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Full-Text Articles in Medicine and Health Sciences
Research On The Protective Effect Of Caffeic Acid Phenethyl Ester On Testicular Damagecaused By Cisplatin, Tayfun Ceylan, Emi̇n Kaymak, Fazi̇le Cantürk Tan, Bi̇rkan Yakan
Research On The Protective Effect Of Caffeic Acid Phenethyl Ester On Testicular Damagecaused By Cisplatin, Tayfun Ceylan, Emi̇n Kaymak, Fazi̇le Cantürk Tan, Bi̇rkan Yakan
Turkish Journal of Medical Sciences
Background/aim: Cisplatin (CP), a chemotherapeutic drug, causes damage to spermatogenic serial cells, Sertoli cells, and Leydig cells in rat testicles. It was aimed to investigate the protective effect of caffeic acid phenethyl ester (CAPE), one of the active ingredients of propolis, in eliminating CP-induced testicular damage. Materials and methods: Group 1 (control group) was given physiological saline solution intraperitoneally (IP) throughout the experiment. Group 2 (CP group) was given a single dose of CP (7 mg/kg) IP on the day 7. Group 3 (CP + CAPE group), was given CAPE (10 μmol/kg/day) IP for 12 days and a single dose …
The Effects Of Different Doses Of Diclofenac Sodium On Newborn Rat Hippocampus Exposed During The Third Trimester, Ebru Eli̇bol, Süleyman Kaplan, Gamze Altun, Abdurrahman Aksoy, Berri̇n Zuhal Altunkaynak
The Effects Of Different Doses Of Diclofenac Sodium On Newborn Rat Hippocampus Exposed During The Third Trimester, Ebru Eli̇bol, Süleyman Kaplan, Gamze Altun, Abdurrahman Aksoy, Berri̇n Zuhal Altunkaynak
Turkish Journal of Veterinary & Animal Sciences
The main aim of the present study was to examine the neurotoxic effects of prenatal exposure to varying doses of diclofenac sodium (DS) on the rat hippocampus. Twenty-eight Wistar albino adult female rats weighing 280-300 g were initially used for pregnancy. When vaginal plaques were seen in female rats, it was accepted as the 0th day of pregnancy. Female rats were divided into five main groups; pure control, saline, low dose DS (3.6 mg/kg), moderate dose DS (9 mg/kg), and high dose DS (18 mg/kg). They were exposed to these treatments during their gestation. After birth, all newborn male rats …
Evaluation Of The Effects Of Bone Morphogenetic Protein-2 On The Healing Of Bonecalvarial Defects In Ovariectomized Rats, Ela Tules Kadi̇roğlu, Fati̇h Karayürek, Mehmet Erdem Akbalik
Evaluation Of The Effects Of Bone Morphogenetic Protein-2 On The Healing Of Bonecalvarial Defects In Ovariectomized Rats, Ela Tules Kadi̇roğlu, Fati̇h Karayürek, Mehmet Erdem Akbalik
Turkish Journal of Veterinary & Animal Sciences
Bone morphogenetic proteins (BMPs) are often used with bone grafts for bone regeneration. The aim of this study was to evaluate the effect of demineralized freeze-dried bone allografts and externally applied rhBMP-2 on bone healing in experimentally generated defects in the calvarium of ovariectomized and nonovariectomized rats via histological and immunohistochemical assays. The current study was carried out on 42 female Wistar rats. After ovariectomy was performed in half of the rats, the rats were divided into three groups: control, allograft, and allograft + BMP. An experimental defect with a diameter of 4 mm was created unilaterally in the parietal …
Evaluation Of The Early Term Healing Effects Of Resveratrol On Corneal Wounds In Rats, Hati̇ce Çi̇lem Perçi̇n, Zülfükar Kadi̇r Saritaş
Evaluation Of The Early Term Healing Effects Of Resveratrol On Corneal Wounds In Rats, Hati̇ce Çi̇lem Perçi̇n, Zülfükar Kadi̇r Saritaş
Turkish Journal of Veterinary & Animal Sciences
The aim of this study was to determine the effects of resveratrol (RES) treatment on corneal wound healing. Randomly divided into 2 groups were 26-week-old male Wistar albino rats. Group 1 was the control group (C) and group 2 was the RES group. A 2-3-mm-long vertical incision was made centrally in the right cornea of each rat to the descemet membrane using loupe magnification (2.5X) and the wounds were sutured using 10/0 nylon material. In the RES group, the rats were fed 30 mg/kg/day RES via oral gavage; the C and RES groups were provided food and water ad libitum …
Comparison Of The Efficacy Between Bilateral Proximal Tubal Occlusion And Total Salpingectomy On Ovarian Reserve And The Cholinergic System: An Experimental Study, Remzi̇ Atilgan, Şehmus Pala, Tuncay Kuloğlu, Cengi̇z Şanli, Şeyda Yavuzkir, Zehra Sema Özkan
Comparison Of The Efficacy Between Bilateral Proximal Tubal Occlusion And Total Salpingectomy On Ovarian Reserve And The Cholinergic System: An Experimental Study, Remzi̇ Atilgan, Şehmus Pala, Tuncay Kuloğlu, Cengi̇z Şanli, Şeyda Yavuzkir, Zehra Sema Özkan
Turkish Journal of Medical Sciences
Background and aim: To compare the effects of bilateral proximal tubal occlusion and bilateral total salpingectomy on ovarian reserve and the cholinergic system via rat experiment. Materials and methods: Twenty-one adult female rats were randomly divided into the following three groups: G1 (n = 7), sham group; G2 (n = 7), bilateral total salpingectomy group; and G3 (n = 7), bilateral proximal tubal occlusion group. Four weeks later, the abdomen of the rats was opened. The right ovarian tissues were stored in 10% formaldehyde, whereas the left ovarian tissues were stored at ?80 °C in aluminum foil. Serum samples were …
What Is The Impact Of Ppar-? Agonist-Rosiglitazone On Ovarian Reserve After Hysterectomy? An Experimental Study, Burcu Gündoğdu Öztürk, Ömer Lütfi̇ Tapisiz, Berna Di̇lbaz, Serkan Bariş Mülazimoğlu, Kami̇l Hakan Müftüoğlu, Betül Dündar, Ümi̇t Göktolga
What Is The Impact Of Ppar-? Agonist-Rosiglitazone On Ovarian Reserve After Hysterectomy? An Experimental Study, Burcu Gündoğdu Öztürk, Ömer Lütfi̇ Tapisiz, Berna Di̇lbaz, Serkan Bariş Mülazimoğlu, Kami̇l Hakan Müftüoğlu, Betül Dündar, Ümi̇t Göktolga
Turkish Journal of Medical Sciences
Background/aim: To evaluate the effects of hysterectomy on rat ovaries and the possible protective role of peroxisome proliferator-activated receptor gamma (PPAR-?) agonist-rosiglitazone against ovarian reserve decrement.Materials and methods: Forty-five adult Wistar albino rats were randomly divided into three groups. Hysterectomy was performed (n = 15) in group 1 [H]; 1 mg/kg/day PPAR-? agonist/rosiglitazone was used for 50 days after hysterectomy (n = 15) in group 2 [H + R]; a sham operation was performed (n = 15) in group 3 [control, C]. Blood samples were collected for anti-Müllerian hormone (AMH) evaluation in all groups and simultaneous ovarian Doppler examination was …