Macrophage Depletion Protects Against Cisplatin-Induced Ototoxicity And Nephrotoxicity, Cathy Yea Won Sung, Naoki Hayase, Peter S T Yuen, John Lee, Katharine Fernandez, Xuzhen Hu, Hui Cheng, Robert A Star, Mark E Warchol, Lisa L Cunningham

2020-Current year OA Pubs

Cisplatin is a widely used anticancer drug with notable side effects including ototoxicity and nephrotoxicity. Macrophages, the major resident immune cells in the cochlea and kidney, are important drivers of both inflammatory and tissue repair responses. To investigate the roles of macrophages in cisplatin-induced toxicities, we used PLX3397, a U.S. Food and Drug Administration-approved inhibitor of the colony-stimulating factor 1 receptor, to eliminate tissue-resident macrophages. Mice treated with cisplatin alone had considerable hearing loss (ototoxicity) and kidney injury (nephrotoxicity). Macrophage ablation resulted in significantly reduced hearing loss and had greater outer hair cell survival. Macrophage ablation also protected against cisplatin-induced …

The Use Of Hearing Tests To Assess Otitis Media With Effusion In Children With Down Syndrome., Mackenzie O'Donnell, Nasrin Sultana, Nasreen Talib, Jason May, Michael Slogic

Manuscripts, Articles, Book Chapters and Other Papers

BACKGROUND: Down syndrome is associated with an increased risk for otitis media with effusion (OME), a childhood condition in which fluid accumulates in the middle ear, potentially leading to hearing loss. The American Academy of Pediatrics Down syndrome guidelines and the American Academy of Otolaryngology - Head and Neck Surgery OME guidelines recommend hearing testing to assess the hearing status of children with Down syndrome diagnosed with OME.

METHODS: Through an Institutional Review Board approved retrospective chart review at Children's Mercy, this project assessed how clinical factors affect the frequency in which children with Down syndrome receive hearing testing after …

Examining The Relationship Between Deafness And Mental Health Status: An Analysis Of The Behavioral Risk Factor Surveillance System (Brfss) 2022, Brianna Stroud-Williams

Capstone Experience

Objective: The objective of the research is to examine the association between mental health status as measured by number of mentally healthy days in the past month and deafness and binge drinking.

Methods: The Behavioral Risk Factor Surveillance System (BRFSS) study was conducted via telephone survey in 50 states, including the District of Columbia and US territories. The sample size is 402,156 participants. Univariate, bivariate, and multivariate regressions, odds ratio, and 95% confidence interval were used to measure the data.

Results: Deaf respondents have 1.56 times the odds of having poor mental health than those who are not deaf. (95% …

Association Between Serum Vitamin D Status And Uterine Leiomyomas: A Case-Control Study, Chukwuemeka Chukwubuikem Okoro, Okechukwu Christian Ikpeze, George Uchenna Eleje, Gerald Okanandu Udigwe, Chukwuemeka Okwudili Ezeama, Joseph Odirichukwu Ugboaja, Chukwunonso Isaiah Enechukwu, Osita Samuel Umeononihu, Chukwudi Anthony Ogabido, Charlotte Blanche Oguejiofor, Tobechi Kingsley Njoku, Richard Obinwanne Egeonu, Chigozie Geoffrey Okafor, Hillary Ikechukwu Obiagwu, Chukwudubem Chinagorom Onyejiaka, Afam Ben Obidike, Christian Ejike Onah, Ifeanyi Uzukwu, Amarachukwu Doris Okoro, Evaristus Chino Ezema, Adaobi Maryann Ibekwe, Joseph Ifeanyichukwu Ikechebelu

Student and Faculty Publications

OBJECTIVE: Uterine leiomyoma is a common gynecological condition that negatively affects women's quality of life. Vitamin D plays an important role in tumor development and progression. However, clinical studies comparing serum vitamin D levels between women with and without uterine leiomyomas are limited and inconclusive. This study aimed to compare serum vitamin D levels in women with and without uterine leiomyomas.

