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Articles 1 - 30 of 45
Full-Text Articles in Medicine and Health Sciences
The American Thoracic Society Research Program: Twenty Years Of Driving Discovery In Respiratory Medicine, Kamran Atabai, M. Safwan Badr, Jack Costello, Karen Ridge, Sharon Rounds, Michelle Turenne, Eric White, Jesse Roman
The American Thoracic Society Research Program: Twenty Years Of Driving Discovery In Respiratory Medicine, Kamran Atabai, M. Safwan Badr, Jack Costello, Karen Ridge, Sharon Rounds, Michelle Turenne, Eric White, Jesse Roman
Division of Pulmonary and Critical Care Medicine Faculty Papers
No abstract provided.
Committing To Genomic Answers For All Kids: Evaluating Inequity In Genomic Research Enrollment., Natalie J. Kane, Ana S A Cohen, Courtney D. Berrios, Bridgette Jones, T Pastinen, Mark A. Hoffman
Committing To Genomic Answers For All Kids: Evaluating Inequity In Genomic Research Enrollment., Natalie J. Kane, Ana S A Cohen, Courtney D. Berrios, Bridgette Jones, T Pastinen, Mark A. Hoffman
Manuscripts, Articles, Book Chapters and Other Papers
PURPOSE: Persistent inequities in genomic medicine and research contribute to health disparities. This analysis uses a context-specific and equity-focused strategy to evaluate enrollment patterns for Genomic Answers for Kids (GA4K), a large, metropolitan-wide genomic study on children.
METHODS: Electronic health records for 2247 GA4K study participants were used to evaluate the distribution of individuals by demographics (race, ethnicity, and payor type) and location (residential address). Addresses were geocoded to produce point density and 3-digit zip code maps showing local and regional enrollment patterns. Health system reports and census data were used to compare participant characteristics with reference populations at different …
Men And Women Differ In Their Interest And Willingness To Participate In Exercise And Sports Science Research, James L. Nuzzo, Robert O. Deaner
Men And Women Differ In Their Interest And Willingness To Participate In Exercise And Sports Science Research, James L. Nuzzo, Robert O. Deaner
Research outputs 2022 to 2026
Unequal proportions of male and female participants in exercise research might be attributed, in part, to differences in interest and willingness to participate. We tested if men and women are equally interested and willing to undergo exercise research procedures and if they consider different factors when deciding to participate. Two samples completed an online survey. Sample 1 (129 men, 227 women) responded to advertisements on social media and survey-sharing websites. Sample 2 (155 men, 504 women) was comprised of undergraduate psychology students. In both samples, men were significantly more interested to learn their muscle mass amount, running speed, jump height, …
S5e3: Can Physics Help Combat Covid-19?, Ron Lisnet, Samuel T. Hess
S5e3: Can Physics Help Combat Covid-19?, Ron Lisnet, Samuel T. Hess
The Maine Question
Numerous medical professionals, biologists and other experts have been combating COVID-19 and the havoc it has wrought since the pandemic began. Physicists have also joined the fray, including one from the University of Maine.
The invention of a new microscope allows Sam Hess, a professor of physics at UMaine, to obtain new insight into the structure of the virus that causes COVID-19 — SARS-COV-2 — and the influenza virus. These findings could help pave the way for effective treatments.
In this episode of “The Maine Question,” Hess discusses the development of this breakthrough in microscope technology and his decades-long quest …
Research Amidst The Pandemic, Howard Burris
Research Amidst The Pandemic, Howard Burris
HCA Healthcare Journal of Medicine
Cancer patients need access to promising investigational therapies, available only through clinical trials, and the emergence of COVID-19 and the resulting pandemic became an emerging threat to fulfilling that need. Many academic medical centers were pausing their clinical research programs, diverting their resources and sheltering their teams. Sarah Cannon, the Cancer Institute of HCA Healthcare, made the decision to stay safe, but stay the course.
Promoting Local Talents To Fight Local Health Issues Step-Up In The Pacific, Aneesa Golshan, Mph, George Hui, Phd,
Promoting Local Talents To Fight Local Health Issues Step-Up In The Pacific, Aneesa Golshan, Mph, George Hui, Phd,
Journal of Health Disparities Research and Practice
This manuscript introduces the abstracts for the University of Hawai'i at Manoa Coordinating Center.
