Medicine and Health Sciences Commons^™

Anxiety And Depression In Patients With Advanced Macular Degeneration: Current Perspectives., Verena R Cimarolli, Robin J Casten, Barry W. Rovner, Vera Heyl, Silvia Sörensen, Amy Horowitz

Department of Medicine Faculty Papers

Age-related macular degeneration (AMD) - despite advances in prevention and medical treatment options - remains prevalent among older adults, often resulting in functional losses that negatively affect the mental health of older adults. In particular, the prevalence of both anxiety and depression in patients with AMD is high. Along with medical treatment options, low vision rehabilitation and AMD-specific behavioral and self-management programs have been developed and have demonstrated effectiveness in improving the mental health of AMD patients. This article reviews the prevalence of anxiety and depression in patients with advanced AMD, discusses potential mechanisms accounting for the development of depression …

Gliopathy Of Demyelinating And Non-Demyelinating Strains Of Mouse Hepatitis Virus., Lawrence C. Kenyon, Kaushiki Biswas, Kenneth S Shindler, Manasi Nabar, Marjorie Stout, Susan T Hingley, Judith B Grinspan, Jayasri Das Sarma

Department of Pathology, Anatomy, and Cell Biology Faculty Papers

Demyelination in the central nervous system induced by neurovirulent strains of Mouse Hepatitis Virus (MHV) is mediated by the viral spike glycoprotein, but it is not clear whether the mechanism of this disease pathology involves direct viral infection of oligodendrocytes. Detailed studies of glial cell tropism of MHV are presented, demonstrating that direct MHV infection of oligodendrocytes differs between demyelinating (RSA59) and non-demyelinating (RSMHV2) viral strains both in vitro and in vivo. Our results indicate that direct injury of mature oligodendrocytes is an important mechanism of virus-induced demyelination. In vivo, RSA59 infection was identified in spinal cord gray and white …

Dysregulation Of The Haem-Haemopexin Axis Is Associated With Severe Malaria In A Case-Control Study Of Ugandan Children., Robyn E Elphinstone, Frank Riley, Tian Lin, Sarah Higgins, Aggrey Dhabangi, Charles Musoke, Christine Cserti-Gazdewich, Raymond F. Regan, H Shaw Warren, Kevin C Kain

Department of Medicine Faculty Papers

BACKGROUND: Malaria is associated with haemolysis and the release of plasma haem. Plasma haem can cause endothelial injury and organ dysfunction, and is normally scavenged by haemopexin to limit toxicity. It was hypothesized that dysregulation of the haem-haemopexin pathway contributes to severe and fatal malaria infections.

METHODS: Plasma levels of haemin (oxidized haem), haemopexin, haptoglobin, and haemoglobin were quantified in a case-control study of Ugandan children with Plasmodium falciparum malaria. Levels at presentation were compared in children with uncomplicated malaria (UM; n = 29), severe malarial anaemia (SMA; n = 27) or cerebral malaria (CM; n = 31), and evaluated …

Download Entire Issue- Jefferson Interprofessional Education And Care Newsletter, Fall 2015, Volume 6, Issue 2

Collaborative Healthcare: Interprofessional Practice, Education and Evaluation (JCIPE)

Download entire issue- Jefferson Interprofessional Education and Care Newsletter, Fall 2015, Volume 6, Issue 2

An Online Approach To Interprofessional Education, E. Adel Herge, Otd, Otr/L, Faota, Amber E. King, Pharmd, Bcps

Collaborative Healthcare: Interprofessional Practice, Education and Evaluation (JCIPE)

Despite increasing interest in providing interprofessional education (IPE) opportunities for health profession students, the logistics of scheduling and integrating diverse curriculums remain challenging. Several models to address these potential barriers have been proposed and utilized (Blue et al, 2010). Faculty from three colleges within Thomas Jefferson University developed an asynchronous online interprofessional course as one solution to overcome logistical barriers to IPE.

