Medicine and Health Sciences Commons^™

Compound 49b: A Novel Beta-Adrenergic Receptor Agonist In The Treatment Of Diabetic Retinopathy, Kimberly Williams-Guy

Theses and Dissertations (ETD)

Diabetic retinopathy is the leading cause of blindness in working Americans. While there are therapeutic regimens for the disease, more effective methods are needed. We have previously shown that a non-specific beta-adrenergic receptor agonist, isoproterenol, was effective in preventing functional and morphological changes associated with diabetic retinopathy in the rat. Isoproterenol also produced left ventricle remodeling suggesting it entered the systemic circulation. We therefore synthesized various novel beta-adrenergic receptor compounds and screened these compounds in vitro for their ability to reduce markers of inflammation and apoptosis. Of the various compounds tested, Compound 49b was able to reduce both inflammation and …

Delayed Onset Muscle Soreness In People With Diabetes; Biomarkers And Nutritional Supplementation, Hani H. Al-Nakhli

Loma Linda University Electronic Theses, Dissertations & Projects

Exercise is important for controlling hemoglobin A1c, and maintaining proper glycemic control in people with diabetes. Exercise also increases the diabetics overall insulin sensitivity, and decreases their dependency on diabetes medication. However, people with diabetes are faced with metabolic and endothelial impairment, which could result in a prolonged sensation of muscle soreness following exercise. This would make it difficult for these people to sustain exercise regimes. Delayed-onset muscle soreness (DOMS) is a common problem in healthy individuals and in people who have diabetes. DOMS is a painful sensation experienced by individuals who have been recently inactive and then over-exercise. Yet, …

Prevalence And Incidence Rates Of Dementia And Cognitive Impairment No Dementia In The Mexican Population: Data From The Mexican Health And Aging Study, Silvia Mejía-Arango, Luis Miguel Gutierrez

School of Medicine Publications and Presentations

Objective

To estimate the prevalence and incidence of dementia and cognitive impairment without dementia (CIND) in the Mexican population.

Methods

The MHAS study is a prospective panel study of health and aging in Mexico with 7,000 elders that represent 8 million subjects nationally. Using measurements of cognition and activities of daily living of dementia cases and CIND were identified at baseline and follow up. Overall incidence rates and specific rates for sex, age and education were calculated.

Results

Prevalence was 6.1% and 28.7% for dementia and CIND, respectively. Incidence rates were 27.3 per 1,000 person-years for dementia and 223 per …

Age At Diagnosis Of Diabetes In Appalachia, Lawrence Barker, Robert Gerzoff, Richard Crespo, Molly Shrewsberry

Family and Community Health

Background

Appalachia is a region of the United States noted for the poverty and poor health outcomes of its residents. Residents of the poorest Appalachian counties have a high prevalence of diabetes and risk factors (obesity, low income, low education, etc.) for type 2 diabetes. However, diabetes prevalence exceeds what these risk factors alone explain. Based on this, the history of poor health outcomes in Appalachia, and personally observed high rates of childhood obesity and lack of concern about prediabetes, we speculated that people in Appalachia with diagnosed diabetes might tend to be diagnosed younger than their non-Appalachian counterparts.

Methods …

Race-Ethnicity As An Effect Modifier Of The Association Between Hbalc And Mortality In U.S. Adults Without Diagnosed Diabetes, Katharina G. Kehl, Hannes M. Findeisen, David W. Fardo, Dennis Bruemmer, David M. Mannino, Wayne T. Sanderson

David M. Mannino

Objective

HbAlc is increasingly appreciated as a risk factor for all-cause and cardiovascular disease (CVD) mortality in the non-diabetic population. In this study, we investigated the association between HbAlc and mortality with a particular focus on the impact of race–ethnicity.

Design

Cohort study.

Methods

We analyzed the association between HbAlc and all-cause and CVD mortality in 12 698 non-diabetic adults 20 years or older from the Third National Health and Nutrition Examination Survey using separate models for people of different race–ethnicity.

