Medicine and Health Sciences Commons^™

Swallow, Breathing And Survival: Sex-Specific Effects Of Opioids., Michael Frazure

Electronic Theses and Dissertations

This dissertation presents a series of studies examining mechanisms of deglutition and respiration, and how these vital processes are impacted by opioids. The experiments in Chapter Two investigated the role of the upper esophagus in airway protection through systematic activation of pharyngeal and esophageal mechanoreceptors in a cat electromyography model. Chapter Three compared effects of opioid administration on breathing and swallowing between male and female rats, and found that females are more susceptible to opioid-induced depression of breathing and swallow than males. Findings from Chapters Two and Three led to the development of a translational model of opioid-induced dysphagia using …

Development Of A Visuoperceptual Measure For Fiberoptic Endoscopic Evaluation Of Swallowing (V-Fees) In Adults With Oropharyngeal Dysphagia: An International Delphi Study, Reinie Cordier, Renée Speyer, Susan Langmore, Deborah Denman, Katina Swan, Daniele Farneti

Research outputs 2022 to 2026

Visuoperceptual evaluation of fiberoptic endoscopic evaluation of swallowing (FEES) is a commonly used assessment in dysphagia or swallowing disorders. Currently, no international consensus exists regarding which visuoperceptual measures to use for the analysis of FEES recordings. Moreover, existing visuoperceptual FEES measures are limited by poor and incomplete psychometric data, identifying an urgent need for developing a visuoperceptual measure to interpret FEES recordings. Following the COSMIN group’s (COnsensus-based Standards for the selection of health Measurement INstruments) psychometric taxonomy and guidelines, this study aimed to establish the content validity of a new visuoperceptual FEES (V-FEES) measure in adults with oropharyngeal dysphagia. Using …

Meta-Analytic Connectivity Modelling Of Healthy Swallowing, Chris R. Tilton

Honors Theses and Capstones

A quantitative, voxel-wise meta-analysis was performed to investigate the brain regions involved in healthy human swallowing. Studies included in the meta-analysis (1) examined water swallowing, saliva swallowing, or both, (2) included healthy, normal subjects, and (3) reported stereotaxic brain activation coordinates in standard space. Following these criteria, a systematic literature review identified 8 studies that met the criteria. An activation likelihood estimation (ALE) meta-analysis and meta-analytic connectivity modelling (MACM) analysis were performed with BrainMap software. Ten clusters with high activation likelihood were found in the bilateral precentral gyri, right insula, left declive, right medial frontal gyrus, right dorsal nucleus of …

Ultrasonography As Biofeedback To Increase Muscle Activation During The Mendelsohn Maneuver In Healthy Adults, Ching-Hsuan Peng

Theses and Dissertations

The purpose of this study was to examine the effect of applying real-time ultrasound as visual feedback in addition to verbal instruction/tactile feedback to facility the accuracy of learning the Mendelsohn maneuver. The Mendelsohn maneuver is one of the commonly used swallowing exercises targeting hyolaryngeal elevation and prolonging upper esophageal sphincter opening during swallow. It was hypothesized that the additional visual cueing provided by ultrasound would significantly increase sEMG activity which may be associated with increased duration and extent of hyolaryngeal elevation during the Mendelsohn maneuver as compared to the effect of verbal instruction/tactile feedback alone. A total of twenty-four …

Increased Episodes Of Aspiration On Videofluoroscopic Swallow Study In Children With Nasogastric Tube Placement., Sarah T. Edwards, Linda Ernst, Ashley K. Sherman, Ann M. Davis

Manuscripts, Articles, Book Chapters and Other Papers

BACKGROUND: Given the limited evidence available, the impact of nasogastric (NG) tube placement on swallowing in children is not well understood. When a child needs to be fed enterally, the current standard is to initially place an NG tube and leave it in place for the first few months of supplemental or total enteral nutrition. It is important to understand if placement of NG tubes has a negative effect on a patient's swallow.

