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Expression Analysis Of Dek, Af4 And Fli1 Genes In All-Trans-Retinoic Acid (Atra) Treated Acute Promyelocytic Leukaemia T(15;17) Patients By Quantitative Real-Time Pcr, Hakan Savli, Sema Sirma, Balint Nagy, Meli̇h Aktan, Günçağ Di̇nçol, Zafer Salcioğlu, Uğur Özbek
Expression Analysis Of Dek, Af4 And Fli1 Genes In All-Trans-Retinoic Acid (Atra) Treated Acute Promyelocytic Leukaemia T(15;17) Patients By Quantitative Real-Time Pcr, Hakan Savli, Sema Sirma, Balint Nagy, Meli̇h Aktan, Günçağ Di̇nçol, Zafer Salcioğlu, Uğur Özbek
Turkish Journal of Medical Sciences
All-trans retinoic acid (ATRA) sensitivity of acute promyelocytic leukaemia (APL) cells is strictly dependent on the presence of t(15;17), but the molecular background of this sensitivity remains obscure. We showed the down- regulation of DEK, AF4 and FLI1 genes in the vitamin D treatment of APL cell line HL-60 , using cDNA array technology in our previous study. This finding prompted us to investigate the expression of these genes in APL patient samples. The effect of ATRA was studied in 6 APL patients carrying t(15;17). Two samples from each patient were compared with a primary diagnostic sample and a sample …