Medicine and Health Sciences Commons^™

Feasibility Of Electronic Medication Monitoring Among Adolescents And Emerging Adults With Sickle Cell Disease, Aimee Hildenbrand, Katherine Kidwell, Meghan Mcgrady, Constance Mara, Charles Quinn, Lori Crosby

Department of Pediatrics Faculty Papers

Purpose: To examine the feasibility of using MEMS® bottles to assess adherence among adolescents and emerging adults with sickle cell disease.

Patients and Methods: Eighteen non-Hispanic Black participants with HbSS (M = 17.8 years; 61% male) were given a MEMS® bottle to store hydroxyurea (n = 14) or deferasirox (n = 4).

Results: One hundred percent initiated MEMS® use and 61% sustained use through the 18-week study; at follow-up, only 11% returned their bottle on time. Barriers to MEMS® use included medication changes and transition to adult care; facilitators included tip sheets and reminders.

Conclusion: While MEMS® is acceptable to …

The Population-Centered Medical Model: A Theory Of Practice For Public Health And Preventive Medicine, Sudit Ranade

Electronic Thesis and Dissertation Repository

Introduction

Public health physicians occupy a unique place in the fields of both medicine and public health. Trained in each field, and often holding positions of authority in public health systems, public health physicians are sometimes challenged to identify their roles in either field of practice. Public health physicians work to achieve population health, but there has been limited theoretical development in this field of practice.

Objectives

The objective of this research was to develop an empirical theory of practice for public health physicians.

Methods

A literature review of current practice models applicable to public health physicians was performed. A …

Kounis Syndrome – Anaphylaxis-Induced Acute Coronary Syndrome, Austin T. Thacker Do, Brachman Herzig Oms, Brendan Robinson Do, Ahad Anjum Do

Advances in Clinical Medical Research and Healthcare Delivery

Kounis syndrome is an underdiagnosed condition in which anaphylaxis triggers vasospastic acute coronary syndrome, either with or without underlying coronary artery disease. The prevalence of this syndrome among hospitalized patients for allergic/hypersensitivity/anaphylactic reactions in the United States is 1.1%, with a 7% rate of all-cause inpatient mortality. This article presents an anaphylaxis-induced acute coronary syndrome case in a patient with underlying coronary artery disease. The pathophysiological mechanism of anaphylactic-induced acute coronary syndrome involves the inflammatory mediators of type I hypersensitivity reactions.

An Exploration Of Complementary And Alternative Medicine Usage Within The Vietnamese Community In Lincoln, Nebraska, Helen Duong

Honors Theses

Lincoln, Nebraska is home to over 5,000 Vietnamese refugees and immigrants, many of whom practice complementary and alternative medicine (CAM) as a result of healing traditions passed down through family members. This thesis explores the use of CAM among the Vietnamese population of Lincoln. The study employs an analysis of the literature on CAM among Vietnamese populations and thematic analysis of interviews conducted with members of the Vietnamese community of Lincoln, NE. Interviews explore perceptions of healthcare quality and access within this community as well as investigate the link between CAM and allopathic (Western) medicine. Findings suggest that certain CAM …

Statistical Modeling Of Extracellular Vesicle Cargo To Predict Clinical Trial Outcomes For Hypoplastic Left Heart Syndrome, Jessica R Hoffman, Hyun-Ji Park, Sruti Bheri, Manu O Platt, Joshua M Hare, Sunjay Kaushal, Judith L Bettencourt, Dejian Lai, Timothy C Slesnick, William T Mahle, Michael E Davis

Journal Articles

Cardiac-derived c-kit+ progenitor cells (CPCs) are under investigation in the CHILD phase I clinical trial (NCT03406884) for the treatment of hypoplastic left heart syndrome (HLHS). The therapeutic efficacy of CPCs can be attributed to the release of extracellular vesicles (EVs). to understand sources of cell therapy variability we took a machine learning approach: combining bulk CPC-derived EV (CPC-EV) RNA sequencing and cardiac-relevant

Committing To Genomic Answers For All Kids: Evaluating Inequity In Genomic Research Enrollment., Natalie J. Kane, Ana S A Cohen, Courtney D. Berrios, Bridgette Jones, T Pastinen, Mark A. Hoffman

Manuscripts, Articles, Book Chapters and Other Papers

PURPOSE: Persistent inequities in genomic medicine and research contribute to health disparities. This analysis uses a context-specific and equity-focused strategy to evaluate enrollment patterns for Genomic Answers for Kids (GA4K), a large, metropolitan-wide genomic study on children.

