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Articles 1 - 10 of 10
Full-Text Articles in Medicine and Health Sciences
Characterization Of Two Outer Membrane Proteins, Flgo And Flgp, That Influence Vibrio Cholerae Motility, Raquel M. Martinez, Madushini N. Dharmasena, Thomas J. Kirn, Ronald K. Taylor
Characterization Of Two Outer Membrane Proteins, Flgo And Flgp, That Influence Vibrio Cholerae Motility, Raquel M. Martinez, Madushini N. Dharmasena, Thomas J. Kirn, Ronald K. Taylor
Dartmouth Scholarship
Vibrio cholerae is highly motile by the action of a single polar flagellum. The loss of motility reduces the infectivity of V. cholerae, demonstrating that motility is an important virulence factor. FlrC is the sigma-54-dependent positive regulator of flagellar genes. Recently, the genes VC2206 (flgP) and VC2207 (flgO) were identified as being regulated by FlrC via a microarray analysis of an flrC mutant (D. C. Morris, F. Peng, J. R. Barker, and K. E. Klose, J. Bacteriol. 190:231-239, 2008). FlgP is reported to be an outer membrane lipoprotein required for motility that functions as a colonization factor. The study reported …
Il-9 As A Mediator Of Th17-Driven Inflammatory Disease, Elizabeth C. Nowak, Casey T. Weaver, Henrietta Turner, Sakhina Begum-Haque, Burkhard Becher, Bettina Schreiner, Anthony J. Coyle, Lloyd H. Kasper, Randolph J. Noelle
Il-9 As A Mediator Of Th17-Driven Inflammatory Disease, Elizabeth C. Nowak, Casey T. Weaver, Henrietta Turner, Sakhina Begum-Haque, Burkhard Becher, Bettina Schreiner, Anthony J. Coyle, Lloyd H. Kasper, Randolph J. Noelle
Dartmouth Scholarship
We report that like other T cells cultured in the presence of transforming growth factor (TGF) beta, Th17 cells also produce interleukin (IL) 9. Th17 cells generated in vitro with IL-6 and TGF-beta as well as purified ex vivo Th17 cells both produced IL-9. To determine if IL-9 has functional consequences in Th17-mediated inflammatory disease, we evaluated the role of IL-9 in the development and progression of experimental autoimmune encephalomyelitis, a mouse model of multiple sclerosis. The data show that IL-9 neutralization and IL-9 receptor deficiency attenuates disease, and this correlates with decreases in Th17 cells and IL-6-producing macrophages in …
Automated Identification Of Tumor Microscopic Morphology Based On Macroscopically Measured Scatter Signatures, Pilar Beatriz Garcia-Allende, Venkataramanan Krishnaswamy, P Jack Hoopes, Kimberley S. Samkoe, Olga M. Conde, Brian W. Pogue
Automated Identification Of Tumor Microscopic Morphology Based On Macroscopically Measured Scatter Signatures, Pilar Beatriz Garcia-Allende, Venkataramanan Krishnaswamy, P Jack Hoopes, Kimberley S. Samkoe, Olga M. Conde, Brian W. Pogue
Dartmouth Scholarship
An automated algorithm and methodology is presented to identify tumor-tissue morphologies based on broadband scatter data measured by raster scan imaging of the samples. A quasi-confocal reflectance imaging system was used to directly measure the tissue scatter reflectance in situ, and the spectrum was used to identify the scattering power, amplitude, and total wavelength-integrated intensity. Pancreatic tumor and normal samples were characterized using the instrument, and subtle changes in the scatter signal were encountered within regions of each sample. Discrimination between normal versus tumor tissue was readily performed using a K-nearest neighbor classifier algorithm. A similar approach worked …
Human Cerebral Neuropathology Of Type 2 Diabetes Mellitus, Peter T. Nelson, Charles D. Smith, Erin L. Abner, Frederick A. Schmitt, Stephen W. Scheff, Gregory J. Davis, Jeffrey N. Keller, Gregory A. Jicha, Daron Davis, Wang-Xia Wang, Adria Hartman, Douglas G. Katz, William R. Markesbery
Human Cerebral Neuropathology Of Type 2 Diabetes Mellitus, Peter T. Nelson, Charles D. Smith, Erin L. Abner, Frederick A. Schmitt, Stephen W. Scheff, Gregory J. Davis, Jeffrey N. Keller, Gregory A. Jicha, Daron Davis, Wang-Xia Wang, Adria Hartman, Douglas G. Katz, William R. Markesbery
Pathology and Laboratory Medicine Faculty Publications
The cerebral neuropathology of Type 2 diabetes (CNDM2) has not been positively defined. This review includes a description of CNDM2 research from before the ‘Pubmed Era’. Recent neuroimaging studies have focused on cerebrovascular and white matter pathology. These and prior studies about cerebrovascular histopathology in diabetes are reviewed. Evidence is also described for and against the link between CNDM2 and Alzheimer's disease pathogenesis. To study this matter directly, we evaluated data from University of Kentucky Alzheimer's Disease Center (UK ADC) patients recruited while non-demented and followed longitudinally. Of patients who had come to autopsy (N = 234), 139 met …
Paracrine Sonic Hedgehog Signalling By Prostate Cancer Cells Induces Osteoblast Differentiation, Samantha M Zunich, Taneka Douglas, Maria Valdovinos, Tiffany Chang
Paracrine Sonic Hedgehog Signalling By Prostate Cancer Cells Induces Osteoblast Differentiation, Samantha M Zunich, Taneka Douglas, Maria Valdovinos, Tiffany Chang
Dartmouth Scholarship
Sonic hedgehog (Shh) and components of its signalling pathway have been identified in human prostate carcinoma and increased levels of their expression appear to correlate with disease progression and metastasis. The mechanism through which Shh signalling could promote metastasis in bone, the most common site for prostate carcinoma metastasis, has not yet been investigated. The present study determined the effect of Shh signalling between prostate cancer cells and pre-osteoblasts on osteoblast differentiation, a requisite process for new bone formation that characterizes prostate carcinoma metastasis.