Ethical And Scientific Pitfalls Concerning Laboratory Research With Non-Human Primates, And Possible Solutions, Constança Carvalho, Augusta Gaspar, Andrew Knight, Luís Vicente
Ethical And Scientific Pitfalls Concerning Laboratory Research With Non-Human Primates, And Possible Solutions, Constança Carvalho, Augusta Gaspar, Andrew Knight, Luís Vicente
Andrew Knight, PhD
Basic and applied laboratory research, whenever intrusive or invasive, presents substantial ethical challenges for ethical committees, be it with human beings or with non-human animals. In this paper we discuss the use of non-human primates (NHPs), mostly as animal models, in laboratory based research. We examine the two ethical frameworks that support current legislation and guidelines: deontology and utilitarianism. While human based research is regulated under deontological principles, guidelines for laboratory animal research rely on utilitarianism. We argue that the utilitarian framework is inadequate for this purpose: on the one hand, it is almost impossible to accurately predict the benefits …
Ethical And Scientific Pitfalls Concerning Laboratory Research With Non-Human Primates, And Possible Solutions, Constança Carvalho, Augusta Gaspar, Andrew Knight, Luís Vicente
Ethical And Scientific Pitfalls Concerning Laboratory Research With Non-Human Primates, And Possible Solutions, Constança Carvalho, Augusta Gaspar, Andrew Knight, Luís Vicente
Morality and Ethics of Animal Experimentation Collection
Basic and applied laboratory research, whenever intrusive or invasive, presents substantial ethical challenges for ethical committees, be it with human beings or with non-human animals. In this paper we discuss the use of non-human primates (NHPs), mostly as animal models, in laboratory based research. We examine the two ethical frameworks that support current legislation and guidelines: deontology and utilitarianism. While human based research is regulated under deontological principles, guidelines for laboratory animal research rely on utilitarianism. We argue that the utilitarian framework is inadequate for this purpose: on the one hand, it is almost impossible to accurately predict the benefits …
Reviewers' Responses To Medical Research Articles, Saba Sohail, Jamshed Akhtar
Reviewers' Responses To Medical Research Articles, Saba Sohail, Jamshed Akhtar
Department of Radiology
Objective: To document the reviewers' responses in terms of reviewers' demographic and professional characteristics, promptness of reply, and duration of reply to the request to review medical research articles for a general biomedical research journal.
Study design: Cross-sectional, observational study.
Place and duration of study: Department of Publications, College of Physicians and Surgeons Pakistan (CPSP), from October to December 2015.
Methodology: Peer reviewed articles edited by a single staff editor were included. Editorials and correspondence were excluded. Manuscript category, discipline, and the total number of reviewers per manuscript were noted. Responses were divided into no response, regrets, and responded, i.e. …
Use And Effectiveness Of The Individual Development Plan Among Postdoctoral Researchers: Findings From A Cross-Sectional Study, Nathan L. Vanderford, Teresa M. Evans, L. Todd Weiss, Lindsay Bira, Jazmin Beltran-Gastelum
Use And Effectiveness Of The Individual Development Plan Among Postdoctoral Researchers: Findings From A Cross-Sectional Study, Nathan L. Vanderford, Teresa M. Evans, L. Todd Weiss, Lindsay Bira, Jazmin Beltran-Gastelum
Toxicology and Cancer Biology Faculty Publications
The individual development plan (IDP) is a career planning tool that aims to assist PhD trainees in self-assessing skills, exploring career paths, developing short- and long-term career goals, and creating action plans to achieve those goals. The National Institutes of Health and many academic institutions have created policies that mandate completion of the IDP by both graduate students and postdoctoral researchers. Despite these policies, little information exists regarding how widely the tool is used and whether it is useful to the career development of PhD trainees. Herein, we present data from a multi-institutional, online survey on the use and effectiveness …
A Cross-Sectional Study Of The Use And Effectiveness Of The Individual Development Plan Among Doctoral Students, Nathan L. Vanderford, Teresa M. Evans, L. Todd Weiss, Lindsay Bira, Jazmin Beltran-Gastelum
A Cross-Sectional Study Of The Use And Effectiveness Of The Individual Development Plan Among Doctoral Students, Nathan L. Vanderford, Teresa M. Evans, L. Todd Weiss, Lindsay Bira, Jazmin Beltran-Gastelum
Toxicology and Cancer Biology Faculty Publications
Background: The Individual Development Plan (IDP) was introduced as a tool to aid in career planning for doctoral trainees. Despite the National Institutes of Health and academic institutions creating policies that mandate the use of IDPs, little information exists regarding the use and effectiveness of the career planning tool.
