Medicine and Health Sciences Commons^™

The Relationships Between Using The Rating Of Perceived Exertion, Metabolic Equivalent And Maximum Heart Rate At Ventilatory Threshold Into Determine Appropriate Exercise Prescription For Intensity In Obese Diabetic Patients: A Preliminary Study, Yan-Wen Chen, Francois Liang, Sen-Wei Tsai, Shih-Yi Lin, I. T. Lee, Sheu-Chen Liu, Shin-Shan Lu

Rehabilitation Practice and Science

Background: The rating of perceived exertion (RPE), metabolic equivalent (MET) and maximum heart rate (HRmax) at ventilatory threshold (VT) are commonly used methods as physiological parameters for monitoring exercise intensity. However, the appropriate levels of training intensity for obese type 2 diabetic diabetes mellitus (type 2 DM) patients have not been established.Purpose: To examine the parameters in obese Type 2 DM patients at ventilatory threshold, the exercise capacity of obese Type 2 DM patients, and to determine the appropriate levels of exercise intensity for exercise prescription in obese type 2 DM patients was investigated.Methods: Twenty obese type 2 DM patients …

Regulation Of Pten Inhibition By The Pleckstrin Homology Domain Of P-Rex2 During Insulin Signaling And Glucose Homeostasis, Cindy Hodakoski, Benjamin D. Hopkins, Douglas Barrows, Sarah M. Mense, Megan Keniry, Karen E. Anderson, Philip A. Kern, Phillip T. Hawkins, Len R. Stephens, Ramon Parsons

Clinical and Translational Science Faculty Publications

Insulin activation of phosphoinositide 3-kinase (PI3K) signaling regulates glucose homeostasis through the production of phosphatidylinositol 3,4,5-trisphosphate (PIP3). The dual-specificity phosphatase and tensin homolog deleted on chromosome 10 (PTEN) blocks PI3K signaling by dephosphorylating PIP3, and is inhibited through its interaction with phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 2 (P-REX2). The mechanism of inhibition and its physiological significance are not known. Here, we report that P-REX2 interacts with PTEN via two interfaces. The pleckstrin homology (PH) domain of P-REX2 inhibits PTEN by interacting with the catalytic region of PTEN, and the inositol polyphosphate 4-phosphatase domain of P-REX2 provides high-affinity binding to the postsynaptic …

Improving An Outpatient Diabetes Program Telephone Follow-Up Process: Evaluating Its Impact On Glycosylated Hemoglobin Levels, Joan B. Niemczewski

Graduate Theses, Dissertations, and Capstones

Telephone follow-up for diabetes self-management is used to facilitate ongoing support for individuals striving to maintain a healthy lifestyle. With the use of telephone follow-up after Diabetes Self-Management Education (DSME), key concepts can be emphasized and goal reinforcement can occur. When successfully managed, improved glycemic control occurs, as evidenced by reductions in glycosylated hemoglobin (A1C) levels. A review of the literature surrounding this topic and description of a capstone scholarly project utilizing findings from the literature to create an evidence-based telephone follow-up pilot study are included. Findings from this study did not reveal statistically significant reductions in A1C levels with …

The Concomitant Relationship Shared By Sleep Disturbances And Type 2 Diabetes: Developing Telemedicine As A Viable Treatment Option, Pennie S. Seibert, Jennifer Valerio, Codieann Dehaas

Pennie S. Seibert

Individually, sleep disturbances and type 2 diabetes pose pervasive challenges to health. In addition, the negative symptomology associated with each condition is exacerbated further when presenting concomitantly. This relationship formulates a destructive loop wherein those with diabetes experience decreased sleep quality, which, in turn, worsens a wide range of health threats experienced by those with diabetes, including obesity and glucose intolerance. Because major lifestyle changes and daily care are needed to effectively manage both diabetes and sleep disturbances, an efficient and timely modality of treatment is essential. Advanced technology incorporating telemedicine and telehealth has the potential to enhance treatment by …

The Impact Of Free Health Screenings At Community Pharmacies On Diabetes, Anna M. Smith, Nicholas C. Daniels, Jessica E. Amtower, Jeniffer George, Jacques N. Allou, Jeb Ballentine, Emily M. Laswell

Pharmacy and Nursing Student Research and Evidence-Based Medicine Poster Session

Title: The Impact of Free Health Screenings at Community Pharmacies on Diabetes

Authors: Jacques Allou, Jessica Amtower, Nicholas Daniels, Jeniffer George, Anna Smith, Jeb Ballentine, Pharm.D., and Emily Laswell, Pharm.D.

