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Full-Text Articles in Medicine and Health Sciences
Sars-Cov-2 Epidemiology And Control, Different Scenarios For Turkey, Eskild Petersen, Ayşe Deni̇z Gökengi̇n
Sars-Cov-2 Epidemiology And Control, Different Scenarios For Turkey, Eskild Petersen, Ayşe Deni̇z Gökengi̇n
Turkish Journal of Medical Sciences
Background/aim: Coronavirus Infectious Disease 2019 (COVID-19) is now a pandemic spreading in most countries including Turkey. Materials and methods: The current knowledge of COVID-19 and the virus causing it, SARS-CoV-2, was reviewed. The epidemiology and control in different countries was compared and the differences discussed. Results: The population attack rates and case fatality rates vary from country to country with Lombardy in northern Italy reporting an attack rate in the general population of 0.37% compared to 0.004% in Hong Kong. The differences are caused by different testing strategies and reporting systems. Conclusion: Turkey is early in the outbreak. Different control …
A Single Center Cohort Of 40 Severe Covid-19 Patients Who Were Treated Withconvalescent Plasma, Ali̇i̇hsan Gemi̇ci̇, Hülya Bi̇lgen, Cem Erdoğan, Abdullah Kansu, Oktay Olmuşçeli̇k, Hüseyi̇n Saffet Beköz, Rumeysa Çakmak, Ali̇ Mert, Ömür Gökmen Sevi̇ndi̇k
A Single Center Cohort Of 40 Severe Covid-19 Patients Who Were Treated Withconvalescent Plasma, Ali̇i̇hsan Gemi̇ci̇, Hülya Bi̇lgen, Cem Erdoğan, Abdullah Kansu, Oktay Olmuşçeli̇k, Hüseyi̇n Saffet Beköz, Rumeysa Çakmak, Ali̇ Mert, Ömür Gökmen Sevi̇ndi̇k
Turkish Journal of Medical Sciences
Background/aim: A SARS-Cov2 infection which was first arised from Wuhan in December 2019 and named as COVID-19. Still there lacks either a specific treatment or a vaccine to treat COVID-19. Convalescent plasma (CP) was previously used successfully to treat SARS-CoV-1 and MERS infections. Health authority in Turkey has published a guideline to integrate this promising option in the treatment process of patients who are prone to high risk of developing severe COVID 19. Materials and Methods: Forty consecutive patients who had received CP at our center were included in the study. Demographics, COVID-19 specific parameters, biomarkers to detect the severity …
The Assessment Of The Serum Levels Of Tweak And Prostaglandin F2∝ In Covid - 19, Demet Yalçin Kehri̇bar, Mustafa Ci̇hangi̇roğlu, Emi̇ne Sehmen, Bahatti̇n Avci, Mustafa Çapraz, Maruf Boran, Caner Günaydin, Meti̇n Özgen
The Assessment Of The Serum Levels Of Tweak And Prostaglandin F2∝ In Covid - 19, Demet Yalçin Kehri̇bar, Mustafa Ci̇hangi̇roğlu, Emi̇ne Sehmen, Bahatti̇n Avci, Mustafa Çapraz, Maruf Boran, Caner Günaydin, Meti̇n Özgen
Turkish Journal of Medical Sciences
Background/aim: It is claimed that aberrant immune response has a more important role than the cytopathic effect of the virus in the morbidity and mortality of the coronavirus disease 2019 (COVID-19). We aimed to investigate the possible roles of tumor necrosis factor-like weak inducer of apoptosis (TWEAK)/Fn14 pathway and leukotrienes (LT) in uncontrolled immune response that occurs in severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Materials and methods: This study included 25 asymptomatic patients and 35 patients with lung involvement who were diagnosed with COVID-19 as well as 22 healthy volunteers. Lung involvement was determined using computed-tomography. Serum TWEAK, LTE4, …
The Factors Predicting Pneumonia In Covid-19 Patients: Preliminary Results From Auniversity Hospital In Turkey, Hasan Selçuk Özger, Pinar Aysert Yildiz, Ümmügülsüm Gaygisiz, Asi̇ye Uğraş Di̇kmen, Zehra Demi̇rbaş Gülmez, Mehmet Yildiz, Esi̇n Şenol, Kenan Hizel, Özlem Güzel Tunçcan, Kayhan Çağlar, Gülendam Bozdayi, Nurdan Köktürk, Tansu Ulukavak Çi̇ftçi̇, Şahender Gülbi̇n Aygencel Bikmaz, Melda Türkoğlu
