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Stx1c Is The Most Common Shiga Toxin 1 Subtype Among Shiga Toxin-Producing Escherichia Coli Isolates From Sheep But Not Among Isolates From Cattle, Kim Brett, Vidiya Ramachandran, Michael A Hornitzky, Karl A Bettelheim, Mark J. Walker, Steven P. Djordjevic

Faculty of Science, Medicine and Health - Papers: part A

Unlike Shiga toxin 2 (stx₂) genes, most nucleotide sequences of Shiga toxin 1 (stx₁) genes from Shiga toxin-producing Escherichia coli (STEC), Shigella dysenteriae, and several bacteriophages (H19B, 933J, and H30) are highly conserved. Consequently, there has been little incentive to investigate variants of stx₁ among STEC isolates derived from human or animal sources. However stx_1OX3, originally identified in an OX3:H8 isolate from a healthy sheep in Germany, differs from other stx₁ subtypes by 43 nucleotides, resulting in changes to 12 amino acid residues, and has been renamed stx_{1c …}