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Depression

Claremont Colleges

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Full-Text Articles in Medicine and Health Sciences

The Relationship Between Body Mass Index And Depression In College Students, Bryn Kable Jan 2023

The Relationship Between Body Mass Index And Depression In College Students, Bryn Kable

CMC Senior Theses

College student mental health has seen a serious decline over the last decade (Esaki-Smith, 2022). One factor that has been linked to both physical and mental disorders is obesity. A common way to operationalize weight is through body mass index (BMI) (Ilman et al., 2015). There is evidence that BMI and depression are correlated linearly in that individuals with higher BMIs have higher levels of depression (Badillo et al., 2022; Simon et al., 2008). The exact mechanisms of this relationship are still generally unknown; thus, the goal of this study was to investigate the relationship between BMI and depression in …

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Oral Contraceptives And Affective Disorders: Neurobiology And Informed Choice, Sophia Mae Drezner Jan 2023

Oral Contraceptives And Affective Disorders: Neurobiology And Informed Choice, Sophia Mae Drezner

Scripps Senior Theses

Pregnancy prevention and female reproductive freedom have been some of the most contested political issues for decades. Abortion, a fundamental part of women’s healthcare, divides liberals and conservatives on an international scale. The consequences of unintended pregnancy without safe and reliable contraception are widespread, disproportionately impacting women of color, trans and non-binary folks, and poorer communities. The birth control pill is the most common form of oral contraception (OC) globally. Many people with ovaries begin the pill or other hormonal contraceptive (HC) methods as young as 11 years old. Exogenous progesterone and estrogen are known to impact mood, affect, physiology, …

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Putative Mechanisms Underlying The Antidepressant Actions Of Ketamine: A Review And Study Proposal, Tristan Reece Jan 2022

Putative Mechanisms Underlying The Antidepressant Actions Of Ketamine: A Review And Study Proposal, Tristan Reece

CMC Senior Theses

Major Depressive Disorder (MDD) is a highly debilitating and common psychiatric disorder that affects over 250 million people globally; it is among the most financially and emotionally burdensome illnesses in the world. Currently approved antidepressants are suboptimal in their efficacy and latency of therapeutic action. In contrast, single administrations of sub-anesthetic ketamine have been shown to rapidly alleviate depressive symptoms within hours, even in treatment-resistant patients. Ketamine is believed to exert these effects by increasing glutamatemediated neurotransmission and promoting rapid neurotrophic factor release, restoring the integrity of neural circuits that are compromised in depression. However, uncertainty surrounding its specific antidepressant …

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The Association Between Social Capital And Depression, Abdulrahman Abudawood Jan 2021

The Association Between Social Capital And Depression, Abdulrahman Abudawood

CGU Theses & Dissertations

Mental health is an integral component of a healthy and balanced life, and deterioration in mental health has a significant impact on the quality of life. Being an active member of the community can positively impact personal mental health and emotional wellbeing. The World Health Organization (WHO) considers Social Capital (SC) a significant determinant of individual mental health. Despite that, there are limited studies analyzing the association between SC and the prevalence or severity of depressive symptoms experienced by suburban residents of the United States. This study aimed to assess the relationships between the six dimensions of SC introduced by …

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A Link Between Gut Microbes & Depression: Microbial Activation Of The Human Kynurenine Pathway, Christina Cobb Jan 2018

A Link Between Gut Microbes & Depression: Microbial Activation Of The Human Kynurenine Pathway, Christina Cobb

CMC Senior Theses

Our gut microbiota is involved in human development, nutrition, and the pathogenesis of gut disorders, but has more recently been implicated as a possible mechanism in the pathophysiology of several brain disorders, including disorders of mood and affect, such as depression. Researchers have referred to this dynamic, bidirectional signaling pathway between the gut and the brain as the “gut-brain axis.” However, most research on this axis has been limited to rodent studies, and there has been little insight into the mechanism behind it. I propose that the kynurenine pathway, where tryptophan is converted to kynurenine, is a compelling mechanism mediating …

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Sceletium Tortuosum And Mesembrine: A Potential Alternative Treatment For Depression, Rebecca Schell Jan 2014

Sceletium Tortuosum And Mesembrine: A Potential Alternative Treatment For Depression, Rebecca Schell

Scripps Senior Theses

Major depressive disorder affects people’s productivity and ability to function in everyday life. The disorder can be attributed to neurochemical imbalances of various neurotransmitters including but not limited to serotonin, dopamine, and norepinephrine. Conventional pharmacological treatments have focused primarily on these three neurotransmitters, and have been shown to be effective in alleviating most of the major symptoms of depression. Although these treatments are effective with most patients, they are known to have adverse side effects, causing patients to seek alternative treatments. Sceletium tortuosum, a succulent plant found in the Cape region of South Africa, has been shown to have …

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