The Factors Predicting Pneumonia In Covid-19 Patients: Preliminary Results From Auniversity Hospital In Turkey, Hasan Selçuk Özger, Pinar Aysert Yildiz, Ümmügülsüm Gaygisiz, Asi̇ye Uğraş Di̇kmen, Zehra Demi̇rbaş Gülmez, Mehmet Yildiz, Esi̇n Şenol, Kenan Hizel, Özlem Güzel Tunçcan, Kayhan Çağlar, Gülendam Bozdayi, Nurdan Köktürk, Tansu Ulukavak Çi̇ftçi̇, Şahender Gülbi̇n Aygencel Bikmaz, Melda Türkoğlu
Turkish Journal of Medical Sciences
Background/aim: Pneumonia is the most serious clinical presentation of COVID-19. This study aimed to determine the demographic, clinical, and laboratory findings that can properly predict COVID-19 pneumonia. Materials and methods: This study was conducted in the Gazi University hospital. All hospitalized patients with confirmed and suspected SARS-CoV-2 infection between 16 March 2020 and 30 April 2020 were analyzed retrospectively. COVID-19 patients were separated into two groups, pneumonia and nonpneumonia, and then compared to determine predicting factors for COVID-19 pneumonia. Variables that had a P-value of less than 0.20 and were not correlated with each other were included in the logistic …
Mobilizing The Research Ecosystem For Scientific Advances Towards Positive Impact In Thecontext Of The Covid-19 Pandemic, Hasan Mandal
Mobilizing The Research Ecosystem For Scientific Advances Towards Positive Impact In Thecontext Of The Covid-19 Pandemic, Hasan Mandal
Turkish Journal of Medical Sciences
This special issue of the Turkish Journal of Medical Sciences is dedicated to providing scientific advances in the process of better understanding the SARS-CoV-2 virus that causes the COVID-19 infection. The special issue is published in a special time in which science-based approaches, cocreation-based collaboration, and the effective utilization and integration of competences have a crucial role during the race against time while combating the COVID-19 pandemic. In this process, the Scientific and Technological Research Council of Turkey (TÜBİTAK), which publishes academic journals including the Turkish Journal of Medical Sciences, has taken rapid action to mobilize the research community. This …
Covid-19, Immune System Response, Hyperinflammation And Repurposingantirheumatic Drugs, Abdurrahman Tufan, Aslihan Avanoğlu Güler, Marco Matucci-Cerinic
Covid-19, Immune System Response, Hyperinflammation And Repurposingantirheumatic Drugs, Abdurrahman Tufan, Aslihan Avanoğlu Güler, Marco Matucci-Cerinic
Turkish Journal of Medical Sciences
In the Wuhan Province of China, in December 2019, the novel coronavirus 2019 (COVID-19) has caused a severe involvement of the lower respiratory tract leading to an acute respiratory syndrome. Subsequently, coronavirus 2 (SARS-CoV-2) provoked a pandemic which is considered a life-threatening disease. The SARS-CoV-2, a family member of betacoronaviruses, possesses singlestranded positive-sense RNA with typical structural proteins, involving the envelope, membrane, nucleocapsid and spike proteins that are responsible for the viral infectivity, and nonstructural proteins. The effectual host immune response including innate and adaptive immunity against SARS-Cov-2 seems crucial to control and resolve the viral infection. However, the severity …
Covid-19: Pathogenesis, Genetic Polymorphism, Clinical Features And Laboratory Findings, Recep Öztürk
Covid-19: Pathogenesis, Genetic Polymorphism, Clinical Features And Laboratory Findings, Recep Öztürk
Turkish Journal of Medical Sciences
COVID-19 caused by a novel agent SARS-CoV-2 progressed to a pandemic condition and resulted in a major public health concern worldwide, leading to social and economic issues at the same time. The pathogenesis of COVID-19 starts with the bonding of the virus to ACE2 receptors expressed in many tissues, and the triggered excessive immune response plays a critical role in the course of the disease. The cytokine storm that occurs upon excessive production of pro-inflammatory cytokines is considered responsible for the severe progression of the disease and the organ damage. However, the accurate pathophysiological mechanism of the disease, which progresses …
