Medicine and Health Sciences Commons^™

Presentations Of Cutaneous Disease In Various Skin Pigmentations: Chronic Atopic Dermatitis, Cecilia Nguyen, Jordan Thompson, Daniel A. Nguyen, Christopher M. Wong, Christian J. Scheufele, Michael Carletti, Stephen E. Weis

HCA Healthcare Journal of Medicine

Atopic dermatitis is a chronic inflammatory skin disorder classically affecting flexural areas of the body. It is present in children and adults, including those with darker skin pigmentation. Chronic lesions are hyperpigmented plaques that are dry, cracked, and/or scaly often with lichenification. Differential diagnoses include psoriasis, seborrheic dermatitis, ichthyosis, and pityriasis rosea. This article will showcase clinical images with varying presentations of chronic atopic dermatitis in a range of age groups and skin colors according to the Fitzpatrick scale.

Homoeopathic Treatment Of A Child With Internet Gaming Disorder And Atopic Dermatitis: A Case Report, Ashish Mahajan, Nidhi Mahajan, Anuradha Singh, Mohan Lal Chopra

Indian Journal of Research in Homoeopathy

Introduction: Internet gaming disorder (IGD) is an emerging disorder, recently added to DSM-5, which has a capacity to reach pandemic proportions in the near future. The Indian mobile gaming market has grown significantly over the past few years with many users spending a significant amount of time on mobile games. A patient initially presenting with atopic dermatitis (AD) was subsequently diagnosed with IGD based on the analysis of his mental symptoms and was managed holistically with homoeopathy. Case Summary: A 3-year-old boy primarily presented with AD. During the interrogation of his mental state, he was found to have …

Dupilumab-Induced Pityriasis Rosea In A 28-Year-Old Male With Atopic Dermatitis., Faraz Yousefian, Margaret Hurley, Liaqat Ali, Marcus Goodman, Katherine Rupley

PCOM Scholarly Papers

No abstract provided.

Evaluation Of Accompanying Allergic Disease In Children With Proven Drug Allergies, Şule Büyük Yaytokgi̇l, Kezban İpek Demi̇r, Özge Yılmaz Topal, Azize Pınar Metbulut, İlknur Külhaş Çeli̇k, Müge Toyran, Ersoy Ci̇velek, Emine Di̇bek Misirlioğlu

Turkish Journal of Medical Sciences

Data on the prevalence of allergic diseases in children with proven drug allergies are limited. We aim to evaluate thefrequency of allergic comorbidity in children with proven common drug allergies.Materials and methods: Children with drug hypersensitivity confirmed by diagnostic allergy tests at our center between January 2010and December 2020 were screened retrospectively. Patients with the most common drug allergies (due to antibiotics, nonsteroidalantiinflammatory drugs [NSAIDs], and antiepileptic drugs) were selected for analysis. Age, sex, the culprit drug, initial reactioncharacteristics, diagnostic test results, and the study physician who diagnosed concomitant allergic diseases were noted.Results: A total of 168 patients (boys, 51.2%) …

Minipuberty Period Of Children With Atopic Dermatitis Compared To Healthy Children, Serkan Bilge Koca, Hatice Eke Güngör, Murat Cansever

Turkish Journal of Medical Sciences

Atopic dermatitis (AD) is an inflammatory, pruritic, noncontagious, chronic relapsing skin disease. Skin barrierabnormalities, excessive T helper 2 activity, and immune dysregulation are held responsible. Androgens have a negative effect on theintegrity of the epidermal skin barrier, while estrogen has a positive effect. We aimed to investigate whether hormones make a differencebetween healthy children and children with AD during minipuberty.Materials and methods: A total of 96 infants (postnatal 4–13 weeks), 48 diagnosed with AD and 48 controls, were included. Each groupconsisted of 23 girls (47.9%) and 25 boys (52.1%). Anthropometric examinations and hormone measurements were compared.Results: The two groups, having …

Introduction Of Probiotics To Improve Eczema Symptoms In Children In One Pediatric Primary Care Practice: A Quality Improvement Project, Christie Potter

