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Full-Text Articles in Medicine and Health Sciences

Effect Of Repeated Dosing Of Delta 9-Tetrahydrocannabinol, The Major Psychoactive Ingredient Of Marijuana, On Memory In Mice, Floride Niyuhire Jan 2004

Effect Of Repeated Dosing Of Delta 9-Tetrahydrocannabinol, The Major Psychoactive Ingredient Of Marijuana, On Memory In Mice, Floride Niyuhire

Theses and Dissertations

Purpose: Marijuana is the most widely used illicit drug in the United States. However, marijuana and cannabinoid derivatives have potential therapeutic uses. Studies in cannabis users have yielded contradictory results with regard to long-term effects on cognitive functions. There is no prospective study assessing this issue, and such studies may raise ethical issues in humans, whereas mice have been shown to exhibit similar cannabinoid-mediated behaviors as humans. The purpose of this study was to assess the consequences of chronic administration of Δ9-THC, the major psychoactive component of marijuana, in a mouse memory model. Methods: In Experiment 1, the dose-response relationship …


Trans-Adaption Of Successful Cigarette Smoking Intervention To Randomised School-Based Cannabis Intervention Trial, Child Health Promotion Unit, Edith Cowan University Jan 2004

Trans-Adaption Of Successful Cigarette Smoking Intervention To Randomised School-Based Cannabis Intervention Trial, Child Health Promotion Unit, Edith Cowan University

Research outputs pre 2011

Despite the emergence of cannabis use as a public health issue of significance in the 21st Century, no school-based interventions specifically addressing cannabis use have been reported in the literature. The prevalence of adolescent cannabis use has risen during the 1990s while the age of onset has decreased. This three-year trial seeks to trans-adapt a successful school-based cigarette smoking program underpinned by harm minimisation (HM) theory (including abstinence messages), into a school-based cannabis intervention trial. This innovative intervention will be compared to the largely abstinence-based drug use prevention activities currently used in W A. The first and second years of …