Gynecological Laparoscopic Surgery In The Shade Of Covid-19 Pandemic, Şadiman Kiykaç Altinbaş, Ömer Lütfi̇ Tapisiz, Yaprak Üstün
Gynecological Laparoscopic Surgery In The Shade Of Covid-19 Pandemic, Şadiman Kiykaç Altinbaş, Ömer Lütfi̇ Tapisiz, Yaprak Üstün
Turkish Journal of Medical Sciences
A global public health problem with a high rate spread and transmission, Coronavirus outbreak has become the most talkedabout matter throughout the world. We are severely affected by the nations with vast numbers of deaths; it was hard to predict such a colossal pandemic with terrifying consequences. Elective surgeries are limited, but situations requiring an urgent gynaecological or obstetric surgical approach must still be performed during the COVID-19 pandemic. Concerns regarding surgical safety and the risk of viral transmission during surgery are of great importance. In this review, we aimed to summarize the concepts related to laparoscopic gynecological surgery during …
The Effects Of Blood Group Types On The Risk Of Covid-19 Infection And Its Clinical Outcome, Hakan Göker, Eli̇fcan Aladağ Karakulak, Haluk Demi̇roğlu, Çağlayan Merve Ayaz Ceylan, Yahya Büyükaşik, Ahmet Çağkan İnkaya, Salih Aksu, Ni̇lgün Sayinalp, İbrahi̇m Celaletti̇n Haznedaroğlu, Ömrüm Uzun, Murat Akova, Osman İlhami̇ Özcebe, Serhat Ünal
The Effects Of Blood Group Types On The Risk Of Covid-19 Infection And Its Clinical Outcome, Hakan Göker, Eli̇fcan Aladağ Karakulak, Haluk Demi̇roğlu, Çağlayan Merve Ayaz Ceylan, Yahya Büyükaşik, Ahmet Çağkan İnkaya, Salih Aksu, Ni̇lgün Sayinalp, İbrahi̇m Celaletti̇n Haznedaroğlu, Ömrüm Uzun, Murat Akova, Osman İlhami̇ Özcebe, Serhat Ünal
Turkish Journal of Medical Sciences
Background/aim: COVID-19 (Coronavirus disease of 2019) is an infectious disease outbreak later on declared as a pandemic, caused by the SARS-CoV-2 (severe acute respiratory syndrome coronavirus-2). It spreads very rapidly and can result in severe acute respiratory failure. The clinical studies have shown that advanced age and chronic diseases increase the risk of infection. However, influence of the blood groups on COVID-19 infection and its outcome remains to be confirmed. The aim of this study is to investigate whether there exists a relationship between the blood groups of the patients and risk of SARS-CoV-2 infection and the clinical outcomes in …
Understanding Dynamics Of Pandemics, Levent Akin, Mustafa Gökhan Gözel
Understanding Dynamics Of Pandemics, Levent Akin, Mustafa Gökhan Gözel
Turkish Journal of Medical Sciences
Along the centuries, novel strain of virus such as influenza produces pandemics which increase illness, death and disruption in the countries. Spanish flu in 1918, Asian flu in 1957, Hong Kong flu in 1968 and swine flu in 2009 were known pandemic which had various characteristics in terms of morbidity and mortality. A current pandemic is caused by novel corona virus originated from China. COVID-19 pandemic is very similar to Spanish, Hong Kong, Asian and swine influenza pandemics in terms of spreading to world by the mobilized people. Burden of pandemic is considered in terms of disease transmissibility and the …
Epidemiology Of Covid-19, Cemal Bulut, Yasuyuki̇ Kato
Epidemiology Of Covid-19, Cemal Bulut, Yasuyuki̇ Kato
Turkish Journal of Medical Sciences
It seems that coronaviruses take an important place in the 21th century history. Five of seven human coronavirus was isolated in this century. Unfortunately, last three of them entered our life with a fear of outbreak, pandemic or death. Last human coronavirus which emerged world from Wuhan China, SARS CoV-2 and its clinical expression, Coronavirus disease (COVID-19) recently taken a significant place in our daily practice. Initial reports showed that, its origin was bats. It transmitted human to human by droplet and contact routes, but some doubt about airborne, fecal or intrauterine transmission also should be removed. Its R0 value …