Doctor of Nursing Practice Scholarly Projects

Background: There is emerging interest in alternative approaches to treating children with eczema because there is currently no allopathic cure. Non-pharmacological approaches are regarded as generally safe, well tolerated, and cost effective. Eczema is a chronic, relapsing inflammatory, itchy skin condition that adversely affects quality of life in many individuals, including children. Eczema interferes with sleep, leads to secondary skin infections, and causes intractable itching. Topical steroids are the current standard of practice in treating patients but, evidence suggests that they can cause unwanted side effects and can lead to serious systemic reactions. The purpose of this quality improvement project …

International Consensus Statement On Allergy And Rhinology: Allergic Rhinitis – 2023, Sarah K. Wise, Cecelia C. Damask, Lauren T. Roland, Charles Ebert, Joshua M. Levy, Sandra Lin, Amber Luong, Kenneth Rodriguez, Ahmad R. Sedaghat, Helene J. Krouse

School of Medicine Publications and Presentations

Background

In the 5 years that have passed since the publication of the 2018 International Consensus Statement on Allergy and Rhinology: Allergic Rhinitis (ICAR-Allergic Rhinitis 2018), the literature has expanded substantially. The ICAR-Allergic Rhinitis 2023 update presents 144 individual topics on allergic rhinitis (AR), expanded by over 40 topics from the 2018 document. Originally presented topics from 2018 have also been reviewed and updated. The executive summary highlights key evidence-based findings and recommendation from the full document.

Methods

ICAR-Allergic Rhinitis 2023 employed established evidence-based review with recommendation (EBRR) methodology to individually evaluate each topic. Stepwise iterative peer review and consensus …

International Consensus Statement On Allergy And Rhinology: Allergic Rhinitis – 2023, Sarah K. Wise, Cecelia C. Damask, Lauren T. Roland, Charles Ebert, Joshua M. Levy, Sandra Lin, Amber Luong, Kenneth Rodriguez, Ahmad R. Sedaghat, Helene J. Krouse

School of Medicine Publications and Presentations

Background

In the 5 years that have passed since the publication of the 2018 International Consensus Statement on Allergy and Rhinology: Allergic Rhinitis (ICAR-Allergic Rhinitis 2018), the literature has expanded substantially. The ICAR-Allergic Rhinitis 2023 update presents 144 individual topics on allergic rhinitis (AR), expanded by over 40 topics from the 2018 document. Originally presented topics from 2018 have also been reviewed and updated. The executive summary highlights key evidence-based findings and recommendation from the full document.

Methods

ICAR-Allergic Rhinitis 2023 employed established evidence-based review with recommendation (EBRR) methodology to individually evaluate each topic. Stepwise iterative peer review and consensus …

Eczema Monkeypoxicum In A Female Patient With Atopic Dermatitis, Emma Napoli, Madeline Frizzell, Clark Gravell, Sergio Vallejo, Shasta Theodore, Karen Chen, Huma Siddiqui, Justin Dunn, Dora Marrufo, Jose Cadena, Patrick J Danaher

Journal Articles

A female patient with atopic dermatitis who had recently received a tattoo presented with severe right ear pain and several vesiculopustular lesions. Over 1 week, she developed approximately 80 widely distributed lesions. Laboratory testing confirmed mpox (previously monkeypox) virus, and no further lesions developed after initiation of oral tecovirimat.

Forum Discussion Indicates Favorable Views Of Jak Inhibitors For Atopic Dermatitis, Nicole Levin, Karan Rajalingam, Ashley Wentworth, Leila Tolaymat

East Florida Research Day 2023

Background: There is increasing discussion online concerning the management of atopic dermatitis (AD). Patients often document their subjective experience of a given treatment. It remains to be determined if the experiences vary based on treatment or align with efficacy.

Objective: To determine which treatments are associated with positive or negative experiences.