Background: Health screenings can be beneficial when looking to detect diseases early on, thus making treatment easier. Free health screenings are typically performed in the community pharmacy setting. This makes it convenient because it is easily accessible and there is no appointment required. Diabetes is currently one of the most significant health issues faced today, with an estimated 7 million Americans going undiagnosed. Health screenings in community pharmacies are valuable …

Diabetes Alters Contraction-Induced Mitogen Activated Protein Kinase Activation In The Rat Soleus And Plantaris, Anjaiah Katta, Deborah L. Preston, Sunil K. Kakarla, Shinichi Asano, Sarath Meduru, Sriram P. Mupparaju, Ellie Yokochi, Kevin M. Rice, Devashish H. Desai, Eric R. Blough

Deborah L Preston

The prescription of anaerobic exercise has recently been advocated for the management of diabetes; however exercise-induced signaling in diabetic muscle remains largely unexplored. Evidence from exercise studies in nondiabetics suggests that the extracellular-signal-regulated kinases (Erk1/2), p38, and c-JUN NH2-terminal kinase (Jnk) mitogen-activated protein kinases (MAPKs) are important regulators of muscle adaptation. Here, we compare the basal and the in situ contraction-induced phosphorylation of Erk1/2- p38- and Jnk-MAPK and their downstream targets (p90rsk and MAPKAP-K2) in the plantaris and soleus muscles of normal and obese (fa/fa) Zucker rats. Compared to lean animals, the time course and magnitude of Erk1/2, p90rsk and …

Diabetes Alters Vascular Mechanotransduction: Pressure-Induced Regulation Of Mitogen Activated Protein Kinases In The Rat Inferior Vena Cava, Kevin M. Rice, Devashish H. Desai, Sunil K. Kakarla, Anjaiah Katta, Deborah L. Preston, Paulette Wehner, Eric R. Blough

Deborah L Preston

Background Diabetes mellitus is an important risk factor for increased vein graft failure after bypass surgery. However, the cellular and molecular mechanism(s) underlying vessel attrition in this population remain largely unexplored. Recent reports have suggested that the pathological remodeling of vein grafts may be mediated by mechanically-induced activation of the mitogen activated protein kinase (MAPK) signaling pathways and the MAPK-related induction of caspase-3 activity. On the basis of these findings, we hypothesized that diabetes may be associated with alterations in how veins "sense" and "respond" to altered mechanical loading. Methods Inferior venae cavae (IVC) from the non-diabetic lean (LNZ) and …

The Impact Of Free Health Screenings At Community Pharmacies On Diabetes, Anna M. Staudt, Nicholas C. Daniels, Jessica E. Amtower, Jeniffer George, Jacques N. Allou, Jeb Ballentine, Emily M. Laswell

Pharmacy Practice Faculty Presentations

Background: Health screenings can be beneficial when looking to detect diseases early on, thus making treatment easier. Free health screenings are typically performed in the community pharmacy setting. This makes it convenient because it is easily accessible and there is no appointment required. Diabetes is currently one of the most significant health issues faced today, with an estimated 7 million Americans going undiagnosed. Health screenings in community pharmacies are valuable to detect high blood glucose levels for patients to be referred for diagnosis and treatment. Previous studies related to health screenings have focused on hypertension and cholesterol, and few have …

Effect Of Functional Starch In Brown Rice And Grain Sorghum On Plasma Glucose And Insulin Responses In Humans, Nicole Marie Poquette