METHODS: Electronic health records for 2247 GA4K study participants were used to evaluate the distribution of individuals by demographics (race, ethnicity, and payor type) and location (residential address). Addresses were geocoded to produce point density and 3-digit zip code maps showing local and regional enrollment patterns. Health system reports and census data were used to compare participant characteristics with reference populations at different …

Quercetin As An Anticancer Candidate For Glioblastoma Multiforme By Targeting Akt1, Mmp9, Abcb1, And Vegfa: An In Silico Study, Muhammad Hermawan Widyananda, Setyaki Kevin Pratama, Arif Nur Muhammad Ansori, Yulanda Antonius, Viol Dhea Kharisma, Ahmad Affan Ali Murtadlo, Vikash Jakhmola, Maksim Rebezov, Mars Khayrullin, Marina Derkho, Emdad Ullah, Raden Joko Kuncoroningrat Susilo, Suhailah Hayaza, Alexander Patera Nugraha, Annise Proboningrat, Amaq Fadholly, Mada Triandala Sibero, Rahadian Zainul

Karbala International Journal of Modern Science

Quercetin, a natural compound present in various fruits and vegetables, shows promise as a potential inhibitor for glioblastoma multiforme (GBM) development. This study aims to examine the anti-GBM potential of Quercetin. The protein target of Quercetin is identified and analyzed using databases such as NCBI, SEA, CTD, and STRING. Protein-protein interaction (PPI) and functional annotation are carried out based on the obtained target proteins. Molecular docking and dynamics simulations are employed using AutoDock Vina and WebGro tools to analyze the interaction between Quercetin and its target proteins. The prediction of protein targets reveals that Quercetin directly targets four proteins associated …

Nursing Education In Complementary Alternative Modalities: A Case Study, Deborah Bird

Dissertations

Purpose: The purpose of this embedded case study was to describe the preparation for and utilization of complimentary alternative modality (CAM) interventions by an experienced Doctor of Nursing Practice (DNP) prepared nurse practitioner (NP) working in an outpatient setting.

Background: Given the widespread use of CAM by the American public and the potential complications involved in combining CAM and standard medical care, a lack of educational preparation in CAM interventions by NPs delivering primary care in outpatient health care settings represents both a potential risk and a missed opportunity to provide holistic patient care. Such a lack of knowledge also …

Stochastic Gradient Descent Method For A Parameter Identification Problem In Elasticity Imaging, Basca Jadamba

Biology and Medicine Through Mathematics Conference

No abstract provided.

Mathematical Modeling Of Immune Response To Sars-Cov-2, Hwayeon Ryu

Biology and Medicine Through Mathematics Conference

No abstract provided.

Modeling The Immune Response To Immunotherapy And Triple Negative Breast Cancer In Mice, Dayton J. Syme, Angelica Davenport, Yun Lu, Anna G. Sorace, Nicholas G. Cogan

Biology and Medicine Through Mathematics Conference

No abstract provided.

Breaking Down Grit: Persistency And Flexibility In The Career Plans Of Military Medical Students., Ryan R Landoll, Krista Highland, Kameha Bell, Anthony R. Artino, Col Lisa K Moores, Michael Soh, Sebastian Uijtdehaage, Steven J Durning, Neil E Grunberg, Ting Dong

Health Sciences Education Research

INTRODUCTION: The field of medicine is experiencing a crisis as high levels of physician and trainee burnout threaten the pipeline of future physicians. Grit, or passion and perseverance for long-term goals, has been studied in high-performing and elite military units and found to be predictive of successful completion of training in adverse conditions. The Uniformed Services University of the Health Sciences (USU) graduates military medical leaders who make up a significant portion of the Military Health System physician workforce. Taken together, an improved understanding of the relationships between burnout, well-being, grit, and retention among USU graduates is critical to the …

Chemoattractant Distribution In Complex Geometry Impacts The Trajectory Of Clustered Cell Migration, Naghmeh Akhavan

Biology and Medicine Through Mathematics Conference

No abstract provided.