Methods: The largest online AD platform was searched for posts that only discussed a singular treatment. The discovered 28,159 posts were rated “positive” or “negative” by DistilBERT, a pre-trained sentiment analysis model that derives from BookCorpus, a collection of 11,038 books containing 74 million sentences. Positive sentiment proportions (PSP), …

Evaluation Of The Serum Squamous-Cell Carcinoma Antigen 2 In Patients With Atopic Dermatitis And Its Relation To Disease Severity, Gehad G. Ibrahim, Hesham N. Khalid, Yasser A. Elghobashy

Menoufia Medical Journal

Objective To study serum squamous-cell carcinoma antigen 2 (SCCA2) in atopic dermatitis (AD) patients compared with controls and question its possible relation to disease severity. Background AD is a very common chronic inflammatory skin disease characterized by intense itching, skin dryness among other features with characteristic exacerbations and remissions with unfavorable response to treatment in many cases. Methods In total, 60 patients were enrolled in this study and divided into two groups: group A: 30 AD patients, group B: 30 healthy controls. AD patients were diagnosed with AD by a dermatologist. Diagnosis of AD was based on the criteria of …

Emollients To Prevent Eczema In High-Risk Infants: An Integrative Review, Julie Armstrong, Nicole K. Rosinski, Alissa V. Fial, Selorm Ansah, Kristin Haglund

Library Faculty Research and Publications

The purpose of this integrative review was to assess the research on topical emollients to prevent atopic dermatitis (AD) also known as eczema, in infants at high risk for this condition. Atopic dermatitis is a common chronic inflammatory skin disorder. Skin barrier dysfunction plays a prominent role in its development. Topical emollients have been hypothesized to enhance the skin barrier and prevent AD.

Methods:

Searches were conducted in September 2021 in PubMed, CINAHL, Cochrane Library, and Web of Science using key word search terms dermatitis, atopic, emollients, petrolatum, and infant, newborn. Inclusion criteria were articles written in English …

Alleviation Of Atopic Dermatitis Symptoms By Implementation Of Standard And Alternative Treatments, Nika Sayvongsa

The Eleanor Mann School of Nursing Undergraduate Honors Theses

Atopic Dermatitis (AD) is a chronic dermatological disease caused by a combination of hereditary and environmental factors. This is a common condition that is primarily diagnosed among children, but can persist throughout adulthood. Twenty peer-reviewed articles are analyzed in this expanded literature review. Various methods were implemented throughout these studies, including randomized, double-blind, placebo-controlled, and single-blind studies; all of the studies shared the objective of evaluating AD alleviation with the use of either standard treatment modalities or alternative/ complementary therapies.

A Clinical And Biochemical Study For Periostin In Atopic Dermatitis, Eman A. E. Badr, Hasnaa Mohamed Nasef, Hesham Nabil Khaled, Wafaa Ahmed Shehata

Menoufia Medical Journal

Objective This work was designed to study the role of periostin in children with atopic dermatitis (AD) and to correlate its level with the severity and chronicity of AD. Background Periostin is a recent mediator in chronic states of allergic diseases and has significant roles in tissue remodeling in allergic inflammation. It has a unique function as an intrinsic mediator in amplifying and preserving allergic skin inflammation and might be a virtual molecule in the development and occurrence of chronicity. Patients and methods The current work examined 40 children with AD and 40 age- and sex-matched healthy controls. Patients underwent …

Impact Of Social Determinants On The Burden Of Asthma And Eczema: Results From A Us Patient Survey., Don A. Bukstein, Adam Friedman, Erika Gonzalez Reyes, Mary Hart, Bridgette Jones, Tonya Winders

Manuscripts, Articles, Book Chapters and Other Papers

INTRODUCTION: Little is known about how patients with asthma and eczema perceive their medical care and burden of disease. A survey was conducted to evaluate the perceptions among the general patient population with asthma and/or eczema regarding disease and treatment burden and barriers to adequate care.

METHODS: An online survey was completed by market research panelists in the USA between March 24, 2020 and April 6, 2020. Eligible participants were at least 18 years of age and endorsed a diagnosis of asthma and/or eczema. Survey responses are described for all participants, by designated racial/ethnic groups, and by income level.