METHODS: This hospital-based case-control study included 150 women who visited a gynecological clinic. The cases included 75 women with uterine leiomyoma, whereas the controls included 75 age-and parity-matched participants without uterine leiomyoma. Serum vitamin D levels were measured in …

Addressing Age-Related Hearing Changes, Vennela Pandaraboyina

Family Medicine Clerkship Student Projects

UVM Milton Family Medicine practice has a significant patient population of elderly adults who are experiencing age-related hearing loss. Age related hearing loss is very common in people over 65 – it’s the third most common chronic physical condition in the US. However due to both social stigma and a lack of health literacy many of them are not having their hearing changes addressed with appropriate audiology assessments and hearing aids. This project sought to further quantify the patient population in Milton with unaddressed age-related hearing loss by talking to local physicians and deaf, deaf/blind, and hard of hearing advocates. …

Hearing Loss As A Risk Factor For Cognitive Decline In The Elderly: A Rapid Review, Natalie Large, Nannette Nicholson

Internet Journal of Allied Health Sciences and Practice

Purpose: The aim of this rapid review was to identify and evaluate evidence exploring hearing loss as a risk factor for cognitive decline in the elderly population. Methods: A literature search was performed in three databases: CINAHL, Cochrane Central, and PubMed. The PRISMA template was used to record the search and selection process. Search criteria included older adults aged 65 and up with diagnosed or self-reported hearing loss and no previous diagnosis of dementia or Alzheimer’s disease. Participants were excluded if they had been diagnosed with dementia or tested for it before the study began. Hearing loss was categorized using …

Vascular And Auditory Changes After Repetitive Traumatic Brain Injury, Courtney Lynn Penn

USF Tampa Graduate Theses and Dissertations

Traumatic brain injury (TBI) affects over 2.87 million people in the US each year. The large majority of these injuries can be classified as mild. However, evidence suggests that even mild TBIs can lead to long-lasting symptoms that greatly impact quality of life. This is particularly true when an individual sustains multiple TBIs (repetitive TBI, rTBI). Much of the damage caused by rTBI is due to secondary injury mechanisms that cause the initial injury site to spread and worsen over time. No therapies currently exist which can mitigate secondary injury, and monitoring this phase of rTBI is difficult. Development of …

Hearing, Cognitive Decline, And The Value Of Hearing Interventions, Lisa M. Price, Jennifer Ren, Victoria Wong Murray, Dylan Trawinski, Ethan Zerpa-Blanco, Sheam Jahan

Rowan-Virtua Research Day

The term “dementia” includes a wide array of diseases. Millions of Americans are affected by these diseases, especially with aging. Its prevalence makes dementia a candidate for exploratory research in understanding its various etiologies and cause-effect relationships in hopes of developing treatment. Numerous studies have been conducted in an attempt to discern whether a causal relationship exists between hearing loss and dementia, as hearing loss frequently precedes dementia. Some publications have reported a correlation between hearing loss treatment and a decreased dementia incidence rate. This review seeks to investigate the associations between hearing loss and dementia, the efficacy of hearing …

Distinct Effects Of Two Hearing Loss-Associated Mutations In The Sarcomeric Myosin Myh7b, Lindsey A Lee, Samantha K Barrick, Ada E Buvoli, Jonathan Walklate, W Tom Stump, Michael Geeves, Michael J Greenberg, Leslie A Leinwand

2020-Current year OA Pubs

For decades, sarcomeric myosin heavy chain proteins were assumed to be restricted to striated muscle where they function as molecular motors that contract muscle. However, MYH7b, an evolutionarily ancient member of this myosin family, has been detected in mammalian nonmuscle tissues, and mutations in MYH7b are linked to hereditary hearing loss in compound heterozygous patients. These mutations are the first associated with hearing loss rather than a muscle pathology, and because there are no homologous mutations in other myosin isoforms, their functional effects were unknown. We generated recombinant human MYH7b harboring the D515N or R1651Q hearing loss-associated mutation and studied …

Audiological Intervention For Late-Identified Children And Teenagers With Hearing Loss, Melissa Wiedeman, Antony Joseph