Results

In our stratified analyses, higher non-diabetic HbAlc levels were associated with all-cause and CVD mortality in non-Hispanic whites …

Association Study Of Candidate Gene Polymorphisms And Obesity In A Young Mexican-American Population From South Texas, Jorge Duran-Gonzalez, Ixiu Ortiz, Enrique Gonzales, Nicole Ruiz, Manti Ortiz, Arthur Gonzalez, Edna K. Sanchez, Eugenia Curet, Susan P. Fisher-Hoch, Anne R. Rentfro, Huiqi Qu, Saraswathy Nair

Health & Biomedical Sciences Faculty Publications and Presentations

Background and Aims

Obesity is increasingly a health problem and a risk factor for diabetes in young Mexican-American populations. Genetic association studies in older, mostly non-Hispanic populations have reported that polymorphisms in the candidate genes HSD11B1, CRP, ADIPOQ, PPARG, ANKK1, ABCC8 and SERPINF1 are associated with obesity or diabetes. We analyzed the polymorphisms rs846910, rs1205, rs1501299, rs1801282, rs1800497, rs757110 and rs1136287in these candidate genes, for association with obesity and metabolic traits in a young Mexican-American population from south Texas.

Methods

Genotyping of the seven common SNPs were performed by allelic discrimination assays in 448 unrelated Mexican Americans (median age = …

Quantifying Polypharmacy In Diabetes Patients In The U.S., Jing Tao

Theses and Dissertations

ix Objectives: To quantify polypharmacy and assess the socio-economic predictors of medication use and expenditure in diabetics. Methods: This study analyzed adult diabetes patients using a nationally representative sample in Medical Expenditure Panel Survey in 2006. Top ten most highly utilized drug classes were identified. Descriptive statistics were used to portray the patients’ medication utilization and spending. Generalized linear models were conducted to assess the socio-economic variants in drug use and spending. Results: On average, a diabetes patient had 45 prescriptions in 2006, for total annual spending of $3,161. A diabetes patient used drugs from 3.43 classes within top ten …

Image Processing – I: Automated System For Macula Detection In Digital Retinal Images, Maryam Mubbashar, Anam Usman, M. Usman Akram

International Conference on Information and Communication Technologies

In the field of medicines, medical image processing plays a vital role to detect the abnormalities of eye or eye diseases like glaucoma and diabetic retinopathy. Macular degeneration is one of the medical conditions that affect the vision of elder people. If not detected in early stages it causes loss of eye sight. This paper presents an automated system for the localization and detection of macula in digital retinal images. In this paper, macula is first localized by making use of localized optic disc centre and enhanced blood vessels. Finally macula is detected by taking the distance from center of …

Appalachian Regional Model For Organizing And Sustaining County-Level Diabetes Coalitions, Richard Crespo, Molly Shrewsberry, Darrlyn Cornelius-Averhart, Henry B. King Jr.

Family and Community Health

This article describes a model for developing diabetes coalitions in rural Appalachian counties and presents evidence of their sustainability. The rural Appalachian coalition model was developed through a partnership between two federal agencies and a regional university. Coalitions go through a competitive application process to apply for one-time $10,000 grants. The project has funded 7 to 9 coalitions annually since 2001, reaching 66 total coalitions in 2008. Sustainability of the coalitions is defined by the number of coalitions that voluntarily report on their programs and services. In 2008, 58 of 66 (87%) coalitions in the Appalachian region continue to function …

Strength Training Improves Muscle Quality And Insulin Sensitivity In Hispanic Older Adults With Type 2 Diabetes, Naomi Brooks, Jennifer E. Layne, Patricia L. Gordon, Ronenn Roubenoff, Miriam E. Nelson, Carmen Castaneda-Sceppa

Carmen Castaneda-Sceppa

Hispanics are at increased risk of morbidity and mortality due to their high prevalence of diabetes and poor glycemic control. Strength training is the most effective lifestyle intervention to increase muscle mass but limited data is available in older adults with diabetes. We determined the influence of strength training on muscle quality (strength per unit of muscle mass), skeletal muscle fiber hypertrophy, and metabolic control including insulin resistance (Homeostasis Model Assessment –HOMA-IR), C-Reactive Protein (CRP), adiponectin and Free Fatty Acid (FFA) levels in Hispanic older adults. Sixty-two community-dwelling Hispanics (>55 y) with type 2 diabetes were randomized to 16 …

Interventions To Improve The Management Of Medically Uninsured Adult Patients With Type 2 Diabetes Mellitus In Primary Care, Community-Based Settings, Lynn Miskovich