Covid-19-Related Anxiety In People Living With Hiv: An Online Cross-Sectional Study, Özlem Kuman Tunçel, Hüsnü Pullukçu, Hüseyi̇n Aytaç Erdem, Behi̇ce Kurtaran, Seli̇n Ece Taşbakan, Meltem Taşbakan
Covid-19-Related Anxiety In People Living With Hiv: An Online Cross-Sectional Study, Özlem Kuman Tunçel, Hüsnü Pullukçu, Hüseyi̇n Aytaç Erdem, Behi̇ce Kurtaran, Seli̇n Ece Taşbakan, Meltem Taşbakan
Turkish Journal of Medical Sciences
Background/aim: The emergence of the coronavirus disease 2019 (COVID-19) outbreak has had an enormous emotional impact on some vulnerable groups, such as people living with human immunodeficiency virus (HIV) (PLHIV). This study was planned with the aim of assessing the anxiety levels of PLHIV and the sources of their anxiety. Materials and methods: A web-based questionnaire was sent to PLHIV using the virtual snowball sampling method. The questionnaire included questions about sociodemographic status, information about HIV infection, and the Beck Anxiety Inventory (BAI). Additionally, some opinions of the participants about COVID-19 were asked. Results: A total of 307 respondents, with …
Chest Ct Features Of The Novel Coronavirus Disease (Covid-19), Furkan Ufuk, Recep Savaş
Chest Ct Features Of The Novel Coronavirus Disease (Covid-19), Furkan Ufuk, Recep Savaş
Turkish Journal of Medical Sciences
A new type of coronavirus (2019-nCoV) is rapidly spreading worldwide and causes pneumonia, respiratory distress, thromboembolic events, and death. Chest computed tomography (CT) plays an essential role in the diagnosis of viral pneumonia, monitoring disease progression, determination of disease severity, and evaluating therapeutic efficacy. Chest CT can show important clues of 2019-nCoV disease (also known as COVID-19) in patients with an appropriate clinic. Prompt diagnosis of COVID-19 is essential to prevent disease transmission and provides close clinical observation of patients with clinically severe disease. Therefore, radiologists and clinicians should be familiar with the CT imaging findings of COVID-19 pneumonia. Herein, …
Covid-19 Experience Of The Major Pandemic Response Center In The Capital: Results Ofthe Pandemic's First Month In Turkey, Hati̇ce Rahmet Güner, İmran Hasanoğlu, Bi̇rcan Kayaaslan, Adalet Aypak, Ayşe Kaya Kalem, Fatma Eser, Burcu Özdemi̇r, Eli̇f Muki̇me Saricaoğlu, Müge Ayhan, Yeşi̇m Aybar Bi̇li̇r, Işil Özkoçak Turan, Deni̇z Erdem, Nevzat Mehmet Mutlu, Turan Buzğan, Bedi̇a Di̇nç
Covid-19 Experience Of The Major Pandemic Response Center In The Capital: Results Ofthe Pandemic's First Month In Turkey, Hati̇ce Rahmet Güner, İmran Hasanoğlu, Bi̇rcan Kayaaslan, Adalet Aypak, Ayşe Kaya Kalem, Fatma Eser, Burcu Özdemi̇r, Eli̇f Muki̇me Saricaoğlu, Müge Ayhan, Yeşi̇m Aybar Bi̇li̇r, Işil Özkoçak Turan, Deni̇z Erdem, Nevzat Mehmet Mutlu, Turan Buzğan, Bedi̇a Di̇nç
Turkish Journal of Medical Sciences
Background/aim: The aim of this study is to evaluate the epidemiological and clinical characteristics and parameters that determined the clinical course and prognosis of the COVID-19 patients admitted to Ankara City Hospital during the first month of the pandemic in Turkey. Materials and methods: SARS-CoV-2 PCR positive patients who were hospitalized between March 10 and April 10, 2020 were included. Results: Among 222 patients, mean age was higher in severe acute respiratory illness (SARI)/critical disease group (P < 0.001). Median time from illness onset to admission and presence of comorbidity, especially coronary artery disease and chronic obstructive pulmonary disease, were significantly higher in the SARI/critical disease group (P < 0.05). Cough and fever were the most common symptoms, while anosmia and loss of taste were observed in 8.6% and 7.7% patients, respectively. The mortality rate was 5.4%. A high neutrophil/lymphocyte ratio; low lymphocyte, monocyte, and platelet count; elevated liver enzymes; low GFR; and high levels of muscle enzymes, ferritin, and