AuD Capstone Projects - Communication Sciences and Disorders

Abstract 1 - Introduction: The family of every child referred for definitive care after a newborn hearing screening should follow up with an audiologist to rule out hearing impairment. Early identification, diagnosis, and intervention are crucial for individualized planning and outcomes. Children who need binaural amplification and are not managed appropriately become exposed to sound deprivation, which leads to diminished speech audibility, sound localization, and speech and language development. Case Presentation: A young child presented to the clinic with an unspecified bilateral mild to moderate hearing loss at 500, 2000, and 4000 Hz. Discussion: Children with monaural amplification have shown …

A Case History Of Non-Causational Autism And Hearing Loss Diagnoses, Alexandra Gray

2023 SLP Posters

This case study looks retroactively at one now 20-year-old white male's case history -- for privacy purposes, our participant will be referred to a ZG -- reviewing his Autism Spectrum Disorder (ASD) diagnosis, his bilateral hearing loss diagnosis, and treatment services he received. This study will review literature relating to those who have had similar dual diagnoses, how one can look like the other by discussing symptoms of both and where they overlap, and what treatment was given to those patients. By the end, the author will infer if the best choices were made given his diagnoses and which diagnosis …

Association Of Hearing Loss And Tinnitus Symptoms With Health-Related Quality Of Life Among Long-Term Oropharyngeal Cancer Survivors, Puja Aggarwal, Marc-Elie Nader, Paul W Gidley, Raj Pratihar, Shirin Jivani, Adam S Garden, Frank E Mott, Ryan P Goepfert, Christopher Wallace Ogboe, Camille Charles, Clifton D Fuller, Stephen Y Lai, G Brandon Gunn, Erich M Sturgis, Ehab Y Hanna, Katherine A Hutcheson, Sanjay Shete

Student and Faculty Publications

BACKGROUND: This study investigated the association of hearing loss and tinnitus with overall health-related quality of life (HRQoL) among long-term oropharyngeal cancer (OPC) survivors.

METHODS: This study included OPC survivors treated between 2000 and 2013 and surveyed from September 2015 to July 2016. Hearing loss and tinnitus were measured by asking survivors to rate their "difficulty with hearing loss and/or ringing in the ears" from 0 (not present) to 10 (as bad as you can imagine). Hearing loss and tinnitus scores were categorized as follows: 0 for none, 1-4 for mild, and 5-10 for moderate to severe. The primary outcome …

Loss Of Pex1 In Inner Ear Hair Cells Contributes To Cochlear Synaptopathy And Hearing Loss., Stephanie A Mauriac, Thibault Peineau, Aamir Zuberi, Cathleen Lutz, Gwénaëlle S G Géléoc

Faculty Research 2022

Peroxisome Biogenesis Disorders (PBD) and Zellweger syndrome spectrum disorders (ZSD) are rare genetic multisystem disorders that include hearing impairment and are associated with defects in peroxisome assembly, function, or both. Mutations in 13 peroxin (PEX) genes have been found to cause PBD-ZSD with ~70% of patients harboring mutations in PEX1. Limited research has focused on the impact of peroxisomal disorders on auditory function. As sensory hair cells are particularly vulnerable to metabolic changes, we hypothesize that mutations in PEX1 lead to oxidative stress affecting hair cells of the inner ear, subsequently resulting in hair cell degeneration and hearing loss. Global …

The Associations Between Diabetes, Cardiovascular Disease And Occupational Hearing Loss In A Cross-Sectional Analysis Of Department Of Energy Nuclear Workers, With A Mendelian Randomization Of Publicly Available Data To Enhance Observational Findings, Jonathan Corbin

Dissertations and Theses

Title: The Associations between Diabetes, Cardiovascular Disease and Occupational Hearing Loss in a Cross-sectional analysis of Department of Energy Nuclear Workers, with a Mendelian Randomization of Publicly Available Data to Enhance Observational Findings

Author: Jonathan Corbin

Advisor: Ghada Soliman, MD, PhD, R.D., CDN

Introduction: Occupational Hearing Loss (OHL) is the most common workplace health condition, and the overall impact of hearing loss (HL) on health is underappreciated. Diabetes and cardiovascular disease (CVD) are two of the most common causes of death and are largely preventable and treatable. Previous research has evaluated associations between OHL and …

Outcome Of Newborn Hearing Screening Program In A Tertiary Care Centre, South India., S. Sija, V. K. Gireeshan, V. T. Ajith Kumar Professor And Head Of The Department, T. V. Rajesh Additional Professor

Journal of Early Hearing Detection and Intervention

Objective

To determine the coverage and outcome of Universal Newborn Hearing Screening (UNHS) Program in Government Medical College Manjeri, South India. To study the prevalence of hearing loss (HL) among those children screened, to describe the characteristics of confirmed cases, and the status of speech and language development acquired by them at follow up.