Methods: We conducted a multi-institutional, online survey to measure IDP use and effectiveness. The survey was distributed to potential respondents via social media and direct email. IDP survey questions were formatted using a five-point Likert scale (strongly agree, agree, neutral, disagree and strongly disagree). For data analysis purposes, responses were grouped …
Translational Research: Ethical Considerations, Yiqing Dong
Translational Research: Ethical Considerations, Yiqing Dong
Honors Program Theses
Translational research (TR) is a new categorization for the efforts of biomedical research and emphasizes efficiency in achieving population health improvements through the application of basic science knowledge in clinical practice. It will be argued that the current emphasis on speed and collaboration with industry established by national policies provides challenges to maintaining the integrity of scientific research. There is no agreed upon definition of TR and the current standard of judging the success of TR focuses on product production. I propose that the principles of beneficence and responsive justice should be used to inform the values of TR and …
The Cancer Immunotherapy Armamentarium: Assessing Applications, Ambitions, And Amplitude, Natisha J. Corum
The Cancer Immunotherapy Armamentarium: Assessing Applications, Ambitions, And Amplitude, Natisha J. Corum
Essential Studies UNDergraduate Showcase
Given the high, and rapidly increasing, incidence of cancer coupled with the enormous cost burden associated with the disease, it has been, and will continue to be, an area of intense focus in biomedical, translational, and clinical research. Research steered towards targeting and manipulating the body’s own immune function to fight cancer has accompanied a paradigm shift in treatment modalities that aims to include more precision/personalized medicine. The positive initial findings and clinical results of recent immunotherapies has precipitated a wave of attention and interest into the field, both in the general public and within the biomedical community. While there …
Bios 6136 - Topics Of Inference In Biostatistics Ii, Lili Yu
Bios 6136 - Topics Of Inference In Biostatistics Ii, Lili Yu
Jiann-Ping Hsu College of Public Health Syllabi
The course will introduce large sample theory, such as law of large numbers and the central limit theorem; sampling distributions of estimators; the basis for inferences derived from hypothesis testing and confidence intervals; and simulation methods. Emphasis will be placed on how these techniques are used in biostatistical problems and applications using examples from the pharmaceutical industry.
Bios 7131 - Survival Analysis, Lili Yu
Bios 7131 - Survival Analysis, Lili Yu
Jiann-Ping Hsu College of Public Health Syllabi
This course introduces statistical methods for analyzing data collected on the time to an event, referred to as survival data, in medical research and other health-related fields. Emphasis will be placed on the application of the methodology and computational aspects rather than theory. The students will learn how to apply SAS procedures to data and interpret the results.