RESULTS: …

Early-Life Farm Exposures And Eczema Among Adults In The Agricultural Lung Health Study, Annah B. Wyss, Thanh T. Hoang, Hilde K. Vindenes, Julie D. White, Sinjini Sikdar, Marie Richards, Laura E. Beane-Freeman, Christine G. Parks, Mikyeong Lee, David M. Umbach, Stephanie J. London

Mathematics & Statistics Faculty Publications

Background

Several studies conducted in Europe have suggested a protective association between early-life farming exposure and childhood eczema or atopic dermatitis; however, few studies have examined associations in adults.

Objectives

We investigated associations between early-life exposures and eczema among 3217 adult farmers and farm spouses (mean age, 62.8 years) in a case–control study nested within an US agricultural cohort.

Methods

We used sampling-weighted logistic regression to estimate odds ratios and 95% confidence intervals for associations between early-life exposures and self-reported doctor-diagnosed eczema (273 cases) and polytomous logistic regression to estimate odds ratios (95% confidence intervals) for a 4-level outcome combining …

Activation-Induced Cell Death Of Nk Cells In Canine Atopic Dermatitis Revealed By Droplet-Sequencing Data Of Peripheral Blood Mononuclear Cells, Natthaporn Kuendee, Denis Puthier, Catherine Nguyen, Kaj Chokeshaiusaha

The Thai Journal of Veterinary Medicine

Atopic dermatitis (AD) is a mutual allergic skin disease between humans and dogs manifesting varieties of similarities in their immune responses to the disease. Recently, activation-induced cell death (AICD) of NK cells was acknowledged as a novel disrupted immunoregulation in human AD. To gain insight into its plausible commotion in canine AD, NK cell expression profiles extracted from PBMC Drop-Sequencing (Drop-Seq) data of normal and AD dogs were analyzed along with human NK cell profiles of healthy and AD patients previously reported. According to the results, a total of 2,689 differentially expressed genes (DEG) between healthy and AD conditions (P≤0.0001) …

Effects Of Phototherapy In Patients With Atopic Dermatitis, Stephanie Krogen

Physician Assistant Scholarly Project Papers

Atopic dermatitis (AD) is a chronic remitting problem faced by many people in our communities of all ages. Atopic dermatitis presents as an erythematous and pruritic rash. There is no cure, only treatments that help alleviate symptoms. The purpose of this literature review is to help determine the best course of action for treatment for patients who suffer from AD. Phototherapy has been growing in popularity and research as an alternate treatment to systemic and pharmacologic therapies. This review was done using PubMed, Clinical Key, DynaMed, and Cochrane. Studies were included that reviewed the side effects and efficacy of each …

Association Between Serum Immunoglobulin E And Soluble E-Selectin, And Atopic Dermatitis, Naglaa M. Ghanayem, Shaimaa S.B. Sherief, Shawky M. El-Farrargy

Menoufia Medical Journal

Objective To study and evaluate the role of both serum immunoglobulin E (IgE) and soluble E-selectin in patients with atopic dermatitis (AD). Background AD is a chronic inflammatory skin disease that is characterized by intense itching and recurrent eczematous lesions. Although it most often starts in infancy. It is also highly prevalent in adults. Assessment of maintenance of AD could be related to serum IgE and soluble E-selectin. Treatment of AD remains a challenge. Patients and methods This case–control study was performed for 40 patients who were age-matched and sex-matched with 20 healthy control cases. The patient group was subdivided …

What Plays A Role In The Severity Of Atopic Dermatitis In Children?, Murat Cansever, Çi̇ğdem Oruç

Turkish Journal of Medical Sciences

Background/aim: Determining the characteristics and risk factors of severe disease is extremely important to combat atopic dermatitis (AD), which has recently shown increasing prevalence. In this study, we aimed to investigate the clinical characteristics of pediatric patients with AD and identifying the factors associated with the severity of the disease. Materials and methods: A total of 304 pediatric patients diagnosed with atopic dermatitis were included in the study. The patients' age at admission, age at onset of symptoms, the presence of atopy history in their family, eosinophil levels obtained from blood counts were recorded, together with the data of cigarette …