Design

Hospital based retro prospective study.

Methods

Data were collected from all newborns who underwent Universal Newborn Hearing Screening (UNHS) over a four-year period (November 2014 to October 2018). Cases with confirmed hearing loss were studied by pre-structured questionnaire and telephonic interview. Speech and language …

Examination Of The Colorful Semantic Approach Via Telepractice For Children Who Are Deaf Or Hard Of Hearing, Samadhi Pusuba Devayalage

Graduate Theses and Dissertations

Introduction: Hearing loss, deafness or hard of hearing are considered to be the inabilityof perceiving sounds beyond 20 dB. Due to a direct impact of a hearing loss, a developing brain undergoes difficulties in acquiring age-appropriate syntax and speech sounds. As a result, children with hearing loss present language, speech, and literacy disabilities. The current study discusses the efficacy of the colorful semantics approach in order to see its impact on sentence structure development. Methodology: A single subject withdrawal experimental study conducted following ABAB model. Two participants (6 years and 10 years) were recruited to the study following an inclusion …

Approaches To Treat Sensorineural Hearing Loss By Hair-Cell Regeneration: The Current State Of Therapeutic Developments And Their Potential Impact On Audiological Clinical Practice, Ashley S. Hinton, Aizhen Yang-Hood, Angela D. Schrader, Christopher Loose, Kevin K. Ohlemiller, Will J. Mclean

2020-Current year OA Pubs

Sensorineural hearing loss (SNHL) is typically a permanent and often progressive condition that is commonly attributed to sensory cell loss. All vertebrates except mammals can regenerate lost sensory cells. Thus, SNHL is currently only treated with hearing aids or cochlear implants. There has been extensive research to understand how regeneration occurs in nonmammals, how hair cells form during development, and what limits regeneration in maturing mammals. These studies motivated efforts to identify therapeutic interventions to regenerate hair cells as a treatment for hearing loss, with a focus on targeting supporting cells to form new sensory hair cells. The approaches include …

Intervention And Outcomes Of Children In Different Types Of Listening And Spoken Language Programs, Jace Wolfe, Sharon Miller, Erin C. Schafer, Amanda M. Rudge, Betsy Moog Brooks, Joanna Smith, Darcy Stowe, Amy L. Birath, Parker Wilson, Elizabeth Fales, Tamara Elder

Journal of Early Hearing Detection and Intervention

This study explores the impact of the type and dosage of listening and spoken language (LSL) services on speech and language outcomes in children with cochlear implants or hearing aids in two LSL programs. Identical demographic variables were collected across the two programs for use in the statistical analyses. Speech and language outcomes were examined at ages 3 and 5 using standardized test measures. At age 3, significant differences in LSL outcomes existed between programs for children using cochlear implants but not for children using binaural hearing aids. However, at age five, outcomes were similar between the different LSL programs …

Management And Complications Of Enlarged Vestibular Aqueduct And Meniere's Disease, Jessica Birkey, Antony Joseph

AuD Capstone Projects - Communication Sciences and Disorders

Introduction: Vestibular aqueducts follow a route through the inner ear that terminates within the skull and, in most circumstances, aqueducts are narrow and bony. An enlarged vestibular aqueduct (EVA) is most commonly caused by a mutation in the SLC26A4 gene. There are other unidentified environmental and genetic causes that produce EVA as well. At the time this case was reported, no surgeries or treatments existed that could repair an EVA. Case presentation: A bilingual male child presented with congenital bilateral EVAs. His EVAs were accompanied by sensorineural hearing loss and language delay. Discussion: Enlarged vestibular aqueducts can affect language learning …

