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Articles 1 - 2 of 2
Full-Text Articles in Medicine and Health Sciences
Coronary Artery Remodeling In A Model Of Left Ventricular Pressure Overload Is Influenced By Platelets And Inflammatory Cells, Fanmuyi Yang, Anping Dong, Paul Mueller, Jessica Caicedo, Alyssa Moore Sutton, Juliana Odetunde, Cordelia J. Barrick, Yuri M. Klyachkin, Ahmed Abdel-Latif, Susan S. Smyth
Coronary Artery Remodeling In A Model Of Left Ventricular Pressure Overload Is Influenced By Platelets And Inflammatory Cells, Fanmuyi Yang, Anping Dong, Paul Mueller, Jessica Caicedo, Alyssa Moore Sutton, Juliana Odetunde, Cordelia J. Barrick, Yuri M. Klyachkin, Ahmed Abdel-Latif, Susan S. Smyth
Internal Medicine Faculty Publications
Left ventricular hypertrophy (LVH) is usually accompanied by intensive interstitial and perivascular fibrosis, which may contribute to arrhythmogenic sudden cardiac death. The mechanisms underlying the development of cardiac fibrosis are incompletely understood. To investigate the role of perivascular inflammation in coronary artery remodeling and cardiac fibrosis during hypertrophic ventricular remodeling, we used a well-established mouse model of LVH (transverse aortic constriction [TAC]). Three days after pressure overload, macrophages and T lymphocytes accumulated around and along left coronary arteries in association with luminal platelet deposition. Consistent with these histological findings, cardiac expression of IL-10 was upregulated and in the systemic circulation, …
Chop Mediates Endoplasmic Reticulum Stress-Induced Apoptosis In Gimap5-Deficient T Cells, Steven Pino, Bryan O'Sullivan-Murphy, Erich Lidstone, Chaoxing Yang, Kathryn Lipson, Agata Jurczyk, Philip Diiorio, Michael Brehm, John Mordes, Dale Greiner, Aldo Rossini, Rita Bortell
Chop Mediates Endoplasmic Reticulum Stress-Induced Apoptosis In Gimap5-Deficient T Cells, Steven Pino, Bryan O'Sullivan-Murphy, Erich Lidstone, Chaoxing Yang, Kathryn Lipson, Agata Jurczyk, Philip Diiorio, Michael Brehm, John Mordes, Dale Greiner, Aldo Rossini, Rita Bortell
Philip J diIorio Jr
Gimap5 (GTPase of the immunity-associated protein 5) has been linked to the regulation of T cell survival, and polymorphisms in the human GIMAP5 gene associate with autoimmune disorders. The BioBreeding diabetes-prone (BBDP) rat has a mutation in the Gimap5 gene that leads to spontaneous apoptosis of peripheral T cells by an unknown mechanism. Because Gimap5 localizes to the endoplasmic reticulum (ER), we hypothesized that absence of functional Gimap5 protein initiates T cell death through disruptions in ER homeostasis. We observed increases in ER stress-associated chaperones in T cells but not thymocytes or B cells from Gimap5(-/-) BBDP rats. We then …