Medicine and Health Sciences Commons^™

Inhibition Of Myeloid Dendritic Cell Accessory Cell Function And Induction Of T Cell Anergy By Alcohol Correlates With Decreased Il-12 Production, Pranoti Mandrekar, Donna Catalano, Angela Dolganiuc, Karen Kodys, Gyongyi Szabo

Gyongyi Szabo

Alcohol consumption inhibits accessory cell function and Ag-specific T cell responses. Myeloid dendritic cells (DCs) coordinate innate immune responses and T cell activation. In this report, we found that in vivo moderate alcohol intake (0.8 g/kg of body weight) in normal volunteers inhibited DC allostimulatory capacity. Furthermore, in vitro alcohol treatment during DC differentiation significantly reduced allostimulatory activity in a MLR using naive CD4(+) T cells, and inhibited tetanus toxoid Ag presentation by DCs. Alcohol-treated DCs showed reduced IL-12, increased IL-10 production, and a decrease in expression of the costimulatory molecules CD80 and CD86. Addition of exogenous IL-12 and IL-2, …

Case Study In Academic And Industry Collaboration: The Development Of An Adolescent Targeted Sun Protection Intervention In Nsw, Melinda Williams, Sandra Jones, Donald Iverson, Peter Caputi, Sofia Potente

Faculty of Health and Behavioural Sciences - Papers (Archive)

Academic and industry collaboration is increasingly identified as a critical element in the future health of Australians through linking theory and practice, with the major priority for academic institutions being the identification of new knowledge and the transfer of this knowledge into changes in policy and health services. Collaborations between academia and industry are increasingly encouraged in Australia by research funding schemes such as ARCLinkage and, more recently, NHMRC Partnerships. While a recent US study suggests that such schemes have a moderate effect on academics’ propensity to work with industry (Bozeman and Gaughan, 2007), industry groups have recognised the value …

Low-Cost Hiv-1 Diagnosis And Quantification In Dried Blood Spots By Real Time Pcr, Nishaki Mehta, Sonia Trzmielina, Bareng Nonyane, Melissa Eliot, Rongheng Lin, Andrea Foulkes, Kristina Mcneal, Arthur Ammann, Vindu Eulalievyolo, John Sullivan, Katherine Luzuriaga, Mohan Somasundaran

Rongheng Lin

BACKGROUND: Rapid and cost-effective methods for HIV-1 diagnosis and viral load monitoring would greatly enhance the clinical management of HIV-1 infected adults and children in limited-resource settings. Recent recommendations to treat perinatally infected infants within the first year of life are feasible only if early diagnosis is routinely available. Dried blood spots (DBS) on filter paper are an easy and convenient way to collect and transport blood samples. A rapid and cost effective method to diagnose and quantify HIV-1 from DBS is urgently needed to facilitate early diagnosis of HIV-1 infection and monitoring of antiretroviral therapy.

METHODS AND FINDINGS: We …

Intra-Individual Variation In Children's Physical Activity Patterns: Implications For Measurement, Kate Ridley, Tim Olds, Beth P. Hands, Dawne Larkin, Helen Parker

Health Sciences Papers and Journal Articles

Children's physical activity (PA) patterns change form day to day. This intra-individual variability affects precision when measuring key physical activity and sedentary behavior variables. This paper discusses strategies to reduce the random error associated with intra-individual variability and demonstrates the implications for assessing PA when varying number of days are sampled. Self-reported data collected on two hundred and ninety eight 13- to 14-year-olds were used to compare estimates of PA and sedentary behaviour derived from between 1 and 7 days of recall data. Large intra-individual coefficients of variation were calculated for physical activity level (14.5%), moderate-to-vigorous physical activity (83.4%), screen …

Confirming The Existence And Size Of Behavioural Segments In The Adolescent Sun Protection Project: Results Of A Nsw Schools Survey, Lance R. Barrie, Sandra C. Jones, Melissa Lynch, Kay Coppa

Faculty of Health and Behavioural Sciences - Papers (Archive)

Sun protection behaviours among Australian adolescents are consistently low. While otherpopulation groups (notably younger children and adults) have responded to social marketingcampaigns and educational interventions, efforts to encourage adolescents to engage in sunprotection have been largely ineffective. This paper reports on the extension of previousqualitative work which identified different behavioural segments within the 14-16 year oldage-group. The present study consisted of a survey of over 2,300 adolescents to confirm theexistence and size of these segments.Keywords: market orientation, loyalty, social, behaviour

Can Social Cognitive Theory Constructs Explain Socio-Economic Variations In Adolescent Eating Behaviours? A Mediation Analysis, Kylie Ball, D Crawford, Francis A. Worsley, Gayle Savige, N Andrianopoulos, A. Macfarlane

Faculty of Health and Behavioural Sciences - Papers (Archive)