Interprofessional Grand Rounds is offered to third year pharmacy students and second year occupational therapy (OT) students in the fall semester. The course utilizes a variety of learning activities to evaluate the influence of current public health and …

Examining Health Mentors’ Perceptions Of Student Teamwork, Deirdre Yarosh, Bs, Ma, Pharmd Student, Elena M. Umland, Pharmd

Collaborative Healthcare: Interprofessional Practice, Education and Evaluation (JCIPE)

Statement of Issue:

With the increasing emphasis on interprofessional teamwork in healthcare, the need to train future health care professionals to work together as a functional team to provide patient-centered care is clear. Limited information exists regarding education of health care students and teamwork training.1,2 This research evaluates student team performance.

Background:

Thomas Jefferson University (TJU) offers a unique, two-year program emphasizing delivery of patient-centered care and providing valuable skill development by pairing interprofessional student teams with a Health Mentor (HM). The HM is an adult community volunteer with one or more chronic health condition(s). Student teams include representatives from …

In Addition To Checking Out A Book, You Can Check Out Your Health Too: A New Partnership Between Jefferson College Of Nursing And The Philadelphia Free Public Library, Kathryn Shaffer, Edd, Rn, Msn, Cne

Collaborative Healthcare: Interprofessional Practice, Education and Evaluation (JCIPE)

At Jefferson Health is all we do, but at Jefferson College of Nursing (JCN), Health is H.E.R.E (humanistic, evidenced-based, reflective, excellence in clinical leaders). With a redesign of the undergraduate nursing curriculum, Jefferson College of Nursing (JCN) has transformed the way nurses of the 22nd century will practice, with a focus on caring for patients in all areas of the care continuum. The newly designed curriculum centers around four themes that are threaded throughout, Innovation, Practice Excellence, Interprofessional Collaboration, and Population Health. JCN believes that patients are partners in their health and that care is a collaborative effort.

To model …

From The Editors, Elizabeth Speakman, Edd, Rn, Anef, Fnap, Christine Arenson, Md, Lauren Collins, Md, Shoshana Sicks, Edm

Collaborative Healthcare: Interprofessional Practice, Education and Evaluation (JCIPE)

This fall has seen a flurry of activity at the Jefferson Center for InterProfessional Education (JCIPE). In September, Lauren Collins, MD, Associate Director of JCIPE, was selected as one of five recipients of the prestigious Macy Faculty Scholars (MFS) program, a two-year career development award supported by the Josiah Macy Jr. Foundation. She now joins a national network of other MFS recipients in helping to re-envision training of health professions students and delivery of collaborative care. Elizabeth Speakman, EdD, RN, ANEF, FNAP, JCIPE Co-Director, completed her three-year Robert Wood Johnson Executive Nurse Fellowship and was recently selected to attend the …

Latest Jcph Capstones In The Jdc, Daniel G. Kipnis, Msi

Jefferson Digital Commons News

A new batch of capstone presentations from the Jefferson College of Population Health have been loaded in the Jefferson Digital Commons.

Aileen Ishuin Macmillan, Aileen Ishuin Macmillan, Kelsey Duinkerken

Jefferson Nursing Oral Histories

Aileen Ishuin MacMillan did not grow up wanting to be a nurse, but after two years of college in Montclair not knowing what she wanted to do, Ms. MacMillan decided by chance to pursue nursing at Jefferson. After graduating in 1976 from the Diploma program she took a job as a nurse in the maternity ward of Thomas Jefferson University Hospital. During her forty year career at Jefferson Ms. MacMillan also completed her BSN at Gwynedd Mercy University. She remains very involved in Jefferson Nursing, serving on both the Jefferson Nursing College Alumni Board and, as president, on the Diploma …

Factors Associated With Tonic-Clonic Seizures In Patients With Drug-Resistant Mesial Temporal Epilepsy., Ali Akbar Asadi-Pooya, Cyrus Rostami, Amin H. Rabiei, Michael R. Sperling

Department of Neurology Faculty Papers

PURPOSE: Among different seizure types, tonic-clonic seizures are more significant because they are more often associated with morbidity. No prior study has been done to investigate risk factors associated with tonic-clonic seizures in patients with mesial temporal epilepsy.