Translational Research: Ethical Considerations, Yiqing Dong
Translational Research: Ethical Considerations, Yiqing Dong
Sound Decisions: An Undergraduate Bioethics Journal
Translational research (TR) is a new categorization for the efforts of biomedical research and emphasizes efficiency in achieving population health improvements through the application of basic science knowledge in clinical practice. It will be argued that the current emphasis on speed and collaboration with industry established by national policies provides challenges to maintaining the integrity of scientific research. There is no agreed upon definition of TR and the current standard of judging the success of TR focuses on product production. I propose that the principles of beneficence and responsive justice should be used to inform the values of TR and …
A Review Of The Institute Of Medicine’S Analysis Of Using Chimpanzees In Biomedical Research, Robert C. Jones, Ray Greek
A Review Of The Institute Of Medicine’S Analysis Of Using Chimpanzees In Biomedical Research, Robert C. Jones, Ray Greek
Robert C. Jones, PhD
We argue that the recommendations made by the Institute of Medicine’s 2011 report, Chimpanzees in Biomedical and Behavioral Research: Assessing the Necessity, are methodologically and ethically confused. We argue that a proper understanding of evolution and complexity theory in terms of the science and ethics of using chimpanzees in biomedical research would have had led the committee to recommend not merely limiting but eliminating the use of chimpanzees in biomedical research. Specifically, we argue that a proper understanding of the difference between the gross level of examination of species and examinations on finer levels can shed light on important methodological …
Non-Animal Methodologies Within Biomedical Research And Toxicity Testing, Andrew Knight
Non-Animal Methodologies Within Biomedical Research And Toxicity Testing, Andrew Knight
Andrew Knight, PhD
Laboratory animal models are limited by scientific constraints on human applicability, and increasing regulatory restrictions, driven by social concerns. Reliance on laboratory animals also incurs marked – and in some cases, prohibitive – logistical challenges, within high-throughput chemical testing programmes, such as those currently underway within Europe and the US. However, a range of non-animal methodologies is available within biomedical research and toxicity testing. These include: mechanisms to enhance the sharing and assessment of existing data prior to conducting further studies, and physicochemical evaluation and computerised modelling, including the use of structure-activity relationships and expert systems. Minimally-sentient animals from lower …
Why Patient-Centered?, Dennis J. Baumgardner
Why Patient-Centered?, Dennis J. Baumgardner
Dennis J. Baumgardner, MD
No abstract provided.
Biomedical Research Leaders: Report On Needs, Opportunities, Difficulties, Education And Training, And Evaluation, Samuel Wilson, Deborah Brown, Jay Moskowitz, Dan Hurley, David Brown, David Brown, Byron Bailey, Michael Mcclain, Marilyn Misenhimer, Judith Buckalew, Thomas Burks
Biomedical Research Leaders: Report On Needs, Opportunities, Difficulties, Education And Training, And Evaluation, Samuel Wilson, Deborah Brown, Jay Moskowitz, Dan Hurley, David Brown, David Brown, Byron Bailey, Michael Mcclain, Marilyn Misenhimer, Judith Buckalew, Thomas Burks
David C. Brown
The National Association of Physicians for the Environment (NAPE) has assumed a leadership role in protecting environmental health in recent years. The Committee of Biomedical Research Leaders was convened at the recent NAPE Leadership Conference: Biomedical Research and the Environment held on 1–2 November 1999, at the National Institutes of Health, Bethesda, Maryland. This report summarizes the discussion of the committee and its recommendations. The charge to the committee was to raise and address issues that will promote and sustain environmental health, safety, and energy efficiency within the biomedical community. Leaders from every important research sector (industry laboratories, academic health …
Iarc Monographs: 40 Years Of Evaluating Carcinogenic Hazards To Humans, Neil E. Pearce, Aaron Blair, Paolo Vineis, Wolfgang Ahrens, Aage Andersom, Josep M. Anto, Bruce K. Armstrong, Andrea A. Baccarelli, Frederick A. Beland, Amy Berrington, Pier Alberto Bertazzi, Linda S. Birnbaum, Ross C. Brownson, John R. Bucher, Kenneth P. Cantor, Elisabeth Cardis, John W. Cherrie, David C. Christiani, Pierluigi Cocco, David Coggon, Pietro Comba, Paul A. Demers, John M. Dement, Jeroen Douwes, Ellen A. Eisen, Lawrence S. Engel, Richard A. Fenske, Lora E. Fleming, Tony Fletcher, Elizabeth Fontham, Francesco Forastiere, Rainer Frentzel-Beyme, Lin Fritschi, Michel Gerin, Marcel Goldberg, Philippe Grandjean, Tom K. Grimsrud, Per Gustavsson, Andy Haines, Patricia Hartge, Johnni Hansen, Michael Hauptmann, Dick Heederik, Kari Hemminki, Denis Hemon, Irva Hertz-Picciotto, Jane A. Hoppin, James Huff, Bengt Jarvholm, Daehee Kang, Margaret R. Karagas