Cognitive Abilities In Hearing Loss: Perceived And Performance Abilities Of Adults Related To Attention, Memory, And Social Cognition, Karah Gottschalk

Theses and Dissertations--Gerontology

Hearing loss is the most common sensory deficit noted in aging adults. It is commonly known to reduce an individual’s ability to detect, identify, and localize sounds and speech and to cause issues in communication. However, there are other less commonly discussed impacts that hearing loss has beyond the auditory system. Literature suggests a correlation between hearing loss and cognition in aging adults. Similar to hearing loss, the domains of cognition experience performance and functional changes across the life span. In an aging adult, changes related to cognition are also suggested to be associated with hearing loss. This study aimed …

The Auditory Radiation In Traumatic Brain Damage: Diffusion Tensor Imaging Study, Jane Walsh

Honors Theses

Hearing loss is a known symptom among people who suffer from traumatic brain injuries. Studies have shown that sensorineural hearing loss is the most common type of hearing loss resulting from traumatic brain injury. However, it is not well understood whether the auditory pathway is affected by traumatic brain injury. In this study, we examined the auditory radiation, using diffusion tensor imaging data and probabilistic tractography. Fifty-three veterans with traumatic brain injury and forty-four veterans without traumatic brain injury are compared. There was no significant difference in fractional anisotropy of the auditory radiation between those with and without traumatic brain …

Vestibular Evoked Myogenic Potentials And Postural Control In Adults With Age-Related Hearing Loss, Steven Michael Doettl

Theses and Dissertations (ETD)

It is well-documented that auditory thresholds decrease with age, which can be referred to as Age-related hearing loss (ARHL). ARHL is one of the most common conditions affecting older adults and is associated with several conditions including decreased postural stability and falls. Age-related changes to auditory function have been attributed to, through histopathological study, specific degradation of the sensory, supporting, and afferent structures of the cochlea. Vestibular function, as measured through vestibular evoked myogenic potentials (VEMPs) also show decreases with age. VEMPs are a measurement of evoked potentials generated by auditory stimulation of the utricle and saccule measured through a …

Language-Deprived Environments: Neonatal Intensive Care Units And Hearing Loss, Margaret Caesar

Undergraduate Honors Thesis Collection

Adequate language exposure is crucial for speech-language development in children. Previous research suggests that decreased language exposure leads to an increased risk for speech-language developmental delays. This study aims to explore the language exposure of two arguably language-deprived environments: Neonatal Intensive Care Units (NICU) and severe-to-profound hearing loss. This is a two-part study that examines caregiver-infant interactions through the analysis of infant-directed speech (IDS). In the first part of the study, researchers transcribed and analyzed pre-recorded Language Environment Analysis (LENA) audio recordings of five (5) infants with severe-to-profound hearing loss (6-months post cochlear implantation). These LENA recordings collected speech, language, …

Social Validity Of Technology Assisted Spoken Language Intervention For Deaf And Hard-Of-Hearing Children, Sandra Grether Phd, Lisa L. Hunter Phd, Robert C. Gibler M.A., Susan Wiley, Bethany Wysocki Au.D., Rajvi Desai Msw, Jareen Meinzen-Derr

Journal of Early Hearing Detection and Intervention

Children who are Deaf or Hard-of-Hearing (DHH) are at-risk for language delays and associated developmental challenges that impact academic, social, and communication skills. Technology Assisted Language Intervention (TALI) is a novel approach that focuses on using augmentative and alternative communication (AAC) as an intervention for children who are DHH. Results from a recent pilot study suggested that TALI may be a viable approach for enhancing spoken language and communication. In this study, we examined the social validity of TALI using interviews and focus groups. We collected qualitative data from parents, caregivers, and professionals working with children who are DHH to …

Tinnitus And Self-Perceived Hearing Handicap In Firefighters: A Cross-Sectional Study, Samson Jamesdaniel, Kareem G Elhage, Rita Rosati, Samiran Ghosh, Bengt Arnetz, James Blessman