Evidence-Based Practice Project Reports

This project measured the effect of a clinical algorithm on the provision of care to medically uninsured adult patients with type 2 diabetes and a low socioeconomic status (SES). Primary providers often fail to implement established standards for diabetes care to their maximal benefit and do not achieve American Diabetes Association (ADA) treatment standards. Saydah, et al. (2004) reported that only 48% of patients with diabetes achieved the recommended HbA1c goal, and 33% reached blood pressure and LDL targets. Goals for all three clinical parameters were obtained by only 7% of patients. The Stetler Model of Evidence-based Practice (EBP) provided …

Strategies To Reduce Disease Burden From Diabetes And Hypertension In Developing World, Waris Qidwai

Department of Family Medicine

No abstract provided.

Medical School Watercooler Newsletter - April 10, 2011, Lindsey Lyle

Watercooler Newsletter

This is the April 10, 2011 edition of the Frederick P. Whiddon College of Medicine's newsletter - Watercooler

Contents Include

• April Med School Café - Potential Cures for Type I Diabetes

• USA Welcomes Pediatrics Practice Director

• Lectures Slated Honoring Legacy of Two of Mobile's Surgeons

• Preliminary Recommendations Released for New Version of MCAT

• USA College of Medicine Hosts 25th Anniversary BEAR Reunion

• Next Week's DSS - Dr. M. Celeste Simon

An Extensible Mathematical Model Of Glucose Metabolism, Caleb L. Adams

Mathematics & Statistics Theses & Dissertations

The American Diabetes Association reports that diabetes is the fifth leading cause of death by disease in the United States. An estimated 23.6 million individuals, or seven percent of the population, have diabetes. Nearly one-third are unaware that they have the disease. The total of the direct and indirect medical costs associated with diabetes in 2007 was projected to be $174 billion, or approximately one out of every ten health care dollars.

One must understand the glucose regulatory system of the healthy body to understand diabetes. Blood glucose concentration returns to a constant level after eating and is maintained during …

Identifying Postpartum Intervention Approaches To Preventing Type 2 Diabetes In Women With A History Of Gestational Diabetes, Jacinda M. Nicklas, Chloe A. Zera, Ellen W. Seely, Zainab S. Abdul-Rahim, Noelle D. Rudloff, Sue E. Levkoff

Faculty and Staff Publications

Background: Women who develop gestational diabetes mellitus (GDM) have an increased risk for the development of type 2 diabetes. Despite this "window of opportunity," few intervention studies have targeted postpartum women with a history of GDM. We sought perspectives of women with a history of GDM to identify a) barriers and facilitators to healthy lifestyle changes postpartum, and b) specific intervention approaches that would facilitate participation in a postpartum lifestyle intervention program.

Methods: We used mixed methods to gather data from women with a prior history of GDM, including focus groups and informant interviews. Analysis of focus groups relied on …

Beliefs About Racism And Health Among African American Women With Diabetes: A Qualitative Study, Julie A. Wagner, Lisa M. Budris, Sophia Belay, Howard A. Tennen

UCHC Articles - Research

Exposure to racism has been linked to poor health outcomes. Little is known about the impact of racism on diabetes outcomes. This study explored African American (AA) women’s beliefs about how racism interacts with their diabetes self-management and control. Four focus groups were conducted with a convenience sample of 28 adult AA women with type 2 diabetes who were recruited from a larger quantitative study on racism and diabetes. The focus group discussions were transcribed verbatim and analyzed by the authors. Women reported that exposure to racism was a common phenomenon, and their beliefs did in fact link racism to …

Improving Diabetic Outcomes With Caring Communication: Identifying Communication Patterning For The Human Diabetic, James R. Kennett Phd

Dissertations

Introduction. The purpose of this study was to identify the influence of caring communication for people living with diabetes (PLD) and the relationship to diabetic outcomes. Caring communication has not been studied for improving diabetic outcomes. Randomized control trials (RCTs) direct care, however people do not do what they told, they need to be included in their care. PLD need a voice to establish what is important to them. Incorporating medical, communication, and nursing science as multidisciplinary approach within a theoretical framework can be predictive diabetic outcomes. Methods. A correlational cross sectional survey design study was done. A sample of …

Vitamin D Levels And Risk Of Dyslipidemia Among Us Children With Diabetes And Obesity, Elsina E. Hagan