Adolescents of low socio-economic position (SEP) are less likely than those of higher SEP to consume diets in line with current dietary recommendations. The reasons for these SEP variations remain poorly understood. We investigated the mechanisms underlying socioeconomic variations in adolescents eating behaviours using a theoretically derived explanatory model. Data were obtained from a community- based sample of 2529 adolescents aged 12 to15 years, from 37 secondary schools in Victoria, Australia. Adolescents completed a webbased survey assessing their eating behaviours, self-efficacy for healthy eating, perceived importance of nutrition and health, social modelling and support and the availability of foods in …

Borderline Personality Disorder: An Overview Of History, Diagnosis And Treatment In Adolescents, Linah Al-Alem, Hatim A. Omar

Pharmacology and Nutritional Sciences Faculty Publications

Borderline personality disorder (BPD) is a cluster B personality disorder. It is characterized by erratic behaviors, emotional instability and one of its hallmarks is self injurious behavior, which starts in adolescence. Patients with BPD are difficult to treat, most have a history of child sexual abuse, about a quarter present with sexual abuse from a caretaker. Although personality disorders are diagnosed only in adults, BPD manifests itself in adolescence in the form of uncontrollable anger, self mutilations, dissociation and other such behaviors. Hence, there is a growing number of scientists discussing the possibility of diagnosing BPD in adolescents. Here, we …

Fitness, Motor Competence And Body Composition As Correlates Of Adolescent Neck/Shoulder Pain: An Exploratory Cross-Sectional Study, Mark Perry, Leon Straker, Peter O'Sullivan, Anne Smith, Beth P. Hands

Health Sciences Papers and Journal Articles

Background: Adolescent neck/shoulder pain (NSP) is a common and sometimes debilitating problem. Several risk factors for this condition have been investigated, but no studies have previously evaluated associations between fitness, motor competence, body composition and adolescent NSP.

Methods: 1608 males and females of mean age 14 years answered questions on their history of NSP (4 measures), and were tested for aerobic fitness, upper and lower limb power, trunk endurance, grip strength, shoulder flexibility, motor competence and anthropometric factors. Univariate and multivariate logistic regressions were used to test for associations between NSP and physical variables.

Results: There were significant gender differences …

Are Pre-Adolescent Girls' Magazines Providing Age-Appropriate Role Models?, Belinda S. Fabrianesi, Sandra C. Jones, Amanda Reid

Faculty of Health and Behavioural Sciences - Papers (Archive)

Purpose – Repeated exposure to unrealistic notions of female beauty and body shapes, and limited gender stereotypes, may result in the internalization of those standards by pre-adolescent girls. The purpose of this content analysis is to examine the celebrity role models to whom young girls are exposed via magazines specifically targeted at the “tween” audience. Female celebrities are contrasted with those in magazines targeted at older adolescent girls. Design/methodology/approach – Two pre-adolescent girls’ magazines, Total Girl and Barbie, and two adolescent girls’ magazines, Dolly and Girlfriend, were analyzed for the first six months of 2005. All photos (including advertising images) …

Differential Neuromuscular Training Effects On Acl Injury Risk Factors In"High-Risk" Versus "Low-Risk" Athletes, Gregory D. Myer, Kevin R. Ford, Jensen L. Brent, Timothy E. Hewett

Kinesiology and Health Promotion Faculty Publications

BACKGROUND: Neuromuscular training may reduce risk factors that contribute to ACL injury incidence in female athletes. Multi-component, ACL injury prevention training programs can be time and labor intensive, which may ultimately limit training program utilization or compliance. The purpose of this study was to determine the effect of neuromuscular training on those classified as "high-risk" compared to those classified as "low-risk." The hypothesis was that high-risk athletes would decrease knee abduction moments while low-risk and control athletes would not show measurable changes.

METHODS: Eighteen high school female athletes participated in neuromuscular training 3x/week over a 7-week period. Knee kinematics and …

Dissociation Of Automatic And Strategic Lexical-Semantics: Functional Magnetic Resonance Imaging Evidence For Differing Roles Of Multiple Frontotemporal Regions, Brian T. Gold, David A. Balota, Sara J. Jones, David K. Powell, Charles D. Smith, Anders H. Andersen

Neuroscience Faculty Publications

Behavioral research has demonstrated three major components of the lexical-semantic processing system: automatic activation of semantic representations, strategic retrieval of semantic representations, and inhibition of competitors. However, these component processes are inherently conflated in explicit lexical-semantic decision tasks typically used in functional magnetic resonance imaging (fMRI) research. Here, we combine the logic of behavioral priming studies and the neurophysiological phenomenon of fMRI priming to dissociate the neural bases of automatic and strategic lexical-semantic processes across a series of three studies. A single lexical decision task was used in all studies, with stimulus onset asynchrony or linguistic relationship between prime and …