Graduate Theses and Dissertations

Diabetes and obesity are chronic illnesses increasing at dramatic rates in the U.S. and around the world. Research has looked to prevent or control diabetes and obesity through functional ingredients such as healthy-dietary carbohydrates to control blood glucose levels. Starch is a principle carbohydrate, which influences blood glucose levels, and measuring starch digestibility fractions can help predict the glucose response in the body. The objectives of this study were to investigate the functional starch content of parboiled brown rice flour and grain sorghum flour, and measure the effects on postprandial plasma glucose and insulin levels of 14 and 10 healthy …

Research Brief: "Peer Mentoring And Financial Incentives To Improve Glucose Control In African American Veterans", Institute For Veterans And Military Families At Syracuse University

Institute for Veterans and Military Families

This brief is about whether peer mentoring and financial incentives given to African American veterans with diabetes improves their glucose levels. In policy and practice, African American veterans should join peer mentoring programs to help them control their diabetes and consult with their physician about peer mentoring; the VHA should create a peer mentoring program for veterans with diabetes to help with diabetes management. Suggestions for future research include using a larger, more diverse sample, looking at how the peer mentoring helps veterans, and looking at the ways in which veterans lowered their glucose levels in addition to taking part …

The Concomitant Relationship Shared By Sleep Disturbances And Type 2 Diabetes: Developing Telemedicine As A Viable Treatment Option, Pennie S. Seibert, Jennifer Valerio, Codieann Dehaas

Psychological Sciences Faculty Publications and Presentations

Individually, sleep disturbances and type 2 diabetes pose pervasive challenges to health. In addition, the negative symptomology associated with each condition is exacerbated further when presenting concomitantly. This relationship formulates a destructive loop wherein those with diabetes experience decreased sleep quality, which, in turn, worsens a wide range of health threats experienced by those with diabetes, including obesity and glucose intolerance. Because major lifestyle changes and daily care are needed to effectively manage both diabetes and sleep disturbances, an efficient and timely modality of treatment is essential. Advanced technology incorporating telemedicine and telehealth has the potential to enhance treatment by …

The Relationship Between Coping Styles In Response To Unfair Treatment And Understanding Of Diabetes Self-Care, Michelle Dyke, Yendelela Cuffee, Jewell Halanych, Richard Mcmanus, Carol Curtin, Jeroan Allison

Richard H. McManus

Purpose This study examined the relationship between coping style and understanding of diabetes self-care among African American and white elders in a southern Medicare-managed care plan. Methods Participants were identified through a diabetes-related pharmacy claim or ICD-9 code and completed a computer-assisted telephone survey in 2006-2007. Understanding of diabetes self-care was assessed using the Diabetes Care Profile Understanding (DCP-U) scale. Coping styles were classified as active (talk about it/take action) or passive (keep it to yourself). Linear regression was used to estimate the associations between coping style with the DCP-U, adjusting for age, sex, education, and comorbidities. Based on the …

Preliminary Assessment Of Diabetic Youth’S Acceptance Of Cinnamon In Treating Diabetes: A Telephone Interview, Valerie Amend, Dawn Vincent, Valerie Amend, Kimberli Pike

Journal of Human Sciences and Extension

Medications in treatment and control of diabetes can be costly for pediatric patients and families. Therefore, individuals may seek complementary and alternative therapies, such as cinnamon, in addition to traditional treatments. The objective of this study was to determine acceptability of using cinnamon in treatment of diabetes in a pediatric population with diabetes. Seventy-six pediatric diabetes patients at a diabetes clinic participated in a one-time telephone interview using an 18-item, validated questionnaire. Descriptive statistics were utilized to determine cinnamon acceptability and preferences. The majority of the subjects were between 16-18 years (43%, n = 33), Caucasian (62%, n = 47), …

Dia-Beat-It: An Online Game For Children And Teenagers With Type 1 Diabetes, Emily M. Stone

Honors Theses and Capstones

No abstract provided.