Masters Theses 1911 - February 2014

Dyslipidemia is increasing among U.S. children, and the prevalence is highest among children with diabetes and obesity. Recently, vitamin D deficiency has been suggested as a possible dietary risk factor for dyslipidemia. Despite the high prevalence of vitamin D deficiency amongst children, virtually no studies have evaluated the association between vitamin D and dyslipidemia among children. We evaluated the vitamin D and dyslipidemia relationship among 240 children and adolescents aged 2 through 21 years who were outpatients of a pediatric endocrinology unit at a large tertiary care facility in Western Massachusetts from April 2008 to April 2010. Eligible children were …

Diabetes Understanding Among Staff Nurses: Examining The Actual Versus Perceived Knowledge In The Acute Care Setting, Rebecca B. Ledbetter

Nursing Theses and Capstone Projects

Diabetes is the fourth leading cause of death world-wide claiming a staggering 3.8 million lives globally each year to related complications (World Health Organization, 2011). Diabetes complications account for 20% of all acute care admissions or 1 in every 5 patients have a diabetes-related condition (American Diabetes Association, 2011). Patient education in the areas of lifestyle modification, healthy eating habits, and proper medication administration is research-supported to clinically decrease the likelihood of acute complications. Bedside, acute care nurses are at the front line of patient education delivery and have the opportunity to determine behavioral stages related to a patient's readiness …

A Comparison Of Patient And Nurse Perception Of Problem Areas Associated With Type 2 Diabetes, Kelley Oglesby

Nursing Theses and Capstone Projects

The purpose of the study was to explore the difference in problem areas perceived and reported by patients with type 2 diabetes and registered nurses caring for patients with type 2 diabetes. Diabetes affects a large number of patients both physically and fiscally. Decreasing perception of problems by nurse case management intervention has the potential to adversely affect patients. A convenience sample of 20 patients and 10 nurses was obtained and completed the Problem Areas in Diabetes (PAID) questionnaire. Statistical analysis found a significant difference in perception of problems among patients and nurses.

The Association Between Neighborhood Walkability, Type 2 Diabetes, And Socioeconomic Status In Residents Of Eight Ohio Counties, Dawn L. Ebron

Master of Public Health Program Student Publications

Objective: Regular physical activity is beneficial in preventing type 2 diabetes. Walking, either for recreation or to travel to a destination, is an inexpensive way to meet physical activity guidelines. Disadvantaged populations with low socioeconomic status (SES) have a higher prevalence of type 2 diabetes and are more likely to live in unwalkable neighborhood. The purpose of this study was to determine the association between SES and neighborhood walkability in eight Ohio counties with highest prevalence of type 2 diabetes in the state.

Methods: Using data from the 2010 Ohio Behavioral Risk Factor Surveillance System (BRFSS) survey and Walk Score …

Mechanisms That Regulate Peripheral Immune Responses To Control Organ Specific Autoimmunity, Gerard F. Hoyne

Health Sciences Papers and Journal Articles

The immune system must balance the need to maintain a diverse repertoire of lymphocytes to be able to fight infection with the need to maintain tolerance to self proteins. The immune system places strict regulation over the ability of T cells to produce the major T cell growth factor interleukin 2 as this cytokine can influence a variety of immune outcomes. T cells require the delivery of two signals one through the antigen receptor and a second through the costimulatory receptor CD28. The immune system uses a variety of E3 ubiquitin ligases to target signaling proteins that function downstream of …

Pilot Study: Barriers To Whole Grain Consumption Among Diabetics Of German Heritage, Nicole Erickson

Master's Theses and Doctoral Dissertations

Whole grains play a cost-effective role in the treatment and prevention of type 2 diabetes, yet consumption remains well below recommendations. This pilot study showed that nonfamilial environmental factors have a strong influence on whole grain consumption among type 2 diabetics of German descent. Dietary records and grain questionnaires were used to probe subjects’ knowledge of the benefits of whole grains, reasons for grain preferences, and actual consumption. For this population (n=18), mean whole grain consumption ( = 48±30 g/d = 3±2 servings/d) was much higher than the national average (μ ≤ 1 serving/d). Misunderstanding of labels negatively influenced whole …

The Influence Of Antidiabetic Medications On The Development And Progression Of Prostate Cancer, Anna Elizabeth Hitron

