex archicortical folding. Here, we aimed to overcome this challenge using a unique combination of three methods. First, we leveraged a histological dataset with unprecedented 3D coverage, BigBrain. Second, we imposed a computational unfolding framework that respects the topological continuity of hippocampal subfields, which are traditionally defined by laminar composition. Third, we adapted neocortical parcellation techniques to map the hippocampus with respect to not only laminar but also morphological features. Unsupervised clustering of these features revealed subdivisions that …

Investigation Of The Early Healing Response To Dicationic Imidazolium-Based Ionic Liquids: A Biocompatible Coating For Titanium Implants, Sutton E. Wheelis, Cláudia Cristina Biguetti, Shruti Natarajan, Lidia Guida, Brian Hedden, Gustavo P. Garlet, Danieli C. Rodrigues

School of Podiatric Medicine Publications and Presentations

Dicationic Imidazolum-based ionic liquids with amino acid anions (IonL) have been proposed as a multifunctional coating for titanium dental implants, as their properties have been shown to address multiple early complicating factors while maintaining host cell compatibility. This study aims to evaluate effects of this coating on host response in the absence of complicating oral factors during the early healing period using a subcutaneous implantation model in the rat. IonLs with the best cytocompatibility and antimicrobial properties (IonL-Phe, IonL-Met) were chosen as coatings. Three different doses were applied to cpTi disks and subcutaneously implanted into 36 male Lewis rats. Rats …

Diagnostic Accuracy Of Ceus Li-Rads For The Characterization Of Liver Nodules 20 Mm Or Smaller In Patients At Risk For Hepatocellular Carcinoma., Jia-Yan Huang, Jia-Wu Li, Qiang Lu, Yan Luo, Ling Lin, Yu-Jun Shi, Tao Li, Ji-Bin Liu, Andrej Lyshchik

Department of Radiology Faculty Papers

Background: American College of Radiology contrast agent–enhanced US Liver Imaging Reporting and Data System (CEUS LI-RADS) was developed to improve the accuracy of hepatocellular carcinoma (HCC) diagnosis at contrast agent2enhanced US. However, to the knowledge of the authors, the diagnostic accuracy of the system in characterization of liver nodules 20 mm or smaller has not been fully evaluated.

Purpose: To evaluate the diagnostic accuracy of CEUS LI-RADS in diagnosing HCC in liver nodules 20 mm or smaller in patients at risk for HCC.

Materials and Methods: Between January 2015 and February 2018, consecutive patients at risk for HCC presenting with …

Randomised Placebo-Controlled Cross-Over Study Examining The Role Of Anamorelin In Mesothelioma (The Anthem Study): Rationale And Protocol, Siao Nge Hoon, Katrina Fyfe, Carolyn J. Peddle-Mcintyre, Samantha Bowyer, Felicity Hawkins, Emily Jeffery, Hui Jun Chih, Jenette Creaney, Anna Nowak, Fraser Brims

Research outputs 2014 to 2021

Introduction Cachexia is common in malignant mesothelioma (MM); half of patients have malnutrition and low skeletal muscle mass. Malnourished patients have worse quality of life (QoL). Weight loss is strongly associated with poor survival. Anamorelin is an oral ghrelin receptor agonist that improves appetite, body weight and QoL in advanced cancer. The aim of this study is to examine the efficacy of anamorelin in improving appendicular skeletal muscle mass (ASM) and patient-reported outcomes in patients with MM with cachexia. Methods and analysis A single-centre, phase II, randomised, placebo-controlled cross-over pilot study with 28-day treatment periods and 3-day washout. Forty patients …

Light And Scanning Electron Microscopic Examination Of The Saanen Goat Heart, Sedef Selvi̇ler Si̇zer, Yonca Beti̇l Kabak, Murat Kabak

Turkish Journal of Veterinary & Animal Sciences

It is important to know the morphological structure of the heart, which is a vital organ of the body, in detail. For this reason, we aimed to examine the morphological structure of the Saanen goat heart using light and scanning electron microscopy (SEM). A total of thirteen Saanen goat hearts were used in the study. To demonstrate the histological structure of the heart, samples taken from 9 hearts were fixed in 10% formaldehyde solution and blocked in paraffin after routine histological procedures. Histological staining was performed on the sections taken from the blocks. Four hearts were fixed in a 2.5% …