Effects Of Fatty Acids And Glycation On Drug Interactions With Human Serum Albumin, Jeanethe Anguizola, Sara B. G. Basiaga, David S. Hage

David Hage Publications

The presence of elevated glucose concentrations in diabetes is a metabolic change that leads to an increase in the amount of non-enzymatic glycation that occurs for serum proteins. One protein that is affected by this process is the main serum protein, human serum albumin (HSA), which is also an important carrier agent for many drugs and fatty acids in the circulatory system. Sulfonylurea drugs, used to treat type 2 diabetes, are known to have significant binding to HSA. This study employed ultrafiltration and high-performance affinity chromatography to examine the effects of HSA glycation on the interactions of several sulfonylurea drugs …

Health Disparity And Structural Violence: How Fear Undermines Health Among Immigrants At Risk For Diabetes, Janet Page-Reeves, Joshua D. Niforatos, Shiraz Mishra, Lidia Regino, Andrew Gingerich, Robert Bulten

Journal of Health Disparities Research and Practice

Diabetes is a national health problem, and the burden of the disease and its consequences particularly affect Hispanics. While social determinants of health models have improved our conceptualization of how certain contexts and environments influence an individual's ability to make healthy choices, a structural violence framework transcends traditional uni-dimensional analysis. Thus, a structural violence approach is capable of revealing dynamics of social practices that operate across multiple dimensions of people’s lives in ways that may not immediately appear related to health. Working with a Hispanic immigrant community in Albuquerque, New Mexico, we demonstrate how structural forces simultaneously directly inhibit access …

Vascular Stem Cells In Diabetic Complications, Emily C. Keats

Electronic Thesis and Dissertation Repository

Diabetes leads to a variety of secondary complications. At the heart of these complications lies endothelial cells (ECs) – cells that take up unregulated plasma glucose, experience various biochemical alterations, and provide the basis for whole organ vascular dysfunctions. With the purpose of generating new vascular networks for the treatment of these chronic complications, my initial work focused on vascular stem cells (VSCs). VSCs have the ability to differentiate into both endothelial (EPC) and mesenchymal (MPC) progenitor cells, both of which are necessary for the creation of stable and functional blood vessels. To establish whether these progenitor populations retain their …

Eat Nuts For Better Diabetes Management, Linda C. Tapsell, Kate M. Dehlsen, Rebecca L. Thorne, Jane E. O'Shea, Qingsheng Zhang

Qingsheng Zhang

Eating walnuts everyday may help reduce insulin levels in people with type 2 diabetes. Smart Food Centre researchers at the University of Wollongong Professor Linda Tapsell, Kate Dehlsen, Beck Thorne, Jane O'Shea and Kiefer Zhang tell you how.

Examination Of The Pediatric Diabetes Routines Questionnaire In Adolescents: Development Of An Adolescent Self-Report Version And Confirmatory Factor Analysis, Jessica Sima Pierce

Dissertations

Previous literature suggests a positive relationship between general child routines and diabetes treatment adherence. However, research examining routines specific to the diabetes regimen is lacking. Recently, the Pediatric Diabetes Routines Questionnaire (PDRQ) was developed as a parent-report measure of diabetes-specific routines for children and adolescents with type 1 diabetes. Though the PDRQ has provided a means to measure routines specific to the diabetes regimen, limitations exist in regard to its use with adolescents. Thus, the goals of this study were to develop and evaluate a parallel adolescent self-report version (PDRQ: Adolescent; PDRQ:A) of the PDRQ and to examine the psychometric …

Does Insulin Secretion In Patients With One Abnormal Glucose Tolerance Test Value Mimic Gestational Diabetes Mellitus?, Tolga Ergin, Arda Lembet, E. Duran, Esra Kuscu, Tayfun Bagis, Esra Saygili, Sertac Batioglu

Eyup Hakan Duran

OBJECTIVE: The purpose of this study was to investigate the insulin response to a 3-hour oral glucose tolerance test and to compare the insulin levels in the gestational diabetes mellitus and single abnormal test value groups with a nondiabetic control group. STUDY DESIGN: One hundred ten Turkish women with uncomplicated pregnancy participated in this prospective controlled study between 24 to 28 weeks of gestation. A 100-g 3-hour oral glucose tolerance test was given, and glucose and insulin plasma levels were assayed. The subjects were classified according to established criteria. Early-phase insulin secretion was assessed by the insulinogenic index. Total insulin …