Iarc Monographs: 40 Years Of Evaluating Carcinogenic Hazards To Humans, Neil E. Pearce, Aaron Blair, Paolo Vineis, Wolfgang Ahrens, Aage Andersom, Josep M. Anto, Bruce K. Armstrong, Andrea A. Baccarelli, Frederick A. Beland, Amy Berrington, Pier Alberto Bertazzi, Linda S. Birnbaum, Ross C. Brownson, John R. Bucher, Kenneth P. Cantor, Elisabeth Cardis, John W. Cherrie, David C. Christiani, Pierluigi Cocco, David Coggon, Pietro Comba, Paul A. Demers, John M. Dement, Jeroen Douwes, Ellen A. Eisen, Lawrence S. Engel, Richard A. Fenske, Lora E. Fleming, Tony Fletcher, Elizabeth Fontham, Francesco Forastiere, Rainer Frentzel-Beyme, Lin Fritschi, Michel Gerin, Marcel Goldberg, Philippe Grandjean, Tom K. Grimsrud, Per Gustavsson, Andy Haines, Patricia Hartge, Johnni Hansen, Michael Hauptmann, Dick Heederik, Kari Hemminki, Denis Hemon, Irva Hertz-Picciotto, Jane A. Hoppin, James Huff, Bengt Jarvholm, Daehee Kang, Margaret R. Karagas
Dartmouth Scholarship
Background: Recently, the International Agency for Research on Cancer (IARC) Programme for the Evaluation of Carcinogenic Risks to Humans has been criticized for several of its evaluations, and also for the approach used to perform these evaluations. Some critics have claimed that failures of IARC Working Groups to recognize study weaknesses and biases of Working Group members have led to inappropriate classification of a number of agents as carcinogenic to humans.
Objectives: The authors of this Commentary are scientists from various disciplines relevant to the identification and hazard evaluation of human carcinogens. We examined criticisms of the IARC classification process …
Bios 7131 - Survival Analysis, Lili Yu
Bios 7131 - Survival Analysis, Lili Yu
Jiann-Ping Hsu College of Public Health Syllabi
This course introduces statistical methods for analyzing data collected on the time to an event, referred to as survival data, in medical research and other health-related fields. Emphasis will be placed on the application of the methodology and computational aspects rather than theory. The students will learn how to apply SAS procedures to data and interpret the results.
Bios 6136 - Topics Of Inference In Biostatistics Ii, Lili Yu
Bios 6136 - Topics Of Inference In Biostatistics Ii, Lili Yu
Jiann-Ping Hsu College of Public Health Syllabi
The course will introduce large sample theory, such as law of large numbers and the central limit theorem; sampling distributions of estimators; the basis for inferences derived from hypothesis testing and confidence intervals; and simulation methods. Emphasis will be placed on how these techniques are used in biostatistical problems and applications using examples from the pharmaceutical industry.
The Three Rs: The Way Forward, Michael Balls, Alan M. Goldberg, Julia H. Fentem, Caren L. Broadhead, Rex L. Burch, Michael F.W. Festing, John M. Frazier, Coenraad F.M. Hendriksen, Margaret Jennings, Margot D.O. Van Der Kamp, David B. Morton, Andrew N. Rowan, Claire Russell, William M.S. Russell, Horst Spielmann, Martin Stephens, William S. Stokes, Donald W. Straughan, James D. Yager, Joanne Zurlo, Bert F.M. Van Zutphen
The Three Rs: The Way Forward, Michael Balls, Alan M. Goldberg, Julia H. Fentem, Caren L. Broadhead, Rex L. Burch, Michael F.W. Festing, John M. Frazier, Coenraad F.M. Hendriksen, Margaret Jennings, Margot D.O. Van Der Kamp, David B. Morton, Andrew N. Rowan, Claire Russell, William M.S. Russell, Horst Spielmann, Martin Stephens, William S. Stokes, Donald W. Straughan, James D. Yager, Joanne Zurlo, Bert F.M. Van Zutphen
Andrew N. Rowan, DPhil
This is the report of the eleventh of a series of workshops organised by the European Centre for the Validation of Alternative Methods (ECVAM), which was established in 1991 by the European Commission. ECVAM's main goal, as defined in 1993 by its Scientific Advisory Committee, is to promote the scientific and regulatory acceptance of alternative methods which are of importance to the biosciences and which reduce, refine or replace the use of laboratory animals. One of the first priorities set by ECVAM was the implementation of procedures which would enable it to become well-informed about the state-of-the-art of non-animal test …
Financial Conflicts Of Interest In Science, Joanna K. Sax
Financial Conflicts Of Interest In Science, Joanna K. Sax
Joanna K Sax
