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Articles 1 - 5 of 5
Full-Text Articles in Medicine and Health Sciences
Alcohol Promotes Mammary Tumor Growth Through Activation Of Vegf-Dependent Tumor Angiogenesis, Yanmin Lu, Fang Ni, Mei Xu, Jinlian Yang, Ji Chen, Zhuo Chen, Xinyi Wang, Jia Luo, Siying Wang
Alcohol Promotes Mammary Tumor Growth Through Activation Of Vegf-Dependent Tumor Angiogenesis, Yanmin Lu, Fang Ni, Mei Xu, Jinlian Yang, Ji Chen, Zhuo Chen, Xinyi Wang, Jia Luo, Siying Wang
Internal Medicine Faculty Publications
Alcohol consumption has been recognized as a risk factor for breast cancer. Experimental studies demonstrate that alcohol exposure promotes the progression of existing mammary tumors. However, the mechanisms underlying this effect remain unclear. In the present study, the role of vascular endothelial growth factor (VEGF) in alcohol promotion of breast cancer development was investigated using a mouse xenograft model of mammary tumors and a three-dimensional (3D) tumor/endothelial cell co-culture system. For the mouse xenograft model, mouse E0771 breast cancer cells were implanted into the mammary fat pad of C57BL6 mice. These mice were exposed to alcohol in their drinking water. …
Role Of The Ang-Tie2 Pathway In The Invasive Recurrence Of Gbm Following Anti-Vegf Therapy, Nahir Cortes Santiago
Role Of The Ang-Tie2 Pathway In The Invasive Recurrence Of Gbm Following Anti-Vegf Therapy, Nahir Cortes Santiago
Dissertations & Theses (Open Access)
Strong pre-clinical and clinical data supporting the effectiveness of bevacizumab, a humanized monoclonal anti-VEGF antibody, for the treatment of gliomas led to its accelerated approval for the treatment of patients with recurrent glioma. However, despite strong anti-tumor effects, upon treatment with bevacizumab, patients will invariably recur with a tumor characterized by enhanced invasiveness and resistance to therapy. This study aims to elucidate the mechanisms leading to this enhanced malignancy with the hope of uncovering new potential therapeutic targets for combined treatment. Using tissue sections from U87-derived glioma bearing mice treated with or without aflibercept (another anti-VEGF antibody) we have gathered …
Mapping The Human Vasculature By In Vivo Phage Display, Julianna Bronk
Mapping The Human Vasculature By In Vivo Phage Display, Julianna Bronk
Dissertations & Theses (Open Access)
In vivo phage display screenings by intravenous injection of a random phage-displayed peptide library allow for the selection of peptides that localize to specific vascular beds. At the University of Texas MD Anderson Cancer Center, we have had the opportunity to perform phage display screenings in cancer patients in order to select for cancer specific targets directly in humans. These targets serve to define biochemical diversity of endothelial cell surfaces and can be validated and explored towards the design of vascular-targeted pharmacology. In the most recent patient screen, samples were recovered from hepatocellular carcinoma (HCC) as well as 26 additional …
Correction: The Role Of Tumor-Associated Macrophages In Tumor Vascularization, Chunqing Guo, Annicole Buranych, Devanand Sarkar, Paul B. Fisher, Xiang-Yang Wang
Correction: The Role Of Tumor-Associated Macrophages In Tumor Vascularization, Chunqing Guo, Annicole Buranych, Devanand Sarkar, Paul B. Fisher, Xiang-Yang Wang
Human and Molecular Genetics Publications
This is a correction to a previously published article.
Optimization Of A Therapeutic Electromagnetic Field (Emf) To Retard Breast Cancer Tumor Growth And Vascularity, Ivan L. Cameron, Marko S. Markov, W. Elaine Hardman Ph.D.
Optimization Of A Therapeutic Electromagnetic Field (Emf) To Retard Breast Cancer Tumor Growth And Vascularity, Ivan L. Cameron, Marko S. Markov, W. Elaine Hardman Ph.D.
Biochemistry and Microbiology
Background: This study provided additional data on the effects of a therapeutic electromagnetic field (EMF) device on growth and vascularization of murine 16/C mammary adenocarcinoma cells implanted in C3H/HeJ mice.
Methods: The therapeutic EMF device generated a defined 120 Hz semi sine wave pulse signal of variable intensity. Murine 16/C mammary adenocarcinoma tumor fragments were implanted subcutaneously between the scapulae of syngeneic C3H mice. Once the tumor grew to 100 mm3, daily EMF treatments were started by placing the cage of mice within the EMF field. Treatment ranged from 10 to 20 milli-Tesla (mT) and was given for 3 to …