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Articles 1 - 5 of 5
Full-Text Articles in Medicine and Health Sciences
Neurovascular Unit Dysfunction With Blood-Brain Barrier Hyperpermeability Contributes To Major Depressive Disorder: A Review Of Clinical And Experimental Evidence, Souhel Najjar, Daniel M. Pearlman, Orrin Devinsky, Amanda Najjar, David Zagzag
Neurovascular Unit Dysfunction With Blood-Brain Barrier Hyperpermeability Contributes To Major Depressive Disorder: A Review Of Clinical And Experimental Evidence, Souhel Najjar, Daniel M. Pearlman, Orrin Devinsky, Amanda Najjar, David Zagzag
Dartmouth Scholarship
About one-third of people with major depressive disorder (MDD) fail at least two antidepressant drug trials at 1 year. Together with clinical and experimental evidence indicating that the pathophysiology of MDD is multifactorial, this observation underscores the importance of elucidating mechanisms beyond monoaminergic dysregulation that can contribute to the genesis and persistence of MDD. Oxidative stress and neuroinflammation are mechanistically linked to the presence of neurovascular dysfunction with blood-brain barrier (BBB) hyperpermeability in selected neurological disorders, such as stroke, epilepsy, multiple sclerosis, traumatic brain injury, and Alzheimer’s disease. In contrast to other major psychiatric disorders, MDD is frequently comorbid with …
Postgraduate Training In Neurosciences - Role Of The Specialty Societies, Junaid Ashraf
Postgraduate Training In Neurosciences - Role Of The Specialty Societies, Junaid Ashraf
Pakistan Journal of Neurological Sciences (PJNS)
No abstract provided.
Challenges Posed By Mental Disorders, Substance Abuse And Neurological Disorders: Need For A Joint Action By Psychiatrists And Neurologists, Mowadat H Rana, Haider A Naqvi
Challenges Posed By Mental Disorders, Substance Abuse And Neurological Disorders: Need For A Joint Action By Psychiatrists And Neurologists, Mowadat H Rana, Haider A Naqvi
Pakistan Journal of Neurological Sciences (PJNS)
No abstract provided.
Understanding The Anatomy Of Dystonia: Determinants Of Penetrance And Phenotype, R. P. Lerner, M. Niethammer, D. Eidelberg
Understanding The Anatomy Of Dystonia: Determinants Of Penetrance And Phenotype, R. P. Lerner, M. Niethammer, D. Eidelberg
Journal Articles
No abstract provided.
Discovery Of New Biomarkers Of Mild Cognitive Impairment And Alzheimer's Disease Risk In Buccal Cells Using Laser Scanning Cytometry, Maxime Francois
Discovery Of New Biomarkers Of Mild Cognitive Impairment And Alzheimer's Disease Risk In Buccal Cells Using Laser Scanning Cytometry, Maxime Francois
Theses: Doctorates and Masters
Previous studies have shown that mild cognitive impairment (MCI) may reflect the early stages of more pronounced neurodegenerative disorders such as Alzheimer’s disease (AD). In clinical practice, patients with AD are not usually identified until the disease has progressed to a stage when primary prevention is no longer possible. Therefore there is a need for a minimally invasive and inexpensive diagnostic to identify those who exhibit cellular pathology indicative of MCI and AD risk so that they can be prioritised for primary prevention. Human buccal cells are accessible in a minimally invasive manner, and exhibit cytological and nuclear morphologies that …