Corr4a And Vrt325 Do Not Reduce The Inflammatory Response To P. Aeruginosa In Human Cystic Fibrosis Airway Epithelial Cells, Laleh Talebian, Bonita Coutermarsh, Jacqueline Y. Channon, Bruce A. Stanton
Corr4a And Vrt325 Do Not Reduce The Inflammatory Response To P. Aeruginosa In Human Cystic Fibrosis Airway Epithelial Cells, Laleh Talebian, Bonita Coutermarsh, Jacqueline Y. Channon, Bruce A. Stanton
Dartmouth Scholarship
P. aeruginosa chronically colonizes the lung in CF patients and elicits a proinflammatory response. Excessive secretion of IL-6 and IL-8 by CF airway cells in response to P. aeruginosa infection in the CF airway is though to contribute to lung injury. Accordingly, the goal of this study was to test the hypothesis that Corr4a and VRT325, investigational compounds that increase ΔF508-CFTR mediated Cl− secretion in human CF airway cells, reduce the pro-inflammatory response to P. aeruginosa.
Ultrasound In Second Year Pathology Medical Education, Richard Hoppmann, Wylie E. Michell, John B. Carter, Carol Mcmahon, Patsy H. Lill, Noel A. Brownlee, Kevin A. Carnevale
Ultrasound In Second Year Pathology Medical Education, Richard Hoppmann, Wylie E. Michell, John B. Carter, Carol Mcmahon, Patsy H. Lill, Noel A. Brownlee, Kevin A. Carnevale
Journal of the South Carolina Academy of Science
No abstract provided.
Identification Of Different Protozoa Species From A Common Buzzard (Buteo Buteo), Özlem Özmen, Mehmet Haligür, Ramazan Adanir
Identification Of Different Protozoa Species From A Common Buzzard (Buteo Buteo), Özlem Özmen, Mehmet Haligür, Ramazan Adanir
Turkish Journal of Veterinary & Animal Sciences
An adult, female common buzzard (Buteo buteo) with paraplegia due to shooting wound on the sacral region was diagnosed with Leucocytozoon toddi, Haemoproteus elani, and Histomonas meleagridis. This is the first report of simultaneous naturally occurring Leucocytozoon toddi, Haemoproteus elani, and Histomonas meleagridis identification in a buzzard.
The Effect Of Seasonality On The Health And Growth Of A Newly Recorded Myxobolus Species Infecting Cultured Sharp Snout Seabream (Diplodus Puntazzo C.), Eleni Golomazou, Fotini Athanassopoulou, Eudokia Karagouni, Lambros Kokkokiris
The Effect Of Seasonality On The Health And Growth Of A Newly Recorded Myxobolus Species Infecting Cultured Sharp Snout Seabream (Diplodus Puntazzo C.), Eleni Golomazou, Fotini Athanassopoulou, Eudokia Karagouni, Lambros Kokkokiris
Turkish Journal of Veterinary & Animal Sciences
The prevalence, intensity, and pathology of a Myxobolus sp. affecting the kidneys of cultured Diplodus puntazzo C. during the period 2003-2005 are described. The study included data collected from the largest farm in southern Greece where a high rate of mortality due to myxosporean infection occurred. Sharp snout seabream reared in sea cages in southern Greece underwent microbiological, parasitological, and histological examinations, while measurement and identification of parasites was performed immediately after sampling. Samplings were made daily from winter 2003 to autumn 2005. Prevalence was estimated for each season (autumn, winter, spring, and summer) each year (2003, 2004, and 2005). …
Encephalitic Sarcocystosis And Its Prophylactic Treatment In Sheep, Özlem Özmen, Şi̇ma Şahi̇nduran, Mehmet Haligür, Bayram Ali̇ Yukari, Gerry M. Dorrestein
Encephalitic Sarcocystosis And Its Prophylactic Treatment In Sheep, Özlem Özmen, Şi̇ma Şahi̇nduran, Mehmet Haligür, Bayram Ali̇ Yukari, Gerry M. Dorrestein
Turkish Journal of Veterinary & Animal Sciences
The aim of this study was to examine the clinical and pathological findings in sheep naturally infected with severe encephalitic sarcocystosis and to evaluate the prophylactic effect of amprolium on the disease. From a flock of approximately 350 animals, 10 sheep were referred to the Veterinary Faculty Clinic with neurological symptoms that developed during the previous 2 weeks. These 10 sheep were clinically and pathologically examined, and the remaining animals in the flock without neurological symptoms were treated. All 10 animals were hypothermic, weak, and unable to stand. Complete blood count and serum biochemical analysis revealed mild leukocytosis, hypoglycemia, hyponatremia, …