IL-6 on admission were found to be associated with SARI/critical disease (P < 0.05). Bilateral ground-glass opacity and patchy infiltration were more frequently seen in the SARI/critical disease group (P < 0.001). Patients older than 65 years had an 8-fold increased risk for development of SARI/critical disease. Conclusion: This cohort study regarding COVID-19 cases in Turkey reveals that older age, presence of comorbidity, bilateral infiltration on CT, high neutrophil/lymphocyte ratio, low monocyte and platelet count, elevated liver enzymes, low GFR, high levels of muscle enzymes, and high levels of ferritin and IL-6 on admission are predictors of SARI and severe disease.
Covid-19 Outbreak Control, Example Of Ministry Of Health Of Turkey, Yasemi̇n Demi̇rbi̇lek, Gülen Pehli̇vantürk, Zeynep Özge Özgüler, Emi̇ne Alp Meşe
Covid-19 Outbreak Control, Example Of Ministry Of Health Of Turkey, Yasemi̇n Demi̇rbi̇lek, Gülen Pehli̇vantürk, Zeynep Özge Özgüler, Emi̇ne Alp Meşe
Turkish Journal of Medical Sciences
Our first COVID-19 case in Turkey was a 44-year-old male who referred to the hospital on March 9, 2020. The first related death occurred on March 17, 2020. Preparedness for the pandemic has been ongoing before the first case was detected. The National Pandemic Plan was published in 2006. The Pandemic Influenza National Preparedness Plan was available after being updated in light of experiences gained during the 2009 Influenza A pandemic. Accordingly, Pandemic Coordination Boards and Operation Centers have been established on the national and provincial levels. This was an adaptable plan to the Novel Coronavirus Disease (COVID-19). We formed …
Coronaviruses And Sars-Cov-2, Mustafa Hasöksüz, Selçuk Kiliç, Fahri̇ye Saraç
Coronaviruses And Sars-Cov-2, Mustafa Hasöksüz, Selçuk Kiliç, Fahri̇ye Saraç
Turkish Journal of Medical Sciences
Coronaviruses (CoVs) cause a broad spectrum of diseases in domestic and wild animals, poultry, and rodents, ranging from mild to severe enteric, respiratory, and systemic disease, and also cause the common cold or pneumonia in humans. Seven coronavirus species are known to cause human infection, 4 of which, HCoV 229E, HCoV NL63, HCoV HKU1 and HCoV OC43, typically cause cold symptoms in immunocompetent individuals. The others namely SARS-CoV (severe acute respiratory syndrome coronavirus), MERS-CoV (Middle East respiratory syndrome coronavirus) were zoonotic in origin and cause severe respiratory illness and fatalities. On 31 December 2019, the existence of patients with pneumonia …
Novel Coronavirus Disease (Covid-19) In Children, Hasan Tezer, Tuğba Bedi̇r Demi̇rdağ
Novel Coronavirus Disease (Covid-19) In Children, Hasan Tezer, Tuğba Bedi̇r Demi̇rdağ
Turkish Journal of Medical Sciences
Coronavirus disease (COVID-19) was firstly reported at the end of 2019. The disease rapidly spread all around the world in a few months and was declared a worldwide pandemic by WHO in March 2020. By April 9, there were 1,436,198 confirmed COVID-19 cases in the world, nearly with 6% mortality rate. This novel infectious disease causes respiratory tract illness that may generally occur as mild upper respiratory tract disease or pneumonia. In older patients and/or patients with underlying conditions, it may result in acute respiratory distress syndrome, multi organ failure and even death. According to the current literature, children account …
Radiological Approaches To Covid-19 Pneumonia, Müşerref Şule Akçay, Tevfi̇k Özlü, Aydin Yilmaz
Radiological Approaches To Covid-19 Pneumonia, Müşerref Şule Akçay, Tevfi̇k Özlü, Aydin Yilmaz
Turkish Journal of Medical Sciences
COVID-19 pneumonia has high mortality rates. The symptoms are undiagnostic, the results of viral nucleic acid detection method (PCR) can delay, so that chest computerized tomography is often key diagnostic test in patients with possible COVID-19 pneumonia. In this review, we discussed the main radiological findings of this infection.