METHODS: In this retrospective study, all drug-resistant mesial temporal epilepsy patients in the database of patients who underwent epilepsy surgery at Jefferson comprehensive epilepsy center were recruited. These patients were prospectively registered in a database from 1986 till 2014. Patients' age, gender, epilepsy risk factors, age at seizure onset, and preoperative seizure type(s) were registered routinely. Potential risk factors associated with experiencing …

Karen Jordan, Karen Jordan, Kelsey Duinkerken

Jefferson Nursing Oral Histories

Born and raised in Philadelphia, Karen Jordan was a member of the civil rights movement in Philadelphia during the 1960s, first becoming involved with the fight to desegregate Girard College. After a semester at Cheyney University Ms. Jordan took time away from school before deciding to study nursing. She enrolled in the Jefferson Diploma Nursing program in 1973 and graduated in 1976. She would later go on to also receive her Bachelor’s in Nursing Science, also from Thomas Jefferson University. Ms. Jordan has spent her long career at Jefferson working as a medical-surgical, oncology, and neonatal nurse. In her free …

Cyclin D1 Silencing Suppresses Tumorigenicity, Impairs Dna Double Strand Break Repair And Thus Radiosensitizes Androgenindependent Prostate Cancer Cells To Dna Damage., F Marampon, G L Gravina, Xiaoming Ju, A Vetuschi, R Sferra, Mathew C Casimiro, S Pompili, C Festuccia, A Colapietro, E Gaudio, E Di Cesare, V Tombolini, Richard Pestell

Department of Cancer Biology Faculty Papers

Patients with hormone-resistant prostate cancer (PCa) have higher biochemical failure rates following radiation therapy (RT). Cyclin D1 deregulated expression in PCa is associated with a more aggressive disease: however its role in radioresistance has not been determined. Cyclin D1 levels in the androgen-independent PC3 and 22Rv1 PCa cells were stably inhibited by infecting with cyclin D1-shRNA. Tumorigenicity and radiosensitivity were investigated using in vitro and in vivo experimental assays. Cyclin D1 silencing interfered with PCa oncogenic phenotype by inducing growth arrest in the G1 phase of cell cycle and reducing soft agar colony formation, migration, invasion in vitro and tumor …

Progtar: A Database Of Prognostically Inversely Correlated Mirnas And Genes (Pics) In Multiple Cancers, Chirayu Pankaj Goswami

Department of Pathology, Anatomy, and Cell Biology Posters

ABSTRACT

PROGTar is a database of Prognostically Inversely Correlated miRNA-mRNA pairs (PIC’s) in 23 cancer types. Partner miRNA and mRNA in a PIC show inverse correlation of expression and opposite hazards. We analyzed miRNA and mRNA expression data downloaded from The Cancer Genome Atlas (TCGA) in a 3 step approach to identify PICs in different cancer types. In first step we performed correlation analysis between miRNAs and mRNAs for each cancer type. This was followed by performing hazard analysis separately for miRNAs and mRNAs using expression data and survival related clinical variables. In the third step we merged the correlation …

Isosorbide Mononitrate In Heart Failure With Preserved Ejection Fraction., Margaret M. Redfield, Kevin J. Anstrom, James A. Levine, Gabe A. Koepp, Barry A. Borlaug, Horng H. Chen, Martin M. Lewinter, Susan M. Joseph, Sanjiv J. Shah, Marc J. Semigran, G. Michael Felker, Robert T. Cole, Gordon R. Reeves, Ryan J. Tedford, W.H. Wilson Tang, Steven E. Mcnulty, Eric J. Velazquez, Monica R Shah, Eugene Braunwald

Division of Cardiology Faculty Papers

BACKGROUND: Nitrates are commonly prescribed to enhance activity tolerance in patients with heart failure and a preserved ejection fraction. We compared the effect of isosorbide mononitrate or placebo on daily activity in such patients.

