Medicine and Health Sciences Commons^™

Inside Out, Spring 2019

Inside Out

Contents:

Spiderweb of Lights, Erica Westlake - Cover

Morning Commute - La Molina, Peru, Sarah Roselli - Inside Cover

Untitled Constellations Kevin Tang - Following Page

Desire, Daisy Zhang - 1

The Cliffs, Kevin Tang - 2

Fish Tails, Sean Considine - 3

Fisherman’s Nook, Boglarka Jordan - 4

Moratorium, Harnoor Kaur - 4

Cain and Abel, Sean Considine - 5

Sunset Outside Philly, Cara Mergner - 5

Abstract Anatomy: Umbilical Cord, Jordyn Tumas - 6

Daughterhood, Danielle Crabtree - 7

Al Kabsa, Sh’Rae Marshall -8

Thinking in Circles, Kerry …

Evanescent - Volume 1, Issue 1

Evanescent

1 - My first 24-hour shift, Marnie Abehouse

3 - Unprepared, Daniel Bahat

5 - #1, Douglas Gouchoe

7 - Harrowing Halloween, Nick Siena

11 - Where do we go from here?, Robert Wilson

15 - Lucky, Marina Heskel

50th Anniversary: Leading The Way In Rehabilitation Medicine (1969-2019), Carol Abbott

Department of Rehabilitation Medicine Posters

No abstract provided.

Structural Basis For The Homotypic Fusion Of Chlamydial Inclusions By The Snare-Like Protein Inca., Gino Cingolani, Michael Mccauley, Anna Lobley, Alexander J Bryer, Jordan Wesolowski, Deanna L Greco, Ravi K Lokareddy, Erik Ronzone, Juan R Perilla, Fabienne Paumet

Department of Biochemistry and Molecular Biology Faculty Papers

Many intracellular bacteria, including Chlamydia, establish a parasitic membrane-bound organelle inside the host cell that is essential for the bacteria's survival. Chlamydia trachomatis forms inclusions that are decorated with poorly characterized membrane proteins known as Incs. The prototypical Inc, called IncA, enhances Chlamydia pathogenicity by promoting the homotypic fusion of inclusions and shares structural and functional similarity to eukaryotic SNAREs. Here, we present the atomic structure of the cytoplasmic domain of IncA, which reveals a non-canonical four-helix bundle. Structure-based mutagenesis, molecular dynamics simulation, and functional cellular assays identify an intramolecular clamp that is essential for IncA-mediated homotypic membrane fusion during …

Single-Cell Gene Expression Analysis Identifies Chronic Alcohol-Mediated Shift In Hepatocyte Molecular States After Partial Hepatectomy., Sirisha Achanta, Aalap Verma, Ankita Srivastava, Harshavardhan Nilakantan, Jan B. Hoek, Rajanikanth Vadigepalli

Department of Pathology, Anatomy, and Cell Biology Faculty Papers

The analysis of molecular states of individual cells, as defined by their mRNA expression profiles and protein composition, has gained widespread interest in studying biological phenomena ranging from embryonic development to homeostatic tissue function and genesis and evolution of cancers. Although the molecular content of individual cells in a tissue can vary widely, their molecular states tend to be constrained within a transcriptional landscape partly described by the canonical archetypes of a population of cells. In this study, we sought to characterize the effects of an acute (partial hepatectomy) and chronic (alcohol consumption) perturbation on the molecular states of individual …

Innovator - Spring 2019

Innovator

8 - A MESSAGE FROM THE PRESIDENT

10 - WHAT’S HAPPENING AT JEFFERSON?

16 - OUR STRATEGIC ACADEMIC FRAMEWORK Jefferson is dedicated to improving lives by redefining humanly possible.

18 - THE BOY FROM BROOKLYN Noted alumnus Harold Ronson leaves his mark on Jefferson.

24 - WE DESIGN THINKING The University has developed a world-class reputation for graduating designers with a demonstrated capacity for developing robust solutions for real-world problems.

30 - UNLEASHING CREATIVITY Provost Mark L. Tykocinski, MD, describes the exciting and productive intersections explored at Jefferson.

32 - AN EVOLUTION ROOTED IN EMPATHY Two industry experts and educators …

Inside Out, Spring 2018

Inside Out

Contents:

Untitled, Jane Jacob - Cover

Guy, Tariro Mupaso - Inside Cover

IM Rounds, Michelle Chen - 1

Histology of the Cerebellum at the Level of the Medulla, Caroline Dunne - 3

Summer Fruit, Kanika Ramchandan 2

Serenity, Chen Zhou - 4

Stage IV, Jordyn Tumas - 5

Pitting Anitha, Ahmed - 6

The Other Hand, Sophia Dang - 6

Dust, Victoria Stevenson - 7

Conflagration, Anitha Ahmed - 8

Sweet Shop - Tangail, Bangladesh, Micaela Langille Collins - 8

Newborn Exam, Jordyn Tumas - 9

The Descent, Jeffrey Lee …

Download Entire Issue: Gibbon Surgical Review, Volume 2, Issue 1, 2019

Gibbon Surgical Review

Table of Contents

4 - The Gibbon Surgical Externship: A Student’s Perspective

6 - Invited Article: The PCOM Wisely Surgical Association and the Philadelphia Surgery Conference

8 - Interview With Thomas Jefferson Cardiothoracic Surgeon, H. Todd Massey, MD

12 - The Life of a Rwandan Surgical Resident

14 - Role Of Technological Advancement In The Context Of Surgical Planning And Execution: Perspective Of Jefferson Surgical Faculty

16 - Interview with William B. Hughes, MD, Director of the Thomas Jefferson University Hospital Burn Center

19 - Women in Surgery: An Interview with Dr. Karen Chojnacki, Vice Chair of Surgical Education at …

Utilizing Livers From Donors Older Than 65: A Single Center Experience, Krishnaraj Mahendraraj, Jorge H. Castro, Sean Devitt, Chad Gorn, Cataldo Doria, Adam Frank, Warren Maley, Carlo G. Ramirez

Adam M. Franks, MD

Conclusions:

Use of liver grafts from older donors presents similar survival outcomes as grafts from younger donor age. Therefore, it offers a viable option to expand the donor pool and increase number of OLTs.

However, there is higher incidence of retransplantation due to primary graft non-function, and longer hospital length of stay observed in the older donor age group.

Further studies using larger patient populations are needed to validate our results.

Racial Disparities In Head And Neck Cancers In An Urban Hospital, Jessica Kraus-Lavy, Charnita Zeigler-Johnson, Scott W Keith, Frances Guiles, David Cognetti, Voichita Bar-Ad, Rita S. Axelrod, Md

Phase 1

Introduction: Head and neck cancer incidence rates are higher for white residents in Philadelphia, while related mortality rates are highest for black residents. It is unclear how risk factors like HPV and smoking contribute to these disparities. The goal of this study is to determine which factors are associated with head and neck cancers in a diverse patient population from a Philadelphia hospital.

Methods: Cancer registry data from Thomas Jefferson University was used to obtain records from 922 head and neck cancer patients. One patient of other race was excluded. Twenty in-situ cancer cases were excluded. Chi-square tests were used …