Covid-19 And Dermatology, Ülker Gül
Covid-19 And Dermatology, Ülker Gül
Turkish Journal of Medical Sciences
Background/aim: Sars-CoV-2 virus infection (COVID-19) was observed in China in the last months of 2019. In the period following, this infection spread all over the world. In March 2020 the World Health Organization announced the existence of a pandemic. The aim of this manuscript is to investigate skin diseases associated with COVID-19 under three main headings: skin problems related to personal protective equipment and personal hygiene measures, skin findings observed in SARS-CoV-2 virus infections, and skin findings due to COVID-19 treatment agents. Materials and methods: In PubMed, Google Scholar databases, skin lesions related to personal protective equipment and personal hygiene …
Covid-19: Prevention And Control Measures In Community, Hati̇ce Rahmet Güner, İmran Hasanoğlu, Fi̇rdevs Aktaş
Covid-19: Prevention And Control Measures In Community, Hati̇ce Rahmet Güner, İmran Hasanoğlu, Fi̇rdevs Aktaş
Turkish Journal of Medical Sciences
On January 30, 2020, the WHO declared the COVID-19 outbreak a public health emergency of international concern and, in March 2020, began to characterize it as a pandemic in order to emphasize the gravity of the situation and urge all countries to take action in detecting infection and preventing spread. Unfortunately, there is no medication that has been approved by the FDA, gone through controlled studies and demonstrated an effect on the virus for this global pandemic. Although there are cures for illnesses and developments made by leaps and bounds in our day, the strongest and most effective weapon that …
Protective Measures For Covid-19 For Healthcare Providers And Laboratory Personnel, Canan Ağalar, Derya Öztürk Engi̇n
Protective Measures For Covid-19 For Healthcare Providers And Laboratory Personnel, Canan Ağalar, Derya Öztürk Engi̇n
Turkish Journal of Medical Sciences
In the COVID-19 pandemic, which affects the whole world, healthcare professionals (HCP) are at high risk of transmission due to their direct contact with patients with COVID-19. Therefore, how to ensure the triage of the patient with acute respiratory symptoms should be determined in advance, the contact distance should be arranged to be at least 2 m, COVID-19 suspect or diagnosed patient should be instructed to wear a surgical mask. During the care of these patients, HCP should wear their personal protective equipment (PPE) in accordance with the procedure and should not neglect hand hygiene. The samples of the patient …
Melatonin, Aging, And Covid-19: Could Melatonin Be Beneficial For Covid-19 Treatment In The Elderly?, Güler Öztürk, Kazi̇me Gonca Akbulut, Şevi̇n Güney
Melatonin, Aging, And Covid-19: Could Melatonin Be Beneficial For Covid-19 Treatment In The Elderly?, Güler Öztürk, Kazi̇me Gonca Akbulut, Şevi̇n Güney
Turkish Journal of Medical Sciences
The aim of this review is to summarize current studies on the relationship between melatonin and aging. Nowadays, age-related diseases come into prominence, and identifying age-related changes and developing proper therapeutic approaches are counted as some of the major issues regarding community health. Melatonin is the main hormone of the pineal gland. Melatonin is known to influence many biological processes in the body, including circadian rhythms, the immune system, and neuroendocrine and cardiovascular functions. Melatonin rhythms also reflect the biological process of aging. Aging is an extremely complex and multifactorial process. Melatonin levels decline considerably with aging and its decline …