The Obesity Epidemic, Lenka Kollar, Evienne Epifano, Molly Mckneight, Jeff Miskovich, Heather Moore

Student Papers in Public Policy

The incidence of chronic, noncommunicable diseases, such as heart disease, is increasing at an alarming rate on the global scale. The growing prevalence of overweight and obesity have led to an upsurge in cases of diabetes and other obesity-related diseases. About 18 million people die every year from heart disease, of which diabetes and obesity are major predisposing factors. Worldwide, more than 1.1 billion adults are overweight, 312 million of which are obese. The number of children that are overweight or obese is also growing (Hossain, Parvez et al.). Obesity, and the associated diseases, has become a worldwide epidemic and …

Diabetes Alters Vascular Mechanotransduction: Pressure-Induced Regulation Of Mitogen Activated Protein Kinases In The Rat Inferior Vena Cava, Kevin M. Rice, Devashish H. Desai, Sunil K. Kakarla, Anjaiah Katta, Deborah L. Preston, Paulette Wehner, Eric R. Blough

Kevin M Rice

Background Diabetes mellitus is an important risk factor for increased vein graft failure after bypass surgery. However, the cellular and molecular mechanism(s) underlying vessel attrition in this population remain largely unexplored. Recent reports have suggested that the pathological remodeling of vein grafts may be mediated by mechanically-induced activation of the mitogen activated protein kinase (MAPK) signaling pathways and the MAPK-related induction of caspase-3 activity. On the basis of these findings, we hypothesized that diabetes may be associated with alterations in how veins "sense" and "respond" to altered mechanical loading. Methods Inferior venae cavae (IVC) from the non-diabetic lean (LNZ) and …

Diabetic Db/Db Mice Exhibit Central Nervous System And Peripheral Molecular Alterations As Seen In Neurological Disorders., A. Ernst, Ajaykumar Narayan Sharma, Khalid M. Elased, P. C. Guest, H. Rahmoune, S. Bahn

Pharmacology and Toxicology Faculty Publications

The db/db mouse is a widely used preclinical model in diabetes research. Recent studies have shown that these mice also display aspects of psychosis and depression-like behaviors as seen in some psychiatric disorders. Here, we have performed multiplex immunoassay and liquid chromatography mass spectrometry profiling of the plasma and brain samples from db/db and control mice to identify altered pathways, which could be related to these behavioral abnormalities. This is the first study to carry out profiling of the brain proteome in this model. Plasma from the db/db mice had increased levels of leptin and insulin, decreased levels of peptide …

Effects Of Short Term High Fat Diet On Obesity And Perivascular Adipose Structure And Function In Mice : Role Of Aldose Reductase, And Aldehyde Metabolizing Enzyme., Daniel Alan Murphy

College of Arts & Sciences Senior Honors Theses

This study was undertaken to determine the effects of high fat diet and aldose reductase deficiency on the structure and function of murine perivascular adipose tissue. Wild type (WT) (C57 bl/6) and aldose reductase knockout (AR-null) mice were aged to 8 or 18 weeks on a normal chow diet then some were switched to a high fat diet for 4 weeks while others remained on the control diet for the same amount of time. Following 4 weeks, mice were euthanized PVAT was analyzed. High fat feeding significantly increased body fat percentage in both age groups of mice and the area …

Effectiveness Of Community Health Workers (Chws) In Coordinating Diabetes Self Management Education (Dsme) For High-Need Appalachian Clients, Frances J. Feltner, Willie Bates

Center of Excellence in Rural Health Presentations

Objective

Examine effectiveness of CHWs in supporting a nurse-led DSME intervention among clients who are characterized by high rates of poverty and poor education.