Effects Of Phototherapy In Patients With Atopic Dermatitis, Stephanie Krogen

Physician Assistant Scholarly Project Posters

Atopic dermatitis is a chronic remitting problem faced by many people in our communities of all ages. Atopic dermatitis (AD) presents as an erythematous and pruritic rash. There is no cure, only treatments that help alleviate symptoms. The purpose of this literature review is to help determine the best course of action for treatment for patients who suffer from AD. Phototherapy has been growing in popularity and research as an alternate treatment to systemic and pharmacologic therapies. This review was done using PubMed, Clinical Key, DynaMed, and Cochrane. Studies were included that reviewed the side effects and efficacy of each …

The Influence Of Sunlight Exposure And Sun Protecting Behaviours On Allergic Outcomes In Early Childhood, Kristina Rueter, Anderson P. Jones, Aris Siafarikas, Paola Chivers, Susan L. Prescott, Debra J. Palmer

Research outputs 2014 to 2021

The dramatic rise in allergic disease has occurred in tandem with recent environmental changes and increasing indoor lifestyle culture. While multifactorial, one consistent allergy risk factor has been reduced sunlight exposure. However, vitamin D supplementation studies have been disappointing in preventing allergy, raising possible independent effects of ultraviolet (UV) light exposure. The aim of this study was to examine whether UV light exposure influences the development of allergic disease in early childhood. Direct sunlight exposure (290–380 nm) in early infancy was measured via UV dosimeters. Outdoor exposure, sun protective behaviours, and allergy outcomes were assessed over the first 2.5 years …

Cyclosporine Shows Benefit As Compared To Methotrexate For Treatment Of Pediatric Atopic Dermatitis Refractory To Topical Medications When Rapidity Of Clinical Response Is Of Key Importance To The Patient, Connor R. Buechler, Steven Daveluy Md

Clinical Research in Practice: The Journal of Team Hippocrates

A clinical decision report appraising El-Khalawany MA, Hassan H, Shaaban D, Ghonaim N, Eassa B. Methotrexate versus cyclosporine in the treatment of severe atopic dermatitis in children: a multicenter experience from Egypt. European Journal of Pediatrics. 2012;172(3):351-356. https://doi.org10.1007/s00431-012-1893-3 for a pediatric patient with severe atopic dermatitis.

Tissue Expression Of Endothelial Selectin In Patients With Atopic Dermatitis, Azza G. A. Farag, Dalia R. A. Sharaky, Eman N. El-Shafey, Sawsan S. Allam

Menoufia Medical Journal

Objective To investigate the role of endothelial selectin (E-selectin) in atopic dermatitis (AD) through evaluation of the immunohistochemical expressions in lesional skin biopsies. Background AD is a chronic, pruritic inflammatory skin disease that occurs most frequently in children. In AD, the inflammatory cascade is initiated by the release of proinflammatory cytokines from atopic keratinocytes. Patients and methods A total of 50 patients with AD and 10 healthy control participants were included in this case–control study. From all participants, skin biopsies were taken, and immunohistochemical staining by E-selectin monoclonal antibodies was done. Results There were significant elevations in E-selectin cellular localization …

Mucocutaneous Findings In Down Syndrome, Menan S. A.. Alghobashy, Mohamed A. Gaber

Menoufia Medical Journal

Objective To study and evaluate the dermatological signs found in patients with Down syndrome (DS). Background The dermatological signs found in patients with DS have been less clear and infrequently studied and must be completely elucidated. Patients and methods This cross-sectional study included 50 patients with DS confirmed clinically. The sample comprised 28 boys and 22 girls. Their ages ranged between 1 and 40 years. We separated the sample into five age groups: 0–5 years, 14 patients; 6–10 years, 22 patients; 11–15 years, eight patients; and older than 16 years, 6 patients. Results Seborrheic dermatitis was the most frequent sign …