METHODS: In this multicenter, double-blind, crossover study, 110 patients with heart failure and a preserved ejection fraction were randomly assigned to a 6-week dose-escalation regimen of isosorbide mononitrate (from 30 mg to 60 mg to 120 mg once daily) or placebo, with subsequent crossover to the other group for 6 weeks. The primary end point was the daily activity level, quantified as the average daily accelerometer …

New Podcast From Radiation Oncology, Daniel G. Kipnis, Msi

Jefferson Digital Commons News

The Department of Radiation Oncology’s first podcast, FAQ: Special focus on the Radiation Oncology Residency Program at Thomas Jefferson University, features a discussion of what separates Jefferson from other residency program and answers commonly asked questions. The podcast is now archived in the Jefferson Digital Commons.

Igf-I Induces Upregulation Of Ddr1 Collagen Receptor In Breast Cancer Cells By Suppressing Mir-199a-5p Through The Pi3k/Akt Pathway., Roberta Matà, Chiara Palladino, Maria Luisa Nicolosi, Anna Rita Lo Presti, Roberta Malaguarnera, Marco Ragusa, Daniela Sciortino, Andrea Morrione, Marcello Maggiolini, Veronica Vella, Antonino Belfiore

Kimmel Cancer Center Faculty Papers

Discoidin Domain Receptor 1 (DDR1) is a collagen receptor tyrosine-kinase that contributes to epithelial-to-mesenchymal transition and enhances cancer progression. Our previous data indicate that, in breast cancer cells, DDR1 interacts with IGF-1R and positively modulates IGF-1R expression and biological responses, suggesting that the DDR1-IGF-IR cross-talk may play an important role in cancer.In this study, we set out to evaluate whether IGF-I stimulation may affect DDR1 expression. Indeed, in breast cancer cells (MCF-7 and MDA-MB-231) IGF-I induced significant increase of DDR1 protein expression, in a time and dose dependent manner. However, we did not observe parallel changes in DDR1 mRNA. DDR1 …

Comprehensive Profiling Of Metaplastic Breast Carcinoma Reveals Frequent Over-Expression Of Pd-L1, Zoran Gatalica, Upasana Joneja, Md, Anatole Ghazalpour, Jeffrey Swensen, Rebecca Feldman, Fred Cai, Sting Chen, Nick Xiao, Sandeep Reddy, Semir Vranić

Department of Pathology, Anatomy, and Cell Biology Resident's Posters

Background:

Metaplastic breast carcinoma (MBC) is a rare subtype of breast carcinoma less responsive to conventional chemotherapy relative to usual breast carcinomas such as ductal and lobular subtype. In molecular terms, MBC usually clusters with triple negative breast cancers (TNBC), but MBCs portray a worse prognosis in comparison with TNBC. Published studies investigating MBCs for specific biomarkers of therapy response are rare and limited by the methodological approaches.

Methods:

297 samples [MBC (n=75), triple-negative breast cancer of no-special-type (TNBC-NOS, n=106), HER2-positive breast cancers (n=32) and luminal breast cancers (n=84)] were profiled using direct sequencing analysis [Illumina MiSeq Next Generation Sequencing …

Physician Executive Leadership: Student-Led Curriculum To Fill Gaps In Traditional Medical Education, Anuj Shah, Ronuk Modi, Jessica Downing, Angela Ugorets, Kathryn Linder, Michael Jacobs, Graham Hale, Jeffrey Fitch, Nicholas Kurtzman, Paul Rosen, Md

Physician Executive Leadership

Students at Sidney Kimmel Medical College (SKMC) have identified a gap in the traditional medical curriculum surrounding topics such as telehealth, the patient experience, health policy, medical malpractice, and health care entrepreneurship and innovation, and in response have initiated a student-centered, student-led, student-driven program called Physician Executive Leadership (PEL). PEL provides students with a variety of avenues to engage with these topics, such as lectures from leaders in each of these fields, easy access to weekly news articles on current events in health care, targeted review sessions on the US health care system, and the opportunity to voice and develop …