Student and Faculty Publications

Firefighters are susceptible to auditory dysfunction due to long-term exposure to noise from sirens, air horns, equipment, and tools used in forcible entry, ventilation, and extrication. In addition, they are exposed to ototoxic chemicals, particularly, during overhaul operations. Studies indicate that 40% of firefighters have hearing loss in the noise-sensitive frequencies of 4 and 6 kHz. Noise-induced hearing loss (NIHL) is often accompanied by tinnitus, which is characterized by ringing noise in the ears. The presence of phantom sounds can adversely affect the performance of firefighters. However, there has been limited research conducted on the prevalence of tinnitus in firefighters. …

Ethnographic Insight Into The Developmentally Diverse Worlds Of Twins: “L & J”, Allison Gallant

Senior Honors Projects

According to the National Institute of Deafness and Other Communication Disorders (2016), approximately 3 of every 1000 infants are born with a detectable level of hearing loss in one or both ears: with 90% of these infants being born to hearing parents. Immediately following the birth of a deaf child, parents are often bombarded with decisions regarding interventions to “fix” their child’s “disability”. This decision can impact how their child will experience the world and others. The situation is a very different stressor when a hearing child is born to deaf parents. Embracing one’s deaf identity and engaging in “deaf …

Knockout Of Pannexin-1 Induces Hearing Loss, Jin Chen, Chun Liang, Liang Zong, Yan Zhu, Hong-Bo Zhao

Otolaryngology--Head & Neck Surgery Faculty Publications

Mutations of gap junction connexin genes induce a high incidence of nonsyndromic hearing loss. Pannexin genes also encode gap junctional proteins in vertebrates. Recent studies demonstrated that Pannexin-1 (Panx1) deficiency in mice and mutation in humans are also associated with hearing loss. So far, several Panx1 knockout (KO) mouse lines were established. In general, these Panx1 KO mouse lines demonstrate consistent phenotypes in most aspects, including hearing loss. However, a recent study reported that a Panx1 KO mouse line, which was created by Genentech Inc., had no hearing loss as measured by the auditory brainstem response (ABR) threshold at low-frequency …

Occupational Noise Exposure Evaluation Of Airline Ramp Workers, Adekunle Ogunyemi

USF Tampa Graduate Theses and Dissertations

Noise exposure is a common hazard to workforce in general although at varying degrees depending on the occupation, as many workers are exposed for long periods of time to potentially hazardous noise.

Every year, twenty-two million workers are exposed to potentially damaging noise at work. In 2015 U.S. businesses paid over $1.5 million in penalties for not protecting workers from noise. (OSHA, 2016). There may be a direct or indirect consequence of the possibilities of overexposure to noise notwithstanding the compulsory hearing protection requests for the occupations with potential hazards, and these exposures usually arise from the various types of …

Development Of An Audiologic Rehabilitation Program Model For Adult Patients Receiving Care At A Graduate Training Facility, Amanda Mcfadden, Antony Joseph

AuD Capstone Projects - Communication Sciences and Disorders

Research has shown that untreated hearing loss can negatively impact a person’s quality of life. The average person with hearing loss waits seven years from the onset of symptoms to pursue hearing aids (Hall, 2014). To decrease the negative effects of hearing loss, hearing technology, by itself, is typically not enough support for even the best users (Kelly et al., 2013). To provide supplementary support for these patients, audiologic rehabilitation (AR) is required. Audiologic rehabilitation is the modern term used to classify treatments that were previously so- called “aural rehabilitation.” Per Boothroyd (2007), aural [audiologic] rehabilitation may be defined as, …

Progressive Age-Dependence And Frequency Difference In The Effect Of Gap Junctions On Active Cochlear Amplification And Hearing, Liang Zong, Jin Chen, Yan Zhu, Hong-Bo Zhao

Otolaryngology--Head & Neck Surgery Faculty Publications

Mutations of Connexin 26 (Cx26, GJB2), which is a predominant gap junction isoform in the cochlea, can induce high incidence of nonsyndromic hearing loss. We previously found that targeted-deletion of Cx26 in supporting Deiters cells and outer pillar cells in the cochlea can influence outer hair cell (OHC) electromotility and reduce active cochlear amplification leading to hearing loss, even though there are no gap junction connexin expressions in the auditory sensory hair cells. Here, we further report that hearing loss and the reduction of active amplification in the Cx26 targeted-deletion mice are progressive and different at high and low …