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Mechanisms Of Glybenclamide-Mediated Anti-Arrhythmia And Ischemic Conditionining In A Rat Model Of Myocardial Infarction: Role Of Yohimbine Treatment, Ömer Bozdoğan, Ersöz Gonca, Eylem Suveren Ti̇ryaki̇, Fati̇h Gökçe

Turkish Journal of Medical Sciences

Glibenclamide (Glyburide), a widely used second-generation sulfonylurea hypoglycemic agent, is a known specific blocker of adenosine triphosphate (ATP) sensitive potassium (K+) channels. Although the blockage of the ATP dependent potassium channel reduces arrhythmia, it increases enfarct size. Yohimbine is an alpha-2 blocker that reduces infarct size as suggested by several studies. We hypothesized that a combination of yohimbine and glibenclamide may be more effective in reducing the arrhythmia following ligation. The arteria descendence (LAD) branch of the left coronary artery in conscious rats was ligated and arrhythmia was recorded during the 15 min following coronary ligation. Sixteen hours after coronary …