The Role Of Allergy Testing In Eczematic Patients: A Benchmark Study, Ashley E. Cox

MSN Capstone Projects

Eczema or atopic dermatitis (AD) is the first visible sign that indicates a much bigger and more complex problem within the body. The first presentation of symptoms is typically in individuals less than six months of age. Concerned parents bring their child to the pediatrician where a course of topical corticosteroids is prescribed, according to current AD treatment guidelines (Weston, & Howe, 2019). Long term use of corticosteroids has proven to be detrimental to the patient’s health, especially pediatric patients, in many ways such as gynecomastia, hypertrichosis, staphylococcal infections, skin atrophy, and worsening of skin diseases, just to name a …

The Assessment Of Skin Sebum And Moisture Content Of Infants With Atopic Dermatitis, Hati̇ce Güneş, Hülya Nazi̇k, Mehmet Yaşar Özkars, Nurgül Parlak, Ayten Yildiz, Ömer Duyuran, Bahaüddi̇n Ahmed Yalçin

Turkish Journal of Medical Sciences

Background/aim: Atopic dermatitis (AD) is a chronic, inflammatory skin disorder characterized by dry skin, pruritus and eczematous lesions. The aim of this study is to evaluate the skin moisture and sebum content of the infants with AD and its relationship between the disease severity. Materials and methods: For this cross-sectional and case-control study we included 49 infants with AD aged between 2 and 24 months and 34 healthy infants with the same age and sex as a control group. Skin moisture and sebum content were measured by the bio- impedance method and recorded. Skin prick tests, total IgE levels and …

Rare Occurrence Of Common Filaggrin Mutations In Turkish Children With Food Allergyand Atopic Dermatitis, Neşe Vardar Acar, Özlem Cavkaytar, Ebru Arik Yilmaz, Ayşe Betül Büyükti̇ryaki̇, Özge Uysal Soyer, Ümi̇t Murat Şahi̇ner, Bülent Eni̇s Şekerel, İbrahi̇m Çağatay Karaaslan, Cansin Saçkesen

Turkish Journal of Medical Sciences

Background/aim: Filaggrin is a protein complex involved in epidermal differentiation and skin barrier formation. Mutations of the filaggrin gene (FLG) are associated with allergen sensitization and allergic diseases like atopic dermatitis (AD), allergic rhinitis, food allergy (FA), and asthma. The aim of the study is to reveal the frequency of change in the FLG gene and determine the association between FLG loss-of-function (LOF) mutations and FA and/or AD in Turkish children. Materials and methods: Four FLG loss-of-function (LOF) mutations known to be common in European populations were analyzed in 128 healthy children, 405 food-allergic children with or without atopic dermatitis, …

Association Between Obesity And History Of Atopy With Atopic Dermatitis In Children: A Cross-Sectional Study, Putu Nila Wardhani Batan, Ariana Ariana, Made Wardhana

Journal of General - Procedural Dermatology & Venereology Indonesia

Background: The prevalence of atopic dermatitis (AD) has rapidly increased in the past 4 decades and has been mostly observed in children. The prevalence of obesity has also significantly increased worldwide, suggesting that the two conditions may be associated.

Methods: This retrospective analytic study involved a cross-sectional design and used secondary data taken from the medical record of patients who visited the Pediatric Dermatology Subdivision at Dermatology and Venereology Polyclinic Sanglah General Hospital from January 2015 to December 2015. Thirty-two samples were selected.

Results: The prevalence ratio of obesity among subjects with AD was 2.178 (95% CI …

Anterior Subcapsular Cataract Secondary To Black Mold Exposure, Katherine B. Lynch Od, Bruce A. Teitelbaum Od

Optometric Clinical Practice

A case report of a 31-year-old woman who developed anterior subacapsular cataracts, and associated dermatological signs, after exposure to black mold. While atopic illness is commonly seen in childhood, a growing body of literature supports adult onset atopic dermatitis. Anterior subcapsular cataracts are pathognomonic for atopic illness, and can support a definitive and expedited dermatologic diagnosis of adult onset disease.