METHODS: We retrospectively reviewed the charts of those children who had videofluoroscopic swallow studies (VFSS) to identify all children who had an NG tube in place at …

Development Of Lip Closing Function During Taking Food Into The Mouth In Children With Down Syndrome, Tomoko Isoda, Fumiyo Tamura, Takeshi Kikutani, Miki Mizukami

International Journal of Orofacial Myology and Myofunctional Therapy

Children with Down Syndrome (DS) show developmental retardation of gross motor function including acquisition of oral movements related to eating and swallowing. To characterize the process of development/acquisition of eating/swallowing function of children with DS, interlabial pressure (IP) during taking food into the mouth was assessed. This study included 99 children with DS (birth to 4 year-old), and 112 age-matched control children showing typical development. IP during taking food into the mouth was measured as an objective index of lip closing function. The system for measuring IP during taking food into the mouth consisted of a strain gauge-pressure sensor connected …

Development Of A Non-Invasive Device For Swallow Screening In Patients At Risk Of Oropharyngeal Dysphagia: Results From A Prospective Exploratory Study, Catriona M. Steele, Rajat Mukherjee, Juha M. Kortelainen, Harri Pölönen, Michael Jedwab, Susan L. Brady, Kayla Brinkman Theimer, Susan Langmore, Luis F. Riquelme, Nancy B. Swigert, Philip M. Bath, Larry B. Goldstein, Richard L. Hughes, Dana Leifer, Kennedy R. Lees, Atte Meretoja, Natalia Muehlemann

Neurology Faculty Publications

Oropharyngeal dysphagia is prevalent in several at-risk populations, including post-stroke patients, patients in intensive care and the elderly. Dysphagia contributes to longer hospital stays and poor outcomes, including pneumonia. Early identification of dysphagia is recommended as part of the evaluation of at-risk patients, but available bedside screening tools perform inconsistently. In this study, we developed algorithms to detect swallowing impairment using a novel accelerometer-based dysphagia detection system (DDS). A sample of 344 individuals was enrolled across seven sites in the United States. Dual-axis accelerometry signals were collected prospectively with simultaneous videofluoroscopy (VFSS) during swallows of liquid barium stimuli in thin, …

The Impact Of Master’S Level Education On The Assessment And Intervention Of Pediatric Swallowing, Andrea Seagren

All Graduate Plan B and other Reports, Spring 1920 to Spring 2023

Purpose: Pediatric swallowing disorders is increasing in prevalence as medical advancements are made. This increase raises the need for more speech-language pathologists (SLPs) to be involved in the assessment and intervention of pediatric swallowing. However, discrepancies exist in the amount and level of education being provided during academic coursework in the area of pediatric swallowing.

Method 1: The investigation had a two-tier approach. Part one included a survey specifically targeting SLPs who graduated within the most recent accreditation standards (2014 to present) and masters level students in their second year of graduate school (n=100). Part two explored academic courses offered …

Oncolog, Volume 63, Number 08, August 2018, Angie N. Meus, Joe Munch, Bryan Tutt

OncoLog MD Anderson's Report to Physicians (All issues)

• High-Dose Radiation Therapy for Pancreatic Cancer: trial tests whether radiomodulating agent GC4419 can enable higher doses of stereotactic body radiation therapy
• Image-Guided Cordotomy for Cancer Pain: Computed tomography-guided cordotomy relieves cancer-related refractory pain
• Esophageal, Pharyngoesophageal Reconstruction: Advanced surgical techniques restore digestive continuity
• Therapy Preserves Swallowing Function: New trial tests different swallowing therapy regimens for head and neck cancer patients undergoing radiation therapy
• OncoLog Says Farewell

Assessment Of Bulbar Function In Amyotrophic Lateral Sclerosis: Validation Of A Self-Report Scale (Center For Neurologic Study Bulbar Function Scale)., R A Smith, E A Macklin, K J Myers, G L Pattee, K L Goslin, G D Meekins, J R Green, J M Shefner, E P Pioro

Articles, Abstracts, and Reports

BACKGROUND AND PURPOSE: Impaired bulbar functions of speech and swallowing are among the most serious consequences of amyotrophic lateral sclerosis (ALS). Despite this, clinical trials in ALS have rarely emphasized bulbar function as an endpoint. The rater-administered Amyotrophic Lateral Sclerosis Functional Rating Scale-Revised (ALSFRS-R) or various quality-of-life measures are commonly used to measure symptomatic benefit. Accordingly, we sought to evaluate the utility of measures specific to bulbar function in ALS.