Metabolic Patterns In Cancer Cells And Tumor Micro-Environment In Diffuse Large B¬Cell Lymphoma: Tumor–Stromal Metabolic Coupling, Mahasweta Gooptu, Md, Alina E. Dulau Florea, Md, Benjamin E. Leiby, Phd, Barbara Pro, Md, John David Sprandio, Jr. Md, Diana Whitaker-Menezes, Phd, Paolo Cotzia, Md, Guldeep Uppal, Md, Jaime Caro, Md, Jerald Z. Gong, Md, Ubaldo E. Martinez-Outshoorn, Md

Department of Medical Oncology Posters

It has previously been suggested that the tumor microenvironment in diffuse large B-cell lymphoma (DLBCL) has prognostic significance. Furthermore, gene expression profiling in DLBCL patients has identified separate subsets with glycolytic and mitochondrial (oxidative phosphorylative) metabolic signatures.

Glycolytic metabolism forms the basis for FDG PET scans, widely used in staging and response assessment in DLBCL. While many assume that the tumor as a whole is primarily glycolytic, the metabolic patterns of cancer cells (C) and surrounding cancer-associated stromal cells (CAS) remain relatively unknown. We investigated the in situ metabolic patterns of C and CAS cells as well as tumor-associated macrophages …

Functional Integrity Of Resting-State Networks Predicts Seizure Outcome After Anterior Temporal Lobectomy, Gaelle Doucet, Xiaosong He, Michael R. Sperling, Ashwini Sharan Md, Joseph I. Tracy

Department of Neurosurgery Posters

Rationale

Predicting seizure outcome (SO) after anterior temporal lobectomy (ATL) is a major clinical goal. With clear evidence that even focal epilepsies disrupt large scale brain networks, resting-state functional connectivity (FC) methods have been increasingly used on a pre-surgical basis to characterize the impact of seizures on brain activity. In this project, we sought to determine whether the functional integrity of resting-state networks (RSNs) prior to surgery can discriminate between patients who obtain good versus poor seizure control after ATL.

Daptomycin Non-Susceptible Mrsa Bacteremia: A Case Report, Jaclyn Cusumano, Pharmd, Anna Marie Morlino, Pharmd, Andrew Moyer, Pharmd

College of Pharmacy Posters

Background

Staphylococcus aureus^{1, 2, 3}

• One of the most common pathogens causing community-acquired and nosocomial infections
• Has rapidly developed resistance to many antibiotics:

Daptomycin ²

• Bactericidal cyclic lipopeptide antibiotic
• Possesses negative charge which attracts calcium to form cationic complex
• Interacts with negatively charged phospholipid heads on bacterial cell membranes, leading to membrane depolarization and cell death

Daptomycin non-susceptible (DNS) S. aureus ^{2, 4, 5}

• Extremely rare - About 60 clinical cases reported
• Defined by an MIC greater than 1 mcg/mL
• Potential mechanisms include:

– Changes in cell membrane and cell wall structure alter daptomycin’s permeability²

• Overexpression and dysregulation …

Mary Woltemate Stec, Mary Woltemate Stec, Kelsey Duinkerken

Jefferson Nursing Oral Histories

Dr. Stec began her nursing career in 1973 as a graduate of Jefferson’s Nursing Diploma School. She would go on to receive her BS in Nursing from the University of Pennsylvania, her MSN from Gwynedd Mercy College, and her PhD in Nursing from Widener University. Dr. Stec has spent the majority of her career as a nursing educator, including as an instructor at Thomas Jefferson University Hospital School of Nursing, Gwynedd Mercy College, and Abington Memorial Hospital Dixon School of Nursing. She is now an Assistant Professor at Temple University. She is also a Certified Nurse Educator, an Evaluator for …