University of Kentucky Master's Theses

The development of prostate tumors has been linked to co-morbid diabetes mellitus (DM) in several studies, potentially through the stimulation of insulin-like growth factor receptor (IGFR). This study evaluates the effect of anti-diabetic medication use on the development of high grade tumors and time to tumor progression compared to non-diabetics. This retrospective, nested case control study identified patients with prostate cancer (PCa) from the Kentucky Medicaid Database. Cases were diagnosed with PCa and DM and using at least one of the following antidiabetic medications; sulfonylureas, insulin, metformin or TZDs. Cases were further stratified on their insulin exposure resulting from therapy. …

Mechanisms Of Translation Arrest Following Focal Brain Ischemia, Monique K. Lewis

Wayne State University Dissertations

MECHANISMS OF TRANSLATION ARREST FOLLOWING FOCAL BRAIN

ISCHEMIA

by

MONIQUE K. LEWIS

August 2011

Advisor: Dr. Donald DeGracia

Major: Physiology

Degree: Doctor of Philosophy

The loss of blood flow to the brain is termed ischemia and the subsequent resumption of blood flow is termed reperfusion. Brain ischemia and reperfusion (I/R) occurs primarily following resuscitation from cardiac arrest and stroke and presents one of the most significant clinical challenges. At present, there are no clinically effective pharmacologic interventions to halt brain damage following I/R. The major Aim of this dissertation will be to investigate possible mechanisms involved in neuron death following …

Effects Of Managed Care On The Health And Health-Care Of The Non-Elderly With Diabetes, Meihua Lu

Wayne State University Dissertations

This dissertation attempts to examine the quality effect of managed care plans (as compared with traditional fee-for-service plans, or FFS) on the health outcome and health care use of patients with diabetes. As the number of diabetics is growing rapidly with many of them are relying on managed care plans, knowing better the effects of different plans on health status and health care utilization is of great interest and significance to consumers, employers, and policymakers, especially at a time that universal health care is under being implemented.

Using up-to-date data from MEPS, a nationally representative survey, I compared 484 HMO …

Assessing Students' Risk Factors For Type Ii Diabetes At A Midwest Public University, Nicole Decourcy Ferrian

All Graduate Theses, Dissertations, and Other Capstone Projects

The purpose of this study was to assess students' risk factors for type II diabetes at a Midwest public university. It further examined students' perceived susceptibility, perceived severity, and self-efficacy of the disease. The design of the cross-sectional study was based on risk factors for type II diabetes listed by the American Diabetes Association and the Health Belief Model's constructs of perceived susceptibility, perceived seriousness, and self-efficacy. A survey was distributed to non-diabetic college students aged 18 and older enrolled in general education courses at a Midwest public university. A purposive sampling of 432 students enrolled in Health 101 and …

The Role Of Trib3 In Insulin Resistance: Its Action As Nutrient Sensor And Regulator Of Insulin Action, Jiarong Lamiquiz

All ETDs from UAB

THE ROLE OF TRIB3 IN INSULIN RESISTANCE: ITS ACTION AS NUTRIENT SENSOR AND REGULATOR OF INSULIN ACTION JIARONG LIU LAMIQUIZ PATHOLOGY ABSTRACT Insulin resistance is a hallmark of Type 2 diabetes (T2DM). A reduced capacity for insulin to stimulate increases in glucose uptake and glucose oxidation in insulin sensitive tissues, such as skeletal muscle and adipose tissue, are common defects in patients with insulin resistance, T2DM, and other related diseases. Tribbles homolog 3 (TRIB3) has been demonstrated to play a role in insulin resistance by serving as a negative regulator of Akt in mouse liver, fat, and pancreas. In a …

Vitamin D And Insulin Sensitivity Among African American And European American Adolescents And Adults, Jessica Alejandra Alvarez

All ETDs from UAB

Adequate vitamin D status is associated with a reduced risk for type 2 diabetes (T2DM); the relationship may be mediated by insulin sensitizing effects of vitamin D. African Americans (AA) are at a greater risk for T2DM and insulin resistance, as well as vitamin D deficiency, compared to European Americans (EA). The primary objective of this dissertation was to investigate the independent relationships of vitamin D with various measures of insulin sensitivity. Investigations were performed in a series of studies involving adolescent and adult female cohorts. The intravenous glucose tolerance test-derived insulin sensitivity index (SI) or the oral glucose tolerance …