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Full-Text Articles in Medicine and Health Sciences
Generation Of Hydrogen Peroxide-Resistant Murine Neuroblastoma Cells: A Target Discovery Platform For Novel Neuroprotective Genes, Annette E. Maczurek, Rebekka Wild, Daunia Laurenti, Megan L. Steele, Lezanne Ooi, Gerald Munch
Generation Of Hydrogen Peroxide-Resistant Murine Neuroblastoma Cells: A Target Discovery Platform For Novel Neuroprotective Genes, Annette E. Maczurek, Rebekka Wild, Daunia Laurenti, Megan L. Steele, Lezanne Ooi, Gerald Munch
Faculty of Science, Medicine and Health - Papers: part A
Oxidative stress has been suggested to play an important role in the pathogenesis of various neurodegenerative diseases including Alzheimer’s disease (AD). Hydrogen peroxide (H2O2), one of the main reactive oxygen species, is converted into the highly toxic ·OH radical in the presence of redox-active transition metals, which then oxidises nucleic acids, lipids and proteins, leading to neurodegeneration and cell death. There is an urgent need to gain more knowledge about relevant therapeutic targets to combat oxidative stress and it neurotoxic effects, and how this knowledge can be utilized to develop novel neuroprotective therapies for AD. One way to identify new …
Peroxisome Proliferator-Activated Receptor Alpha Target Genes, Maryam Rakhshandehroo, Bianca Knoch, Michael Muller, Sander Kersten
Peroxisome Proliferator-Activated Receptor Alpha Target Genes, Maryam Rakhshandehroo, Bianca Knoch, Michael Muller, Sander Kersten
Illawarra Health and Medical Research Institute
The peroxisome proliferator-activated receptor alpha (PPARα) is a ligand-activated transcription factor involved in the regulation of a variety of processes, ranging from inflammation and immunity to nutrientmetabolism and energy homeostasis. PPARα serves as amolecular target for hypolipidemic fibrates drugs which bind the receptor with high affinity. Furthermore, PPARα binds and is activated by numerous fatty acids and fatty acid-derived compounds. PPARα governs biological processes by altering the expression of a large number of target genes. Accordingly, the specific role of PPARα is directly related to the biological function of its target genes. Here, we present an overview of the involvement …