METHODS: We assessed bulbar functions in 120 patients with ALS, with clinicians first making direct observations of the degree of speech, swallowing and salivation impairment in these subjects. Clinical diagnosis …

Creation And Initial Validation Of The International Dysphagia Diet Standardisation Initiative Functional Diet Scale, Catriona M. Steele, Ashwini M. Namasivayam-Macdonald, Brittany T. Guida, Julie A. Cichero, Janice Duivestein, Ben Hanson, Peter Lam, Luis F. Riquelme

NYMC Faculty Publications

OBJECTIVE: To assess consensual validity, interrater reliability, and criterion validity of the International Dysphagia Diet Standardisation Initiative Functional Diet Scale, a new functional outcome scale intended to capture the severity of oropharyngeal dysphagia, as represented by the degree of diet texture restriction recommended for the patient. DESIGN: Participants assigned International Dysphagia Diet Standardisation Initiative Functional Diet Scale scores to 16 clinical cases. Consensual validity was measured against reference scores determined by an author reference panel. Interrater reliability was measured overall and across quartile subsets of the dataset. Criterion validity was evaluated versus Functional Oral Intake Scale (FOIS) scores assigned by …

Saliva Production And Enjoyment Of Real-Food Flavors In People With And Without Dysphagia And/Or Xerostomia, Angela M. Dietsch, Cathy A. Pelletier, Nancy Pearl Solomon

Department of Special Education and Communication Disorders: Faculty Publications

Non-food gustatory stimulation has multiple potential therapeutic benefits for people with dysphagia and xerostomia. This study examined palatability and saliva flow associated with dissolvable flavored films. Taste strips with real-food flavors dissolved on the tongues of 21 persons with dysphagia and/or xerostomia and 21 healthy age- and sex-matched adults while sublingual gauze pads absorbed saliva over randomized 3-min trials. Participants rated taste enjoyment for each trial on a hedonic general labeled magnitude scale. Flavored strips elicited more saliva than baseline for both groups, and production was higher for controls than patients (M = 2.386 and 1.091 g, respectively; p = …

The Effect Of Chronic Obstructive Pulmonary Disease On Swallowing, Jessica R. Torres

Senior Honors Projects, 2010-2019

This work is composed of a literature review, research review, and self-reflective essay. The anatomy and physiology of normal swallowing and respiration are reviewed. Additionally, the effect of chronic obstructive pulmonary disease (COPD) on these processes is discussed. The research goal was to determine how lung volume changes adapt the physiology of swallowing in individuals with COPD. The research project was designed and conducted by Teresa Drulia, M.S., CCC-SLP. COPD participants (n=9, mean age=72, 6 male) were compared to older healthy individuals (n=10, mean age= 59, 3 male). Participants completed swallows of 20cc of water at four lung volume conditions: …

Oncolog, Volume 61, Number 02, February 2016, Joe Munch, Bryan Tutt, C Graber

OncoLog MD Anderson's Report to Physicians (All issues)

• Overcoming Challenges in Cutaneous T Cell Lymphomas: Cutaneous T Cell lymphomas (CTCLs) not only are largely incurable but also make patients miserable with itching, burning skin and unsightly lesions. Because CTCL can resemble various benign skin conditions, many patients are diagnosed at an advanced and difficult-to-treat stage. But ongoing clinical trials may offer patients with CTCL improved treatments and better quality of life.
• Swallowing Therapy Improves Function and Quality of Life for Patients with Head and Neck Cancer: In patients with head and neck cancer, loss of swallowing function may result from radiation therapy, surgery, or the cancer itself and …

The Impact Of Lingual Resistance Training In Two Individuals With Amyotrophic Lateral Sclerosis: A Case Series, Raele Donetha Robison