Methods

Study Population/Research Design: New Kentucky Homeplace clients (3,217) ages 18-65+ from a 26-county study area who were processed prior to study starting date July 1, 2011. The 30.6% (983) of clients who had been told by a health professional they were diabetic, could speak English, and were willing to sign IRB consent were eligible to participate. Women who were diagnosed with diabetes during pregnancy were not eligible. Clients were able to enroll on a first-come …

An Exploration Of The Barriers To Diabetes Management Among West African Immigrants In The United States, Oluseyi Grace Abioye-Akanji

Master's Theses, Dissertations, Graduate Research and Major Papers Overview

Purpose: To explore the barriers to diabetes management among West African immigrants living in Rhode Island. Study Design and Methods: Semi-structured interviews with adults (N=5); men (n=2), women (n=3), Nigerian (n=3), Liberian (n=1), and Ghanaian (n=1) ages ≥18 with Type 1 or Type 2 diabetes, living in Rhode Island. Demographic information of the participants was obtained using a questionnaire. Interviews were conducted by the researcher and lasted approximately 50 minutes, and were scheduled to accommodate participants’ needs. Interviews were audio-taped and statements of the study participants were recorded. Subjects were redirected to clarify responses when necessary. Content analysis and coding, …

Patient Perspectives Of Nutrition In Healthcare: An Exploratory Study, Matthew Gary Petersen

Undergraduate Honors Capstone Projects

Healthcare is one of the most debated and controversial issues facing our nation and the world today. From availability to affordability, healthcare influences the lives of millions of people daily. For more than a decade the World Health Organization has called for an integrated approach to improve global health by improving patient adherence to prescribed treatments. Despite this, very little improvement has been made in adherence trends since the 1980's. Some current research has focused on improved adherence through an understanding of the patient's perspective of healthcare. By understanding how the patient sees healthcare, physicians are able to provide more …

Cardiovascular Disease Among Diabetic Women With Bilateral Oophorectomy., Duke Appiah

Electronic Theses and Dissertations

Cardiovascular Disease (CVD) is the leading cause of death in women and the risk is increased threefold in diabetics. In postmenopausal diabetics, the ovary responds to hyperinsulinemia by increasing secretion of testosterone precursors which increases the risk of CVD. Data from the National Health and Nutrition Examination Survey (1988-2010) and the Study of Osteoporotic Fractures were used to test the hypothesis that a history of bilateral oophorectomy -surgical removal of both ovaries-would decrease the risk of CVD among postmenopausal diabetic women due to reduced androgen levels. Logistic regression, discrete time logit model, B-Spline regression and Cox proportional hazards models were …

Long-Term Effects Of Increased Dietary Polyunsaturated Fat From Walnuts On Metabolic Parameters In Type Ii Diabetes, Cassandra Quick, Marijka Batterham, Linda Tapsell, Lynda Gillen, Karen Charlton, Sze Yen Tan, Grigorijs Teuss, Sayne Mam Dalton

Karen E. Charlton

Background/Objectives: Most dietary interventions have metabolic effects in the short term, but long-term effects may require dietary fat changes to influence body composition and insulin action. This study assessed the effect of sustained high polyunsaturated fatty acids (PUFA) intake through walnut consumption on metabolic outcomes in type II diabetes.Subjects/Methods: Fifty overweight adults with non-insulin-treated diabetes (mean age 54±8.7 years) were randomized to receive low-fat dietary advice ±30 g per day walnuts targeting weight maintenance (around 2000 kcal, 30% fat) for 1 year. Differences between groups were assessed by changes in anthropometric values (body weight, body fat, visceral adipose tissue) and …

Obesity Indicators By Race/Ethnicity For Diagnosis Of Cardiometabolic Diseases For A Us Representative Sample Of Adults, Joan A. Vaccaro, Fatma G. Huffman

Department of Dietetics and Nutrition

Background: Obesity, a growing epidemic, is a preventable risk factor for cardiometabolic diseases. Obesity and cardiometabolic diseases affect Hispanics and African Americans more than non-Hispanic Caucasians. This study examined the relationship among race/ethnicity, obesity diagnostic measures (body mass index, waist circumference, subscapular and triceps skinfold thickness), and cardiometabolic risk factors (hyperglycemia, high, non-high-density lipoprotein cholesterol, low, high-density lipoprotein cholesterol, and hypertension) for adults across the United States.

Methods: Using data from two-cycles of the National Health and Examination Survey (NHANES) 2007-2010, and accounting for the complex sample design, logistic regression models were conducted comparing obesity indicators in Mexican Americans, other …