Pk/Pd Modeling Coupled With A Phenotype-Structured Population Model For Reducing Drug Resistance, Lifeng Han

Biology and Medicine Through Mathematics Conference

No abstract provided.

Modeling Epithelial-Mesenchymal Transition In A 3d Multicellular Model Of Tgf-Β1 Signaling, Kristin Kim, Chris Lemmon

Biology and Medicine Through Mathematics Conference

No abstract provided.

All Clear: A Workbook For Sexually Active Accutane Users Who Can Become Pregnant, Taylor Petersen

Honors Projects

Accutane is a pill-based derivative of Vitamin A used to treat cystic acne. The process to start and continue the medication each month is tedious and full of potential for error. This is especially true for female patients who are able to become pregnant as they have the additional step of monitoring and updating their birth control through an online portal. Patients are treated like numbers and there is little to no customization within Accutane treatment from patient to patient. To make this worse, reliable information about the drug is scarce and many turn to social media platforms or other …

Medical Cannabis In Mississippi: Practitioner Education And Continuing Research, Andrea Cleveland

Honors Theses

Use of medical cannabis in Mississippi was legalized in February 2022 following many years of cannabis research at the University of Mississippi. Issues immediately became apparent, beginning with the lack of education about medical cannabis among providers. A 2017 study showed that the majority of physicians are not exposed to information about medical cannabis despite its legalization in 37 states. Another issue with Mississippi’s medical cannabis program is the cost of the product itself. The most effective way to decrease spending on medication is for patients to have access to medication that is guaranteed to work. Further research on cannabis …

Growing The Pipeline Of Men Of Color In Medicine, Mark Martin, Jacquelyn Gerhart, Marcine Pickron-Davis

Research Day

INTRODUCTION: Healthcare professions suffer from an imbalance in the number of culturally and ethnically diverse providers and the populations they serve. This poster presentation will illustrate our commitment to mitigating the dearth of underrepresented men in medicine. Currently, African Americans make up 13% of the U.S. population, but only 4% of U.S. doctors and less than 7% of U.S. medical students. (Of active U.S. doctors in 2013, 48.9% were white, 11.7% were Asian, 4.4% were Hispanic or Latinx, and 0.4% were American Indian or Alaska Native.) (HBR, August 10, 2018). In 1986, 57% of black medical school graduates were men …

Healthcare Disparities And Hispanic Immigrants: A Systematic Review Of The Literature, William C. Greenman Iii

Chancellor’s Honors Program Projects

No abstract provided.

A Machine Learning Approach For Predicting Clinical Trial Patient Enrollment In Drug Development Portfolio Demand Planning, Ahmed Shoieb

Masters Theses

One of the biggest challenges the clinical research industry currently faces is the accurate forecasting of patient enrollment (namely if and when a clinical trial will achieve full enrollment), as the stochastic behavior of enrollment can significantly contribute to delays in the development of new drugs, increases in duration and costs of clinical trials, and the over- or under- estimation of clinical supply. This study proposes a Machine Learning model using a Fully Convolutional Network (FCN) that is trained on a dataset of 100,000 patient enrollment data points including patient age, patient gender, patient disease, investigational product, study phase, blinded …

Pharmacists’ Perceptions And Knowledge Of The Legalization Of Medical Marijuana In Mississippi, Faith Houston

Honors Theses

The legalization of medical cannabis in Mississippi was a debated topic among all citizens. This thesis specifically explored pharmacists’ perceptions and knowledge as medical professionals who will be involved with patients certified to use medical cannabis. Information was gathered using a voluntary online survey on the Qualtrics platform to produce a cross-sectional, descriptive study.

