Medicine and Health Sciences Commons^™

The Use Of Omega-3 Concentrate To Relieve Coxofemoral Osteoarthritic Pain In Dogs, Amornrate Sastravaha, Nirut Suwanna, Chayakrit Sinthusingha, Jatuporn Noosud, Em-On Olanratmanee, Atthaporn Roongsitthichai

The Thai Journal of Veterinary Medicine

The current study aimed to assess the effect of using omega-3 concentrate to relieve coxofemoral osteoarthritic pain in dogs. In total, ten dogs with coxofemoral OA were orthopedically evaluated at the coxofemoral joints in order to grade the pain severity. Pain scores were assessed from lameness at walk and trot (1-6), pain on manipulation (1-3), and range of motion (1-4). All dogs orally received omega-3 concentrate (Omacor®, Banner Pharmacaps Europe BV, the Netherlands) for successively four weeks. During the study, they were evaluated for pain scores on a weekly basis. The results revealed that mean body weight of the patients …

Genestation 1.0: A Synthetic Resource Of Diverse Evolutionary And Functional Genomic Data For Studying The Evolution Of Pregnancy-Associated Tissues And Phenotypes, Mara Kim, Brian A. Cooper, Rohit Venkat, Julie B. Phillips, Haley R. Eidem, Jibril Hirbo, Sashank Nutakki, Scott M. Williams, Louis J. Muglia, J. Anthony Capra, Kenneth Petren, Patrick Abbot, Antonis Rokas, Kriston L. Mcgary

Dartmouth Scholarship

Mammalian gestation and pregnancy are fast evolving processes that involve the interaction of the fetal, maternal and paternal genomes. Version 1.0 of the GEneSTATION database (http://genestation.org) integrates diverse types of omics data across mammals to advance understanding of the genetic basis of gestation and pregnancy-associated phenotypes and to accelerate the translation of discoveries from model organisms to humans. GEneSTATION is built using tools from the Generic Model Organism Database project, including the biology-aware database CHADO, new tools for rapid data integration, and algorithms that streamline synthesis and user access. GEneSTATION contains curated life history information on pregnancy and …

Comparison Of Systolic Blood Pressure Between Normal And Asymptomatic Degenerative Mitral Valve Diseased In Small Breed Dogs, Sirilak Disatian Surachetpong, Kamonwan Pradit, Panyarat Chongsawat, Salinrat Titada, Sasita Suwantarat

The Thai Journal of Veterinary Medicine

Degenerative mitral valve disease (DMVD) is the major cause of mitral valve regurgitation and heart failure in dogs. The regurgitation of mitral valve may affect blood pressure without clinical presentation. The aims of this study were to compare the systolic blood pressure between normal dogs and dogs affected with asymptomatic DMVD (class B ACVIM classification) and to determine the relationship between echocardiographic values and blood pressure levels. The systolic blood pressure of small breed dogs, weighing less than 10 kilogram, that were normal (n=22) and newly diagnosed with DMVD (n=21) was measured. The average of systolic blood pressure determined by …

Efficacy Of Scalp Electroencephalography (Eeg) As A Supportive Diagnostic Tool In Canine Epilepsy Using Dexmedetomidine, Pichayaporn Soison, Waraporn Aumarm, Bordin Tiraphut, Chalermpol Lekcharoensuk, Apasri Lusawat, Kanjana Unnwongse, Khwanrat Wangphonphatthanasiri, Ubol Paramee

The Thai Journal of Veterinary Medicine

The objectives of the present study were to evaluate the electroencephalography (EEG) patterns between healthy and epileptic dogs, to analyze the diagnostic value of scalp EEG for canine epilepsy under sedation with dexmedetomidine and to provide canine standard protocol. EEG of 29 epileptic dogs and 17 control dogs was recorded. Normal patterns, interictal epileptiform, and non-epileptiform abnormalities were interpreted using visual analysis by board-certified epileptologists. Results revealed that 34% of the dogs with epilepsy did not show discernible abnormalities on their EEG recordings. Approximately 38% of the epileptic dogs presented interictal epileptiform discharges, 28% had only non-epileptiform discharges, and 24% …

Free-Roaming Dogs In Developing Countries: The Benefits Of Capture, Neuter, And Return Programs, Jennifer Jackman, Andrew N. Rowan

Jennifer Jackman, Ph.D.

This chapter provides an overview of animal welfare and public health problems associated with free-roaming dog populations and strategies to resolve these problems. Placing CNR programs in the context of earlier dog and rabies control methods, the chapter explores CNR’s potential to overcome some of the shortcomings of earlier approaches and to improve animal welfare, reduce dog population growth, and prevent the spread of rabies and other canine-transmitted diseases. Constraints and current debates on current implementation of CNR programs are also examined.

Alternating Magnetic Field-Induced Hyperthermia Increases Iron Oxide Nanoparticle Cell Association/Uptake And Flux In Blood-Brain Barrier Models, Mo Dan, Younsoo Bae, Thomas A. Pittman, Robert A. Yokel

Pharmaceutical Sciences Faculty Publications

PURPOSE: Superparamagnetic iron oxide nanoparticles (IONPs) are being investigated for brain cancer therapy because alternating magnetic field (AMF) activates them to produce hyperthermia. For central nervous system applications, brain entry of diagnostic and therapeutic agents is usually essential. We hypothesized that AMF-induced hyperthermia significantly increases IONP blood-brain barrier (BBB) association/uptake and flux.

METHODS: Cross-linked nanoassemblies loaded with IONPs (CNA-IONPs) and conventional citrate-coated IONPs (citrate-IONPs) were synthesized and characterized in house. CNA-IONP and citrate-IONP BBB cell association/uptake and flux were studied using two BBB Transwell^® models (bEnd.3 and MDCKII cells) after conventional and AMF-induced hyperthermia exposure.

RESULTS: …

The Accuracy Of The Patellar Reflex For Localization Of The Site Of A Single Level Thoracolumbar Disc Herniation In Dogs, Mohammed Abdelhakiem, Yuuhi Asai, Hiroaki Kamishina, Masaaki Katayama, Yuji Uzuka

Turkish Journal of Veterinary & Animal Sciences

The patellar reflex was used in this study to determine the site of thoracolumbar spinal cord dysfunction (T3-L3 or L4-L6) as a result of disc herniation. The results of neurological examinations were compared with the findings of CT myelography. This study was conducted on 21 dogs, selected from a total of 26 dogs confirmed to have a single thoracolumbar lesion. Results revealed that the accuracy of the patellar reflex for lesion localization was 71.4%. The accuracy of the patellar reflex (normal or hyperreflexic) for lesion localization in the T3-L3 segment in 15 dogs was 100%, while the accuracy of the …