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Full-Text Articles in Medicine and Health Sciences

Next-Generation Crispr Gene-Drive Systems Using Cas12a Nuclease, Sara Sanz Juste, Emily M Okamoto, Christina Nguyen, Xuechun Feng, Víctor López Del Amo Oct 2023

Next-Generation Crispr Gene-Drive Systems Using Cas12a Nuclease, Sara Sanz Juste, Emily M Okamoto, Christina Nguyen, Xuechun Feng, Víctor López Del Amo

Journal Articles

One method for reducing the impact of vector-borne diseases is through the use of CRISPR-based gene drives, which manipulate insect populations due to their ability to rapidly propagate desired genetic traits into a target population. However, all current gene drives employ a Cas9 nuclease that is constitutively active, impeding our control over their propagation abilities and limiting the generation of alternative gene drive arrangements. Yet, other nucleases such as the temperature sensitive Cas12a have not been explored for gene drive designs in insects. to address this, we herein present a proof-of-concept gene-drive system driven by Cas12a that can be regulated …


Assessing The Role Of Distance To Level I Trauma Units On Atv Rollovers, Tractor Rollovers, And Machinery Entanglement Outcomes, Andrew K. Schissel Aug 2023

Assessing The Role Of Distance To Level I Trauma Units On Atv Rollovers, Tractor Rollovers, And Machinery Entanglement Outcomes, Andrew K. Schissel

Capstone Experience

All-Terrain Vehicle (ATV) rollovers, tractor rollovers, and machinery entanglements cause traumatic injuries to agricultural workers. Response time of first responders combined with travel to trauma units can take a significant amount of time in rural areas, potentially leading to an increased risk of fatal outcomes for those involved in these incidents. The aim of this study is to determine if distance to a level I trauma unit is a factor in the outcomes of these incidents. ATV rollovers, tractor rollovers, and machinery entanglement injuries and fatalities, collected from a 7-state Midwestern region were entered into a GIS system along with …


What Regenerative Agriculture Can Teach Medical Students About Human Health, David Ebbott, Dimitrios Papanagnou May 2023

What Regenerative Agriculture Can Teach Medical Students About Human Health, David Ebbott, Dimitrios Papanagnou

Department of Emergency Medicine Faculty Papers

No abstract provided.


Movements And Resource Selection Of Wild Pigs Associated With Growth Stages Of Corn, Bethany A. Friesenhahn, Randall W. Deyoung, Michael J. Cherry, Humberto L. Perotto-Baldivieso, Kurt C. Vercauteren, Nathan P. Snow Jan 2023

Movements And Resource Selection Of Wild Pigs Associated With Growth Stages Of Corn, Bethany A. Friesenhahn, Randall W. Deyoung, Michael J. Cherry, Humberto L. Perotto-Baldivieso, Kurt C. Vercauteren, Nathan P. Snow

USDA Wildlife Services: Staff Publications

Wild pigs (Sus scrofa) are one of the most successful invasive species globally and are often implicated in agricultural damage. This damage is expected to increase as ranges of wild pigs expand, impacting the human food supply and increasing costs of food production. Our objective was to evaluate movement behaviors of wild pigs relative to resource availability and landscape features in an agriculture-dominated landscape, with a goal of informing management practices for reducing damage to corn. We monitored hourly movements of adult wild pigs relative to corn crops using GPS collars during the 2019 and 2020 growing seasons (Feb–Sept) in …


Towards A Food-Secure Future In An Era Of Uncertainty: Cultivating Resilience In Vulnerable Smallholder Food Systems, Maya Moore Jan 2023

Towards A Food-Secure Future In An Era Of Uncertainty: Cultivating Resilience In Vulnerable Smallholder Food Systems, Maya Moore

Graduate College Dissertations and Theses

Smallholder food systems in sub-Saharan Africa and other tropical regions are at the crux of the “triple threat” of the Anthropocene: climate change, biodiversity loss and food insecurity. At the same time, they are considered pivotal to the global food system transformation needed to address these challenges. However, while there have been many proposed pathways to achieve desired outcomes, smallholders are often constrained in their ability to adapt and transform. Therefore, in this three-article dissertation, I use mixed methods to study traditional food security coping strategies and apply socio-psychological behavioral intention theories to understand the cognitive factors behind farmers’ decisions …