From the information gathered, it was apparent that pharmacists in Mississippi have varying opinions regarding medical marijuana. Some are in favor of using these products, and some are not. However, as cannabis has been officially accepted and put into patient's medical plans both current and future …

She Whose Words Helped Me To See, Tara Mckenna

be Still

This paper is a reflection on the interconnectedness of teachers and physician healers. Still, it identifies lessons that physicians can learn from educators in our lives and the importance of integrating these tools into how we teach patients about medicine.

A Physician's Most Important Teachers, Rachel Pray

be Still

I hope to never lose sight of the reasons why I became a physician: to make deep, real connections with patients while they may be going through one of the worst or most uncertain time of their lives - offering comfort and expertise to ease their worries - and to assist them in becoming the best, healthiest, happiest versions of themselves. Remembering my "why" has helped me overcome the struggles and trials of medical school, and I will continue to hold it close to me throughout my medical career.

Learning From The Best!, Michelle N. Won

be Still

Thank you to all the NSU preceptors of Punta Gorda, Florida.

The Art Of Teaching In Medicine, Mariam Dar

be Still

A reflection on the aspects and importance of teaching in medicine.

Correcting Misinformation In The Clinic: A New Course For Medical Students, Rachel Brill, Stacy Brody, Ian Roberts

Himmelfarb Library Faculty Posters and Presentations

No abstract provided.

Protocol Development For Digisection: Making A Case For Standardizing Educational Technology Use For Digital Dissection And Anatomical Studies., Joshua Owolabi

PCOM Scholarly Papers

The changes that have characterized advancements in anatomical sciences and medical education have significantly influenced pedagogies and the mode of delivery of teaching and training in the context of medical education. Another reality is the impact of educational technology (EdTech) penetration and integration into medical sciences and education. These events have undoubtedly influenced certain traditional practices and pedagogies including dissection. For example, EdTech and innovations have introduced virtual human images and three-dimensional (3D) human body representations for the purposes of teaching and dissection. Another instance includes the fact that the old dissection guides for gross anatomy, which follow the traditional …

Chatgpt & Doctors: The Medical Dream Team, Ishan S. Abdullah, Aditya Loganathan, Randall W. Lee

URGENT Matters

No abstract provided.

The Restrictive Factors And Practical Path Of Sports-Medical Integration Under The Background Of Covid-19 Pandemic, Yonghuan Chen, Yanan Jiang, Xiangning Yan

International Journal of Physical Activity and Health

This paper explored the restrictive factors of realizing the integration of sports and medicine in China under the background of “COVID-19 pandemic” and analyzed the path of realizing the integration of sports and medicine by combining it with “Healthy China” strategy and “National Fitness Program”. We used document and expert interview method. In the new era, people’s desire for a better life has become the most extensive demand, and the sudden outbreak of epidemic makes people’s demand for health become the first demand. The importance of people’s health raises “Healthy China” as the national development strategy, which has become the …

Brivaracetam To Treat Partial Onset Seizures In Adults., Dustin Latimer, David Le, Evan P. Falgoust, Patrick Ingraffia, Alaa Abd-Elsayed, Elyse M. Cornett, Rupin Singh, Joohee Choi, Giustino Varrassi, Adam M. Kaye, Alan D. Kaye, Latha Ganti

School of Pharmacy Faculty Articles

PURPOSE OF REVIEW: Seizures are a hyperexcitable, and hypersynchronous imbalance between excitatory and inhibitory factors (E/I imbalance) in neurotransmission, and epilepsy is the recurrent manifestation of seizures within a reasonable time frame and without being attributable to a reversible cause. Brivaracetam is a derivative of the antiepileptic agent, levetiracetam, that is used as adjuvant therapy for focal onset seizures. It was approved by the FDA in 2016 and has shown promising results with minimal adverse effect reactions in clinical trials.

RECENT FINDINGS: Brivaracetam has been used in multiple clinical trials at various dosages in adults that have partial-onset seizures refractory …