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Full-Text Articles in Medicine and Health Sciences
Editorial: Regulation And Dysfunction Of Csk And Chk., Shudong Zhu, Dianzheng Zhang
Editorial: Regulation And Dysfunction Of Csk And Chk., Shudong Zhu, Dianzheng Zhang
PCOM Scholarly Papers
No abstract available.
Regulation, Targets And Functions Of Csk., Shudong Zhu, Hui Wang, Kamakshi Ranjan, Dianzheng Zhang
Regulation, Targets And Functions Of Csk., Shudong Zhu, Hui Wang, Kamakshi Ranjan, Dianzheng Zhang
PCOM Scholarly Papers
The Src family kinases (SFK) plays an important role in multiple signal transduction pathways. Aberrant activation of SFKs leads to diseases such as cancer, blood disorders, and bone pathologies. By phosphorylating and inactivating SFKs, the C-terminal Src kinase (CSK) serves as the key negative regulator of SFKs. Similar to Src, CSK is composed of SH3, SH2, and a catalytic kinase domain. However, while the Src kinase domain is intrinsically active, the CSK kinase domain is intrinsically inactive. Multiple lines of evidence indicate that CSK is involved in various physiological processes including DNA repair, permeability of intestinal epithelial cells (IECs), synaptic …