Katherine Kingsley Kinsey, Katherine Kingsley Kinsey, Kelsey Duinkerken

Jefferson Nursing Oral Histories

Dr. Kinsey received her nursing diploma from the Jefferson Hospital School of Nursing in 1963 and later a BS in Education and School Health from Millersville University. She also has a BS in Nursing, Magna Cum Laude, a MS in Nursing in Community Health, and a PhD in Education, all from the University of Pennsylvania. She currently serves as the Nurse Administrator and Principal Investigator for the Philadelphia Nurse-Family Partnership (NFP), the Mabel Morris Family Home Visit Program (MM), and other early childhood initiatives. Previously, Dr. Kinsey was a tenured professor at La Salle University School of Nursing where she …

Bepress Notes Jdc Feedback Feature, Daniel G. Kipnis, Msi

Jefferson Digital Commons News

In October we posted What People are Saying About the JDC to highlight the new Jefferson Digital Commons feedback feature (how to submit it and how to view what others have said).

Dr. John H. Gibbon, Jr. And Jefferson's Heart-Lung Machine: Commemoration Of The World's First Successful Bypass Surgery, F. Michael Angelo

Posters: Jefferson History

On May 6, 1953 at Jefferson Medical College Hospital, Dr. John Heysham Gibbon, Jr., his staff, and with the help of his latest-designed heart-lung machine, “Model II,” closed a very serious septal defect between the upper chambers of the heart of eighteen-year-old Cecelia Bavolek. This was the first successful intercardiac surgery of its kind performed on a human patient. Ms. Bavolek was connected to the device for three-quarters of an hour and for 26 crucial minutes, the patient totally depended upon the machine’s artificial cardiac and respiratory functions. “Jack” Gibbon did not follow this epoch-making event by holding an international …

African American Graduates Of Jefferson Medical College: The First Hundred Years, F. Michael Angelo

Posters: Jefferson History

Beginnings…

The story of early African American physicians begins in 18th century Philadelphia with James Derham who is recognized as the first black allopathic (regular, non-sectarian) medical doctor. The first medical school in the U.S. to admit an African American was Rush Medical College in Chicago that awarded, in 1847, David J. Peck his degree. Dr. Peck came to the “Quaker City” to set up his practice the same year that the A.M.A. was formed, also here in Philadelphia. In 1877, Jefferson doctors protested the seating of the delegates from Howard University, the nation’s most important black medical school, in …

United States Medicine, Women And Jefferson Medical College, F. Michael Angelo

Posters: Jefferson History

Timeline of women at Jefferson Medical College.

Latin Heritage Month. Carlos Juan Finlay: Outrageous, Courageous And Correct, Dorothy E. Berenbrok

Posters: Jefferson History

In 1855, a modest Cuban physician named Carlos Juan Finlay graduated from Jefferson Medical College. He was among JMC’s first dozen Hispanic graduates, initially signing the registrar’s log as “Charles”. He left Philadelphia at the age of 22 to begin private practice. Preceptor and close friend S. Weir Mitchell, among others, urged Finlay to work among the burgeoning Spanishspeaking population in New York City, but he returned to Cuba and set up practice in Matanzas, a town near Havana. He took a binocular microscope with him, similar to one used byMitchell, which would serve him well for many years.

During …

Intraventricular Sialidase Administration Enhances Gm1 Ganglioside Expression And Is Partially Neuroprotective In A Mouse Model Of Parkinson's Disease., Jay S Schneider, Thomas N Seyfried, Hyo-S Choi, Sarah Kidd

Department of Pathology, Anatomy, and Cell Biology Faculty Papers

BACKGROUND: Preclinical and clinical studies have previously shown that systemic administration of GM1 ganglioside has neuroprotective and neurorestorative properties in Parkinson's disease (PD) models and in PD patients. However, the clinical development of GM1 for PD has been hampered by its animal origin (GM1 used in previous studies was extracted from bovine brains), limited bioavailability, and limited blood brain barrier penetrance following systemic administration.

OBJECTIVE: To assess an alternative therapeutic approach to systemic administration of brain-derived GM1 to enhance GM1 levels in the brain via enzymatic conversion of polysialogangliosides into GM1 and to assess the neuroprotective potential of this approach. …