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Articles 1 - 2 of 2
Full-Text Articles in Medicine and Health Sciences
Cancer-Induced Fatigue And Skeletal Muscle Wasting: The Role Of Exercise, Sadeeka Al-Majid, Donna O. Mccarthy
Cancer-Induced Fatigue And Skeletal Muscle Wasting: The Role Of Exercise, Sadeeka Al-Majid, Donna O. Mccarthy
College of Nursing Faculty Research and Publications
Fatigue is the most frequently reported symptom by cancer patients. Many of these patients perceive fatigue as the most distressing symptom associated with their illness because it imposes limitations on their physical activity level. Skeletal muscle wasting, which occurs as part of cancer cachexia, is one of the mechanisms that contribute to fatigue. Cancer induced skeletal muscle wasting may occur despite normal food intake and is not prevented by nutritional supplementation. Evidence suggests that endurance exercise ameliorates cancer-related fatigue. There is no compelling evidence to support that exercise induced reduction in fatigue is related to preservation of muscle mass. Resistance …
Expression Of The 8 Kda Heat Shock Protein (Ubiquitin) In Psoriasis, İbrahi̇m Pi̇ri̇m, Teoman Erdem, Necmetti̇n Akdeni̇z, Yaşar Nuri̇ Şahi̇n
Expression Of The 8 Kda Heat Shock Protein (Ubiquitin) In Psoriasis, İbrahi̇m Pi̇ri̇m, Teoman Erdem, Necmetti̇n Akdeni̇z, Yaşar Nuri̇ Şahi̇n
Turkish Journal of Medical Sciences
The 8kDa protein (ubiquitin) is a member of the small heat shock protein (hsb) family. Ubiquitin may additionally be involved in the pathogenesis of various diseases. Intracellular accumulation of ubiquitin has been detected in patients with neurodegenerative disease, brain ischemia, cancer, rheumatoid arthritis and haemodialysis. Sixteen biopsy samples from patients with psoriasis who were treated by PUVA and the same samples from these patients before PUVA treatment were investigated by immunohistochemistry on formalin-fixed paraffin- embedded tissue sections, using anti-ubiquitin antibody. In psoriatic epidermis, ubiquitin was mostly expressed in basal layers with a cytoplasmic staining pattern. Various cells of the dermis …