Effect Of Prebiotics On The Growth Performance, Haematological, Biochemical, Andhistological Parameters Of African Catfish (Clarias Gariepinus) In Recirculatingaquaculture System, Ercüment Genç, Münevver Ayçe Genç, Doğukan Kaya, Fai̇k Sertel Seçer, Abdolsaleh Qaranji̇ki̇, Derya Güroy

Turkish Journal of Veterinary & Animal Sciences

In this study, African catfish (Clarias gariepinus) was investigated under controlled conditions in recirculating aquaculture system (RAS). The experiment tested the effects of three different dietary prebiotics (FOS: fructooligosaccharide, GOS: galactooligosaccharide, and MOS: mannanoligosaccharide) in two levels (1 g/kg and 2 g/kg) and a control diet on the growth performance, survival rate, haematological and biochemical parameters, and small intestinal and liver histology of the African catfish. Better growth results were obtained in MOS (2 g/kg) supplementation, and there was a statistical difference (P < 0.05) between the MOS (2 g/kg) and the control group. Haematological parameters (erythrocyte sedimentation rate, red blood cell, white blood cell, lymphocyte, neutrophil, and glucose) were similar among all groups (P > 0.05) while some (alanine aminotransferase, aspartate aminotransferase enzymes, and monocyte) were significantly different (P < 0.05). The MOS (2 g/kg) group had longer villi length values than the control group. There was no difference among the groups in terms of small intestine histomorphology and liver tissues in fish. According to the results of this experiment, it can be said that MOS addition has a positive effect on growth parameters and could improve health conditions in Clarias gariepinus culture.

Morphological, Histological, And Molecular Evidence Of Myxobolus Spinacurvatura(Cnidaria: Myxosporea) From Mugil Cephalus In The Turkish Black Sea Coast, Banu Yardimci, Gökmen Zafer Pekmezci̇, Cenk Soner Bölükbaş, Melek Özpi̇çak, Savaş Yilmaz, Nazmi̇ Polat

Turkish Journal of Veterinary & Animal Sciences

In the present study, a total of 30 M. cephalus captured from the Samsun coast of the Black Sea, Turkey were examined for myxozoa infections. Different sizes of whitish and rounded cyst-like plasmodia were macroscopically detected in the liver and intestine wall of M. cephalus. Morphological and histological examinations were performed. The SSU rDNA was amplified using nested PCR and myxosporean-specific primers. The present Myxobolus species was identified as M. spinacurvatura based on the spore morphology and host/organ specificity. In the present study, morphological, histological, and molecular data on M. spinacurvatura were presented. Furthermore, BLASTn research showed that SSU rDNA …

A Prospective Study Comparing Tendon-To-Bone Interface Healing Using An Interposition Bioresorbable Scaffold With A Vented Anchor For Primary Rotator Cuff Repair In Sheep., Jeremiah Easley, Christian Puttlitz, Eileen Hackett, Cecily Broomfield, Lucas Nakamura, Michael Hawes, Charles Getz, Mark Frankle, Patrick St Pierre, Robert Tashjian, P Dean Cummings, Joseph Abboud, Derek Harper, Kirk Mcgilvray

Department of Orthopaedic Surgery Faculty Papers

BACKGROUND: The purpose of this study was to evaluate the biomechanical and histologic properties of rotator cuff repairs using a vented anchor attached to a bioresorbable interpositional scaffold composed of aligned PLGA (poly(l-lactide-co-glycoside)) microfibers in an animal model compared to standard anchors in an ovine model.

METHODS: Fifty-six (n = 56) skeletally mature sheep were randomly assigned to a repair of an acute infraspinatus tendon detachment using a innovative anchor-PLGA scaffold device (Treatment) or a similar anchor without the scaffold (Control). Animals were humanely euthanized at 7 and 12 weeks post repair. Histologic and biomechanical properties of the repairs were …