USF Tampa Graduate Theses and Dissertations

Introduction: Amyotrophic Lateral Sclerosis (ALS) is a fatal and progressive disease characterized by the deterioration of motor neurons within the body. This degeneration leads to bulbar dysfunction in the form of an impaired ability to communicate and swallow. Currently, bulbar dysfunction is treated via compensatory methods aimed at maximizing comfort and safety that include environmental adaptations, augmentative and assistive communication and gastrostomy tube placement to replace speech and oral feeding. The role of active intervention is controversial in this patient population and no investigations have examined the potential role lingual exercise might play in ALS bulbar management. The purpose of …

Hyolaryngeal Kinematics And Swallow Patterning In Normal And Disordered Swallowing, Seng Mun Wong

Dissertations, 2014-2019

Hyoid and laryngeal movements contribute to laryngeal vestibule closure and upper esophageal sphincter (UES) opening for safe swallowing. However, the extent of movement required for achieving these goals, and the interaction between hyoid and laryngeal movements during swallowing are unknown. Despite impairment in vestibule closure and UES opening, patients with dysphagia may exhibit reduced, increased or similar hyolaryngeal displacements as healthy individuals. This limits the delineation between normal and disordered swallowing. We investigated whether anatomical differences in hyolaryngeal positions and the extent of laryngeal vestibule opening at rest would better predict hyolaryngeal displacements and the extent of vestibule closure during …

Quantitative Investigation Of Effect Of Age And Bolus Characteristics On Laryngeal Movement During Swallowing, Tsui-Fen Yang, Rai-Chi Chan, Shinn-Shing Lee, Jia-Chi Wang

Rehabilitation Practice and Science

Objective: The purpose of this study was to investigate the physiologic changes of swallowing along with normal aging, and to study the influences on swallowing of gender and food consistency.Methods: One hundred adult men and women aged 24 to 80 participated. Each subject underwent a swallowing evaluation, in which a surface transducer was placed on the neck to detect laryngeal movement when they performed a dry swallow and wet swallow for different food consistencies. Main outcome measures included mean onset, mean amplitude and mean duration of the deglutition wave.Results: In this study, the onset of the dry swallow deglutition wave …

Oncolog Volume 54, Number 01, January 2009, John Lebas, Sunni Hosemann

OncoLog MD Anderson's Report to Physicians (All issues)

• Redefining Cancer Care
• Early-Stage Laryngeal Cancer
• House Call: Trouble Sleeping? Getting Help Can Improve Your Health

Does Verbal Communication Impairment Affect Quality Of Life In Amyotrophic Lateral Sclerosis Patients?, Jason Michael Duff

PCOM Psychology Dissertations

The purpose of this study was to examine the self-perceived QOL in ALS patients. Literature will be presented on the incidence, prevalence, prognosis, diagnosis and management of ALS, QOL studies for ALS, the role of the multidisciplinary team, the impairments and dysfunction that ALS patients experience, communication issues, and the development of ALS specific instruments to measure QOL. The "bulbar dysfunction" that ALS patients experience in salivation management, speech, and swallowing were examined in detail. The objectives of this research study were to investigate the following hypotheses: 1. QOL will differ among ALS patients with varying levels of speech, swallowing, …

Oncolog, Volume 47, Number 01, January 2002, Dawn Chalaire, Mariann Crapanzano

OncoLog MD Anderson's Report to Physicians (All issues)

• Preserving and Restoring the Ability to Swallow in Patients with Head and Neck Cancer Requires a Team Approach
• Modified Barium Swallow Helps Speech Pathologists Determine What Patients Are Able to Eat
• House Call: Common Cancers, Common Symptoms
• Portal Vein Embolization Offers More Pateints an Opportunity for Potentially Curative Hepatic Resection

Oral Stereognosis And Two-Point Discrimination Ability Of Anterior Tongue Thrusters And Normal Swallowers, Lawrence Jay Friedman

University of the Pacific Theses and Dissertations

The present study was designed to determine whether differences exist between frontal tongue thrusters and normal swallowers on tasks or oral stereognosis and two-point discrimination.