This article proposes that an analysis of behavior may be utilized to create an effective policy addressing financial conflicts of interest. Importantly, this article focuses on the academics that conduct basic science. An understanding of the background of the public-private interaction is critical to fully appreciate the rise of the financial conflicts of interest in biomedical science. Part II of this Article describes the rise of financial conflicts of interest and the types of harms that can occur in the absence of effective policy to regulate financial conflicts of interest. Part III describes the current system addressing conflicts of interest, …
A Review Of The Institute Of Medicine’S Analysis Of Using Chimpanzees In Biomedical Research, Robert C. Jones, Ray Greek
A Review Of The Institute Of Medicine’S Analysis Of Using Chimpanzees In Biomedical Research, Robert C. Jones, Ray Greek
Biomedicine and Animal Models in Research Collection
We argue that the recommendations made by the Institute of Medicine’s 2011 report, Chimpanzees in Biomedical and Behavioral Research: Assessing the Necessity, are methodologically and ethically confused. We argue that a proper understanding of evolution and complexity theory in terms of the science and ethics of using chimpanzees in biomedical research would have had led the committee to recommend not merely limiting but eliminating the use of chimpanzees in biomedical research. Specifically, we argue that a proper understanding of the difference between the gross level of examination of species and examinations on finer levels can shed light on important methodological …
Current Trends In Undergraduate Medical And Dental Research: A Picture From Pakistan, Waqar Jeelani, Sanaa Masood Aslam, Asrar Elahi
Current Trends In Undergraduate Medical And Dental Research: A Picture From Pakistan, Waqar Jeelani, Sanaa Masood Aslam, Asrar Elahi
Department of Surgery
Abstract
BACKGROUND:
Initiatives taken over the last few years have led us to the day when most of the medical and dental institutions in the developed countries have established a strong research culture at undergraduate level but the situation is quite the contrary in Pakistan. This study was carried out to investigate the current trends in undergraduate medical and dental research and to highlight the research barriers.
METHODS:
A cross-sectional study was conducted at six medical and dental colleges of Rawalpindi and Islamabad. A structured questionnaire was used to collect data from 300 students. Results were recorded as percentages. Findings …
Why Patient-Centered?, Dennis J. Baumgardner
Why Patient-Centered?, Dennis J. Baumgardner
Journal of Patient-Centered Research and Reviews
No abstract provided.
A Community Of Practice: Librarians In A Biomedical Research Network, Danielle Dejager-Loftus, Barbara Harvey, David Midyette
A Community Of Practice: Librarians In A Biomedical Research Network, Danielle Dejager-Loftus, Barbara Harvey, David Midyette
Barbara C. Harvey
Providing library and reference services within a biomedical research community presents special challenges for librarians, especially those in historically lower-funded states. These challenges can include understanding needs, defining and communicating the library’s role, building relationships, and developing and maintaining general and subject specific knowledge. This article describes a biomedical research network and the work of health sciences librarians at the lead intensive research institution with librarians from primarily undergraduate institutions and tribal colleges. Applying the concept of a community of practice to a collaborative effort suggests how librarians can work together to provide effective reference services to researchers in biomedicine.
Are Changes To The Common Rule Necessary To Address Evolving Areas Of Research? A Case Study Focusing On The Human Microbiome Project, Diane Hoffmann, J. Fortenberry, Jacques Ravel
Are Changes To The Common Rule Necessary To Address Evolving Areas Of Research? A Case Study Focusing On The Human Microbiome Project, Diane Hoffmann, J. Fortenberry, Jacques Ravel
Diane Hoffmann
This article examines ways in which research conducted under the Human Microbiome Project, an effort to establish a “reference catalogue” of the micro-organisms present in the human body and determine how changes in those micro-organisms affect health and disease, raise challenging issues for regulation of human subject research. The article focuses on issues related to subject selection and recruitment, group stigma, and informational risks, and explores whether: (1) the Common Rule or proposed changes to the Rule adequately address these issues and (2) the Common Rule is the most appropriate vehicle to provide regulatory oversight and guidance on these topics.